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Mitogen-Activated Protein Kinases and Hypoxic/Ischemic Nephropathy

Fengbao Luo, Jian Shi, Qianqian Shi, Xianlin Xu, Ying Xia, Xiaozhou He
2016 Cellular Physiology and Biochemistry  
Tissue hypoxia/ischemia is a pathological feature of many human disorders including stroke, myocardial infarction, hypoxic/ischemic nephropathy, as well as cancer. In the kidney, the combination of limited oxygen supply to the tissues and high oxygen demand is considered the main reason for the susceptibility of the kidney to hypoxic/ischemic injury. In recent years, increasing evidence has indicated that a reduction in renal oxygen tension/blood supply plays an important role in acute kidney
more » ... jury, chronic kidney disease, and renal tumorigenesis. However, the underlying signaling mechanisms, whereby hypoxia alters cellular behaviors, remain poorly understood. Mitogen-activated protein kinases (MAPKs) are key signaltransducing enzymes activated by a wide range of extracellular stimuli, including hypoxia/ ischemia. There are four major family members of MAPKs: the extracellular signal-regulated kinases-1 and -2 (ERK1/2), the c-Jun N-terminal kinases (JNK), p38 MAPKs, and extracellular signal-regulated kinase-5 (ERK5/BMK1). Recent studies, including ours, suggest that these MAPKs are differentially involved in renal responses to hypoxic/ischemic stress. This review will discuss their changes in hypoxic/ischemic pathophysiology with acute kidney injury, chronic kidney diseases and renal carcinoma.
doi:10.1159/000447812 pmid:27544204 fatcat:rbznyzjuhvemfmdopyfutpvwei

Semantic-aware Speech to Text Transmission with Redundancy Removal [article]

Tianxiao Han, Qianqian Yang, Zhiguo Shi, Shibo He, Zhaoyang Zhang
2022 arXiv   pre-print
Deep learning (DL) based semantic communication methods have been explored for the efficient transmission of images, text, and speech in recent years. In contrast to traditional wireless communication methods that focus on the transmission of abstract symbols, semantic communication approaches attempt to achieve better transmission efficiency by only sending the semantic-related information of the source data. In this paper, we consider semantic-oriented speech to text transmission. We propose
more » ... novel end-to-end DL-based transceiver, which includes an attention-based soft alignment module and a redundancy removal module to compress the transmitted data. In particular, the former extracts only the text-related semantic features, and the latter further drops the semantically redundant content, greatly reducing the amount of semantic redundancy compared to existing methods. We also propose a two-stage training scheme, which speeds up the training of the proposed DL model. The simulation results indicate that our proposed method outperforms current methods in terms of the accuracy of the received text and transmission efficiency. Moreover, the proposed method also has a smaller model size and shorter end-to-end runtime.
arXiv:2202.03211v1 fatcat:xmyou3btrbgcddmdats445rg7y

Semantic-preserved Communication System for Highly Efficient Speech Transmission [article]

Tianxiao Han, Qianqian Yang, Zhiguo Shi, Shibo He, Zhaoyang Zhang
2022 arXiv   pre-print
Deep learning (DL) based semantic communication methods have been explored for the efficient transmission of images, text, and speech in recent years. In contrast to traditional wireless communication methods that focus on the transmission of abstract symbols, semantic communication approaches attempt to achieve better transmission efficiency by only sending the semantic-related information of the source data. In this paper, we consider semantic-oriented speech transmission which transmits only
more » ... the semantic-relevant information over the channel for the speech recognition task, and a compact additional set of semantic-irrelevant information for the speech reconstruction task. We propose a novel end-to-end DL-based transceiver which extracts and encodes the semantic information from the input speech spectrums at the transmitter and outputs the corresponding transcriptions from the decoded semantic information at the receiver. For the speech to speech transmission, we further include a CTC alignment module that extracts a small number of additional semantic-irrelevant but speech-related information for the better reconstruction of the original speech signals at the receiver. The simulation results confirm that our proposed method outperforms current methods in terms of the accuracy of the predicted text for the speech to text transmission and the quality of the recovered speech signals for the speech to speech transmission, and significantly improves transmission efficiency. More specifically, the proposed method only sends 16% of the amount of the transmitted symbols required by the existing methods while achieving about 10% reduction in WER for the speech to text transmission. For the speech to speech transmission, it results in an even more remarkable improvement in terms of transmission efficiency with only 0.2% of the amount of the transmitted symbols required by the existing method.
arXiv:2205.12727v1 fatcat:s6tdxdqdyvgohmqt5vbi5fpjsm

