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Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins
2016
Journal of Biomedical Semantics
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The nuclear magnetic resonance (NMR) spectroscopic data for biological macromolecules archived at the BioMagResBank (BMRB) provide a rich resource of biophysical information at atomic resolution. ...
Conclusions: We have developed BMRB/XML and BMRB/RDF and demonstrate their use in performing a federated SPARQL query linking the BMRB to other databases through standard semantic web technologies. ...
Findings
Background The BioMagResBank (BMRB; http://www.bmrb.wisc.edu/) is a worldwide data repository for experimental and derived data gathered from nuclear magnetic resonance (NMR) spectroscopic studies ...
doi:10.1186/s13326-016-0057-1
pmid:27927232
pmcid:PMC5143449
fatcat:kidpbvthwbgzjko7jvgesbepqm
Biomedical Semantic Resources for Drug Discovery Platforms
[chapter]
2017
Lecture Notes in Computer Science
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Increasingly semantic Web technologies are being developed and used including ontologies, triple stores and combinations thereof. ...
The biomedical research community is providing large-scale data sources to enable knowledge discovery from the data alone, or from novel scientific experiments in combination with the existing knowledge ...
Similarly we categorise libraries and databases in five categories that comprise (i) Gene, Gene Expression and Protein Databases, (ii) Pathway databases, (iii) Chemical and Structure Databases including ...
doi:10.1007/978-3-319-70407-4_34
fatcat:2bzddzat5zdcrinfwd6m4xqlai
XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments
2010
Genome Biology
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XGAP has simple load formats for any type of genotype, epigenotype, transcript, protein, metabolite or other phenotype data. ...
Readers can download a standard XGAP (http://www.xgap.org) or auto-generate a custom version using MOLGENIS with programming interfaces to R-software and web-services or user interfaces for biologists. ...
Acknowledgements The authors thank CASIMIR (funded by the European Commission under contract number LSHG-CT-2006-037811, [70] ; Table 7) , and GEN2PHEN, a FP7 project funded by the European Commission ...
doi:10.1186/gb-2010-11-3-r27
pmid:20214801
pmcid:PMC2864567
fatcat:kz73rzypunb5ll7f3oxxj2utve
Systems medicine: evolution of systems biology from bench to bedside
2015
Wiley Interdisciplinary Reviews: Systems Biology and Medicine
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Systems biology integrates the mass of heterogeneous high-throughput data and predictive computational modeling to understand biological functions as system-level properties. ...
At the same time, systems biology seeks to assist in drug discovery, drug optimization, drug combinations, and drug repositioning by investigating the molecular mechanisms of action of drugs at a system's ...
This work was supported in part by NIH grants 1K08HL111207-01A1 (to BAM), and HL061795, HL108630 (MAPGen Consortium), HG007690 (to JL), and the Pulmonary Hypertension Association (to BAM). ...
doi:10.1002/wsbm.1297
pmid:25891169
pmcid:PMC4457580
fatcat:l4446pjeazanxakj2jwlt26l5m
Natural product drug discovery in the artificial intelligence era
2022
Chemical Science
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Natural products (NPs) are primarily recognized as privileged structures to interact with protein drug targets. ...
Their unique characteristics and structural diversity continue to marvel scientists for developing NP-inspired medicines, even... ...
magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and combinations thereof. ...
doi:10.1039/d1sc04471k
pmid:35282622
pmcid:PMC8827052
fatcat:jyfupubc2bgb7p4v6b62apgtfq
Biological and Medical Sciences
1971
Annals of the New York Academy of Sciences
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Not surprisingly the percentage of basic research is high, in accordance with the horizontal nature of several of the BMS RIs. ...
Figure 31 illustrates an estimate of the contribution of each individual BMS RI to research activities across this spectrum, from basic medical/ biological research and innovation activities to activities ...
Conventional MRI is only the first of an array of methods that will eventually comprise the nuclear magnetic resonance (NMR) diagnostic armamentarium. ...
doi:10.1111/j.1749-6632.1971.tb41309.x
fatcat:6zdkjtuojrdwhib3lpdzoq7i3u
Biological and Medical Sciences
1989
The gerontologist
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Not surprisingly the percentage of basic research is high, in accordance with the horizontal nature of several of the BMS RIs. ...
Figure 31 illustrates an estimate of the contribution of each individual BMS RI to research activities across this spectrum, from basic medical/ biological research and innovation activities to activities ...
Conventional MRI is only the first of an array of methods that will eventually comprise the nuclear magnetic resonance (NMR) diagnostic armamentarium. ...
doi:10.1093/geront/29.1.137a
fatcat:32k4evfphzhdddo3ikpfvbwcgi
Identifying disease mutations in genomic medicine settings: current challenges and how to accelerate progress
2012
Genome Medicine
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We thank Peter Krawitz, Degui Zhi, Shane McCarthy, Jason O'Rawe, Edwin Nyambi, Reid Robison and three anonymous reviewers for helpful comments and suggestions for the manuscript. ...
