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Purkinje cell loss in experimental autoimmune encephalomyelitis

Allan MacKenzie-Graham, Seema K. Tiwari-Woodruff, Gaurav Sharma, Cynthia Aguilar, Kieumai T. Vo, Lauren V. Strickland, Laurie Morales, Boma Fubara, Melanie Martin, Russell E. Jacobs, G. Allan Johnson, Arthur W. Toga (+1 others)
<span title="">2009</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
The proapoptotic marker caspase-3 was detected in Purkinje cells and a significant decrease in Purkinje cell number was found in EAE.  ...  The objective of this study was to link brain atrophy visualized by neuroimaging to its underlying neuropathology using the MS model, experimental autoimmune encephalomyelitis (EAE).  ...  We have previously demonstrated gray matter atrophy in the cerebella of mice with experimental autoimmune encephalomyelitis (EAE), the most widely used model of MS, and found a correlation between this  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2009.06.073">doi:10.1016/j.neuroimage.2009.06.073</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19589388">pmid:19589388</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2754586/">pmcid:PMC2754586</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7hhj45oxf5dknmctzqtbltkb5q">fatcat:7hhj45oxf5dknmctzqtbltkb5q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180725105126/https://authors.library.caltech.edu/17691/3/nihms130656.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/21/bf/21bfdf50e609f59e4f7be234c786f0ab7d3ce89a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2009.06.073"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754586" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neurological paraneoplastic syndromes

U Nath, R Grant
<span title="1997-12-01">1997</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vfqybd3urvewjdty7rmzdqb2bi" style="color: black;">Journal of Clinical Pathology</a> </i> &nbsp;
Although significant advances have been made in diagnosis, fuirther research is needed in the detection of autoantibodies and the elucidation of their role in the aetiology of neurological disease.  ...  The identification of antibodies in the serum or cerebrospinal fluid in central nervous system paraneoplastic syndromes confirms the clinical diagnosis of a paraneoplastic syndrome and allows early identification  ...  There is severe loss of Purkinje cells throughout the cerebellum, with or without lymphocytic infiltration, with remaining cells showing axonal swelling.'  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1136/jcp.50.12.975">doi:10.1136/jcp.50.12.975</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/9516876">pmid:9516876</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC500375/">pmcid:PMC500375</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ctibbmv3lrdgdnnqmu2vucmhei">fatcat:ctibbmv3lrdgdnnqmu2vucmhei</a> </span>
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Neuroprotective effects of vascular endothelial growth factor A in the experimental autoimmune encephalomyelitis model of multiple sclerosis

Wensheng Lin
<span title="">2017</span> <i title="Medknow"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/m6pfdut7njabrnem2aglbngpgi" style="color: black;">Neural Regeneration Research</a> </i> &nbsp;
Interestingly, both axon degeneration and neuron loss occur early in the CNS of animals undergoing experimental autoimmune encephalomyelitis (EAE), the primary animal model used in MS research (Stanojlovic  ...  Neuroprotective effects of vascular endothelial growth factor A in the experimental autoimmune encephalomyelitis model of multiple sclerosis Multiple sclerosis (MS) is a chronic inflammatory disease of  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4103/1673-5374.198982">doi:10.4103/1673-5374.198982</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28250748">pmid:28250748</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5319243/">pmcid:PMC5319243</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rq2edd7xrfd75awru566rcqlna">fatcat:rq2edd7xrfd75awru566rcqlna</a> </span>
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Recent advance in immunological tests in paraneoplastic neurological syndrome

