A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
Despite playing various kinds of roles across genres from 1949 and 1965, Chen Qiang acquired stardom mainly due to his remarkable screen performance as villainous landlords in socialist China. ... For many audiences in socialist China, Chen Qiang was the ultimate incarnation of evil within a socialist state-the class enemy. ... The Negative Characters, Performance Context and the Production of Affect Prior to performing on the silver screen, Chen Qiang received theatre training at Lu Xun Academy of Fine Arts in 1938 at the Chinese ...doi:10.1080/17508061.2015.1040287 fatcat:y4rvnu26sbbijkjrysd2ppq3ue
General information For product purification by flash column chromatography, silica gel (200~300 mesh) and light petroleum ether (bp. 60~90 o C) and ethyl acetate are used. All solvents were purified and dried by standard techniques, and distilled prior to use. All organic extracts were dried over MgSO4, unless otherwise noted. IR spectra were recorded on a fourier transform infrared spectrometer. 1 H and 13 C NMR spectra were taken on a Bruker, AM-400 or AM-600 spectrometer with TMS as andoi:10.1039/c0cc02612c pmid:21120242 fatcat:gbnnrjejjvfgpk73xsdymvhpha
more »... nal standard and CDCl3 as solvent. The MS data were obtained with EI (70 eV). HRMS data were determined on a Bruker Daltonics APEXII 47e FT-ICR spectrometer. Melting points were measured on a melting point apparatus and are uncorrected. Starting material 6 is known compound. Compound 7. To a solution of 5.0261 g (21.30 mmol) of dione 6 in THF (140 mL) at -78 o C under argon was added ethynylmagnesium chloride (0.6 M, 35.5 mL, 21.30 mmol). The mixture was stirred for 7.5 h at -78 o C and then quenched with water (5 mL). After warming up to room temperature, the reaction mixture was diluted with Et 2 O (100 mL) and saturated aqueous NH 4 Cl (50 mL). The aqueous phase was extracted with Et 2 O (3 x 50 mL), then the combined organic extracts were dried over MgSO 4 , filtered and concentrated. Chromatography (15% EtOAc/petroleum ether) afforded the crude product as a yellow oil (3.5014 g). The above crude product was dissolved in pyridine (35 mL) at 40 o C under argon, DMAP (350 mg, 2.87 mmol) and methanesulfonyl chloride (7.0 mL, 90.44 mmol) was added. After stirring for 30min, the solution allowed to cool on ice-water bath. The reaction was diluted with Et 2 O (30 mL) and quenched with water (10 mL). The biphasic mixture was vigorously stirred for 30 min prior to separation of the layers. The organic phase was washed with water (2 x 20 mL) followed by back-extraction of the combined aqueous extracts with Et 2 O (3 x 50 mL). The combined organic extracts were dried over MgSO 4 , filtered and concentrated to yield a yellow oil which was then purified via column chromatography (15% EtOAc/petroleum ether to 25% EtOAc/petroleum ether) to afford compound 7 (3.6205 g, 50% yield, two steps) as a light yellow oil; 1 H NMR (400MHz, CDCl 3 ) δ 0.93-0.97 (t, J = 6.4 Hz, 3H), 1.63-1.69 (m, 2H), 1.84-1.88 (m, 3H), 1.89-2.04 (m, 3H), 2.51 (s, 2H), 2.59-2.62 (m, 4H), 2.71-2.72 (d, J = 2.4 Hz, 1H), 3.09 (s, 3H), 4.54 (s, 1H), 4.81-4.82 (d, J = 1.2 Hz, Supplementary Material (ESI) cm -1 ; MS (EI) m/z 340, 311, 261, 245, 201, 173, 131; HRMS (ESI) Calcd. for C 17 H 28 NO 5 S (M+NH 4 ) + : 358.1683, Found 358.1676, Error: 2.0 ppm. Compound 5. The mesylate 7 (406.6 mg, 1.20 mmol) was treated with NaN 3 (233.2 mg, 3.59 mmol) in 4 mL of DMF at 40 o C under argon. After 1.5 h, the mixture was diluted with Et 2 O (10 mL) at 0 o C, and washed with water (2 x 10 mL). The organic phase was dried over MgSO 4 , filtered and concentrated to yield a yellow oil which was purified via column chromatography (15% EtOAc/ petroleum ether) to give the desired azide 5 (288.3 mg, 84% yield) as a light yellow oil; 1 H NMR (400MHz, CDCl 3 ) δ 0.93-0.97 (t, J = 6.4 Hz, 3H), 1.42-1.49 (m, 2H), 1.82-1.93 (m, 5H), 1.95-2.03 (m, 1H), 2.50 (s, 2H), 2.57-2.61 (m, 5H), 3.98-4.02 (dt, cm -1 ; MS (EI) m/z 287, 258, 244, 216, 188, 136; HRMS (ESI) Calcd. for C 16 H 25 N 4 O 2 (M+NH 4 ) + : 305.1972, Found 305.1969, Error: 1.0 ppm. Compound 4. To a solution of the azide 5 (2.5755 g, 8.97 mmol) in CH2Cl2 (90 mL) at -15 o C under argon was added TiCl4 (10.83 mL, 1M in CH2Cl2). The resulting mixture was stirred at-15 o C for 20 min, then it was quenched with 15 mL water. The aqueous phase was extracted with CH 2 Cl 2 (3 x 20 mL), then the combined organic extracts were dried over MgSO 4 , filtered and concentrated to give a solid. Chromatography (20% EtOAc/petroleum ether to 35% EtOAc/petroleum ether) afforded 4 (1.6647 g , 72% yield) as an amorphous yellow solid; 1 H NMR (400MHz, CDCl 3 ) δ 0.98-1.01 (t, J = 3.2 Hz, 3H), 1.92-2.08 (m, 5H), 2.16-2.34 (m, 5H), 2.41-2.56 (m, 1H), 2.53-2.72 (m, 3H), 3.25-3.33 (m, 1H), 4.80-4.81 (d, J = 6.4 Hz, 1H), 4.86 (s, 1H), 4.91-4.92 (d, J = 1.6 Hz, 1H); 13 C NMR (100M,
