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Promise and pitfalls of g-ratio estimation with MRI

Jennifer S.W. Campbell, Ilana R. Leppert, Sridar Narayanan, Mathieu Boudreau, Tanguy Duval, Julien Cohen-Adad, G. Bruce Pike, Nikola Stikov
2017 NeuroImage  
It details the methodology for imaging the g-ratio with MRI, and describes the known pitfalls and challenges in doing so.  ...  MRI based g-ratio imaging was first conceived in 2011, and expanded to be feasible in full brain with preliminary results in 2013.  ...  of Canada (NS, 2016-06774, and JCA, 435897-2013), the Montreal Heart Institute Foundation, the Fonds de  ... 
doi:10.1016/j.neuroimage.2017.08.038 pmid:28822750 fatcat:wlhlcxpi2vhazbnmntlletlgc4

MR quantitative biomarkers of non-alcoholic fatty liver disease: technical evolutions and future trends

Guido Ligabue, Giulia Besutti, Riccardo Scaglioni, Chiara Stentarelli, Giovanni Guaraldi
2013 Quantitative Imaging in Medicine and Surgery  
MRI, with the new refined techniques which provide a robust quantitative biomarker of hepatic steatosis (PDFF) evaluated on the whole liver parenchyma, is a promising non-invasive alternative to LB as  ...  to address respectively T1 effect, T2* effect, and the multifrequency interference effects of fat protons, allowing to use MRI to estimate LFC based on PDFF.  ...  Acknowledgements Disclosure: The authors declare no conflict of interest.  ... 
doi:10.3978/j.issn.2223-4292.2013.08.01 pmid:24040614 pmcid:PMC3759141 fatcat:ui4rqvwwmre5nj6thfeiyidukq

Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging

Siawoosh Mohammadi, Martina F. Callaghan
2020 Journal of Neuroscience Methods  
This review summarizes the most recent developments in the field, while also providing methodological background pertinent to aggregate g-ratio weighted mapping, and discussing pitfalls associated with  ...  Advances in MRI data acquisition and signal modelling have put in vivo mapping of the g-ratio, across the entire white matter, within our reach.  ...  Challenges for aggregated g-ratio mappingAn important prerequisite of g-ratio mapping with MRI is that the biomarkers of MVF and AVF be accurate.  ... 
doi:10.1016/j.jneumeth.2020.108990 pmid:33129894 pmcid:PMC7840525 fatcat:s5z7wz75iradpb2ytoacty4dmi

Towards in vivo g-ratio mapping using MRI: unifying myelin and diffusion imaging [article]

Siawoosh Mohammadi, Martina F. Callaghan
2020 arXiv   pre-print
As such, it summarizes the most recent developments in the field, while also providing methodological background pertinent to aggregate g-ratio weighted mapping, and discussing pitfalls associated with  ...  Advances in MRI data acquisition and signal modelling have put in vivo mapping of the g-ratio, across the entire white matter, within our reach.  ...  Challenges for aggregated g-ratio mapping The most important prerequisite of g-ratio mapping with MRI is that the biomarkers of MVF and AVF be accurate.  ... 
arXiv:2005.13150v1 fatcat:bsl3saen3jagnhniks4cjfq3ca

Right heart imaging in patients with heart failure

Myriam Amsallem, Tatiana Kuznetsova, Kate Hanneman, Andre Denault, François Haddad
2016 Current Opinion in Cardiology  
Recent findings-Recent developments have been made in the field of deformation imaging of the right heart, which may improve risk stratification of patients with heart failure and pulmonary hypertension  ...  The emergence of novel MRI sequences, such as native T1 mapping, allows better detection and quantification of myocardial fibrosis and could allow better prediction of post-surgical recovery of the right  ...  Dominik Fleischmann (from the Division of Radiology, at Stanford University, USA) for his assistance with the review and mentorship, and Prof.  ... 
doi:10.1097/hco.0000000000000315 pmid:27467173 pmcid:PMC5133417 fatcat:u5ixl2trgbej3e5jnhs43lyebu

