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Vision-based Estimation of MDS-UPDRS Gait Scores for Assessing Parkinson's Disease Motor Severity [article]

Mandy Lu, Kathleen Poston, Adolf Pfefferbaum, Edith V. Sullivan, Li Fei-Fei, Kilian M. Pohl, Juan Carlos Niebles, Ehsan Adeli
2020 arXiv   pre-print
The physical severity of PD impairments can be quantified through the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), a widely used clinical rating scale.  ...  This is the first benchmark for classifying PD patients based on MDS-UPDRS gait severity and could be an objective biomarker for disease severity.  ...  The Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) [10] is the most commonly used method in clinical and research to assess the severity of these motor symptoms.  ... 
arXiv:2007.08920v1 fatcat:rzvzn3s7cjfgrbc372nhcoqwvi

A Clinically Interpretable Computer-Vision Based Method for Quantifying Gait in Parkinson's Disease

Samuel Rupprechter, Gareth Morinan, Yuwei Peng, Thomas Foltynie, Krista Sibley, Rimona S. Weil, Louise-Ann Leyland, Fahd Baig, Francesca Morgante, Ro'ee Gilron, Robert Wilt, Philip Starr (+2 others)
2021 Sensors  
Gait is a core motor function and is impaired in numerous neurological diseases, including Parkinson's disease (PD).  ...  The severity of gait impairment in Parkinson's disease can be estimated using a single patient video, recorded using a consumer mobile device and within standard clinical settings; i.e., videos were recorded  ...  We thank the team at Machine Medicine Technologies for labelling the videos with ROIs. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/s21165437 pmid:34450879 pmcid:PMC8399017 fatcat:o5zyo6vo2jg2faurjncqervts4

Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinson's disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: The 'Exenatide-PD3' study

Nirosen Vijiaratnam, Christine Girges, Grace Auld, Marisa Chau, Kate Maclagan, Alexa King, Simon Skene, Kashfia Chowdhury, Steve Hibbert, Huw Morris, Patricia Limousin, Dilan Athauda (+14 others)
2021 BMJ Open  
Assessments are performed at baseline, week 12, 24, 36, 48, 60, 72, 84 and 96 weeks.The primary outcome is the comparison of Movement Disorders Society Unified Parkinson's Disease Rating Scale part 3 motor  ...  IntroductionParkinson's disease (PD) is a common neurodegenerative disorder with substantial morbidity. No disease-modifying treatments currently exist.  ...  We thank the Cure Parkinson's Trust and Parkinson's UK for their assistance in the setup and increasing the awareness of this study. Contributors The study concept and design was conceived by TF.  ... 
doi:10.1136/bmjopen-2020-047993 pmid:34049922 fatcat:6dnsushckbarlin3kxsif6dvfu

Clinician versus machine: Reliability and responsiveness of motor endpoints in Parkinson's disease

Dustin A. Heldman, Alberto J. Espay, Peter A. LeWitt, Joseph P. Giuffrida
2014 Parkinsonism & Related Disorders  
Background-Enhancing the reliability and responsiveness of motor assessments required to demonstrate therapeutic efficacy is a priority for Parkinson's disease (PD) clinical trials.  ...  The objective of this study is to determine the reliability and responsiveness of a portable kinematic system for quantifying PD motor deficits as compared to clinical ratings.  ...  Acknowledgments This work was supported by NIH/NINDS under grant 1R43NS074627-01A1.  ... 
doi:10.1016/j.parkreldis.2014.02.022 pmid:24661464 pmcid:PMC4028404 fatcat:opbjyazw5bcxnnzsof3zo3bgw4

The Smart-Insole Dataset: Gait Analysis Using Wearable Sensors with a Focus on Elderly and Parkinson's Patients

Chariklia Chatzaki, Vasileios Skaramagkas, Nikolaos Tachos, Georgios Christodoulakis, Evangelia Maniadi, Zinovia Kefalopoulou, Dimitrios I. Fotiadis, Manolis Tsiknakis
2021 Sensors  
A neurologist specialized in movement disorders evaluated the performance of the participants by rating four items of the MDS-Unified Parkinson's Disease Rating Scale.  ...  disease.  ...  In our work, the MDS-UPDRS has been used as a guideline for the clinical examination of motor signs of Parkinson's Disease.  ... 
doi:10.3390/s21082821 pmid:33923809 pmcid:PMC8073163 fatcat:bd46qln32vdb3lvgmjyzsgyr2y

