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Assessment of a multi-layered diffuse correlation spectroscopy method for monitoring cerebral blood flow in adults

Kyle Verdecchia, Mamadou Diop, Albert Lee, Laura B. Morrison, Ting-Yim Lee, Keith St. Lawrence
2016 Biomedical Optics Express  
The method was first validated with phantom experiments. Next, experiments were conducted in a pig model of the adult head with a mean extracerebral tissue thickness of 9.8 ± 0.4 mm.  ...  Diffuse correlation spectroscopy (DCS) is a promising technique for brain monitoring as it can provide a continuous signal that is directly related to cerebral blood flow (CBF); however, signal contamination  ...  Another possibility to quantify blood flow indices measured by DCS is direct calibration by an all-optical modality [37] .  ... 
doi:10.1364/boe.7.003659 pmid:27699127 pmcid:PMC5030039 fatcat:5swwr7yalreubgeryvrbi6kccq

Imaging hemodynamic response after ischemic stroke in mouse cortex using visible-light optical coherence tomography

Siyu Chen, Qi Liu, Xiao Shu, Brian Soetikno, Shanbao Tong, Hao F. Zhang
2016 Biomedical Optics Express  
The sO 2 of vessels in the penumbra region also dropped below normal range after focal ischemia. optical imaging system for in vivo investigation of cerebral oxygen delivery and energy metabolism," Biomed  ...  Vis-OCT can retrieve blood oxygen saturation (sO 2 ) mapping using intrinsic optical absorption contrast while providing high-resolution anatomical vascular structures at the same time.  ...  Pulsinelli, "Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model," J. Cereb. Blood Flow Metab. 9(5), 589-596 (1989). 17. V. J. Srinivasan, J. Y.  ... 
doi:10.1364/boe.7.003377 pmid:27699105 pmcid:PMC5030017 fatcat:wggyhncbovdnlfnivltae6ebka

Assessment of the best flow model to characterize diffuse correlation spectroscopy data acquired directly on the brain

Kyle Verdecchia, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Keith St. Lawrence
2015 Biomedical Optics Express  
Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults," Neurocrit.  ...  instead of by the expected random flow model.  ...  Verdecchia was supported by a scholarship from a Queen Elisabeth II Graduate Scholarship in Science and Technology (QEII-GSST).  ... 
doi:10.1364/boe.6.004288 pmid:26600995 pmcid:PMC4646539 fatcat:phxgqzxbonad7luqhjg3bidy5q

Microvascular imaging: techniques and opportunities for clinical physiological measurements

John Allen, Kevin Howell
2014 Physiological Measurement  
tumour microenvironment, and quantifying cerebral blood flow.  ...  The cauterization process gave rise to a reduction in cerebral blood flow, followed by a transient increase in perfusion.  ... 
doi:10.1088/0967-3334/35/7/r91 pmid:24910968 fatcat:lsrpnj3l4rgjjmendyoejmqdl4


2013 Cerebrovascular Diseases  
Cerebral autoregulation is an important physiological mechanism that assists in maintaining cerebral blood flow relatively constant in the face of constantly changing blood pressure.  ...  The development of transcranial Doppler has allowed us to examine the response of cerebral flow velocity to beat by beat changes in blood pressure.  ...  Methods: We conducted a retrospective review, in a middle size clinic (120 beds), in Clínica Alemana de Temuco, involving patients who underwent ST with a protocol of 2 hours, associated to tPA, between  ... 
doi:10.1159/000351748 pmid:23712294 fatcat:kuw65edukrgkfdsnvwgsbj2r4m

This was the year that was: brain barriers and brain fluid research in 2019

Richard F. Keep, Hazel C. Jones, Lester R. Drewes
2020 Fluids and Barriers of the CNS  
This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and pressing needs.  ...  Topics include recent advances related to: the cerebral endothelium and the neurovascular unit; the choroid plexus, arachnoid membrane; cerebrospinal fluid and the glymphatic hypothesis; the impact of  ...  tau and this was reviewed in-depth by Hladky and Barrand [99] .  ... 
doi:10.1186/s12987-020-00181-9 pmid:32138786 fatcat:ueypzgfddjfsrg5fcccvfitvi4

Joint Meeting 2009 of the Society for Microcirculation and Vascular Biology (GfMVB) and the Swiss Society for Microcirculation (SSM)

2009 Journal of Vascular Research  
Methods: Transient focal cerebral ischemia was induced in G-CSF knock out mice by left middle cerebral artery occlusion (MCAO).  ...  P03-P23 rAAV-cotransfection of VEGF-A and PDGF-B induces therapeutic neovascularization in chronic hindlimb ischemia (rabbit) and resolves hibernating myocardium in a chronic pig model: role of vessel  ...  In conclusion, these data suggest that lymphatic drainage plays a pivotal role in mounting an adaptive immune response.  ... 
doi:10.1159/000245770 fatcat:u3zdqn6bcvhlhaqfda4my52jwy