Magnetic resonance imaging of brain angiogenesis after stroke

Peter R. Seevinck, Lisette H. Deddens, Rick M. Dijkhuizen
2010 Angiogenesis  
Finally, we discuss some pitfalls and limitations that may critically affect the accuracy and interpretation of MRI-based measures of (neo)vascularization after stroke.  ...  The initial changes in local perfusion and tissue status underlying loss of brain function are increasingly investigated with noninvasive imaging methods.  ...  Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided  ... 
doi:10.1007/s10456-010-9174-0 pmid:20552268 pmcid:PMC2911530 fatcat:rl7v223bdre3xopackdwqilw4u

Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!

Min Zhang, Gaëlle Hugon, Caroline Bouillot, Radu Bolbos, Jean-Baptiste Langlois, Thierry Billard, Frédéric Bonnefoi, Biao Li, Luc Zimmer, Fabien Chauveau
2019 Contrast Media & Molecular Imaging  
The present study describes an optimization of the LPC model and highlights the use of MRI for controlling the variability and pitfalls of the model.  ...  Ex vivo autoradiography with a fluorine radiotracer should be preferred, to adequately evaluate and compare radiotracers for the assessment of myelin content.  ...  Min Zhang was supported by the National Natural Science Foundation of China (81501499), Shanghai Jiaotong University Med-X Interdisciplinary Research Funding (YG2017MS61), and Shanghai Pujiang Program  ... 
doi:10.1155/2019/9294586 pmid:31281236 pmcid:PMC6594279 fatcat:tg4562ht5zbx3fzzy3x4oxzv6y

The Performance of MRI-Based Cerebral Blood Flow Measurements in Acute and Subacute Stroke Compared With 15O-Water Positron Emission Tomography: Identification of Penumbral Flow

O. Zaro-Weber, W. Moeller-Hartmann, W.-D. Heiss, J. Sobesky
2009 Stroke  
Material and Methods-Comparative CBF MRI and CBF PET were performed in patients with acute and subacute stroke.  ...  The quantitative congruence was best for the MRI-CBF threshold Ͻ20 mL/100 g/min (median C-ratio: 1.0), reaching a proportion of voxels correctly classified as hypoperfused of 76% and a proportion of voxel  ...  Acknowledgments We express our gratitude to the members of the neurocritical care unit (Department of Neurology), to the staff of the MRI facility (Department of Neuroradiology), and especially to the  ... 
doi:10.1161/strokeaha.108.540914 pmid:19461037 fatcat:eiooqdcliravjjkvrysylglkom

The role of diffusion tensor imaging in brain tumor surgery: A review of the literature

Adriaan R.E. Potgieser, Michiel Wagemakers, Arjen L.J. van Hulzen, Bauke M. de Jong, Eelco W. Hoving, Rob J.M. Groen
2014 Clinical neurology and neurosurgery (Dutch-Flemish ed. Print)  
Although there are many limitations and pitfalls associated with this technique, DTI can provide valuable additional diagnostic information to the neurosurgeon.  ...  The effect of brain shift and the limitations of the technique are highlighted, followed by a comprehensive discussion on its objective value.  ...  A thorough knowledge of its limitations and potential pitfalls is indispensable for the interpretation and safe application of this promising new technique.  ... 
doi:10.1016/j.clineuro.2014.06.009 pmid:25016239 fatcat:ph4r5zrbyrae7cqbneyqa4fiym

Echocardiographic evaluation of the right heart

Matthias Schneider, Thomas Binder
2018 Wiener Klinische Wochenschrift  
A thorough analysis of right ventricular size and function, as well as estimation of pulmonary artery pressures is an important part of every echocardiographic examination.  ...  It gives a practical approach for estimation of right ventricular size and function, as well as pulmonary artery pressure.  ...  (ratio <1).  ... 
doi:10.1007/s00508-018-1330-3 pmid:29556779 pmcid:PMC6061659 fatcat:qnbcs7eilner5nr3alvfmfn6pi

Brain microstructure by multi-modal MRI: Is the whole greater than the sum of its parts?

