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Protein synthesis is associated with high-speed dynamics and broad-band stability of functional hubs in the brain

Peter J. Hellyer, Erica F. Barry, Alberto Pellizzon, Mattia Veronese, Gaia Rizzo, Matteo Tonietto, Manuel Schütze, Michael Brammer, Marco Aurélio Romano-Silva, Alessandra Bertoldo, Federico E. Turkheimer
2017 NeuroImage  
Using a Dynamic connectivity approach, we also demonstrate that broad-band dynamic measures of Functional Connectivity (FC), are inversely correlated with protein turnover, suggesting greater stability  ...  of FC in highly interconnected hub regions is supported by protein synthesis.  ...  Whilst our analysis is broadly exploratory in nature, we test the hypothesis that functional network hubs are associated with high levels of protein synthesis, independent of basal levels of metabolism  ... 
doi:10.1016/j.neuroimage.2017.04.062 pmid:28465163 pmcid:PMC5519503 fatcat:pim4admf6nexnadwcfgbrvgooi

Arc is a flexible modular protein capable of reversible self-oligomerization

Craig Myrum, Anne Baumann, Helene J. Bustad, Marte Innselset Flydal, Vincent Mariaule, Sara Alvira, Jorge Cuéllar, Jan Haavik, Jonathan Soulé, José Maria Valpuesta, José Antonio Márquez, Aurora Martinez (+1 others)
2015 Biochemical Journal  
We conclude that hArc is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes.  ...  The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory.  ...  We thank Jarl Underhaug (University of Bergen) for assistance in data analysis, Joanna Kirkpatrick (Proteomics CoreFacility, EMBL, Heidelberg, Germany) for the mass spectrometric analysis, and Peter Gimeson  ... 
doi:10.1042/bj20141446 pmid:25748042 pmcid:PMC4422259 fatcat:kpmgxft6mbesdodenivbodqwze

Disruption of Neurosynaptic Physiology and Neuron Network Dysfunction in Brain Disorders: An Environmental and Occupational Health Perspective

Abhay Kumar Pandey
2017 Alzheimer's & Neurodegenerative Diseases  
The mounting challenge of prevention and management of pollution inflicted disruption of neurophysiology associated with brain dysfunction and diseases in contemporary world may be better addressed by  ...  Disruptions in structure and function of neurotransmission elements and protein networks contribute to pathogenesis of neuropsychiatric diseases.  ...  Tasks that involves working memory is associated with increased EEG synchronization especially, in the theta band and possibly also in alpha band.  ... 
doi:10.24966/and-9608/100009 fatcat:t6fdusaa6fca5gbxvnnjloneb4

Disruption of Neurosynaptic Physiology and Neuron Network Dysfunction in Brain Disorders: an Environmental and Occupational Health Perspective

Abhay Kumar Pandey
2017 Activitas Nervosa Superior  
The mounting challenge of prevention and management of pollution inflicted disruption of neurophysiology associated with brain dysfunction and diseases in contemporary world may be better addressed by  ...  Disruptions in structure and function of neurotransmission elements and protein networks contribute to pathogenesis of neuropsychiatric diseases.  ...  Tasks that involves working memory is associated with increased EEG synchronization especially, in the theta band and possibly also in alpha band.  ... 
doi:10.1007/s41470-017-0007-y fatcat:3kau4o6u7zhe3pexhfuqqzoe2u

Efficient Coding in the Economics of Human Brain Connectomics

Dale Zhou, Christopher W. Lynn, Zaixu Cui, Rastko Ciric, Graham L. Baum, Tyler M. Moore, David R. Roalf, John A. Detre, Ruben C. Gur, Raquel E. Gur, Theodore D. Satterthwaite, Dani S. Bassett
2021 Network Neuroscience  
Lastly, compression efficiency is predictive of behavior—beyond the conventional network efficiency metric—for cognitive domains including executive function, memory, complex reasoning, and social cognition  ...  In doing so, we introduce the metric of compression efficiency, which quantifies the trade-off between lossy compression and transmission fidelity in structural networks.  ...  Adolescence is 1291 associated with genomically patterned consolidation of the hubs of the human brain connectome.  ... 
doi:10.1162/netn_a_00223 fatcat:uzzgizrljvd73be5lrrsyfehiy

