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The potential for liquid biopsies in the precision medical treatment of breast cancer

Victoria A Forte, Dany K Barrak, Mostafa Elhodaky, Lily Tung, Anson Snow, Julie E Lang
2016 Cancer Biology and Medicine  
This review serves to elucidate the detection, characterization, and clinical application of CTCs and ctDNA with the goal of precision treatment of breast cancer.  ...  Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology.  ...  EMT, metastasis, and the presence of CTCs 99 .  ... 
doi:10.28092/j.issn.2095-3941.2016.0007 pmid:27144060 pmcid:PMC4850125 fatcat:q3ja5fgo3vcvvlxrvmpchk7jiu

Open elbow dislocation associated with distal ischemia in children about one case and review of the literature

Noureddine Redjil, Mwinyanne Narcisse Dabire, Pierre Weber
2015 The Pan African Medical Journal  
and hypoesthesia in the territory of the median nerve.  ...  The surgical health care included a careful debridement, a reduction and scanning of the neurovascular bundle of humerus with reappearance of pulses after 45 minutes.  ...  However the hand remained hot and well colored. Furthermore the child had no motor deficit but a hypoesthesia in the territory of the median nerve.  ... 
doi:10.11604/pamj.2015.21.128.6553 pmid:26327965 pmcid:PMC4546717 fatcat:tc2dx4ddfffazjqrnkc73vmsna

The potential for liquid biopsies in the precision medical treatment of breast cancer

Victoria A. Forte, Victoria A. Forte, Dany K. Barrak, Mostafa Elhodaky, Lily Tung, Anson Snow, Julie E. Lang, Dany K. Barrak, Mostafa Elhodaky, Lily Tung, Anson Snow, Julie E. Lang
2016 Cancer Biology and Medicine  
This review serves to elucidate the detection, characterization, and clinical application of CTCs and ctDNA with the goal of precision treatment of breast cancer.  ...  Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology.  ...  EMT, metastasis, and the presence of CTCs 99 .  ... 
doi:10.20892/j.issn.2095-3941.2016.0007 fatcat:f44t6istbnh6dmb4mrizhoqqzq

A heavy metal baseline score predicts outcome in AML

Maro Ohanian, Philippe Telouk, Steven Kornblau, Francis Albarede, Peter Ruvolo, Rebecca S. S. Tidwell, Adriana Plesa, Rashmi Kanagal‐Shamanna, Eva‐Laure Matera, Jorge Cortes, Arch Carson, Charles Dumontet
2020 American Journal of Hematology  
Despite abundant epidemiological data linking metals to leukemia and other cancers, baseline values of toxic and essential metals in patients with leukemia and the clinical impact of these metals remain  ...  The adverse prognostic effect of this combination was maintained on multivariate analysis.  ...  | A Novel metal score predicts survival in AML The findings of this study led us to explore the prognostic significance of combinations of various deficiencies and elevations of essential and toxic  ... 
doi:10.1002/ajh.25731 pmid:31944361 fatcat:55utmww2j5govni4xg5uqf27ae

TP53 Status and Response to Treatment in Breast Cancers

Mariana Varna, Guilhem Bousquet, Louis-François Plassa, Philippe Bertheau, Anne Janin
2011 Journal of Biomedicine and Biotechnology  
The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens.  ...  In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes.TP53mutation is reported to be a factor for good prognosis in some studies, while in others it is  ...  Acknowledgments The authors would like to thank Gabriela Hortopan (University of California, San Francisco, Calif, USA) for helpful comments on the manuscript.  ... 
doi:10.1155/2011/284584 pmid:21760703 pmcid:PMC3114547 fatcat:do6uqd4mknecfb4rk6ocmus6he