Reduction of spontaneous cortical beta bursts in Parkinson's disease is linked to symptom severity [article]

Mikkel C. Vinding, Panagiota Tsitsi, Josefine Waldthaler, Robert Oostenveld, Martin Ingvar, Per Svenningsson, Daniel Lundqvist
2019 bioRxiv   pre-print
of symptom severity in Parkinson's disease or evaluate treatment effectiveness.  ...  Importantly, our results also revealed a relationship between beta bursts rate and motor symptom severity in PD.  ...  later-stage Parkinson's disease) 32 or if they are due to uncertainties in the methods used to quantify beta activity.  ... 
doi:10.1101/775494 fatcat:cejiwwimm5dbtcxgwzg7wpsexu

How Wearable Sensors Can Support Parkinson's Disease Diagnosis and Treatment: A Systematic Review

Erika Rovini, Carlo Maremmani, Filippo Cavallo
2017 Frontiers in Neuroscience  
MDS-UPDRS (MDS-UPDRS III).  ...  The idea is to quantify the motor skills of the patients, finding a way to measure the items proposed in MDS-UPDRS III.  ...  This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fnins.2017.00555 pmid:29056899 pmcid:PMC5635326 fatcat:iizmav6sn5dxvbgkat2dm6mt6e

Smartphone-Based Evaluation of Postural Stability in Parkinson's Disease Patients During Quiet Stance

Luigi Borzì, Silvia Fornara, Federica Amato, Gabriella Olmo, Carlo Alberto Artusi, Leonardo Lopiano
2020 Electronics  
This tool can be used for early detection of PD motor signs, disease follow-up and fall prevention.  ...  Postural instability is one of the most troublesome motor symptoms of Parkinson's Disease (PD). It impairs patients' quality of life and results in high risk of falls.  ...  PS is clinically assessed following the MDS-UPDRS (Movement Disorder Society-Unified Parkinson's Disease Rating Scale) part-III recommendations [7] .  ... 
doi:10.3390/electronics9060919 fatcat:2uynfhvwqbco5oefol47whap5i

Innovative Performance Measurement: an Integrative Perspective of Stakeholder's View

Palmira López-Fresno, Fernando Fernández-González
2014 Nang Yan Business Journal  
The paper includes findings from an empirical case study of measuring Parkinson's Disease Neurosurgery process, including stakeholder's view with an integrative perspective.  ...  BPM involves the use of innovative performance measurement systems to follow up, coordinate, control and improve processes and overall business efficacy and efficiency.  ...  The research focused on quantifying effectiveness of Parkinson's disease neurosurgery DBS.  ... 
doi:10.2478/nybj-2014-0033 fatcat:n3gn3c6jijecrdntsdvrqxlk5y

Detecting Parkinson's Disease From an Online Speech-task [article]

Wasifur Rahman, Sangwu Lee, Md. Saiful Islam, Victor Nikhil Antony, Harshil Ratnu, Mohammad Rafayet Ali, Abdullah Al Mamun, Ellen Wagner, Stella Jensen-Roberts, Max A. Little, Ray Dorsey, Ehsan Hoque
2020 arXiv   pre-print
Using these features, we trained several machine learning algorithms.  ...  We achieved 0.75 AUC (Area Under The Curve) performance on determining presence of self-reported Parkinson's disease by modeling the standard acoustic features through the XGBoost -- a gradient-boosted  ...  (MDS-UPDRS) Goetz et al  ... 
arXiv:2009.01231v4 fatcat:avf2qyjekza7fkezz6zxdgpnqi

A Multi-layer Gaussian Process for Motor Symptom Estimation in People with Parkinson's Disease