Precondition for simulating low-speed turbulence is studied in this paper. Against the stiffness of the time-dependent scheme applied to low-speed turbulence, the precondition based on conservative variables is developed, which adopts an implicit iterative method for solving main control equations coupled with turbulence transport equations. In order to ensure the iterative solution stable, a reference Mach number, the dual-time stepping no-matrix scheme, and the method for processingdoi:10.7498/aps.64.134701 fatcat:5pp4ac2ibvbevlipfxen2cbiya
more »... the source terms of turbulence equations etc. have been developed reasonably, making the software platform unified for all-speed turbulence. Reference Mach number is defined in terms of global and local velocity by a single parameter, and the parameter can be used to control stability, numerical result accuracy, and switch of the precondition. The dual-time stepping LU-SGS method based on conservative variable precondition is developed, realizing no-matrix iterative solution for unsteady flow problems. Against the stiffness in solving the main control equations coupled with turbulence transport equations, the dissipation term of the turbulence equations is processed implicitly, which can enhance main diagonal dominance of the turbulence equations and make the iteration with greater stability. In simulating the turbulence in a nozzle and around a square cylinder or an airfoil, the precondition depicts correctly the structural character of the flowfield; and the computational results are in good agreement with those of theory and experiment etc., and its iterative convergence and numerical accuracy is excellent. It is shown that the precondition in this paper for low-speed turbulence is very effective.
Lithium (Li) metal anodes have attracted considerable interest due to their ultrahigh theoretical gravimetric capacity and very low redox potential. However, the issues of nonuniform lithium deposits (dendritic Li) during cycling are hindering the practical applications of Li metal batteries. Herein, we propose a concept of ion redistributors to eliminate dendrites by redistributing Li ions with Al-doped Li6.75La3Zr1.75Ta0.25O12 (LLZTO) coated polypropylene (PP) separators. The LLZTO withdoi:10.1126/sciadv.aat3446 fatcat:343bnwtzabanvde25yfhtmrzwi
more »... dimensional ion channels can act as a redistributor to regulate the movement of Li ions, delivering a uniform Li ion distribution for dendrite-free Li deposition. The standard deviation of ion concentration beneath the LLZTO composite separator is 13 times less than that beneath the routine PP separator. A Coulombic efficiency larger than 98% over 450 cycles is achieved in a Li | Cu cell with the LLZTO-coated separator. This approach enables a high specific capacity of 140 mAh g−1 for LiFePO4 | Li pouch cells and prolonged cycle life span of 800 hours for Li | Li pouch cells, respectively. This strategy is facile and efficient in regulating Li-ion deposition by separator modifications and is a universal method to protect alkali metal anodes in rechargeable batteries.
Shock waves, vorticity waves, and entropy waves are fundamental discontinuity waves in nature and arise in supersonic or transonic gas flow, or from a very sudden release (explosion) of chemical, nuclear, electrical, radiation, or mechanical energy in a limited space. Tracking these discontinuities and their interactions, especially when and where new waves arise and interact in the motion of gases, is one of the main motivations for numerical computation for the gas dynamics equations. In thisarXiv:1205.4433v1 fatcat:63ngrrurrnelzjuxgeqar3qxzi
more »... paper, we discuss some historic and recent developments, as well as mathematical challenges, in designing and formulating efficient numerical methods and algorithms to compute weak entropy solutions for the Euler equations for gas dynamics.
