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Protocol Techniques for Testing Radiotherapy Accelerators [chapter]

Kenneth J. Turner, Qian Bing
2002 Lecture Notes in Computer Science  
The paper describes a novel application of protocol specification and testing methods to radiotherapy accelerators.  ...  The nature of radiotherapy accelerators is briefly explained. It is argued that these complex safety-critical systems need a systematic basis for testing their software.  ...  Ji He for their insights into test generation.  ... 
doi:10.1007/3-540-36135-9_6 fatcat:65c5rykgengvxjk5mcqzmzidoa

Survey of Equipment Quality Control in Radiotherapy Centres in Croatia: First Results

Slaven Jurković, Ana Diklić, Mladen Kasabašić, Đeni Radojčić, Manda Švabić, Ana Ivković, Dario Faj
2011 Arhiv za Higijenu Rada i Toksikologiju  
The tests were defi ned and performed according to protocols developed at two university hospitals. Test results varied largely between the centres. This calls for harmonisation of QC protocols.  ...  As a fi rst step, we defi ned a set of tests to check different parameters of linear accelerators and simulators in these centres.  ...  For that purpose, we defi ned a set of tests for QC parameters based on the existing QC protocols and tested linear accelerators and simulators in six radiation therapy centres in Croatia.  ... 
doi:10.2478/10004-1254-62-2011-2103 pmid:21971110 fatcat:4ewdm7n4wjaptinumi66suxhoe

The Role of Radiotherapy in the Definitive and Postoperative Treatment of Advanced Head and Neck Cancer

Robert Semrau
2017 Oncology Research and Treatment  
Modern Radiotherapy Techniques For its probability of accurate dose prescription, IMRT has been recognized as the standard radiotherapy technique in SCCHN.  ...  Therefore, using accelerated radiotherapy protocols is no longer recommended in concurrent radiochemotherapy.  ... 
doi:10.1159/000477128 pmid:28521321 fatcat:4b5ykhqypfcw7ovtjl4et7cmyi

Stereotactic radiosurgery of prostate cancer – dose distribution for VMAT and CyberKnife techniques

Krzysztof Ślosarek, Wojciech Osewski, Aleksandra Grządziel, Małgorzata Stąpór-Fudzińska, Marta Szlag
2016 Polish Journal of Medical Physics And Engineering  
For this purpose different biomedical accelerators are used. The aim of this study is to compare dose distributions for two techniques: VMAT and CyberKnife.  ...  Statistical analysis was performed for the two groups of patients treated by VMAT technique (25 patients), and CyberKnife technique (15 patients).  ...  The analysis is performed for two groups of patients treated with different protocols on two different biomedical accelerators.  ... 
doi:10.1515/pjmpe-2016-0007 fatcat:4p2buu4tgbdnjjjvwh3wybnvna

Awareness and surveillance of radiation treatment schedules reduces head and neck overall treatment time

Rasmus Lübeck Christiansen, Janne Gornitzka, Pia Andersen, Morten Nielsen, Lars Johnsen, Anders Smedegaard Bertelsen, Ruta Zukauskaite, Jørgen Johansen, Christian Rønn Hansen
2019 Technical Innovations & Patient Support in Radiation Oncology  
National radiotherapy guidelines of the Danish Head and Neck Cancer Group (DAHANCA) recommend a maximum OTT of 41 days for moderately accelerated radiation treatment (6 fractions/week) and 48 days for  ...  Overall treatment time (OTT) is essential for local tumour control and survival in radiotherapy of head and neck cancer (HNC).  ...  Major protocol deviations were observed in 3 and 27 cases for accelerated and non-accelerated patients, respectively.  ... 
doi:10.1016/j.tipsro.2019.01.002 pmid:32095592 pmcid:PMC7033770 fatcat:rwgrqwj6gve5lk6nfejjgnguia

Test generation for radiotherapy accelerators

Kenneth J. Turner
2004 International Journal on Software Tools for Technology Transfer (STTT)  
The approach is applied to a case study in which tests are generated for radiotherapy accelerators used in cancer treatment.  ...  Test suites are generated by a transition tour that either visits every transition at least once (for infinite behaviour) or follows every path (for finite behaviour).  ...  Ji He implemented most of the test generation tool. The author thanks Dr. Jan Tretmans (University of Nijmegen) for his insights into test generation.  ... 
doi:10.1007/s10009-004-0148-7 fatcat:pgfyfkckabepphfxokst4lje7y

