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Protein Interaction Z Score Assessment (PIZSA): an empirical scoring scheme for evaluation of protein-protein interactions
2019
Nucleic Acids Research
Preserved Fulltext
Our web server, PIZSA (http://cospi.iiserpune.ac.in/pizsa), assesses the likelihood of protein-protein interactions by assigning a Z Score computed from interface residue contacts. ...
Attractively, our server offers a platform for users to upload their own potentials and could serve as an ideal testing ground for this class of scoring schemes. ...
ACKNOWLEDGEMENTS We would like to thank members of the COSPI lab at IISER Pune for valuable discussions and insights. ...
doi:10.1093/nar/gkz368
pmid:31114890
pmcid:PMC6602501
fatcat:24nfxwzosjbsrcysyxekx7ezam
Predicting and designing therapeutics against the Nipah virus
2019
PLoS Neglected Tropical Diseases
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
An important contribution of this study is the increased structural characterization of Nipah proteins by approximately 90% of what is deposited in the PDB. ...
In addition, we have carried out molecular dynamics simulations on all the designed protein-peptide complexes and on 13 of the top shortlisted small molecule ligands to check for stability and to estimate ...
Raghavan Varadarajan for useful discussions. ...
doi:10.1371/journal.pntd.0007419
pmid:31830030
pmcid:PMC6907750
fatcat:oid2rx2lvvhfpkcucu64eor26u
Predicting and Designing therapeutics against the Nipah virus
[article]
2019
bioRxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
An important contribution of this study is the increased structural characterization of Nipah proteins by approximately 90% of what is deposited in the PDB. ...
In addition, we have carried out molecular dynamics simulations on all the designed protein-peptide complexes to check for stability and to estimate binding strengths. ...
Acknowledgements The authors would like to acknowledge Swastik Mishra, Yogendra Ramtirtha and Kundan Kumar for useful discussions. ...
doi:10.1101/623603
fatcat:vlb4n7n4pjbsdmabioj7675zl4
Interplay between p300 and HDAC1 regulate acetylation and stability of Api5 to regulate cell proliferation
[article]
2020
bioRxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
This study also demonstrates that the regulation of acetylation and deacetylation of Api5 is an essential factor for the progression of the cell cycle. ...
Api5, is a known anti-apoptotic and nuclear protein that is responsible for inhibiting cell death in serum-starved conditions. ...
Madhusudhan, Protein 609 Interaction Z Score Assessment (PIZSA): an empirical scoring scheme for evaluation 610 of protein-protein interactions. ...
doi:10.1101/2020.11.22.393256
fatcat:bxbydy6b5jga3l5ue7hg2oatp4