RNA Protein Granules ModulatetauIsoform Expression and Induce Neuronal Sprouting

Katharina Moschner, Frederik Sündermann, Heiko Meyer, Abel Pereira da Graca, Neele Appel, Achim Paululat, Lidia Bakota, Roland Brandt
2014 Journal of Biological Chemistry  
The neuronal microtubule-associated protein Tau is expressed in different variants, and changes in Tau isoform composition occur during development and disease.  ...  We report that RNP granule formation is associated with increased neurite formation and enhanced process growth.  ...  G3BP1 and IMP1 constructs; Maik Drechsler for help with in situ hybridization, and Vanessa Herkenhoff for technical assistance.  ... 
doi:10.1074/jbc.m113.541425 pmid:24755223 pmcid:PMC4059124 fatcat:iaz72it6prhd3alpp2iwiu7ydy

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2 [article]

Alexia Martinez de Paz, Leila Khajavi, Helene Martin, Rafael Claveria-Gimeno, Susanne tom Dieck, Manjinder Singh Cheema, Jose Vicente Sanchez-Mut, Malgorzata Moksa, Annaick Carles, Nick Brodie, Taimoor I Sheikh, Melissa Freeman (+11 others)
2018 bioRxiv   pre-print
MeCP2, a chromatin-binding protein associated with Rett syndrome, has two main isoforms, MeCP2-E1 and MeCP2-E2, with 96% amino acid identity differing in a few N-terminal amino acid residues.  ...  Here, we show that the N-terminal domains (NTD) of MeCP2-E1 and E2 modulate the ability of the methyl binding domain (MBD) to interact with DNA as well as influencing the turnover rates, binding dynamics  ...  E1 co-eluted proteins include spectrin β 1, lamin B2, the band 4.1 proteins B and N and matrin 3 (the latter was previously reported to interact with E1 in neuronal nuclei (41)), components of the nuclear  ... 
doi:10.1101/392092 fatcat:szd7wkjow5dp3gzgynsombvjwy

WDR92 Is Required for Axonemal Dynein Heavy Chain Stability in Cytoplasm

Ramila S. Patel-King, Miho Sakato-Antoku, Maya Yankova, Stephen M. King, Erika L. F. Holzbaur
2019 Molecular Biology of the Cell  
These data indicate that WDR92 is a key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm and suggest that cytoplasmic/IFT dynein heavy chains utilize  ...  WDR92 associates with a prefoldin-like co-chaperone complex and known dynein assembly factors.  ...  We also thank David Mitchell (SUNY Upstate Medical University) for his advice concerning the DAP1/PF13 gene model, and Yuqing Hou and George Witman (University of Massachusetts Medical School) for antibody  ... 
doi:10.1091/mbc.e19-03-0139 pmid:31116681 pmcid:PMC6727741 fatcat:epfjhqpfcjdwhgrt5jukthqnp4

Connexin multi-site phosphorylation: Mass spectrometry-based proteomics fills the gap

Vincent C. Chen, Joost W. Gouw, Christian C. Naus, Leonard J. Foster
2013 Biochimica et Biophysica Acta - Biomembranes  
At the most fundamental level, the introduction of sequence-altering, modifications introduces changes in protein conformation, activity, charge, stability and localization.  ...  With the growing prominence of mass spectrometry in biology and medicine, we are now getting a glimpse of the richness of connexin phosphate signals.  ...  The proteome is highly dynamic, with a broad range of individual protein concentrations ranging from several million to only a few copies/cell [31] .  ... 
doi:10.1016/j.bbamem.2012.02.028 pmid:22421184 fatcat:avzs6kfd5bclplqlgn5bcm542q