However, -CHEN ET AL. -CHEN ET AL. -CHEN ET AL. -CHEN ET AL. ... The pH values of the x axis are referred to the H 2 O 2 solutions before mixing with the strongly acidified aqueous solution of titanium sulphate CHEN ET AL. ... ORCID Qiang Chen https://orcid.org/0000-0002-8688-1085 APPENDIX A Energ y of positive lons impinging on the liquid surface in a dc atmospheric pressure plasmaliquid system with the liquid being a cathode ...doi:10.1049/hve2.12189 fatcat:prkkem24fje4xonezwdl7q3c6i
There are over 100 serotypes of enterovirus species A-D, which are the common cause of various symptoms in infants, such as meningitis, encephalitis and hand foot mouth disease (HFMD). This study aims to investigate the epidemiological characteristics of enteroviruses in Hangzhou, Zhejiang province, China, and to provide relevant information to guide public health responses and interventions. Methods: Systematic surveillance was conducted on enterovirus infections. Samples were collected fromdoi:10.1186/s12985-015-0294-4 pmid:25884568 pmcid:PMC4403759 fatcat:rca6wwhanzextn2mfe6hoh4lka
more »... ildren admitted to the inpatient wards and outpatient departments between January 2010 and December 2012 in the Children's Hospital, Zhejiang University School of Medicine. Enteroviruses from all specimens were detected by RT-PCR using a commercialized detection kit. Results: From 13026 samples collected and examined, 2673 (21.21%) were found positive for enteroviruses. The annual enterovirus-positive rate decreased from 32.78% in 2010 to 14.23% in 2012. Positivity rate for enteroviruses was highest among children aged less than 5 years. The monthly positivity rate for enterovirus infection ranged from 2.6% to 34.83%, with a peak in June and July. Serotypes causing severe symptoms such as HFMD including EV71 and CA16 were decreasing, while the proportion of unidentified EV serotypes causing herpangina and viral encephalitis were on the rise. Conclusions: EV infection is highly prevalent among young children in Hangzhou, as it is in the most other parts of the world. Further surveillance using methods that can subtype all EVs is warranted to better monitor these infections and their etiology.
It is widely accepted that the zinc element is crucial in human beings. Zinc has gained more attention during the COVID-19 pandemic due to its utilization for the treatment and prevention of respiratory tract infections. However, some studies also pointed out that zinc intake might cause unwanted side effects and even be dangerous when overdosed. To reveal the relationship between zinc intake and health outcomes, we performed an umbrella review from human studies. In total, the umbrella reviewdoi:10.3389/fnut.2022.798078 pmid:35211497 pmcid:PMC8861317 fatcat:g3nhhcovvff6zgaqf4ftotexua
more »... ncluded 43 articles and identified 11 outcomes for dietary zinc intake and 86 outcomes for supplementary zinc intake. Dietary zinc intake in the highest dose would decrease the risk of overall and specific digestive tract cancers, depression, and type 2 diabetes mellitus (T2DM) in adults. Supplementary zinc consumption in adults was linked to an improvement of depression, antioxidant capacity and sperm quality, higher serum zinc concentration, and lower concentration of inflammatory markers. Zinc supplementation in children would reduce the incidence of diarrhea and pneumonia, improve zinc deficiency and boost growth. However, zinc might not decrease all-cause mortality in adults or the in-hospital mortality of COVID-19. And better maternal and neonatal outcomes may not derive from pregnant women who consumed higher or lower doses of zinc supplementation (>20 mg/day and <20 mg/day, respectively). Dose-response analyses revealed that a daily 5 mg increment of zinc would lower the risk of colorectal and esophageal cancer, whereas a large dose of zinc supplementation (daily 100 mg) showed no benefit in reducing prostate cancer risk.
