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Production of Inflected Novel Words in Older Adults With and Without Dementia

Alexandre Nikolaev, Eve Higby, JungMoon Hyun, Minna Lehtonen, Sameer Ashaie, Merja Hallikainen, Tuomo Hänninen, Hilkka Soininen
2020 Cognitive Science  
We administered a simple speech elicitation task involving Finnish-conforming pseudo-words and real Finnish words to healthy older adults, individuals with mild cognitive impairment, and individuals with  ...  Inflecting novel words in a language with complex inflectional paradigms provides a good opportunity to observe how language processes change in normal and abnormal aging.  ...  In Finnish, all savi-and vesi-type words have two syllables, whereas 1,180 out of 4,557 lasi-type words have two syllables.  ... 
doi:10.1111/cogs.12879 pmid:32761679 fatcat:3flav2nv6zds5gkzojw6id3iem

Effects of morphological family on word recognition in normal aging, mild cognitive impairment, and Alzheimer's disease

Alexandre Nikolaev, Sameer Ashaie, Merja Hallikainen, Tuomo Hänninen, Eve Higby, JungMoon Hyun, Minna Lehtonen, Hilkka Soininen
2019 Cortex  
However, elderly controls and individuals with MCI or AD seemed to rely more on form overlap than young adults.  ...  in 22 Finnish speakers with AD, 24 with MCI, and 17 cognitively healthy elderly.  ...  AN was supported by the department of Foreign Languages and Translational Studies at the University of Eastern Finland. ML was supported by the Academy of Finland (grant #288880). r e f e r e n c e s  ... 
doi:10.1016/j.cortex.2018.10.028 pmid:30612700 fatcat:isxl2hgz6jbbnkgbrq5iisrr3i

Brain Plasticity in Poststroke Aphasia: What Is the Contribution of the Right Hemisphere?

Hans Karbe, Alexander Thiel, Gerald Weber-Luxenburger, Karl Herholz, Josef Kessler, Wolf-Dieter Heiss
1998 Brain and Language  
His performance in writing names of objects and pictures matching were poor, and could not write down some words during writing and dictation tasks.  ...  When he went home after one month, she found that the patient had difficulty with word-finding.  ...  Borgwaldt and A. Bose. Presented by: Bose, Arpita  ... 
doi:10.1006/brln.1998.1961 pmid:9710490 fatcat:ugrdv3cwxrblzhfkez4uuhvzdi

The basal ganglia and rule-governed language use: evidence from vascular and degenerative conditions

C. E. Longworth
2005 Brain  
the regular past tense as a sequence of morphemes, either in comprehension or production, in contrast to the claims of the Declarative/Procedural Model.  ...  (the smallest meaningful units in language) into complex words (e.g. talk-ed, talk-ing).  ...  We also wish to thank Professor Barbara Sahakian, Professor Trevor Robbins and Dr Raymond Knott for their help with this research.  ... 
doi:10.1093/brain/awh387 pmid:15659423 fatcat:p2wmati6w5dezlz66biiox6aja

Natural Language Processing as an Emerging Tool to Detect Late-Life Depression

Danielle D. DeSouza, Jessica Robin, Melisa Gumus, Anthony Yeung
2021 Frontiers in Psychiatry  
older adults with other clinical conditions, and discuss future directions including the use of complementary AI strategies to fully capture the spectrum of LLD.  ...  In this review, we will provide rationale for the use of NLP methods to study depression using speech, summarize previous research using NLP in LLD, compare findings to younger adults with depression and  ...  Two recent studies suggested that certain acoustic speech features may help differentiate depression and dementia, or dementia with and without comorbid depression (66, 71) , but this topic requires further  ... 
doi:10.3389/fpsyt.2021.719125 pmid:34552519 pmcid:PMC8450440 fatcat:63ubhpoft5hr7hxcwhqukrsori

CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

Ane-Victoria Idland, Roser Sala-Llonch, Tom Borza, Leiv Otto Watne, Torgeir Bruun Wyller, Anne Brækhus, Henrik Zetterberg, Kaj Blennow, Kristine Beate Walhovd, Anders Martin Fjell
2017 Neurobiology of Aging  
Acknowledgements The research presented in this thesis was carried out at the Department of Geriatric Medicine,  ...  main findings ...................................................................................... 67 5.1.1 Consequences of amyloid and tau pathology in older adults without dementia 68 5.1.2 Novel  ...  patients with and without dementia.  ... 
doi:10.1016/j.neurobiolaging.2016.09.012 pmid:27794264 fatcat:6sgqujw7jjclhg7mxtvoqptvjy

Deficits in irregular past-tense verb morphology associated with degraded semantic knowledge

K Patterson, M.A Lambon Ralph, J.R Hodges, J.L McClelland
2001 Neuropsychologia  
The study reported here evaluated the past-tense verb abilities of 11 patients with semantic dementia, a neurodegenerative condition characterised by degraded semantic knowledge.  ...  In this alternative view, neuropsychological dissociations are explained by reduced input from word meaning that plays a greater role in successful generation of the past-tense for lower frequency irregular  ...  Acknowledgements We are grateful for enlightening discussions of the issues and/or helpful comments on the original version of the manuscript from Helen Bird, Marc Joanisse, David Plaut and Mark Seidenberg  ... 
doi:10.1016/s0028-3932(01)00008-2 pmid:11311301 fatcat:a57sjrlxe5ftjpxkad2ldvebiq

Greek neurolinguistics: The State of the Art

Stavroula Stavrakaki
2005 Journal of Greek Linguistics  
More specific issues concerning the effect of word class on language production and comprehension, the status of the inflected and derived words in the mental lexicon, the effect of regularity on impaired  ...  Two non-fluent patients and twenty-four normal adults participated in simple and primed 6 lexical decision experiments; specifically, they performed non-word judgements 7 for inflected and derived words  ... 
doi:10.1075/jgl.6.10sta fatcat:k55qzp4ofjad3dvqba3vzo452u