The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives

Jennifer A. Ross, Elisabeth J. Van Bockstaele
2021 Frontiers in Psychiatry  
We share our contemporary perspective and the hypotheses of others in the context of our current technological capabilities and future developments that will be required to move forward in this area of  ...  Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction, and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and psychosis on the other  ...  The theta band (4-8 Hz) is associated with mental tasks that require a high degree of focus, such as learning or recalling information (100) .  ... 
doi:10.3389/fpsyt.2020.601519 pmid:33584368 pmcid:PMC7873441 fatcat:hfbkrasizzb3rhgrlw7igolyqe

Beta2 Oscillations in Hippocampal-Cortical Circuits During Novelty Detection

Arthur S. C. França, Nils Z. Borgesius, Bryan C. Souza, Michael X. Cohen
2021 Frontiers in Systems Neuroscience  
In this work, we combined multisite local field potential (LFP) recordings with novelty-related behavioral tasks in mice to describe the oscillatory dynamics associated with novelty detection in the CA1  ...  Novelty detection is a core feature of behavioral adaptation and involves cascades of neuronal responses—from initial evaluation of the stimulus to the encoding of new representations—resulting in the  ...  Another possibility is the delay being related to the stability of the place field that is followed by the dynamic of beta2 (Berke et al., 2008) .  ... 
doi:10.3389/fnsys.2021.617388 pmid:33664653 pmcid:PMC7921172 fatcat:gfiw3lv665brxd4itbnjpwywqu

2017 ASCB Annual Meeting Abstracts

David G. Drubin
2017 Molecular Biology of the Cell  
beta -arrestins and has important functions in the regulation of receptor signaling.  ...  We showed previously that internalization and lysosomal sorting of GPCRs is important for the temporal and spatial dynamics of receptor signaling and appropriate cellular responses.  ...  A broad range of membrane proteins display anomalous diffusion on the cell surface.  ... 
doi:10.1091/mbc.e17-10-0618 pmid:29237772 pmcid:PMC5739290 fatcat:3msjrn3omzcybfanlagykayauy

Award Winners and Abstracts of the 31st Annual Symposium of The Protein Society, Montreal, Canada, July 24-27, 2017

2017 Protein Science  
(ExM), was recently discovered, enabling physical magnification and high resolution imaging of fixed cell lines and mouse brain tissue with conventional, optical microscopes (Chen, Tillberg, Boyden, 2015  ...  In the present study, we aimed to improve the ExM method for imaging of proteins in human clinical tissue samples, for diagnostic pathology and research.  ...  Proteins commonly fold into a single native state, a basin on the energy landscape low enough to be stable in solution and broad enough to allow motions associated with protein function.  ... 
doi:10.1002/pro.3349 pmid:29280217 fatcat:jrxtwzblare37gxsvc5szbwuhu

Fractals in the Nervous System: conceptual Implications for Theoretical Neuroscience [article]

Gerhard Werner
2010 arXiv   pre-print
This essay is presented with two principal objectives in mind: first, to document the prevalence of fractals at all levels of the nervous system, giving credence to the notion of their functional relevance  ...  The final Section consists of general reflections on the implications of the reviewed data, and identifies what appear to be issues of fundamental importance for future research in the rapidly evolving  ...  of chaotic dynamics in EEG: sensitivity to initial conditions is of course prominent; it is also associated with broad-band power spectra and a fractal attractor dimension.  ... 
arXiv:0910.2741v2 fatcat:nj6zeigotrdnrkaoivgcjxcuke

The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs

Wang-Xia Wang, Paresh Prajapati, Peter T. Nelson, Joe E. Springer
2020 Molecular Neurobiology  
Disruption of contact between the mitochondria and ER is associated with a variety of pathophysiological conditions including neurodegenerative diseases.  ...  The mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are specific ER domains that contact the mitochondria and function to facilitate communication between ER and mitochondria.  ...  Execution of miRNA function is carried out in association with an Argonaute (AGO) proteincontaining complex, and the gene regulatory activities are widely believed to occur mostly in the cytoplasm.  ... 
doi:10.1007/s12035-020-01937-y pmid:32451872 fatcat:vdf5ezbuzzaz5i52ey2rwew6by
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