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PyPNS: Multiscale Simulation of a Peripheral Nerve in Python

Carl H. Lubba, Yann Le Guen, Sarah Jarvis, Nick S. Jones, Simon C. Cork, Amir Eftekhar, Simon R. Schultz
2018 Neuroinformatics  
We present a peripheral nerve simulator that combines biophysical axon models and numerically solved and idealised extracellular space models in one environment.  ...  Bioelectronic Medicines that modulate the activity patterns on peripheral nerves have promise as a new way of treating diverse medical conditions from epilepsy to rheumatism.  ...  PyPNS Overview Every PyPNS simulation describes one peripheral nerve consisting of an arbitrary number of unmyelinated and myelinated axons, each with a certain diameter and trajectory.  ... 
doi:10.1007/s12021-018-9383-z pmid:29948844 fatcat:z5g7sb6dl5ggpec37hpzdvzoye

A multiscale approach to axon and nerve stimulation modeling: A review

M. Stefano, F. Cordella, A. Loppini, S. Filippi, L. Zollo
2021 IEEE transactions on neural systems and rehabilitation engineering  
In particular, we evaluate different nerve cell models considering different ion channels present in neurons and provide a guideline on multiscale numerical simulations of electrical nerve fibers stimulation  ...  stimulation by implanted electrodes in peripheral nerve fibers.  ...  A peripheral nerves simulator (PyPNS) was recently developed in Python by Lubba et al. [89] . In this computational model unmyelinated and myelinated fibers are considered.  ... 
doi:10.1109/tnsre.2021.3054551 pmid:33497336 fatcat:p3fodu42rjalzprweyxqgcido4

Low-dimensional representations of neural time-series data with applications to peripheral nerve decoding

Carl Henning Thore Lubba, Simon Schultz, Nicholas Jones, Galvani Bioelectronics
Coming from a different direction of more general time-series analysis, we embedded a set of peripheral nerve recordings in a space of main firing characteristics by dimensionality reduction in a high-dimensional  ...  We here explore ways of creating nerve-based feedback for the implanted systems to act in a dynamically adapting closed loop.  ...  Lubba, CH, Le Guen, Y, Jarvis, S, Jones, N S, Cork, S C, Eftekhar, A, Schultz, SR (2018). PyPNS: Multiscale simulation of a peripheral nerve in Python. Neuroinformatics, 17(1), pp. 63-81.  ... 
doi:10.25560/80541 fatcat:c7rco6jgkjhk7petsnkuscrz2m