Automated computerized analysis of speech in psychiatric disorders

Alex S. Cohen, Brita Elvevåg
2014 Current Opinion in Psychiatry  
Summary-Computer based assessments of natural language afford a framework with which to measure communication disturbances in adults with SMI.  ...  The clinical relevance of these novel metrics has been demonstrated by showing their relationship to functional outcome measures, their in vivo link to classic 'language' regions in the brain, and, in  ...  References and recommended reading Papers of particular interest, published within the annual period of review, have been highlighted as:  ... 
doi:10.1097/yco.0000000000000056 pmid:24613984 pmcid:PMC4212642 fatcat:tr2qgkapfbd23l55x4vckmvzim

Dissociations in Processing Past Tense Morphology: Neuropathology and Behavioral Studies

Lorraine K. Tyler, Paul deMornay-Davies, Rebekah Anokhina, Catherine Longworth, Billi Randall, William D. Marslen-Wilson
2002 Journal of Cognitive Neuroscience  
In this study, we tested five nonfluent aphasic patients, all of whom had extensive left hemisphere (LH) damage involving the left inferior frontal gyrus and underlying structures, and four patients with  ...  & Neuropsychological research showing that the regular ("jump-jumped") and irregular ("drive/drove") past tense inflectional morphology can dissociate following brain damage has been important in testing  ...  Acknowledgments We thank Mike Cooper for helping with the studies reported here and Dr F. Manes for his assistance with the lesion tracings.  ... 
doi:10.1162/089892902317205348 pmid:11798389 fatcat:ccnfuzdinbgjzenernne4effve

Utility of Machine Learning Approach with Neuropsychological Tests in Predicting Functional Impairment of Alzheimer's Disease

Seyul Kwak, Dae Jong Oh, Yeong-Ju Jeon, Da Young Oh, Su Mi Park, Hairin Kim, Jun-Young Lee
2021 Journal of Alzheimer's Disease  
older adults with no impairment (n = 285), mild cognitive impairment (n = 1,057), and Alzheimer's disease (n = 1,300).  ...  Methods: In this study, the neuropsychological battery (CERAD-K) and assessment of functioning level (Clinical Dementia Rating scale and Instrumental Activities of Daily Living) were administered to 2,642  ...  in older adults.  ... 
doi:10.3233/jad-215244 pmid:34924390 pmcid:PMC8925128 fatcat:klgre5ymqnghdm4g3tp7zfy54m

What can developmental disorders tell us about the neurocomputational constraints that shape development? The case of Williams syndrome

2003 Development and Psychopathology  
The uneven cognitive phenotype in the adult outcome of Williams syndrome has led some researchers to make strong claims about the modularity of the brain and the purported genetically determined, innate  ...  Such arguments have particularly been marshaled with respect to language.  ...  exist in both general-and the subsequent process of development and did not correspond to the simple removal izing inflectional regularities to novel word forms (wug-wugged) and the differential in-of  ... 
doi:10.1017/s0954579403000476 fatcat:vhyxrerisbbgjpyxcvli5gfnuu

Action versus animal naming fluency in subcortical dementia, frontal dementias, and Alzheimer's disease

C. Davis, J. Heidler-Gary, R. F. Gottesman, J. Crinion, M. Newhart, A. Moghekar, D. Soloman, D. Rigamonti, L. Cloutman, A. E. Hillis
2010 Neurocase  
We hypothesized patients with subcortical dementia, e.g., normal pressure hydrocephalus (NPH) and patients with dementias predominantly affecting frontal cortex, e.g., behavioral variant frontotemporal  ...  A total of 234 participants, including healthy controls (n = 20) and patients diagnosed with NPH (n =144), AD (n = 33), bv-FTD (n = 22) or PNFA (n = 15) were administered animal fluency, action fluency  ...  Acknowledgments The research reported in this paper was supported by NIH (NIDCD), through RO1 DC 05375. We gratefully acknowledge this support and the participation of the patients.  ... 
doi:10.1080/13554790903456183 pmid:20104387 pmcid:PMC4059509 fatcat:tqddsoq7kjaqpkn2hff7vjo5ia

Lexical acquisition in progressive aphasia and frontotemporal dementia

Ryan Murray, Phyllis Koenig, Shweta Antani, Gwyneth Mccawley, Murray Grossman
2007 Cognitive Neuropsychology  
, semantic, and thematic matrix information associated with the new word.  ...  We investigated the characteristics of language difficulty in frontotemporal dementia (FTD) by exposing these patients to a new verb in a naturalistic manner and then assessing acquisition of the grammatical  ...  A total of 8 of the sentences with "lour" placed the new verb in a sentence slot normally occupied by a verb, twice without grammatical inflection and six times with a bound grammatical morpheme (equally  ... 
doi:10.1080/02643290600890657 pmid:18416483 fatcat:oshmzrygonbdncqcxhcx7ul2r4

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

David A. Bennett, Lei Yu, Philip L. De Jager
2014 Biochemical Pharmacology  
Cognitive decline, Alzheimer's disease (AD) and other causes are major public health problems worldwide. With changing demographics, the number of persons with dementia will increase rapidly.  ...  The treatment and prevention of AD and other dementias, therefore, is an urgent unmet need.  ...  We also thank the participants of the Religious Orders Study and Rush Memory and Aging Project for their participation in these studies and the staff of the Rush Alzheimer's Disease Center.  ... 
doi:10.1016/j.bcp.2014.01.037 pmid:24508835 pmcid:PMC4054869 fatcat:aqrvwb4ktfendotguhc36vz6km
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