Acknowledgements We apologize to those whose work we could not cite due to reference limitations. ...
A compromise might be along the lines of what has occurred with the disruptive technology magnetic resonance imaging (MRI), which has been deployed in many hospitals but also at stand-alone MRI diagnostic ...
doi:10.1186/gm359
pmid:22830651
pmcid:PMC3580414
fatcat:c6ui7sn4gfetjbmvuqe4becloi
Machine Learning Methods for Histopathological Image Analysis: A Review
[article]
2021
arXiv
pre-print
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One of the ways of accelerating such an analysis is to use computer-aided diagnosis (CAD) systems. ...
In addition, we present a list of publicly available and private datasets that have been used in HI research. ...
The number of publications related to the field of this research is presented in Figure 3 . ...
arXiv:2102.03889v1
fatcat:ylrsildl4nenho22erndvpjcjy
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
2018
Natural product reports (Print)
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disseminating raw nuclear magnetic resonance (NMR) data, independently of, and in parallel with, classical publishing outlets. ...
With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of ...
Acknowledgements
Acknowledgements The lead authors (JBM and GFP) and the CENAPT co-authors wish to acknowledge support through grant U41 AT008706 from NCCIH and ODS/NIH. We are also grateful to Ms. ...
doi:10.1039/c7np00064b
pmid:30003207
pmcid:PMC6350634
fatcat:334k3rvc6ffyja6hflp7jeokji
Self-Organized Evolutionary Process in Sets of Interdependent Variables near the Midpoint of Phase Transition in K-Satisfiability
[chapter]
2001
Lecture Notes in Computer Science
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Ackerman, John T Strategic Studies Quarterly: An Air Force-Sponsored Strategic Forum for Military, Government, and Academic Professionals. Volume 2, Number 1 -7 Acuff, Hugh F ...
NRL's principal task is the development and orderly flow of research results for Navy applications and technology transfer. ...
activities with potential application for nuclear weapons. ...
doi:10.1007/3-540-45443-8_20
fatcat:ght26tu6avh57kkp54kifofaee
Alternatives to animal use in research, testing, and education
1988
Annales de l'Institut Pasteur: Immunologie
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Concerns focus on balancing societal needs for continued progress in biomedical and behavioral research, for toxicity testing to safeguard the public, and for education in the life sciences with desires ...
In this assessment, OTA analyzes the scientific, regulatory, economic, legal, and ethical considerations involved in alternative technologies in biomedical and behavioral research, toxicity testing, and ...
The Navy in fiscal year 1985 allocated $58 million for the life sciences or biomedical research. ...
doi:10.1016/0769-2625(88)90076-1
fatcat:6qph3stknzah7pu2zi6t5sh6ca
Alternatives to animal use in research, testing and education
1990
Food and Chemical Toxicology
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Concerns focus on balancing societal needs for continued progress in biomedical and behavioral research, for toxicity testing to safeguard the public, and for education in the life sciences with desires ...
In this assessment, OTA analyzes the scientific, regulatory, economic, legal, and ethical considerations involved in alternative technologies in biomedical and behavioral research, toxicity testing, and ...
The Navy in fiscal year 1985 allocated $58 million for the life sciences or biomedical research. ...
doi:10.1016/0278-6915(90)90029-m
fatcat:twxfjmkepjelfjejuunmi2k2yi
Alternatives to animal use in research, testing, and education
1988
European Journal of Medicinal Chemistry
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Concerns focus on balancing societal needs for continued progress in biomedical and behavioral research, for toxicity testing to safeguard the public, and for education in the life sciences with desires ...
In this assessment, OTA analyzes the scientific, regulatory, economic, legal, and ethical considerations involved in alternative technologies in biomedical and behavioral research, toxicity testing, and ...
The Navy in fiscal year 1985 allocated $58 million for the life sciences or biomedical research. ...
doi:10.1016/0223-5234(88)90017-7
fatcat:upcuogj32rcuhiposqatpfjeu4
Alternatives to animal use in research, testing, and education
1988
Annales de l Institut Pasteur Microbiologie
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Concerns focus on balancing societal needs for continued progress in biomedical and behavioral research, for toxicity testing to safeguard the public, and for education in the life sciences with desires ...
In this assessment, OTA analyzes the scientific, regulatory, economic, legal, and ethical considerations involved in alternative technologies in biomedical and behavioral research, toxicity testing, and ...
The Navy in fiscal year 1985 allocated $58 million for the life sciences or biomedical research. ...
doi:10.1016/0769-2609(88)90117-2
fatcat:57ydhlrq2ng7vgbvlqxtqpxgau
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