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PROTEIN INTERACTIONS AND DISEASE PHENOTYPES IN THE ABC TRANSPORTER SUPERFAMILY

LIBUSHA KELLY, RACHEL KARCHIN, ANDREJ SALI
2006 Biocomputing 2007  
Given the importance of intra-and inter-protein interactions in the ABC transporters, coupled with the large body of data on disease-associated  ...  In humans, clinical studies have implicated mutations in 19 of the 48 known ABC transporters in diseases such as cystic fibrosis and adrenoleukodystrophy.  ...  Kathy Giacomini, Jason Gow and Marco Sorani (UCSF) for helpful discussions about membrane transporters.  ... 
doi:10.1142/9789812772435_0006 fatcat:my5ag4vlxnfvzeti6y4526bwsi

Probabilistic Orthology Analysis of the ATP-Binding Cassette Transporters: Implications for the Development of Multiple Drug Resistance Phenotype

C. Fisher, T. Coleman, N. Plant
2012 Drug Metabolism And Disposition  
In addition, using protein sequences from species important in the design and evaluation of novel chemicals, namely human, macaque, rat, mouse, and dog, we have undertaken probabilistic orthology analysis  ...  , difference in these proteins.  ...  In addition, we present the first complete human phylogeny across the entire superfamily, demonstrating segregation between sequences that encode ABC transporters evoking the MDR phenotype and those which  ... 
doi:10.1124/dmd.112.045062 pmid:22511348 pmcid:PMC3382838 fatcat:wlui2oex6be43isjycw73h2jsy

Transporters in the Paracoccidioides brasiliensis transcriptome: insights on drug resistance

Christiane da Silva Costa, Flávia Caixeta Albuquerque, Rosângela Vieira Andrade, Gina Camilo de Oliveira, Mauro Fernandes de Almeida, Marcelo de Macedo Brigido, Andrea Queiroz Maranhão
2005 Genetics and Molecular Research  
In cancer cells and in pathogens, and particularly in fungi, some of these proteins have been pointed out as responsible for an important phenotype known as multidrug resistance (MDR).  ...  In the present study, we tried to identify in the Paracoccidioides brasiliensis transcriptome, transporter-ortholog genes from the two major classes: ATP binding cassette and major facilitator superfamily  ...  ACKNOWLEDGMENTS Research supported by MCT/CNPq, CNPq, CAPES, FUB, and UFG.  ... 
pmid:16110453 fatcat:acgqqjbwr5f7rmg45p7lylrojy

ATP-Binding Cassette (ABC) Transporters and Their Role in Inflammatory Bowel Disease (IBD)

Reena Kumari
2018 Biomedical Journal of Scientific & Technical Research  
ATP-binding cassette (ABC) transporters are a large superfamily of membrane proteins with various functions and are also expressed on apical lining of intestine.  ...  Therefore regulating the ABC transporter may be useful in controlling the symptoms or treatment of disease.  ...  Inflammatory bowel disease is mainly of two types: ATP-Binding Cassette (ABC) Transporters ATP-binding cassette (ABC) transporters are a large superfamily of membrane proteins with varying functions  ... 
doi:10.26717/bjstr.2018.05.0001141 fatcat:fxapas23rfhydp2o7qtgudgm5q

The molecular genetics of familial intrahepatic cholestasis

P L M JANSEN
2000 Gut  
There is a growing list of genetic diseases caused by defects of one of the members of the ATP binding cassette (ABC) transporter superfamily. 1 ABC transporters mediate the energy dependent transport  ...  ABC transporters are important in almost every human cell or organ and therefore the spectrum of diseases caused by defects of these proteins is diverse and includes: liver diseases (progressive familial  ... 
doi:10.1136/gut.47.1.1 pmid:10861251 pmcid:PMC1727973 fatcat:um2odvli5vf4vkca6eladbzrxq

Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains

Libusha Kelly, Hisayo Fukushima, Rachel Karchin, Jason M. Gow, Leslie W. Chinn, Ursula Pieper, Mark R. Segal, Deanna L. Kroetz, Andrej Sali
2010 Protein Science  
The human ATP-binding cassette (ABC) transporter superfamily consists of 48 integral membrane proteins that couple the action of ATP binding and hydrolysis to the transport of diverse substrates across  ...  Kathleen Giacomini and Robert Stroud for helpful discussions on the work.  ...  Acknowledgments The authors would like to thank Dr. Adrian S. Ray (Gilead Sciences, Inc.) for expert technical assistance with the MRP4 functional assay. They thank Drs.  ... 
doi:10.1002/pro.491 pmid:20799350 pmcid:PMC3005782 fatcat:owz3hno4bfhbxfjh23ihlja5cu

Page 696 of Cellular and Molecular Life Sciences Vol. 61, Issue 6 [page]

2004 Cellular and Molecular Life Sciences  
D. (2002) ABC transporters as phenotypic mark- ers and functional regulators of stem cells.  ...  Cancer Biol. 8: 183-191 Borst P. and Elferink O. (2002) Mammalian ABC transporters in health and disease. Annu. Rev. Biochem. 71: 537-592 Gottesman M.  ... 