Experimental research on impulse coupling effect of a multi-pulse laser on an aluminum target

Qianqian Shi Qianqian Shi, Yan Zhang Yan Zhang, Kunpeng Wang Kunpeng Wang, Chenglin Wang Chenglin Wang, Peng Zhao Peng Zhao
2018 Chinese Optics Letters (COL)  
Impact and torsion pendulums are applied in impulse coupling experiments of high-energy laser irradiation of space debris. It is difficult to achieve a multi-pulse experiment and thus hard to analyze the multi-pulse impulse coupling effect. Here, we designed a new recoil impulse experimental measurement system of non-contact, multidegrees of freedom, and multi-pulse irradiation. The system used a low-pressure and low-temperature vacuum chamber to simulate the space environment, the pinning
more » ... t of magnetic levitation to achieve aluminum target suspension, and high-speed cameras to record the displacement over time to calculate the impulse of the target. Then the impulse coupling experiment of multi-pulse laser irradiation on the aluminum target was performed. The result shows that the multi-pulse impulse coupling effect is not the linear accumulation of coupling results by every single-pulse and multi-pulse coefficient that decreases with the increase of the number of pulses, and eventually stabilizes as the decrease gets smaller.
doi:10.3788/col201816.121401 fatcat:44utwoqrmzeqbhfs5mhv3nzgxa

Direct imaging of liquid-nanoparticle interface with atom probe tomography [article]

Shi. Qiu, Changxi Zheng, Qi Zhou, Dashen Dong, Qianqian Shi, Vivek Garg, Shuo Zhang, Wenlong Cheng, Ross K.W. Marceau, Gang Sha, Jing Fu
2020 arXiv   pre-print
Understanding the structure and chemical composition at the liquid-nanoparticle (NP) interface is crucial for a wide range of physical, chemical and biological processes. In this study, direct imaging of the liquid-NP interface by atom probe tomography (APT) is reported for the first time, which reveals the distributions and the interactions of key atoms and molecules in this critical domain. The APT specimen is prepared by controlled graphene encapsulation of the solution containing
more » ... es on a metal tip, with an end radius in the range of 50 nm to allow field ionization and evaporation. Using Au nanoparticles (AuNPs) in suspension as an example, analysis of the mass spectrum and three-dimensional (3D) chemical maps from APT provides a detailed image of the water-gold interface with near-atomic resolution. At the water-gold interface, the formation of an electrical double layer (EDL) rich in water (H2O) molecules has been observed, which results from the charge from the binding between the trisodium-citrate layer and the AuNP. In the bulk water region, the density of reconstructed H2O has been shown to be consistent, reflecting a highly packed density of H2O molecules after graphene encapsulation. This study is the first demonstration of direct imaging of liquid-NP interface using APT with results providing an atom-by-atom 3D dissection of the liquid-NP interface.
arXiv:2005.08452v1 fatcat:ringwa3rxje4bhobb3ucmumf5m

Cooperative Evolutionary Game and Applications in Construction Supplier Tendency

Qianqian Shi, Jianbo Zhu, Qian Li
2018 Complexity  
Major construction projects have a great influence on the national economy and society, wherein cooperative relationship between construction suppliers plays an increasingly significant role in the overall supply chain system. However, the relationships between suppliers are noncontractual, multistage, dynamic, and complicated. To gain a deeper insight into the suppliers' cooperative relationships, an evolutionary game model is developed to explore the cooperation tendency of multisuppliers. A
more » ... eplicator dynamic system is further formulated to investigate the evolutionary stable strategies of multisuppliers. Then, fourteen "when-then" type scenarios are concluded and classified into six different evolutionary tracks. Meanwhile, the critical influencing factors are identified. The results show that the suppliers' production capacity, owner-supplier contract, and the owner's incentive mechanism influence the cooperation tendency of suppliers directly. The managerial implications contribute to insightful references for a more stable cooperative relationship between the owner and suppliers.
doi:10.1155/2018/8401813 fatcat:wmq423ynovhdlmchgctefrcr5q

The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function [article]