Chen wrote and revised the manuscript. H. Chen supervised the project. All the authors reviewed this manuscript. Supplementary Optical source for TESP-3D system. ... Chen conceived the high-speed 3D single-pixel imaging scheme and designed the experimental system. J. Teng and Q. Guo performed the experiment, collected the data, and processed the data. J. Teng, Q. ...arXiv:1901.04141v1 fatcat:3tdca7q7cvbbpfrayq7p6dbaee
Among these cultivation modes, the heterotrophic cultivation mode offers many advantages that can enable fast growth and high biomass productivity for microalgae (Chen et al., 2020) , while photoautotrophic ... organisms also possess a second enzyme, phosphoenolpyruvate carboxylase (PEPC) that can efficiently fix carbon as it catalyzes the reaction of CO 2 and phosphoenolpyruvic acid to produce oxaloacetic acid (Chen ... Copyright © 2021 Zhang, Zhao, Chen, Zhu, Xu, Wu, Han and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...doi:10.3389/fbioe.2021.638726 pmid:34095093 pmcid:PMC8176925 doaj:a8ff1a607de54ccc90a9c7d953e07d3b fatcat:55evgy6esbbd7gegworsqjzbx4
Some new species of this genus have been published (Chen and Tsi 1984; Liu and Chen 2001 , 2002 , 2003 Metusala 2017) . ... Paphiopedilum belongs to the subfamily Cypripedioideae (Orchidaceae), and distributes from tropical Asia to the Pacific islands, with some species extending to subtropical areas (Chen et al. 2009; Pridgeon ...doi:10.1080/23802359.2019.1642168 pmid:33365651 pmcid:PMC7706870 fatcat:47xofdoesbay5fnuw7c6ja5gri
The Solute Carrier Family 12 (SLC12) encodes electroneutral cation-chloride cotransporters (CCCs) that are fundamental in cell volume regulation and chloride homeostasis. Dysfunction of CCCs engenders abnormality in renal function and neuro-system development. Here we presented structure of the full length human potassium-chloride co-transporter 2 (KCC2) and 3 (KCC3), the KCC3 mutants in phosphorylation mimic (P-mimic) and dephosphorylation mimic (DP-mimic) status, and KCC3 in complex withdoi:10.1101/2020.02.22.960815 fatcat:dbvio3eqc5f2bi65y53s5hnxdu
more »... ydroIndenyl)Oxy] Alkanoic acid (DIOA), a specific inhibitor of KCCs, at resolution of 2.7 Å - 3.6 Å. A small N-terminal loop is bound at the intracellular vestibule of the transport path, arresting the transporter in an auto-inhibition state. The C-terminal domain (CTD) of KCCs is structure-solved for the first time, revealing two conserved phosphorylation harboring segments (PHSs), which exhibit different conformation between P-mimic and DP-mimic mutants, explaining the inhibitory effect of phosphorylation. DIOA is located in between the two transmembrane domains, tightly bound to the loop between TM10 and TM11, locking the transporter in inward-facing conformation. Together, our study makes important steps in understanding the sophisticated regulation mechanisms of KCCs, with prospect for the specific drug development.
Lithium metal has been regarded as the future anode material for high-energy-density rechargeable batteries due to its favorable combination of negative electrochemical potential and high theoretical capacity. However, uncontrolled lithium deposition during lithium plating/stripping results in low Coulombic efficiency and severe safety hazards. Herein, we report that nanodiamonds work as an electrolyte additive to co-deposit with lithium ions and produce dendrite-free lithium deposits.doi:10.1038/s41467-017-00519-2 pmid:28839134 pmcid:PMC5571184 fatcat:vsdg5onpejb57jtyzn43m7xbem
more »... nciples calculations indicate that lithium prefers to adsorb onto nanodiamond surfaces with a low diffusion energy barrier, leading to uniformly deposited lithium arrays. The uniform lithium deposition morphology renders enhanced electrochemical cycling performance. The nanodiamond-modified electrolyte can lead to a stable cycling of lithium | lithium symmetrical cells up to 150 and 200 h at 2.0 and 1.0 mA cm -2 , respectively. The nanodiamond co-deposition can significantly alter the lithium plating behavior, affording a promising route to suppress lithium dendrite growth in lithium metal-based batteries.
Theorem 4.1 (Chen-Perthame ). ... The existence problem for usual gases with general values γ ∈ (1, 5 3 ] was solved in Chen  and Ding-Chen-Luo  (also see  ). ...arXiv:1005.2713v1 fatcat:ltzricl3kbaxljjqzjacrsm6fq
Embedding-based entity alignment (EEA) has recently received great attention. Despite significant performance improvement, few efforts have been paid to facilitate understanding of EEA methods. Most existing studies rest on the assumption that a small number of pre-aligned entities can serve as anchors connecting the embedding spaces of two KGs. Nevertheless, no one investigates the rationality of such an assumption. To fill the research gap, we define a typical paradigm abstracted fromarXiv:2110.10871v1 fatcat:gca53at2abbvrbum2guj7r63xa
more »... EEA methods and analyze how the embedding discrepancy between two potentially aligned entities is implicitly bounded by a predefined margin in the scoring function. Further, we find that such a bound cannot guarantee to be tight enough for alignment learning. We mitigate this problem by proposing a new approach, named NeoEA, to explicitly learn KG-invariant and principled entity embeddings. In this sense, an EEA model not only pursues the closeness of aligned entities based on geometric distance, but also aligns the neural ontologies of two KGs by eliminating the discrepancy in embedding distribution and underlying ontology knowledge. Our experiments demonstrate consistent and significant improvement in performance against the best-performing EEA methods.
« Previous Showing results 1 — 15 out of 33,965 results