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Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema

Chia-Wen Chiang, Yong Wang, Peng Sun, Tsen-Hsuan Lin, Kathryn Trinkaus, Anne H. Cross, Sheng-Kwei Song
2014 NeuroImage  
We also examined the feasibility of applying 25-direction diffusion encoding scheme for DBSI analysis on coherent white matter tracts.  ...  Results from both phantom experiments and simulations suggested that the 25-direction diffusion scheme provided comparable DBSI estimation of both fiber diffusion parameters and extra-fiber cellularity  ...  This study was supported in part by the grants from National Institute of Health R01-NS047592 (S.  ... 
doi:10.1016/j.neuroimage.2014.06.064 pmid:25017446 pmcid:PMC4165711 fatcat:4b2lkncqznhvjouxfhiv7tupwa

Understanding the Physiopathology Behind Axial and Radial Diffusivity Changes—What Do We Know?

Pawel J. Winklewski, Agnieszka Sabisz, Patrycja Naumczyk, Krzysztof Jodzio, Edyta Szurowska, Arkadiusz Szarmach
2018 Frontiers in Neurology  
FigURe 1 | Example of maps computed from diffusion tensor imaging of the brain: (A) mean diffusivity, (B) axial diffusivity (λ║), (C) radial diffusivity (λ┴), and (D) fractional anisotropy. 2 Winklewski  ...  Interpretation of Axial and Radial Diffusivity Frontiers in Neurology | www.frontiersin.org February 2018 | Volume 9 | Article 92  ...  ACKnOwLeDgMenTS We would like to thank Agata Majewska for the excellent technical support, including preparation of figures.  ... 
doi:10.3389/fneur.2018.00092 pmid:29535676 pmcid:PMC5835085 fatcat:6kp7scprhvfjzpdppanfaul34e

The Impact of Edema and Fiber Crossing on Diffusion MRI Metrics: DBSI vs. Diffusion ODF [article]

Zezhong Ye, Sam E. Gary, Peng Sun, Sourajit Mitra Mustafi, George Russell Glenn, Fang-Cheng Yeh, Harri Merisaari, Guo-Shu Huang, Hung-Wen Kao, Chien-Yuan Lin, Yu-Chien Wu, Jens H. Jensen (+1 others)
2019 bioRxiv   pre-print
However, DTI is an inadequate simplification of diffusion modeling in the presence of co-existing inflammation, edema, and crossing nerve fibers.  ...  Lastly, we demonstrate DBSI's superiority over DTI for recovering and delineating white matter tracts in peritumoral edema for preoperative planning of surgical resection.  ...  INTRODUCTION Diffusion tensor imaging (DTI) does not accurately estimate diffusion parameters in the presence of extra-fiber pathology, e.g., edema and cell infiltration.  ... 
doi:10.1101/821082 fatcat:k6d4ap3wd5dh7krbwz54kejo5i

Current Clinical Brain Tumor Imaging

Javier E. Villanueva-Meyer, Marc C. Mabray, Soonmee Cha
2017 Neurosurgery  
Neuroimaging plays an ever evolving role in the diagnosis, treatment planning, and posttherapy assessment of brain tumors.  ...  The utility of both structural and physiological MRI in the post-therapeutic brain evaluation is also reviewed with special attention to the challenges presented by pseudoprogression and pseudoresponse  ...  tumor displacement of the adjacent white matter tracts (Figures 6 and 7) . 87, 88 FA represents the degree of directionality of water diffusion and in the normal brain reflects the presence of intact  ... 
doi:10.1093/neuros/nyx103 pmid:28486641 pmcid:PMC5581219 fatcat:oe6ltednajbl7abco255koy25i

Diffusion basis spectrum imaging in post-hemorrhagic hydrocephalus of prematurity [article]

Albert M. Isaacs, Jeffrey J. Neil, James P. McAllister, Sonika Dahiya, Leandro Castaneyra-Ruiz, Harri Merisaari, Haley E. Botteron, Dimitrios Alexopoulous, Ajit George, Sun Peng, Diego Morales, Yan Yan (+3 others)
2021 medRxiv   pre-print
White matter cellular infiltration occurred in all tracts.  ...  fibers to assess axonal and myelin integrity, fiber density, and extra-fiber pathologies including cellularity, edema, and inflammation.  ...  ACKNOWLEDGEMENTS We thank the IDDRC at Washington University for assistance with data collection; the children and their families for participating in the study, and we appreciate the support of our funding  ... 
doi:10.1101/2021.01.12.21249706 fatcat:iyve7mu76vd4jdobkqdace7dae

Diffusion-tensor imaging in brain tumors

Nail Bulakbaşı
2009 Imaging in Medicine  
Current applications of DTI and magnetic resonance tractography allow accurate delineation of the eloquent white matter tracts and their relation with tumoral tissue.  ...  REVIEW Diffusion-tensor imaging (DTI) is the only novel imaging technique that is able to demonstrate white matter tracts and their structural changes related to different brain pathologies.  ...  The color intensity is directly proportional to the amount of diffusional anisotropy. future science group Diffusion-tensor imaging in brain tumors REVIEW increased tumoral cellularity or tortuosity, which  ... 
doi:10.2217/iim.09.20 fatcat:yovyeye3pvd6rcvw763sp6rrai

Diffusion-weighted imaging: basic concepts and application in cerebral stroke and head trauma

Thierry A. G. M. Huisman
2003 European Radiology  
In addition, full-tensor DWI can evaluate the microscopic architecture of the brain, in particular white matter tracts, by measuring the degree and spatial distribution of anisotropic diffusion within  ...  DWI can differentiate between lesions with decreased and increased diffusion.  ...  of vasogenic edema.  ... 
doi:10.1007/s00330-003-1843-6 pmid:14534804 fatcat:ngpeargmt5csrdq3a4tcobjm4e