Yang Shi, Hao Chen, Zhennan Shi, Jiaojiao Guo, Kao-jung Chang, Qianqian Chen, Marcia Haigis, Conghui Yao
2019 bioRxiv   pre-print
Mitochondrial DNA (mtDNA) gene expression is coordinately regulated pre- and post-transcriptionally, and its perturbation can lead to human pathologies. Mitochondrial ribosomal RNAs (mt-rRNAs) undergo a series of nucleotide modifications following release from polycistronic mitochondrial RNA (mtRNA) precursors, which is essential for mitochondrial ribosomal biogenesis. Cytosine N4 methylation (m4C) at position 839 of the 12S small subunit (SSU) mt-rRNA was detected decades ago, however, its
more » ... enesis and function have not been elucidated in details. Here we demonstrate that human Methyltransferase Like 15 (METTL15) is responsible for 12S mt-rRNA m4C839 both in vivo and in vitro. We tracked the evolutionary history of RNA m4C methyltransferases and revealed the difference in substrates preference between METTL15 and its bacterial ortholog rsmH. Additionally, unlike the very modest impact on ribosome upon loss of m4C methylation in bacterial SSU rRNA, we found that depletion of METTL15 specifically causes severe defects in mitochondrial ribosome assembly, which leads to an impaired translation of mitochondrial protein-coding genes and a decreased mitochondrial respiration capacity. Our findings point to a co-evolution of methylatransferase specificities and modification patterns in rRNA with differential impact on prokaryotic ribosome versus eukaryotic mitochondrial ribosome.
doi:10.1101/809756 fatcat:cvrlmw2uq5fwlcnmphws2atdsu

Query Understanding for Natural Language Enterprise Search [article]

Francisco Borges, Georgios Balikas, Marc Brette, Guillaume Kempf, Arvind Srikantan, Matthieu Landos, Darya Brazouskaya, Qianqian Shi
2020 arXiv   pre-print
Natural Language Search (NLS) extends the capabilities of search engines that perform keyword search allowing users to issue queries in a more "natural" language. The engine tries to understand the meaning of the queries and to map the query words to the symbols it supports like Persons, Organizations, Time Expressions etc.. It, then, retrieves the information that satisfies the user's need in different forms like an answer, a record or a list of records. We present an NLS system we implemented
more » ... as part of the Search service of a major CRM platform. The system is currently in production serving thousands of customers. Our user studies showed that creating dynamic reports with NLS saved more than 50% of our user's time compared to achieving the same result with navigational search. We describe the architecture of the system, the particularities of the CRM domain as well as how they have influenced our design decisions. Among several submodules of the system we detail the role of a Deep Learning Named Entity Recognizer. The paper concludes with discussion over the lessons learned while developing this product.
arXiv:2012.06238v1 fatcat:t5ck2jmaqngexgmgoylpoqt3ua

Nanoparticle Superlattices: The Roles of Soft Ligands

Kae Jye Si, Yi Chen, Qianqian Shi, Wenlong Cheng
2017 Advanced Science  
doi:10.1002/advs.201700179 pmid:29375958 pmcid:PMC5770676 fatcat:m2sxprxhdbb5ljkvthxso4swia

Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?

Jianxiong Jiang, Jiange Qiu, Qianqian Li, Zhi Shi
2017 Trends in Cancer  
Elevated cyclooxygenase-2 (COX-2) and the associated inflammation within the brain contribute to glioblastoma development. However, medical use of COX inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE 2 ) has emerged as a principal mediator for COX-2 cascade-driven gliomagenesis. Are PGE 2 terminal synthases and receptors feasible therapeutic targets for glioblastoma?
doi:10.1016/j.trecan.2016.12.002 pmid:28718447 pmcid:PMC5518646 fatcat:kmy4hn4tjzg2bp3f44zou62fay

Differences in Tfh Cell Response between the Graft and Spleen with Chronic Allograft Nephropathy

Jian Shi, Xianlin Xu, Fengbao Luo, Qianqian Shi, Xiaozhou He, Ying Xia
2017 Cell Transplantation  
We have recently found that Tfh cells exist in the renal allograft and spleen of CAN rats (Shi et al., unpublished data) .  ...  Moreover, our pilot studies have indicated that Tfh cells are present in the follicular structures of both renal graft and spleen (Shi et al., unpublished data) .  ... 
doi:10.3727/096368916x692816 pmid:27524795 pmcid:PMC5657687 fatcat:ywxzv5w2jng6dkqsdhrjxyrgfi

Major Differences in Hypoxia Tolerance and P38 Regulation Among Different Renal Cells