19th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics. Rome, Italy, May10-13, 2014: Abstracts

2014 Cerebrovascular Diseases  
In the carotid sinus, in addition to the red laminar flow a blue coded area -so called flow separation zone -can be observed.  ...  Conclusion: Color-coded duplex ultrasonography is a valuable method in neurovascular diagnostics.  ...  as anatomic and time resolved contrast-enhanced MRA (TWIST).  ... 
doi:10.1159/000363090 pmid:24820383 fatcat:klgzz6jqb5cw7apjjr4mzpcjjy

Mechanics of the brain: perspectives, challenges, and opportunities

Alain Goriely, Marc G. D. Geers, Gerhard A. Holzapfel, Jayaratnam Jayamohan, Antoine Jérusalem, Sivabal Sivaloganathan, Waney Squier, Johannes A. W. van Dommelen, Sarah Waters, Ellen Kuhl
2015 Biomechanics and Modeling in Mechanobiology  
The multi-disciplinary analysis of these various phenomena and pathologies presents new opportunities and suggests that mechanical modeling is a central tool to bridge the scales by synthesizing information  ...  Despite a clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electro-I'll say that again, E = 2r .  ...  A first study evaluated visual evoked potentials in guinea pig optic nerves before and after stretch (Bain and Meaney 2000) .  ... 
doi:10.1007/s10237-015-0662-4 pmid:25716305 pmcid:PMC4562999 fatcat:fzay725anncctcjtuj2r2f2xfq


2011 Journal of Vascular Research  
PID is associated with cerebral blood flow (CBF) changes due to tight neurovascular coupling.  ...  changes in cortical membrane potential and CBF changes by multi-modal imaging of the rat cerebral cortex under multifocal ischemia caused by multiplex embolisation.  ...  This research was supported by and UrB of RAS (project 10-1-SP-257). J. Allen, J. R Frame and A. Murray Physiol.  ... 
doi:10.1159/000332604 fatcat:egmxzxdg6bcyhn7iuw3qmwnjmi

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  This study was funded by MINECO SAF2014-54070-JIN. Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ...  Arterial spin labeling was used to measure cerebral blood flow, dynamic contrast enhanced MRI to measure blood volume, and 18F-FDG-PET to measure cerebral glucose metabolism.  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

25th Conference of the European Society for Microcirculation. Budapest, Hungary, August 26–29, 2008

2008 Journal of Vascular Research  
any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specifi ed fee to the Copyright Clearance Center (see  ...  No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by  ...  in an increased local cerebral blood flow and a moderately increased density of large vessels resulting in a decrease in local cerebral blood flow.  ... 
doi:10.1159/000144991 fatcat:3nbmpjrvyvdrxaimpgurvmgl2i

Scientific paper sessions

2009 Neuroradiology  
In MB-EN, cortex isointensity was present on T2WI, a low signal on T1WI with marked enhancement (a central scar-like pattern), and a multinodular appearance.  ...  MATERIALS AND METHODS MR examinations and clinical and pathology reports from 4 institutions, for a total of 28 patients with histologically proven diagnosis of MB, were retrospectively analyzed.  ...  Perfusion maps of cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time were generated by the deconvolution method.  ... 
doi:10.1007/s00234-009-0561-4 fatcat:o5kffdrey5e7pp6rpqpvepbowy

Noninvasive imaging

2001 Journal of the American College of Cardiology  
In a subgroup of the pts with sinus rhythm (NSR) the LAA-EF was significantly less in pts with clot (31.2 + 13.2 Vs 41.2 + 11.5% p50% diameter stenosis.  ...  There are not enough studies properly evaluating LAA function in a large number of patients (pts) with isolated severe MS.  ...  Background: We have developed a new color 3D method for quantifying AR flow by subtracting forward mitral from forward Ao flow, which we have tested in a chronic animal model.  ... 
doi:10.1016/s0735-1097(01)80006-1 fatcat:ghklt3w3zze3le5gwnpbbfvrrm


2006 Neuroradiology  
This stent appears to be a valuable alternative to ballon-expandable coronary stents. O10.4  ...  A pulsatile flow circulation system was used. Embolic clots were produced using pig blood plasma.  ...  technique that dynamically resolves the time differences in contrast agent arrival.  ... 
doi:10.1007/s00234-006-0137-5 pmid:16932977 fatcat:sjmqiubb35gx7kxn4uofb732cq
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