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Production of Inflected Novel Words in Older Adults With and Without Dementia
2020
Cognitive Science
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We administered a simple speech elicitation task involving Finnish-conforming pseudo-words and real Finnish words to healthy older adults, individuals with mild cognitive impairment, and individuals with ...
Inflecting novel words in a language with complex inflectional paradigms provides a good opportunity to observe how language processes change in normal and abnormal aging. ...
In Finnish, all savi-and vesi-type words have two syllables, whereas 1,180 out of 4,557 lasi-type words have two syllables. ...
doi:10.1111/cogs.12879
pmid:32761679
fatcat:3flav2nv6zds5gkzojw6id3iem
Effects of morphological family on word recognition in normal aging, mild cognitive impairment, and Alzheimer's disease
2019
Cortex
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However, elderly controls and individuals with MCI or AD seemed to rely more on form overlap than young adults. ...
in 22 Finnish speakers with AD, 24 with MCI, and 17 cognitively healthy elderly. ...
AN was supported by the department of Foreign Languages and Translational Studies at the University of Eastern Finland. ML was supported by the Academy of Finland (grant #288880). r e f e r e n c e s ...
doi:10.1016/j.cortex.2018.10.028
pmid:30612700
fatcat:isxl2hgz6jbbnkgbrq5iisrr3i
Brain Plasticity in Poststroke Aphasia: What Is the Contribution of the Right Hemisphere?
1998
Brain and Language
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His performance in writing names of objects and pictures matching were poor, and could not write down some words during writing and dictation tasks. ...
When he went home after one month, she found that the patient had difficulty with word-finding. ...
Borgwaldt and A. Bose. Presented by: Bose, Arpita ...
doi:10.1006/brln.1998.1961
pmid:9710490
fatcat:ugrdv3cwxrblzhfkez4uuhvzdi
The basal ganglia and rule-governed language use: evidence from vascular and degenerative conditions
2005
Brain
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the regular past tense as a sequence of morphemes, either in comprehension or production, in contrast to the claims of the Declarative/Procedural Model. ...
(the smallest meaningful units in language) into complex words (e.g. talk-ed, talk-ing). ...
We also wish to thank Professor Barbara Sahakian, Professor Trevor Robbins and Dr Raymond Knott for their help with this research. ...
doi:10.1093/brain/awh387
pmid:15659423
fatcat:p2wmati6w5dezlz66biiox6aja
Natural Language Processing as an Emerging Tool to Detect Late-Life Depression
2021
Frontiers in Psychiatry
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older adults with other clinical conditions, and discuss future directions including the use of complementary AI strategies to fully capture the spectrum of LLD. ...
In this review, we will provide rationale for the use of NLP methods to study depression using speech, summarize previous research using NLP in LLD, compare findings to younger adults with depression and ...
Two recent studies suggested that certain acoustic speech features may help differentiate depression and dementia, or dementia with and without comorbid depression (66, 71) , but this topic requires further ...
doi:10.3389/fpsyt.2021.719125
pmid:34552519
pmcid:PMC8450440
fatcat:63ubhpoft5hr7hxcwhqukrsori
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults
2017
Neurobiology of Aging
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Acknowledgements The research presented in this thesis was carried out at the Department of Geriatric Medicine, ...
main findings ...................................................................................... 67 5.1.1 Consequences of amyloid and tau pathology in older adults without dementia 68 5.1.2 Novel ...
patients with and without dementia. ...
doi:10.1016/j.neurobiolaging.2016.09.012
pmid:27794264
fatcat:6sgqujw7jjclhg7mxtvoqptvjy
Deficits in irregular past-tense verb morphology associated with degraded semantic knowledge
2001
Neuropsychologia
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The study reported here evaluated the past-tense verb abilities of 11 patients with semantic dementia, a neurodegenerative condition characterised by degraded semantic knowledge. ...
In this alternative view, neuropsychological dissociations are explained by reduced input from word meaning that plays a greater role in successful generation of the past-tense for lower frequency irregular ...
Acknowledgements We are grateful for enlightening discussions of the issues and/or helpful comments on the original version of the manuscript from Helen Bird, Marc Joanisse, David Plaut and Mark Seidenberg ...
doi:10.1016/s0028-3932(01)00008-2
pmid:11311301
fatcat:a57sjrlxe5ftjpxkad2ldvebiq
Greek neurolinguistics: The State of the Art
2005
Journal of Greek Linguistics
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More specific issues concerning the effect of word class on language production and comprehension, the status of the inflected and derived words in the mental lexicon, the effect of regularity on impaired ...
