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Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy [article]

Sara Lorio, Jan Sedlacik, Po-Wah So, Harold G. Parkes, Roxana Gunny, Ulrike Loebel, Yao-Feng Li, Emma Dixon, Sophie Adler, J. Helen Cross, Torsten Baldeweg, Thomas S. Jacques (+2 others)
2020 biorxiv/medrxiv   pre-print
AbstractObjectiveMalformations of cortical development (MCD), including focal cortical dysplasia (FCD), are the most common cause of drug-resistant focal epilepsy in children.  ...  /sub-cortical tissue alterations in MCD lesions and in particular that χ changes in FCDIIb lesions were consistent with reduced iron, co-localised with low myelin and increased calcium and zinc content  ...  Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi: 10.1016/j.neuroimage.2021.118102 .  ... 
doi:10.1101/2020.09.15.20157123 fatcat:mq2vb2p4xzcbvjqg3khe4zvqlm

Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy

Sara Lorio, Jan Sedlacik, Po-Wah So, Harold G. Parkes, Roxana Gunny, Ulrike Löbel, Yao-Feng Li, Olumide Ogunbiyi, Talisa Mistry, Emma Dixon, Sophie Adler, J. Helen Cross (+4 others)
2021 NeuroImage  
Malformations of cortical development (MCD), including focal cortical dysplasia (FCD), are the most common cause of drug-resistant focal epilepsy in children.  ...  Synchrotron radiation X-ray fluorescence (SRXRF) was performed on brain tissue resected from 4 patients to map changes in iron, calcium and zinc and relate them to MRI parameters.  ...  Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi: 10.1016/j.neuroimage.2021.118102 .  ... 
doi:10.1016/j.neuroimage.2021.118102 pmid:34058334 fatcat:xkwpebkiejghffwuf2ptuppcvq

46th Annual Congress of the Canadian Neurological Sciences Federation

2011 Canadian Journal of Neurological Sciences  
Nanoparticles were assessed for MRI labelling of the brain for a period of 3 weeks, and the contrast persisted in location over this time period and could be distinguished with MRI from iron associated  ...  Global volumes of each tissue revealed no change up to age of 50-59 group and decline afterward.  ...  already listed in the previous table, those too general to be informative, and those not reasonably associated with the use of the drug.  ... 
doi:10.1017/s0317167100017078 fatcat:ls3brekxcnd75hsemllula2duq

Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience: Eilat, Israel, November 25–27, 2007

2007 Neural Plasticity  
Both the number of members of the society and those participating in the annual meeting is constantly increasing, and it is anticipated that this year about 600 scientists will convene at the Princess  ...  The Israel Society for Neuroscience—ISFN—was founded in 1993 by a group of Israeli leading scientists conducting research in the area of neurobiology.  ...  The effects of music background on sleep efficiency, anxiety and depression in Schizophrenia patients  ... 
doi:10.1155/2007/30585 pmid:25148070 pmcid:PMC2366074 fatcat:u4tjfw6shnaxpnzwezieeiqnpm

American Association of Neuropathologists, Inc. Abstracts of the 88th Annual Meeting June 21–24, 2012 Chicago, IL

2012 Journal of Neuropathology and Experimental Neurology  
Conclusions: Primary GBMO is a subgroup of GBM associated with longer survival and a younger age group but shows no difference in the frequency of LOH of 1p/19q, MGMT and IDH1 mutation compared with other  ...  Methods: We examined 288 cases of primary GBM and assessed the molecular markers in 57 GBMO and 50 cases of other primary GBM, correlating the data with clinical parameters and outcome.  ...  CONCLUSIONS: Our study reveals an association between cortical malformation and medically intractable epilepsy in children with SWS.  ... 
doi:10.1097/nen.0b013e31825c0526 fatcat:ar5fg5erg5dxffwuyjhyuau7zi

Abstracts of the 15th Annual Meeting of the Israel Society for Neuroscience (Eilat, Israel, December 3–5, 2006)

2007 Neural Plasticity  
Both the number of members of the society and of those participating in the annual meeting is constantly increasing, and it is anticipated that this year about 600 scientists will convene at the Princess  ...  The Israel Society for Neuroscience (ISFN) was founded in 1993 by a group of Israeli leading scientists conducting research in the area of neurobiology.  ...  Acknowledgments: we thank Yael Handler, Mor Nahum, and Sarit Szpiro for their contribution.  ... 
doi:10.1155/2007/73079 fatcat:6ttewkzqh5cmzb433ffyv3t5xi

Proceedings of the World Molecular Imaging Congress 2020, October 7-9, 2020: General Abstracts

2022 Molecular Imaging and Biology  
Results: In HGG xenografts, intratumoral distribution of pan800 correlated with the EGFR expression and the fluorescence signal.  ...  Age, combined with IDH-wildtype cerebral tumor, was predictive of positive EGFR protein expression in patients.  ...  channel (Fig. 1f , and red arrows): microvascular sprouting (D3-D6, Fig. 1j,k ), anastomoses and flow establishment (D7-D9), and development of sinusoidal vessels (D7-D15).  ... 
doi:10.1007/s11307-021-01691-0 pmid:34982363 pmcid:PMC8725637 fatcat:ipn7hwekzzh6nbsk6dr2mzuhhm