Chin-Shih Fong
<span title="">2005</span> <i > <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rdlbzjobpvek7jzw35okdizv5y" style="color: black;">Acta neurologica Taiwanica</a> </i> &nbsp;
The recent advances in understanding of the autoimmune pathology of these disorders should lead to more effective treatment options.  ...  Any portion of the nervous system may be involved in paraneoplastic syndromes.  ...  Microscopic appearances include mild perivascular inflammatory changes, loss of Purkinje cells, and abnormalities in the dentate nuclei'19'.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15835287">pmid:15835287</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/czij4oirrbcxlkvshmcvzksoeu">fatcat:czij4oirrbcxlkvshmcvzksoeu</a> </span>
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Paraneoplastic and Other Autoimmune Encephalitides: Antineuronal Antibodies, T Lymphocytes, and Questions of Pathogenesis

John E. Greenlee, Noel G. Carlson, Justin R. Abbatemarco, Ida Herdlevær, Stacey L. Clardy, Christian A. Vedeler
<span title="2022-01-17">2022</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4kchoxo3jrfubkck3y7nfncina" style="color: black;">Frontiers in Neurology</a> </i> &nbsp;
the attempts that have been made to reproduce human neuronal injury in tissue culture models and experimental animals.  ...  Antibodies in the second group, as exemplified by anti-Yo antibody, found in patients with rapidly progressive cerebellar syndrome, and anti-Hu antibody, associated with encephalomyelitis, react with intracellular  ...  1 week No Purkinje cell loss.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2021.744653">doi:10.3389/fneur.2021.744653</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35111121">pmid:35111121</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8801577/">pmcid:PMC8801577</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vwl2652earfmpcikyc4aq6j7iy">fatcat:vwl2652earfmpcikyc4aq6j7iy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220125202737/https://fjfsdata01prod.blob.core.windows.net/articles/files/744653/pubmed-zip/.versions/1/.package-entries/fneur-12-744653/fneur-12-744653.pdf?sv=2018-03-28&amp;sr=b&amp;sig=IBk8ciAY83Y5YLtnuiG90LWbp3KTuxim0n1nCqKpXwA%3D&amp;se=2022-01-25T20%3A28%3A06Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fneur-12-744653.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/18/f0/18f0c11951c0a7f571a53fd2bfe6b91ddfef0d9b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2021.744653"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801577" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Another autoantibody in paraneoplastic neurological disease

Bethan Lang
<span title="">1999</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
At autopsy, two of the four patients showed © Oxford University Press 1999 selective Purkinje cell loss with local inflammatory infiltrates, mainly CD8 ϩ T cells.  ...  Mouse strains bearing different MHC molecules produce antibodies on immunization with recombinant Yo protein, but do not cause Purkinje cell loss. Clin Neurol Neurosurg 1995a; 95: 97-100.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/122.1.3">doi:10.1093/brain/122.1.3</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/10050889">pmid:10050889</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6lhglnjfjvaozkrzjo2hoerqwe">fatcat:6lhglnjfjvaozkrzjo2hoerqwe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180727010701/https://watermark.silverchair.com/1220003.PDF?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAaQwggGgBgkqhkiG9w0BBwagggGRMIIBjQIBADCCAYYGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM8yEYTOtRT12skk8jAgEQgIIBVyX9S-q77UwyXuOuQyCCCcAPr0ELEfNd4vwger8YkSAxQ8u5x_ybohcZVS1usxaTPz1mUnOpX37pmpFYN5-Imw9R6MZEI2wOTSd4uHl7erUi1tYWyGDgJlf3C5xgyh-bDeeD_rnZ0sPVKH3jeOqFm_Nka_iK3PWuJ6X7dygc-k7N7CTwxcl4RU3_VvmviJ6XQVVFTRCm-DjbKNk0mMFGFcHlbJpAElK7cURi_bP_jcYrW0H_C0I9SWhRaOhZwB6D80BRhP_GbRJFRIHvQ_H37LMOoQXN1xtbREa4f81st0ac8WCdM2kHILl2i8DHglvF3jtrsatljY0jTmsFlw_Bw64MivOCRHCKkV3oHY1iFNT-wINg4HdE4MWFuTNFvJ0EC-J7cqCsQoEqdJOfghMwTQgPCLgzxcVFdklDc2msrI2O29JIbora0V1pTPAkTnO7BGiVtoNewdc" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ef/35/ef35382d4fe6447c6b69c7a98cfe2b49564b5821.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/122.1.3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a>

Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje cells

K. Kemp, D. Gordon, D. C. Wraith, E. Mallam, E. Hartfield, J. Uney, A. Wilkins, N. Scolding
<span title="2011-01-10">2011</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4xnndzuhkvghrpc7pi2qfkpavy" style="color: black;">Neuropathology and Applied Neurobiology</a> </i> &nbsp;
Methods and results: Human MSCs were intravenously injected into mice with experimental autoimmune encephalomyelitis (EAE) and control mice.  ...  After 22 days, mouse Purkinje cells expressing human Golgi Zone were found within the Purkinje cell layer of the cerebellum, indicating that fusion and heterokaryon formation had occurred.  ...  Figure 4 . 4 An increase in mouse Purkinje cells expressing human Golgi Zone in experimental autoimmune encephalomyelitis (EAE) vs. naïve mice treated with intra-venous human MSCs.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1365-2990.2010.01122.x">doi:10.1111/j.1365-2990.2010.01122.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20819172">pmid:20819172</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4150530/">pmcid:PMC4150530</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4g3dhdifb5apvfid2boebb2gpa">fatcat:4g3dhdifb5apvfid2boebb2gpa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211223920/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4150530&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/20/13/2013d975c7a34da2c727ea5800d78f161999928e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1365-2990.2010.01122.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150530" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Role of Plasma Membrane Calcium ATPase Isoform 2 in Neuronal Function in the Cerebellum and Spinal Cord

M. P. KURNELLAS, A. K. LEE, K. SZCZEPANOWSKI, S. ELKABES
<span title="2007-02-15">2007</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hs2remnzfbfmnf33cof2z4ajhi" style="color: black;">Annals of the New York Academy of Sciences</a> </i> &nbsp;
We found that lack of PMCA2 leads to a reduction in the number of motor neurons in the spinal cord of PMCA2-null mice and to abnormal changes in molecular pathways in Purkinje cells.  ...  The distinct role of plasma membrane calcium ATPase 2 (PMCA2) in the function of different neuronal subpopulations in the central nervous system is not well understood.  ...  Earlier studies in our laboratory indicated a significant decrease in the levels of PMCA2 in the inflamed spinal cord of rats and mice affected by experimental autoimmune encephalomyelitis (EAE), an animal  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1196/annals.1387.025">doi:10.1196/annals.1387.025</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17446469">pmid:17446469</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cgddvg4idzadflzp7mdhfhijme">fatcat:cgddvg4idzadflzp7mdhfhijme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808205242/http://cmbn.rutgers.edu/download/student-publications/Role-of-plasma-membrane-calcium-ATPase-isoform-2-in-neuronal-function-in-the-cerebellum-and-spinal-cord.-.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7a/b5/7ab5e62d2172133a6e088b02476947bab1698758.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1196/annals.1387.025"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Cell Fusion along the Anterior-Posterior Neuroaxis in Mice with Experimental Autoimmune Encephalomyelitis

Sreenivasa R. Sankavaram, Mikael A. Svensson, Tomas Olsson, Lou Brundin, Clas B. Johansson, Thomas Dittmar
<span title="2015-07-24">2015</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Results Using a well-characterized model for heterokaryon formation in the cerebellum (experimental autoimmune encephalomyelitis -a mouse model of multiple sclerosis), we report for the first time that  ...  Purkinje cells are among the largest neurons in the central nervous system and accordingly can harbor two nuclei.  ...  In the rodent model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), massively increased fusion rates occur in the cerebellum as compared to non-inflamed animals.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0133903">doi:10.1371/journal.pone.0133903</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26207625">pmid:26207625</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4514791/">pmcid:PMC4514791</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wt3seqchwzciljqmbrfkqwtvna">fatcat:wt3seqchwzciljqmbrfkqwtvna</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171011020350/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133903&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1e/df/1edf68c537bbf710196f5f7e81291492a5ba0c18.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0133903"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514791" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications

Lidia Yshii, Chloé Bost, Roland Liblau
<span title="2020-06-02">2020</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/t7exsmmojvgjnhq3pflf7pk6zq" style="color: black;">Frontiers in Immunology</a> </i> &nbsp;
In PCD, the deleterious adaptive immune response targets self-antigens aberrantly expressed by tumor cells, mostly gynecological cancers, and physiologically expressed by the Purkinje neurons of the cerebellum  ...  and autoimmunity.  ...  In experimental autoimmune encephalomyelitis (EAE), a classical animal model of multiple sclerosis, BBB-endothelial cells express CCL2, CCL19, and CCL21, which mediate firm arrest of CCR2+ monocytes and  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fimmu.2020.00991">doi:10.3389/fimmu.2020.00991</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32655545">pmid:32655545</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7326021/">pmcid:PMC7326021</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2st26vb4oba3dbnkffai57hkk4">fatcat:2st26vb4oba3dbnkffai57hkk4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210716101219/https://hal-univ-tlse3.archives-ouvertes.fr/hal-03154898/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/73/a7/73a720d0b29b4fb4ba7380bf0285a30b243a5977.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fimmu.2020.00991"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326021" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

S. Du, N. Itoh, S. Askarinam, H. Hill, A. P. Arnold, R. R. Voskuhl
<span title="2014-02-03">2014</span> <i title="Proceedings of the National Academy of Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nvtuoas5pbdsllkntnhizy4f4q" style="color: black;">Proceedings of the National Academy of Sciences of the United States of America</a> </i> &nbsp;
We have previously shown in an MS model, experimental autoimmune encephalomyelitis, that autoantigen-sensitized XX lymph node cells, compared with XY, are more encephalitogenic.  ...  We found that experimental autoimmune encephalomyelitis mice with an XY sex chromosome complement in the CNS, compared with XX, demonstrated greater clinical disease severity with more neuropathology in  ...  We have previously shown in an MS model, experimental autoimmune encephalomyelitis, that autoantigen-sensitized XX lymph node cells, compared with XY, are more encephalitogenic.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1307091111">doi:10.1073/pnas.1307091111</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24550311">pmid:24550311</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3932937/">pmcid:PMC3932937</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vo3ht4y2sva3dkypnanggpjgpi">fatcat:vo3ht4y2sva3dkypnanggpjgpi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180728113828/http://www.pnas.org/content/pnas/111/7/2806.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/38/ce/38cea3d760dc2b3fdf61df9d744a2bf95e577824.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1307091111"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932937" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cell fusion in the brain: two cells forward, one cell back

Kevin Kemp, Alastair Wilkins, Neil Scolding
<span title="2014-06-05">2014</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fu2v5yy75zfitiwkzgznutnkvq" style="color: black;">Acta Neuropathologica</a> </i> &nbsp;
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s)  ...  A single GFP-positive Purkinje cell found within the cerebellum of a BM chimeric mouse (expressing GFP-tagged bone marrow) with experimental autoimmune encephalomyelitis (EAE).  ...  Consequently, significant loss in Purkinje cell numbers as a result of toxic, autoimmune, genetic and neurodegenerative insults generally leads to irreversible reduced motor function and ataxia.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00401-014-1303-1">doi:10.1007/s00401-014-1303-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24899142">pmid:24899142</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4201757/">pmcid:PMC4201757</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/whfbki53dvdwfekjk6455dgdzy">fatcat:whfbki53dvdwfekjk6455dgdzy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171016001029/http://publisher-connector.core.ac.uk/resourcesync/data/Springer-OA/pdf/8ef/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjEwMDcvczAwNDAxLTAxNC0xMzAzLTEucGRm.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5f/fb/5ffb2d81c14afa0af27d57556034b9d6dc6e46d2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00401-014-1303-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201757" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Inhibition of Vascular Endothelial Growth Factor Receptor 2 Exacerbates Loss of Lower Motor Neurons and Axons during Experimental Autoimmune Encephalomyelitis