Two non-fluent patients and twenty-four normal adults participated in simple and primed 6 lexical decision experiments; specifically, they performed non-word judgements 7 for inflected and derived words ...
doi:10.1075/jgl.6.10sta
fatcat:k55qzp4ofjad3dvqba3vzo452u
Automated computerized analysis of speech in psychiatric disorders
2014
Current Opinion in Psychiatry
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Summary-Computer based assessments of natural language afford a framework with which to measure communication disturbances in adults with SMI. ...
The clinical relevance of these novel metrics has been demonstrated by showing their relationship to functional outcome measures, their in vivo link to classic 'language' regions in the brain, and, in ...
References and recommended reading Papers of particular interest, published within the annual period of review, have been highlighted as: ...
doi:10.1097/yco.0000000000000056
pmid:24613984
pmcid:PMC4212642
fatcat:tr2qgkapfbd23l55x4vckmvzim
Dissociations in Processing Past Tense Morphology: Neuropathology and Behavioral Studies
2002
Journal of Cognitive Neuroscience
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In this study, we tested five nonfluent aphasic patients, all of whom had extensive left hemisphere (LH) damage involving the left inferior frontal gyrus and underlying structures, and four patients with ...
& Neuropsychological research showing that the regular ("jump-jumped") and irregular ("drive/drove") past tense inflectional morphology can dissociate following brain damage has been important in testing ...
Acknowledgments We thank Mike Cooper for helping with the studies reported here and Dr F. Manes for his assistance with the lesion tracings. ...
doi:10.1162/089892902317205348
pmid:11798389
fatcat:ccnfuzdinbgjzenernne4effve
Utility of Machine Learning Approach with Neuropsychological Tests in Predicting Functional Impairment of Alzheimer's Disease
2021
Journal of Alzheimer's Disease
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older adults with no impairment (n = 285), mild cognitive impairment (n = 1,057), and Alzheimer's disease (n = 1,300). ...
Methods: In this study, the neuropsychological battery (CERAD-K) and assessment of functioning level (Clinical Dementia Rating scale and Instrumental Activities of Daily Living) were administered to 2,642 ...
in older adults. ...
doi:10.3233/jad-215244
pmid:34924390
pmcid:PMC8925128
fatcat:klgre5ymqnghdm4g3tp7zfy54m
What can developmental disorders tell us about the neurocomputational constraints that shape development? The case of Williams syndrome
2003
Development and Psychopathology
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The uneven cognitive phenotype in the adult outcome of Williams syndrome has led some researchers to make strong claims about the modularity of the brain and the purported genetically determined, innate ...
Such arguments have particularly been marshaled with respect to language. ...
exist in both general-and the subsequent process of development and did not correspond to the simple removal izing inflectional regularities to novel word forms (wug-wugged) and the differential in-of ...
doi:10.1017/s0954579403000476
fatcat:vhyxrerisbbgjpyxcvli5gfnuu
Action versus animal naming fluency in subcortical dementia, frontal dementias, and Alzheimer's disease
2010
Neurocase
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We hypothesized patients with subcortical dementia, e.g., normal pressure hydrocephalus (NPH) and patients with dementias predominantly affecting frontal cortex, e.g., behavioral variant frontotemporal ...
A total of 234 participants, including healthy controls (n = 20) and patients diagnosed with NPH (n =144), AD (n = 33), bv-FTD (n = 22) or PNFA (n = 15) were administered animal fluency, action fluency ...
Acknowledgments The research reported in this paper was supported by NIH (NIDCD), through RO1 DC 05375. We gratefully acknowledge this support and the participation of the patients. ...
doi:10.1080/13554790903456183
pmid:20104387
pmcid:PMC4059509
fatcat:tqddsoq7kjaqpkn2hff7vjo5ia
Lexical acquisition in progressive aphasia and frontotemporal dementia
2007
Cognitive Neuropsychology
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, semantic, and thematic matrix information associated with the new word. ...
We investigated the characteristics of language difficulty in frontotemporal dementia (FTD) by exposing these patients to a new verb in a naturalistic manner and then assessing acquisition of the grammatical ...
A total of 8 of the sentences with "lour" placed the new verb in a sentence slot normally occupied by a verb, twice without grammatical inflection and six times with a bound grammatical morpheme (equally ...
doi:10.1080/02643290600890657
pmid:18416483
fatcat:oshmzrygonbdncqcxhcx7ul2r4
Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease
2014
Biochemical Pharmacology
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Cognitive decline, Alzheimer's disease (AD) and other causes are major public health problems worldwide. With changing demographics, the number of persons with dementia will increase rapidly. ...
The treatment and prevention of AD and other dementias, therefore, is an urgent unmet need. ...
We also thank the participants of the Religious Orders Study and Rush Memory and Aging Project for their participation in these studies and the staff of the Rush Alzheimer's Disease Center. ...
doi:10.1016/j.bcp.2014.01.037
pmid:24508835
pmcid:PMC4054869
fatcat:aqrvwb4ktfendotguhc36vz6km
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