Mara Cercignani, Samira Bouyagoub
2017 NeuroImage  
A strategy to overcome this limitation lies in the combination of more than one technique, to exploit the relative contributions of differing physiological and pathological substrates to selected MRI contrasts  ...  This paper will attempt to provide an overview of the advantages and limitations of these two philosophies.  ...  The g-ratio is equal to the ratio of the inner-to-outer diameter of a myelinated axon, and is known to be associated with the speed of conduction along the axon (Rushton, 1934) .  ... 
doi:10.1016/j.neuroimage.2017.10.052 pmid:29097317 fatcat:rdao2mkqevfdzoqz5c2s7hlb3y

Methods for measurement of gastric motility

Lawrence A. Szarka, Michael Camilleri
2009 American Journal of Physiology - Gastrointestinal and Liver Physiology  
The standard meal for scintigraphic gastric emptying consists of 4 ounces of Eggbeaters or equivalent egg white substitute, 2 slices of bread (120 kcal), strawberry jam (30 g, 74 kcal), and water (120  ...  appropriate normal values with some of the meals used.  ...  Ultrasound estimates of t 1/2 liquid emptying time (110) are closely correlated with the results with scintigraphy. PITFALLS.  ... 
doi:10.1152/ajpgi.90467.2008 pmid:19147807 fatcat:5m2peza2zve37fneqqmkzdwn2a

Tumour progression or pseudoprogression? A review of post-treatment radiological appearances of glioblastoma

S. Abdulla, J. Saada, G. Johnson, S. Jefferies, T. Ajithkumar
2015 Clinical Radiology  
been observed in multiple studies and is estimated to occur in about 24 20% of patients following GBM treatment. 6-10 In a large study by Taal et al. 11 50% of patients 25 treated with chemoRT for GBM  ...  Using 2D CSI-254 MRS an elevated Cho/NAA ratio 62 and NAA/Cr ratio 63 have been found to correlate with 255 recurrent tumour (figure 4 and 5) 64 .  ... 
doi:10.1016/j.crad.2015.06.096 pmid:26272530 fatcat:e6bzkoa6wfbrnib3uoh6qynghi

Cell-Assisted Lipotransfer: A Systematic Review of Its Efficacy

Navid Mohamadpour Toyserkani, Marlene Louise Quaade, Jens Ahm Sørensen
2016 Aesthetic Plastic Surgery  
Materials and Methods A systematic search was performed on PubMed and other databases to identify all preclinical and clinical studies where CAL with ASCs was compared with conventional lipotransfer.  ...  The aim of this review was to systematically review the current preclinical and clinical evidence for the efficacy of CAL compared with conventional lipotransfer.  ...  They used a total of 0.8 g with varying ratios between fat and SVF. The ratios were 1/3, 1/4, 1/5, and 1/6 SVF.  ... 
doi:10.1007/s00266-016-0613-1 pmid:26893280 pmcid:PMC4819466 fatcat:ei22wrrz6rezblzj7wgw3b3e5e

Perspectives on the Role of Magnetic Resonance Imaging (MRI) for Noninvasive Evaluation of Diabetic Kidney Disease

José María Mora-Gutiérrez, María A. Fernández-Seara, Rebeca Echeverria-Chasco, Nuria Garcia-Fernandez
2021 Journal of Clinical Medicine  
This review article outlines the most promising MRI techniques in the study of DKD, with the purpose of stimulating their clinical translation as possible tools for the diagnosis, follow-up, and monitoring  ...  Therefore, the use of novel renal MRI techniques is an attractive step forward in the comprehension of DKD, both in its pathogenesis and in its detection and surveillance in the clinical practice.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/jcm10112461 fatcat:ufemowvewjfhdf6h37lbda4ws4
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