Muriel Lang, Franz Pfister, Jacob Frohner, Kian Abedinpour, Daniel Pichler, Urban Fietzek, Terry Um, Dana Kulic, Satoshi Endo, Sandra Hirche
2019 IEEE Transactions on Biomedical Engineering  
We use clinically adopted severity measures as annotations for training the models, thus allowing our multi-layer Gaussian process prediction models to estimate not only their presence but also their severities  ...  Thus, a frequent and objective PD assessment is highly valuable for effective health management of people with Parkinson's disease (PwP).  ...  Commonly, the Movement Disorder Society sponsored Unified PD Rating Scale (MDS-UPDRS) is used, wherein motor symptoms are assessed on a 5-level rating scale [25] , [26] .  ... 
doi:10.1109/tbme.2019.2900002 pmid:30794163 fatcat:uueyb4fh3reybbzl4nk24u5lpq

Exercise- and strategy-based physiotherapy-delivered intervention for preventing repeat falls in people with Parkinson's: the PDSAFE RCT

Ann Ashburn, Ruth Pickering, Emma McIntosh, Sophia Hulbert, Lynn Rochester, Helen C Roberts, Alice Nieuwboer, Dorit Kunkel, Victoria A Goodwin, Sarah E Lamb, Claire Ballinger, Kim Chivers Seymour
2019 Health Technology Assessment  
Prespecified subgroup analysis (i.e. disease severity and FoG) revealed a PDSAFE differing effect; the intervention may be of benefit for people with moderate disease but may increase falling for those  ...  Objective To estimate the effect of a physiotherapy programme for fall prevention among people with Parkinson's disease.  ...  FES-I, FoG and MDS-UPDRS) is reported in Subgroup analysis In the statistical analysis plan, a subgroup analysis excluding participants with severe disease by virtue of a MDS-UPDRS score of ≥ 59 or H  ... 
doi:10.3310/hta23360 pmid:31339100 pmcid:PMC6680369 fatcat:b73uyq5djffz5of3iawgaenttq

Characterizing and Detecting Freezing of Gait using Multi-modal Physiological Signals [article]

Ying Wang, Floris Beuving, Jorik Nonnekes, Mike X Cohen, Xi Long, Ronald M Aarts, Richard Van Wezel
2020 arXiv   pre-print
under the Precision-Recall curve of 0.94+/-0.05.  ...  Freezing-of-gait a mysterious symptom of Parkinsons disease and defined as a sudden loss of ability to move forward.  ...  This work was strongly supported by Dutch Parkinson's disease Association (Parkinson Vereniging).  ... 
arXiv:2009.12660v1 fatcat:nw2mvrldfvbahpcnzjlsfzj5ni

Target-Specific Action Classification for Automated Assessment of Human Motor Behavior from Video [article]

Behnaz Rezaei, Yiorgos Christakis, Bryan Ho, Kevin Thomas, Kelley Erb, Sarah Ostadabbas, Shyamal Patel
2019 arXiv   pre-print
Objective monitoring and assessment of human motor behavior can improve the diagnosis and management of several medical conditions.  ...  Over the past decade, significant advances have been made in the use of wearable technology for continuously monitoring human motor behavior in free-living conditions.  ...  battery of clinical motor assessments from the Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS) [46] administered by a trained clinician with experience in movement disorders  ... 
arXiv:1909.09566v1 fatcat:prcmfivlzjgidflcpla3xqeopi

A Multi-layer Gaussian Process for Motor Symptom Estimation in People with Parkinson's Disease [article]

Muriel Lang, Franz M.J. Pfister, Jakob Fröhner, Kian Abedinpour, Daniel Pichler, Urban Fietzek, Terry T. Um, Dana Kulić, Satoshi Endo, Sandra Hirche
2018 arXiv   pre-print
We use clinically adopted severity measures as annotations for training the models, thus allowing our multi-layer Gaussian process prediction models to estimate not only their presence but also their severities  ...  Thus, a frequent and objective PD assessment is highly valuable for effective health management of people with Parkinson's disease (PwP).  ...  Several specific motor tasks of 10 patients with idiopathic PD were recorded using IMU sensors. Every task was rated by a movement disorder specialist according to the MDS-UPDRS rating scale.  ... 
arXiv:1808.10663v2 fatcat:ngjzrc26snbg3d7j42byzlria4
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