Qianqian Shi, Jian Shi, Fengbao Luo, Guanglai Song, Xiaozhou He, Ying Xia
2018 Cellular Physiology and Biochemistry  
Background/Aims: Mitogen-activated protein kinases (MAPKs) are involved in the cellular response to hypoxia and their dysregulation may contribute to the progression and pathology of diverse human renal diseases. Recent studies suggest that the regulation of MAPK responses to hypoxic stress may be different in different cells, even within the same organ. However, it is unclear if MAPKs are differentially regulated in different renal cells in hypoxia. This work was carried out to clarify this
more » ... damental issue. Methods: We cultured normal rat kidney epithelial (NRK-52E) cells, human kidney epithelial (HK-2) cells and human renal cell adenocarcinoma (769-P) cells simultaneously under normoxia and hypoxia (1% O 2 ) for 24-72 hours. The protein levels of P-ERK1/2, ERK1/2, P-p38, p38 and eEF2K were detected by western blotting. The morphology of all cells was examined using light microscopy. Results: Under the same hypoxic condition, P-ERK1/2 was up-regulated in all renal cells. Meanwhile,P-p38 in NRK-52E cells was markedly increased after hypoxia for 24-72 hours, while it appeared to show no appreciable change in HK-2 and 769-P cells exposed to hypoxia for 24-48 hours and significantly decreased in these cells after 72 hours hypoxia. On the other hand,hypoxia markedly down-regulated the expression of eukaryotic elongation factor-2 kinase (eEF2K) in all three cells. Under microscopy, NRK-52E cells had no visible injury after 72 hours hypoxia, while HK-2 and 769-P cells were mostly damaged under the same condition. Conclusions: Our data suggest that in response to prolonged hypoxic stress, ERK1/2 and p38 are differentially regulated in three renal cells, while eEF2K is largely down-regulated in all of these cells.
doi:10.1159/000489188 pmid:29689570 fatcat:reavig77yncnhfzmpxqlf62esq

Incentive Mechanism of Prefabrication in Mega Projects with Reputational Concerns

Qianqian Shi, Jianbo Zhu, Marcel Hertogh, Zhaohan Sheng
2018 Sustainability  
Shi et al. [35] and Feng et al. [36] explored the cooperation tendency of prefabricated producers by considering incentive mechanism in mega projects. Wu et al.  ... 
doi:10.3390/su10041260 fatcat:ejbrmmjv6rbddlmxcggex5o7l4

Did Industrial Centralization Strategy in Shanghai's Suburbs Lead to Economic Growth?

Qianqian Yang, Yishao Shi, Liangliang Zhou
2022 Sustainability  
Industrial centralization is an important policy choice in the industrial economy era. The purpose of this paper is to evaluate the overall performance and the influential effects of the industrial centralization strategy in the suburbs of Shanghai. The results show that (1) the strategy of industrial concentration in the suburbs of Shanghai effectively promoted economic growth; (2) on different spatial scales, there are visible differences in the impact of industrial concentration on the
more » ... mance of industrial land; (3) industrial concentration has significantly improved industrial energy utilization efficiency; and (4) industrial concentration has narrowed the gap of economic development among the suburbs, but it has not resulted in a corresponding narrowing of the urban-rural gap. The main recommendations are to pay more attention to the high-end and centralization of urban industries in the central city, promote the interactive development of manufacturing and service industries as well as the integrated development of industry and city, moderately control the scale and speed of industrial suburbanization and residential suburbanization, promote the transformation of the traditional industrial land into "industry + R&D + business and office + exhibition" and further narrow the income gap between and within regions.
doi:10.3390/su14020856 fatcat:6jlegqva3bbevnqunae62pedra

MicroRNA-877 acts as a tumor suppressor by directly targeting eEF2K in renal cell carcinoma

2015 Oncology Letters  
MicroRNAs (miRNAs) are involved in tumorigenesis. However, little is known about their role in renal cell carcinoma (RCC). In the present study, the function of the miRNA miR-877 in RCC was investigated, and its expression levels in blood and paired RCC tissues were measured by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Bioinformatics analysis predicted eukaryotic elongation factor-2 kinase (eEF2K) to be the potential mRNA target of miR-877, which was verified by
more » ... iferase assay. The expression levels of eEF2K in RCC tissues were evaluated by western blot analysis and qPCR. The proliferation and migration abilities of RCC cells were measured by MTT and in vitro wound healing assays, respectively. The present results indicated that the expression levels of miR-877 were downregulated in blood and paired RCC tissues, whereas the expression levels of eEF2K were upregulated in RCC tissues. In addition, overexpression of miR-877 and knockdown of eEF2K significantly reduced the proliferation and migration abilities of RCC cells in vitro. Furthermore, miR-877 affected the eEF2K/eEF2 signaling pathway in these cells. In conclusion, the present study has demonstrated that miR-877 suppresses the proliferation and migration abilities of RCC cells by modulating the eEF2K/eEF2 signaling cascade. Therefore, miR-877 may be considered a potential biomarker for the diagnosis of RCC.
doi:10.3892/ol.2015.4072 pmid:26893763 pmcid:PMC4734253 fatcat:cockt5phtvgmbp7yvy6afikmla
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