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Our web server, PIZSA (http://cospi.iiserpune.ac.in/pizsa), assesses the likelihood of protein-protein interactions by assigning a Z Score computed from interface residue contacts. ... Attractively, our server offers a platform for users to upload their own potentials and could serve as an ideal testing ground for this class of scoring schemes. ... ACKNOWLEDGEMENTS We would like to thank members of the COSPI lab at IISER Pune for valuable discussions and insights. ...doi:10.1093/nar/gkz368 pmid:31114890 pmcid:PMC6602501 fatcat:24nfxwzosjbsrcysyxekx7ezam
An important contribution of this study is the increased structural characterization of Nipah proteins by approximately 90% of what is deposited in the PDB. ... In addition, we have carried out molecular dynamics simulations on all the designed protein-peptide complexes and on 13 of the top shortlisted small molecule ligands to check for stability and to estimate ... Raghavan Varadarajan for useful discussions. ...doi:10.1371/journal.pntd.0007419 pmid:31830030 pmcid:PMC6907750 fatcat:oid2rx2lvvhfpkcucu64eor26u
An important contribution of this study is the increased structural characterization of Nipah proteins by approximately 90% of what is deposited in the PDB. ... In addition, we have carried out molecular dynamics simulations on all the designed protein-peptide complexes to check for stability and to estimate binding strengths. ... Acknowledgements The authors would like to acknowledge Swastik Mishra, Yogendra Ramtirtha and Kundan Kumar for useful discussions. ...doi:10.1101/623603 fatcat:vlb4n7n4pjbsdmabioj7675zl4
This study also demonstrates that the regulation of acetylation and deacetylation of Api5 is an essential factor for the progression of the cell cycle. ... Api5, is a known anti-apoptotic and nuclear protein that is responsible for inhibiting cell death in serum-starved conditions. ... Madhusudhan, Protein 609 Interaction Z Score Assessment (PIZSA): an empirical scoring scheme for evaluation 610 of protein-protein interactions. ...doi:10.1101/2020.11.22.393256 fatcat:bxbydy6b5jga3l5ue7hg2oatp4