Update on brain tumor imaging: from anatomy to physiology

S Cha
2006 American Journal of Neuroradiology  
of collimated axonal bundles and myelin sheath create a unique situation to measure and tract fiber orientation, especially in large white matter tracts such as the corticospinal tract.  ...  along the white matter tracts.  ... 
pmid:16551981 pmcid:PMC7976984 fatcat:2czbv3ddpbghzcmyvc7qfp6oli

Diffusion MRI and the detection of alterations following traumatic brain injury

Elizabeth B. Hutchinson, Susan C. Schwerin, Alexandru V. Avram, Sharon L. Juliano, Carlo Pierpaoli
2017 Journal of Neuroscience Research  
The objective of this paper is to present a basic review and comparison across dMRI methods as they pertain to the detection of the most commonly observed tissue and cellular alterations following TBI.  ...  Furthermore, model dependencies and relative limitations may impact the implementation of these approaches and the interpretation of abnormalities in their metrics.  ...  in the parenchyma or extracellular fluid has increased (vasogenic edema).  ... 
doi:10.1002/jnr.24065 pmid:28609579 pmcid:PMC5729069 fatcat:5wmsqpm3tjfvjbv6abmob2s2u4

Current contribution of diffusion tensor imaging in the evaluation of diffuse axonal injury

Daphine Centola Grassi, David Macedo da Conceição, Claudia da Costa Leite, Celi Santos Andrade
2018 Arquivos de Neuro-Psiquiatria  
These changes can be seen in neuroimaging studies as hemorrhagic focal areas and diffuse edema.  ...  In such scenarios, diffuse tensor imaging (DTI) plays an important role because it provides further information on white matter integrity that is not obtained with standard magnetic resonance imaging sequences  ...  Diffusion weighted imaging shows hyperintensities in pathological conditions, such as in areas of high cellularity density (tumors), abnormal cellular uptake of water (cytotoxic edema) or entrapment of  ... 
doi:10.1590/0004-282x20180007 pmid:29809237 fatcat:ougge5n3z5dhrpzwwdvevmllau

Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice

Xiaojie Wang, Matthew F. Cusick, Yong Wang, Peng Sun, Jane E. Libbey, Kathryn Trinkaus, Robert S. Fujinami, Sheng-Kwei Song
2014 NMR in Biomedicine  
Diffusion tensor imaging-derived directional diffusivity and anisotropy indices have been applied to characterize white matter disorders.  ...  Lenaldekar greatly reduced relapse severity and protected white matter integrity in these experimental autoimmune encephalomyelitis mice.  ...  In addition, DBSI enables the estimation of increased cellularity (restricted diffusion) and vasogenic edema (hindered isotropic diffusion) associated with inflammation.  ... 
doi:10.1002/nbm.3129 pmid:24816651 pmcid:PMC4071074 fatcat:5tslqbdv3bdc5ki3skybjypmr4

Free water elimination and mapping from diffusion MRI

Ofer Pasternak, Nir Sochen, Yaniv Gur, Nathan Intrator, Yaniv Assaf
2009 Magnetic Resonance in Medicine  
We were able to segment the edema into areas according to the condition of the underlying tissue. In addition, the volume of free water is suggested as a new quantitative contrast of diffusion MRI.  ...  Applying the method on datasets from a healthy subject and a patient with edema yielded corrected DTI indices and a more complete tract reconstruction that passed next to the ventricles and through the  ...  FA was selectively increased for the edematous area that contained white matter tracts, but was not increased in the area of the tumor (contoured with yellow).  ... 
doi:10.1002/mrm.22055 pmid:19623619 fatcat:vx27rsoe6jh7rhyondwbw7myxu

Diffusion and perfusion weighted magnetic resonance imaging for tumor volume definition in radiotherapy of brain tumors

Lu Guo, Gang Wang, Yuanming Feng, Tonggang Yu, Yu Guo, Xu Bai, Zhaoxiang Ye
2016 Radiation Oncology  
This review examines recent studies that utilized diffusion and perfusion MRI for tumor volume definition in radiotherapy of brain tumors, and it presents the opportunities and challenges in the integration  ...  are important for the improvement of the correlation between histopathologic results and MRI parameter images.  ...  Availability of data and materials Not applicable.  ... 
doi:10.1186/s13014-016-0702-y pmid:27655356 pmcid:PMC5031292 fatcat:33qjhv3jj5fdlpwqmzhn5zk6ji

Differentiating Glioblastomas from Solitary Brain Metastases: An Update on the Current Literature of Advanced Imaging Modalities

Austin-John Fordham, Caitlin-Craft Hacherl, Neal Patel, Keri Jones, Brandon Myers, Mickey Abraham, Julian Gendreau
2021 Cancers  
In this review, we provide an update on all the current evidence regarding the identification and differentiation of glioblastomas from solitary brain metastases.  ...  Diffusion tensor imaging can be used to detect changes in mean diffusivity.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cancers13122960 fatcat:6atthw2llraojefyqv3fplbcqm

Advanced MRI of Adult Brain Tumors

Geoffrey S. Young
2007 Neurologic clinics  
depiction of the orientation and integrity of white matter tracts.  ...  Based on promising initial results in differentiating infiltrative tumor from vasogenic edema and in characterizing the extent of glioma white matter infiltration by FA, early reports of the development  ... 
doi:10.1016/j.ncl.2007.07.010 pmid:17964022 fatcat:vthna6mzq5a25p63hacllvcybu
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