PORTAF – postoperative radiotherapy of non-small cell lung cancer: accelerated versus conventional fractionation – study protocol for a randomized controlled trial

R. Bütof, M. Simon, S. Löck, E. G. C. Troost, S. Appold, M. Krause, M. Baumann
2017 Trials  
Our own retrospective data suggest an advantage of shorter OTT also for postoperative radiotherapy in this patient group.  ...  Methods/design: This is a multicenter, prospective randomized trial investigating whether an accelerated course of postoperative radiotherapy with photons or protons (7 fractions per week, 2 Gy fractions  ...  Cordelia Hoinkis are acknowledged for their efforts in quality assurance and homogenization of the irradiation technique.  ... 
doi:10.1186/s13063-017-2346-0 pmid:29262836 pmcid:PMC5738814 fatcat:yu4fpv22evgu5iywss2p43xlpq

A randomized controlled trial testing a hyaluronic acid spacer injection for skin toxicity reduction of brachytherapy accelerated partial breast irradiation (APBI): a study protocol

Gerson M. Struik, Jeremy Godart, Gerda M. Verduijn, Inger-Karine Kolkman-Deurloo, Kim C. de Vries, Raymond de Boer, Linetta B. Koppert, Erwin Birnie, Ali Ghandi, Taco M. Klem, Jean-Philippe Pignol
2018 Trials  
A randomized controlled trial testing a hyaluronic acid spacer injection for skin toxicity reduction of brachytherapy accelerated partial breast irradiation (APBI) Struik, Gerson M.; Godart, Jeremy; Verduijn  ...  Funding GS receives a financial research support through the Theia Foundation (no. 2016244), the Coolsingel Foundation (no. 444), and the Franciscus Friends Fund (Brachytherapy for Breast Cancer Research  ...  S T U D Y P R O T O C O L Open Access A randomized controlled trial testing a hyaluronic acid spacer injection for skin toxicity reduction of brachytherapy accelerated partial breast irradiation (APBI)  ... 
doi:10.1186/s13063-018-3035-3 fatcat:swrirn7gzbdznmjno6q3amkuka

Hypofractionated Radiotherapy Using Simultaneous Integrated Boost Technique with Concurrent and Adjuvant Temozolomide for Glioblastoma

Manal M. S. Elghareeb, Hanan Ahmed Wahba, Ahmed M. El- Demeri, Mohamed Elashry, Rasha Abd El Ghany Khedr
2020 Journal of Cancer and Tumor International  
Aim: This study was conducted to assess the safety and efficacy of postoperative hypofractionated radiotherapy (HRT) using simultaneous integrated boost (SIB) technique for glioblastoma (GBM) compared  ...  to conventional radiotherapy (CRT).  ...  The accelerated radiotherapy protocols and using higher doses per fraction will reduce the treatment duration,so may have a radiobiological advantage and decrease the In our study, the patients  ... 
doi:10.9734/jcti/2020/v10i430134 fatcat:xqrkkhugofhpfiivcxkpiflci4

Pilot Study on Continuous Hyperfractionated Accelerated Radiotherapy(CHART) and High Dose Rate Brachytherapy in Locally Advanced Cervical Cancer

Biswa Mohan Biswal, Nik Min Ahmad, Zainal Abidin Hanafia, Ahmad Zakaria, Nor Hayati Othman
2011 Journal of Cancer Science & Therapy  
The response to above radiotherapy protocol and morbidity pattern was evaluated. Results: All patients completed planned CHART external radiotherapy.  ...  Continuous hyperfractionated accelerated radiotherapy (CHART) is an altered fractionation scheme used to reduce overall treatment time, overcome tumor repopulation thus could be an option in cervical carcinoma  ...  Hasmat Zakaria for their contributions and advise.  ... 
doi:10.4172/1948-5956.1000073 fatcat:sgo3mh4gx5a5vm6f5svfj6q6ve

Induction chemotherapy followed by concurrent chemotherapy and definitive high-dose radiotherapy for patients with locally advanced non-small-cell lung cancer (stages IIIa/IIIb): a pilot phase I/II trial