Milos Stanojlovic, Xiaosha Pang, Yifeng Lin, Sarrabeth Stone, Marija Cvetanovic, Wensheng Lin, Robert Shin Fujinami
<span title="2016-07-28">2016</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are inflammatory demyelinating and neurodegenerative diseases in the central nervous system (CNS).  ...  cord of mice undergoing EAE, but did not alter Purkinje neuron loss in the cerebellum or upper motor neuron loss in the cerebral cortex.  ...  Introduction Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are T-cell-mediated autoimmune diseases of the central nervous system (CNS), characterized by inflammatory  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0160158">doi:10.1371/journal.pone.0160158</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27466819">pmid:27466819</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4965096/">pmcid:PMC4965096</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nc2t6dmyrfgn3hurxokp42jpga">fatcat:nc2t6dmyrfgn3hurxokp42jpga</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171011233130/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0160158&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b9/e5/b9e5e6d6acd276cb156fc3df819da1dff90b6718.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0160158"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965096" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neuroimmunology - The Past, Present and Future

Erik Nutma, Hugh Willison, Martino Gianvito, Sandra Amor
<span title="2019-02-15">2019</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qvy5o6l7tragnoevlfdjyslk2m" style="color: black;">Clinical and Experimental Immunology</a> </i> &nbsp;
We propose future perspectives including molecular biological studies and experimental models that may have the potential to push many areas of neuroimmunology.  ...  Neuroimmunology as a separate discipline has its roots in the fields of neurology, neuroscience and immunology.  ...  Acknowledgements This review was written in celebration of the 60 years' anniversary of the foundation of the British Society of Immunology, and following the 13th ISNI meeting in  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/cei.13279">doi:10.1111/cei.13279</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30768789">pmid:30768789</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6693969/">pmcid:PMC6693969</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/d3fj4uprqnhllc2yikh3qj73nu">fatcat:d3fj4uprqnhllc2yikh3qj73nu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200502111110/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6693969&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5f/43/5f43955f3c35d173d8dfe09fdbc40560be748d2a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/cei.13279"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693969" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Paraneoplastic Diseases of the Central Nervous System

Jonathan Galli, John Greenlee
<span title="2020-03-06">2020</span> <i title="F1000 Research Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lz7xw3k77zcg5f66jhfurufu64" style="color: black;">F1000Research</a> </i> &nbsp;
Prompt initiation of immunotherapy is essential in the treatment of patients with paraneoplastic neurological disease, often more effective in cell surface antibodies in comparison to intracellular antibodies  ...  to cell death.  ...  A definitive association of autoimmunity in paraneoplastic neurological disease came through work by Greenlee and Brashear 7 and Jaeckle et al. 8 , who demonstrated antibodies to cerebellar Purkinje  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.12688/f1000research.21309.1">doi:10.12688/f1000research.21309.1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32194943">pmid:32194943</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7062203/">pmcid:PMC7062203</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2g3rqauelbfndlosnnk5nb3yg4">fatcat:2g3rqauelbfndlosnnk5nb3yg4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200307200256/https://f1000researchdata.s3.amazonaws.com/manuscripts/23466/49ddd1f9-0693-4584-8b1c-607481035e33_21309_-_john_greenlee.pdf?doi=10.12688/f1000research.21309.1&amp;numberOfBrowsableCollections=20&amp;numberOfBrowsableInstitutionalCollections=5&amp;numberOfBrowsableGateways=23" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/41/db/41db6b0dc83ce63a6de0325b921a8f872fb59174.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.12688/f1000research.21309.1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062203" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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