Human ATP-binding cassette (ABC) transporter family

Vasilis Vasiliou, Konstandinos Vasiliou, Daniel W Nebert
2008 Human Genomics  
In mammals, ABC transporters are expressed predominantly in the liver, intestine, blood -brain barrier, blood -testis barrier, placenta and kidney.  ...  ABC transporters also participate in the movement of most drugs and their metabolites across cell surface and cellular organelle membranes; thus, defects in these genes can be important in terms of cancer  ...  The writing of this paper was funded, in part, by NIH grants R01 EY11490 (V.V.) and P30 ES06096 (D.W.N.).  ... 
doi:10.1186/1479-7364-3-3-281 pmid:19403462 pmcid:PMC2752038 fatcat:kcokyoqiubevne5oyc6fb5oucm

Non-Target Site Mechanisms of Fungicide Resistance in Crop Pathogens: A Review

Mengjun Hu, Shuning Chen
2021 Microorganisms  
A majority of modern fungicides act to disrupt a biochemical function via binding a specific target protein in the pathway.  ...  The rapid emergence of resistance in plant pathogens to the limited number of chemical classes of fungicides challenges sustainability and profitability of crop production worldwide.  ...  ABC/MFS Genes in Plant Pathogenic Fungi Overall, ascomycetes, zygomycetes, and basidiomycetes tend to have a significantly smaller number of ABC superfamily proteins and MFS transporters, compared to oomycetes  ... 
doi:10.3390/microorganisms9030502 pmid:33673517 fatcat:abfyo4pmqff6xkmv5k6jqtlose

ABC transporters in the protozoan parasite Leishmania

J M Pérez-Victoria, A Parodi-Talice, C Torres, F Gamarro, S Castanys
2001 International Microbiology  
ATP-binding cassette (ABC) transporters constitute one of the biggest and most conserved protein families in the evolutionary scale.  ...  Here, we review the current knowledge about ABC transporters in Leishmania spp, with special attention to their relationship with the drug-resistance phenotype.  ...  -T was the recipient of a fellowship from the Agencia EspanÄ ola de Cooperacio n Internacional (Becas MUTIS) and C.T. of a fellowship from Fundacio n Ramo n Areces.  ... 
doi:10.1007/s10123-001-0031-2 pmid:11820434 fatcat:yflrkdbna5a67ah25evmguhuw4

Structural Features of the ATP-Binding Cassette (ABC) Transporter ABCA3

Alessandro Paolini, Antonella Baldassarre, Ilaria Del Gaudio, Andrea Masotti
2015 International Journal of Molecular Sciences  
In this review we reported and discussed the structural features of the ATP-Binding Cassette (ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to obtain a reliable  ...  Thus, clinicians need a reliable structure to locate relevant mutations of this transporter and make genotype/phenotype correlations of patients affected by ABCA3-related diseases.  ...  Antonella Baldassarre and Ilaria Del Gaudio contributed to the manuscript organization and writing. Andrea Masotti coordinated the work, wrote and revised the manuscript and figures.  ... 
doi:10.3390/ijms160819631 pmid:26295388 pmcid:PMC4581316 fatcat:vp74eb2nxngh3grkpxze62invu

Membrane transporter proteins: a challenge for CNS drug development

François Girardin
2006 Dialogues in Clinical Neuroscience  
) are ATP-dependent efflux transporters expressed in the blood-brain barrier They belong to the superfamily of ABC transporters, which export drugs from the intracellular to the extracellular milieu.  ...  Many drug transporters are members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter superfamily or the solute-linked carrier (SLC) class.  ...  The ABC superfamily (ABC transporters) comprises the main efflux membrane transporters for drug elimination, and the solute-linked carriers (SLC transporters) are invlolved with influx and efflux transport  ... 
pmid:17117613 pmcid:PMC3181821 fatcat:fnqm7imymvhebl7lql4pnqwb54

ABC multidrug transporters in schistosomes and other parasitic flatworms

Robert M. Greenberg
2013 Parasitology international  
Some of the best studied multidrug transporters are members of the ancient and very large ATP-binding cassette (ABC) superfamily of efflux transporters.  ...  In this review, we examine recent studies that help define the role of schistosome ABC transporters in regulating drug susceptibility, and in normal schistosome physiology, including reproduction and excretory  ...  Acknowledgments This work was supported by NIH grant R01 AI073660 and in part by NIH grant R21 AI100505. I thank Ravi Kasinathan for helpful discussions.  ... 
doi:10.1016/j.parint.2013.02.006 pmid:23474413 pmcid:PMC3726539 fatcat:jurxdzj6uneqjmmaehcdp4o67u

Characterization and Analysis of Conserved Motifs in a Peroxisomal ATP-binding Cassette Transporter

Noam Shani, Amalia Sapag, David Valle
1996 Journal of Biological Chemistry  
The adrenoleukodystrophy protein (ALDP) and the 70-kDa peroxisomal membrane protein are half ATPbinding cassette (ABC) transporters in the human peroxisome membrane.  ...  Proteins homologous to ALDP and the 70-kDa peroxisomal membrane protein have been discovered in other eukaryotic organisms and form a growing group of peroxisomal half ABC transporters.  ...  ATP-binding cassette (ABC) 1 transporters are members of a superfamily of membrane proteins involved in the transport of a variety of molecules across biological membranes (1, 2) .  ... 
doi:10.1074/jbc.271.15.8725 pmid:8621506 fatcat:4ks2czkdnjgmzmsityprnqklq4

Inferring defense-related gene families in Arabidopsis and wheat

Rong-Cai Yang, Fred Y. Peng, Zhiqiu Hu
2017 BMC Genomics  
and ABC proteins.  ...  The 11 gene families included ABC, NLR and START, the three families that are already known to confer rust resistance in wheat, and eight new families.  ...  The funding agency has no role in the design of the study and collection, analysis, and interpretation of data, and in writing the manuscript.  ... 
doi:10.1186/s12864-017-4381-3 pmid:29258426 pmcid:PMC5738178 fatcat:xdqkohic2jdxjgne5m2nz64xse
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