C. Pottgen
2002 Annals of Oncology  
Three cycles of cisplatin/etoposide (PE) were followed by hyperfractionated accelerated radiotherapy (HF-RTx; 1.5 Gy bid up to a total dose of 45 Gy in 3 weeks) concurrent with one cycle of PE.  ...  The aim of this pilot phase I/II investigation was to test the feasibility and toxicity of a definitive multimodality protocol in patients with irresectable NSCLC stages IIIA (N2) and IIIB.  ...  [28] have tested a protocol of induction chemotherapy, comparable to that in the Cancer and Leukemia Group B (CALGB) 8433 trial, followed by standard radiotherapy combined with daily low-dose cisplatin  ... 
doi:10.1093/annonc/mdf050 pmid:11996471 fatcat:jxe7yhnnd5aajmxegdrardlcu4

SPLIT-COURSE ACCELERATED HYPERFRACTIONATED RADIOTHERAPY IN HEAD AND NECK CARCINOMA- AN EXPERIENCE IN TERMS OF LOCAL TUMOUR CONTROL AND TOXICITY
English

Ramesh Arya, Vinay Shivhare, Preeti Jain, Allwin George, Love Goyal, Minal Iyer, Vaibhav Saini
2017 Journal of Evolution of Medical and Dental Sciences  
BACKGROUND Radiotherapy alone was long the standard nonsurgical therapy for locally advanced disease.  ...  Using the technique of opposed parallel fields and split-course accelerated hyper-fractionation with similar dose per fraction and reduced boost volume during the second part of treatment schedule.  ...  Many strategies and radiation technique with different outcomes are predicted with a hope to improve survival for advanced tumour.  ... 
doi:10.14260/jemds/2017/713 fatcat:elws72tlmnejdaudnphtlzqqpa

A Verification of Treatment Protocol in Fractionated Radiotherapy by Biological Dosimetry

İdil ÖNER,, Tuncay ORTA, Melek Özlem K OLUSAYIN, Süreyya GÜNEBAKAN
2011 Journal of Nuclear Medicine & Radiation Therapy  
In addition to requirements in scientific research for raising standarts, radiation dose calculation and preparing the treatment setup for patient according to the treatment protocol is important in delivering  ...  Studies that were performed with radiotherapy patients have also confirmed that MN technique is reliable and conveinent technique in estimating equivalent whole body dose that patient receives during fractional  ... 
doi:10.4172/2155-9619.1000116 fatcat:mlpbkoo6rbgb7hvtf4n5pz54vm

Phase 1 Study of Accelerated Hypofractionated Radiation Therapy With Concurrent Chemotherapy for Stage III Non-Small Cell Lung Cancer: CALGB 31102 (Alliance)

James J. Urbanic, Xiaofei Wang, Jeffrey A. Bogart, Thomas E. Stinchcombe, Lydia Hodgson, Steven E. Schild, Lyudmila Bazhenova, Olwen Hahn, Ravi Salgia, Everett E. Vokes
2018 International Journal of Radiation Oncology, Biology, Physics  
Purpose: Investigate the safety of accelerated hypofractionated radiotherapy (AHRT) with concurrent chemotherapy (CT) for inoperable stage III non-small-cell lung cancer (NSCLC).  ...  Patients and Methods: The primary objectives were to define the maximally tolerable course of accelerated radiotherapy and describe toxicities of therapy. Total radiotherapy remained at 60 Gy.  ...  Radiation quality assurance was supported by National Cancer Institute of the National Institutes of Health under Award Numbers CA29511 for the Quality Assurance Review Center CA180803 for the Imaging  ... 
doi:10.1016/j.ijrobp.2018.01.046 pmid:29487024 pmcid:PMC6173195 fatcat:kfvpurqttjherej3ziy35iqzaa

Hypofractionated Accelerated Chemo-radiotherapy (Chemo-HypoAR) With Cisplatin and Liposomal Doxorubicin for the Treatment of Patients With Uterine Sarcomas

SPYROS DOMOXOUDIS, IOANNIS M. KOUKOURAKIS, AXIOTIS G. GIAKZIDIS, MICHAEL I. KOUKOURAKIS
2019 In Vivo  
Concurrent hypofractionated and accelerated chemo-radiotherapy (chemo-HypoAR) is feasible and provides excellent survival figures.  ...  radiotherapy (2.7 Gy/fraction for 14 fractions followed by one fraction of 6-8 Gy dose to the vagina).  ...  A 3D-conformal radiotherapy technique was applied, using 4-fields (box). Radiotherapy was given with an 18 MV linear accelerator endowed with a multileaf collimator.  ... 
doi:10.21873/invivo.11646 pmid:31471414 pmcid:PMC6755002 fatcat:5lqtl6b3afdwjkcmassjbsqtbu
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