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells

Keith H. K. Wong, Shannon N. Tessier, David T. Miyamoto, Kathleen L. Miller, Lauren D. Bookstaver, Thomas R. Carey, Cleo J. Stannard, Vishal Thapar, Eric C. Tai, Kevin D. Vo, Erin S. Emmons, Haley M. Pleskow (+7 others)
2017 Nature Communications  
All other data are available within the Article and Supplementary Information, or available from the corresponding authors upon request.  ...  All RNA-sequencing data have been deposited in NCBI GEO under accession number GSE104209.  ...  Our findings that stored whole blood remains fully responsive to thrombin stimulation (Fig. 2c ) led us to target GPIIb/IIIa, which is the most abundant receptor on platelets and mediates fibrinogen binding  ... 
doi:10.1038/s41467-017-01705-y pmid:29170510 pmcid:PMC5700979 fatcat:xsexg22aeje65fdwp6vfyva34u

Recent advances in the biology and treatment of B-cell acute lymphoblastic leukemia

Mehrdad Hefazi, Mark R Litzow
2018 Blood and Lymphatic Cancer : Targets and Therapy  
Conventional cytotoxic chemotherapies have resulted in high cure rates of up to 90% in pediatric ALL, but the outcomes for adult patients remain suboptimal with 5-year survival rates of only 30%-40%.  ...  The use of pediatric-inspired regimens for adolescent and young adults, and the advent of tyrosine kinase inhibitors and novel targeted therapies, including monoclonal antibodies and chimeric antigen receptor  ...  [7] [8] [9] The need for improved outcomes for adult ALL has led to major advancements in the understanding of the disease biology, the refinement of prognostic markers, and the development of novel  ... 
doi:10.2147/blctt.s170351 pmid:31360093 pmcid:PMC6467350 fatcat:akyze7nncrb3fogotck4urxvey

The contamination of young people's notions about narcotics and psychoactive substances as a threat to psychological security

Yury P. Zinchenko, Olga Yu. Zotova, Lyudmila V. Tarasova, Igor V. Gaidamashko
2016 Psychology in Russia: State of Art  
The results are of prognostic importance for understanding young people's attitudes toward drugs and PAS and can be used to design programs and measures directed to the prevention of PAS and drug abuse  ...  In the course of the research the following hypothesis was tested: in young people's perceptions about drugs and PAS there are differences in emotional coloring, coherence, and tolerance. J.-C.  ...  Acknowledgements The article is written under the Russian Scientific Fund grant (project № 16-18-00032) "Trust and personality subjective wellbeing as foundation of modern society psychological security  ... 
doi:10.11621/pir.2016.0204 fatcat:u6i7i2ri4jgmfppkxpvkhnkhj4

Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers

Allyson L. Byrd, Menghan Liu, Kei E. Fujimura, Svetlana Lyalina, Deepti R. Nagarkar, Bruno Charbit, Jacob Bergstedt, Etienne Patin, Oliver J. Harrison, Lluís Quintana-Murci, Ira Mellman, Darragh Duffy (+2 others)
2020 Journal of Experimental Medicine  
Using a genome-based taxonomy, we found biological sex was the strongest driver of community composition.  ...  As microbial therapeutics are increasingly being tested in diverse patient populations, it is essential to understand the host and environmental factors influencing the microbiome.  ...  Acknowledgments We thank all the donors for their participation in the study. We thank J. Segre and F. Tamburini for critical reading of the manuscript and helpful comments. We also thank J.  ... 
doi:10.1084/jem.20200606 pmid:33175106 fatcat:rolpgqv3hjgjdijppsqp6jfvzm

Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1

Aliaksandr A. Yarmishyn, Yi-Ping Yang, Kai-Hsi Lu, Yi-Chen Chen, Yueh Chien, Shih-Jie Chou, Ping-Hsing Tsai, Hsin-I. Ma, Chian-Shiu Chien, Ming-Teh Chen, Mong-Lien Wang
2020 Cancer Cell International  
Conclusions Given the fact that both proteins are master regulators of gene expression, and both of them are unfavorable factors in GBM, we suggest that in any future studies aimed to uncover the prognostic  ...  Methods and results In this study, we investigated the expression of five YTH family proteins in different GBM microarray datasets from the Oncomine database, and identified YTHDF1 as the most highly overexpressed  ...  The medium was aspirated, and 500 µl of DMSO was added and mixed until purple color was formed. 200 µl of the cell samples were measured using a plate reader at 560 nm and 670 nm.  ... 
doi:10.1186/s12935-020-01696-9 pmid:33317545 fatcat:33zqnqarvzczxnfgqnpjd5ojgq

Colorimetric Paper-Based Sensors against Cancer Biomarkers

Mariana C. C. G. Carneiro, Ligia R. Rodrigues, Felismina T. C. Moreira, Maria Goreti F. Sales
2022 Sensors  
We highlight recent works reporting the use of paper in the development of colorimetric sensors for cancer biomarkers, such as proteins, nucleic acids, and others.  ...  This review includes an overview of the use of paper for the development of sensing devices focusing on colorimetric detection and their application to cancer biomarkers.  ...  Conflicts of Interest: The authors declare no conflict of interest. Sensors 2022, 22, 3221  ... 
doi:10.3390/s22093221 pmid:35590912 pmcid:PMC9102172 fatcat:2v55yg5f2rabve7ahisvx7dp2e

Developments in real-time PCR research and molecular diagnostics

Stephen A Bustin
2010 Expert Review of Molecular Diagnostics  
The chip sits in an optical detection device about the size of a portable DVD player, indeed the optical detection module is similar to the optical detection system of a DVD player and uses a blue LED  ...  and applications that underlie the popularity of quantitative real-time PCR technology in all areas of life science research, as well as in clinical diagnostics.  ... 
doi:10.1586/erm.10.65 pmid:20843195 fatcat:dxah3o5wrfa4pi4zspvjtsvqje

Challenges in Using Circulating miRNAs as Cancer Biomarkers

Paola Tiberio, Maurizio Callari, Valentina Angeloni, Maria Grazia Daidone, Valentina Appierto
2015 BioMed Research International  
Independent studies have shown the feasibility of using these small RNAs as tools for the diagnosis and prognosis of different types of malignancies as well as for predicting and possibly monitoring treatment  ...  In fact, critical issues are represented by nonuniform sample choice, handling, and processing, as well as by blood cell contamination in sample preparation and lack of consensus for data normalization  ...  The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the paper.  ... 
doi:10.1155/2015/731479 pmid:25874226 pmcid:PMC4385632 fatcat:54qe6hrnnvctpgyz2iffsjrrxi

Abdominal Wall Reconstruction

Jesse Selber
2018 Seminars in Plastic Surgery  
into account underlying patient comorbidities and the presence of wound contamination during the repair (Fig 10) .  ...  Highlighting the difficulty of managing ECFs in the presence of large abdominal wall defects, these authors noted that the predominant negative prognostic factor for spontaneous closure of a fistula was  ... 
doi:10.1055/s-0038-1666839 pmid:30046285 fatcat:ehvhp4fidza5xaki3y4erjw2ku

Pyroptosis-Related Gene Signatures Can Robustly Diagnose Skin Cutaneous Melanoma and Predict the Prognosis

Anji Ju, Jiaze Tang, Shuohua Chen, Yan Fu, Yongzhang Luo
2021 Frontiers in Oncology  
In conclusion, the expression signatures of pyroptosis-related genes are effective and robust in the diagnosis and prognosis of SKCM, which is related to immunity.  ...  Pyroptosis, a kind of pro-inflammatory programmed cell death, has been linked to cancer in recent studies. However, the value of pyroptosis in the diagnosis and prognosis of SKCM is not clear.  ...  the presence of GSDME may not be caused by immune cell contamination.  ... 
doi:10.3389/fonc.2021.709077 fatcat:gjetxm5ndfbd5bh6kgkvwwgmey
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