Abstracts from the 51st European Society of Human Genetics Conference: Oral Presentations

2019 European Journal of Human Genetics  
Few of the 140 loci displayed nominally significant associations with their target biomarker in the Greek and Ugandan samples. The polygenic scores were associated I. D'Atri 1 , L. Li 2 , X.  ...  In keeping with these findings, Clcc1 +/-KO mice displayed depressed electroretinogram and photoreceptor number.  ...  Multiple malformations of cortical development are associated with abnormal centrosomal protein function.  ... 
doi:10.1038/s41431-019-0407-4 fatcat:3d23n3msz5fulchpvpfipze6pq

Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts

2022 Molecular Imaging and Biology  
Results: In all of the phantom and patients' MRI studies the post-processed images proved to have higher resolution and contrast as compared with images reconstructed by conventional methods.  ...  In general, the values of CNR reached a plateau at around 8 iterations with an average improvement factor of about 1.7 for processed MRI images.  ...  The nanocluster system with a high selectivity showed the potential for fluorescence imaging and the integrating of gold and MMAE demonstrated excellent concurrent chemotherapy-radiotherapy efficacy, which  ... 
doi:10.1007/s11307-021-01693-y pmid:34982365 pmcid:PMC8725635 fatcat:4sfb3isoyfdhfbiwxfr55gvqym

Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters

2020 European Journal of Human Genetics  
Resistance to fatigue and muscle stiffness are considered risk factors for ACL injury.  ...  The aim of our study was to determine the influence of ACTN3 rs1815739 on ACL rupture in Italian, Japanese, Polish and Russian population samples.  ...  If the predominant presentation of patients is that of an epileptic encephalopathy including severe drug resistance, only some cases (4/26) with severe ID and treatable epilepsy with later age at onset  ... 
doi:10.1038/s41431-020-00741-5 pmid:33262486 fatcat:m6by7js7kfbi5ayebbpywf6ppu

https://dergipark.org.tr/anatomy/issue/44888/558887
Abstracts for the 17th Turkish Neuroscience Congress, 4–7 April 2019, Trabzon, Turkey

2019 Anatomy (International Journal of Experimental and Clinical Anatomy)  
mental map- model of experimental epilepsy.  ...  a role in Üsküdar University, Istanbul, Turkey drug metabolism, are changed by mutations that occur with SNPs, microsatellite repeats, insertion and deletion. 1/1000 Quantitative electroencephalography  ... 
doi:10.2399/ana.19.001s fatcat:cxihq27bmbcdzddf4xvqyudqsq

Abstracts of the 11th Annual Meeting of the Israel Society for Neuroscience

2002 Neural Plasticity  
More spe.cifically, results revealed siggificant differences between nsomniacs and good sleepers n learning, and in resistance to proactive interference, and close to significant in temporal memory.  ...  Thus, directed convergence combined with parallel growth of dendrites shapes the synaptie map in cultured neuronal networks.  ...  participating in resistance and susceptibility to glutamate toxicity Schori H. 1. and Schwartz M.  ... 
doi:10.1155/np.2002.65 pmid:12516548 pmcid:PMC2565399 fatcat:6o7uzh2mtfawdao4mzwue32m2y

Poster Presentations

2014 Acta Physiologica  
It not only maintains protein quality control but is also involved in critical cellular processes such as apoptosis, antigen presentation and the development of neurodegenerative and vascular diseases.  ...  Aim of this study was to examine the changes in the expression profile of multiple purinergic signaling molecules in leukocytes, particular different T cell subsets infiltrating the lung after acute lung  ...  This work was supported by the "Stiftung Rheinland-Pfalz für Innovation" (961-386261/957) and the "Research Initiative Membrane Biology".  ... 
doi:10.1111/apha.12270 fatcat:jeilsxhrmbddlkur2fpfckliwm

Detecting AGG Interruptions in Male and Female FMR1 Premutation Carriers by Single-Molecule Sequencing

Simon Ardui, Valerie Race, Alena Zablotskaya, Matthew S. Hestand, Hilde Van Esch, Koenraad Devriendt, Gert Matthijs, Joris R. Vermeesch
2017 Human Mutation  
Around 5% of NF1 children present with congenital bowing of a long bone resulting in fracture and pseudarthrosis (PA).  ...  Combined with the observation that NF1-PA is always localized in the same skeletal regions, suggests involvement of additional local factors in the development of NF1-PA.  ...  The MRI of the brain showed progressive cortical atrophy.  ... 
doi:10.1002/humu.23150 pmid:27883256 fatcat:qmpsup5qrvg5xaeiqzg4xcmwj4

ACRT-SCTS Scholar Abstracts

2010 Clinical and Translational Science  
In 1030 H, only younger age and low serum calcium were associated with the higher odds of vitamin D deficiency.  ...  METHODS AND POPULATION: We evaluated trends in admission for PN for all children <18yrs from 1985-2006 using the Office of Statewide Health Planning and Development database, a database that captures all  ...  The means of Calcium, Niacin, Zinc, Thiamin, Iron, Riboflavin, and vitamin B12 in our population when compared to the dietary reference intake recommendation means were significantly higher (p<0.05) SIGNIFICANCE  ... 
doi:10.1111/j.1752-8062.2010.00181_2.x fatcat:lwvd6nteozgezazejeqpjupawu
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