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Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: A quantitative fiber tracking study

Natalie M. Zahr, Torsten Rohlfing, Adolf Pfefferbaum, Edith V. Sullivan
2009 NeuroImage  
Differential correlations between FA or diffusivity in fiber tracts and scores on Problem Solving, Working Memory, or Motor factors provide convergent validity to the biological meaningfulness of the integrity  ...  , Working Memory, and Motor.  ...  Acknowledgments This work was supported by grants from the National Institutes of Health [NIA (AG17919) and NIAAA (AA10723, AA12388)].  ... 
doi:10.1016/j.neuroimage.2008.09.046 pmid:18977450 pmcid:PMC2632960 fatcat:jmzuazq5yfdlbgwqxx64n655tu

Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: Relations to timed performance

Edith V. Sullivan, Torsten Rohlfing, Adolf Pfefferbaum
2010 Neurobiology of Aging  
Using our quantitative fiber tracking approach, we assessed fiber tract integrity of samples of major white matter cortical, subcortical, interhemispheric, and cerebellar systems (11 bilateral and 2 callosal  ...  The integrity of white matter, as measured in vivo with diffusion tensor imaging (DTI), is disrupted in normal aging.  ...  This work was supported by the National Institute on Aging (AG017919) and National Institute on Alcohol Abuse and Alcoholism (AA010723 and AA012388).  ... 
doi:10.1016/j.neurobiolaging.2008.04.007 pmid:18495300 pmcid:PMC2815144 fatcat:ky7ztwlvendvpbc7dqjqaavowu

Longitudinal Study of Callosal Microstructure in the Normal Adult Aging Brain Using Quantitative DTI Fiber Tracking

Edith V. Sullivan, Torsten Rohlfing, Adolf Pfefferbaum
2010 Developmental Neuropsychology  
of age-related degradation in fiber bundles, notable in the genu, fornix, and uncinate fibers; functional relations were observed between Working Memory Problem Solving, and Motor factor scores and DTI  ...  In an initial study using quantitative fiber tracking in normal aging, we observed higher diffusivity and fewer imaging-defined fiber bundles in the anterior but not posterior segments of the corpus callosum  ... 
doi:10.1080/87565641003689556 pmid:20446131 pmcid:PMC2867078 fatcat:lsso3cgqo5hbxikht6f7ryheqy

Cingulum Microstructure Predicts Cognitive Control in Older Age and Mild Cognitive Impairment

C. Metzler-Baddeley, D. K. Jones, J. Steventon, L. Westacott, J. P. Aggleton, M. J. O'Sullivan
2012 Journal of Neuroscience  
Twenty healthy controls and 25 individuals with amnestic mild cognitive impairment (MCI), an early stage of age-associated cognitive deterioration, underwent cognitive testing, including several measures  ...  The relationship between cognitive control and microstructure of connections within the cingulum, a major white matter tract and conduit of projections to prefrontal sites, was probed in vivo in humans  ...  by age, education, and visual/verbal working memory.  ... 
doi:10.1523/jneurosci.3299-12.2012 pmid:23223284 pmcid:PMC6621654 fatcat:6v6nfe7xjvg5ng24tbkouasfse

Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study

Aristotle N. Voineskos, Tarek K. Rajji, Nancy J. Lobaugh, Dielle Miranda, Martha E. Shenton, James L. Kennedy, Bruce G. Pollock, Benoit H. Mulsant
2012 Neurobiology of Aging  
Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging.  ...  Our findings suggest that decline in the microstructural integrity of white matter fibers can account for cognitive decline in normal aging.  ...  memory and problem-solving domains correlated with the microstructural integrity of the genu and the fornix and several fiber systems were also correlated with motor performance.  ... 
doi:10.1016/j.neurobiolaging.2010.02.009 pmid:20363050 pmcid:PMC2945445 fatcat:vlscoe7wwrfwdcy23olcv27r5i

Methods of MRI-based structural imaging in the aging monkey

N. Makris, D.N. Kennedy, D.L. Boriel, D.L. Rosene
2010 Methods  
While cortical neurons are largely preserved in the cerebral cortex, including primary motor and visual cortex as well as prefrontal association cortex there is marked breakdown of axonal myelin and an  ...  for normal aging monkeys to elucidate the underlying neurobiological mechanisms of functional senescence in the aging non-human primate.  ...  These fiber tracts are mainly association and commissural fibers interconnecting the associative cortical areas of the different lobes.  ... 
doi:10.1016/j.ymeth.2009.06.007 pmid:19577648 pmcid:PMC3774020 fatcat:g5zp353a65cvjdxpcnpspxsohe

MR Diffusion Tensor Imaging: A Window into White Matter Integrity of the Working Brain

Sandra Chanraud, Natalie Zahr, Edith V. Sullivan, Adolf Pfefferbaum
2010 Neuropsychology Review  
The advent of in vivo diffusion tensor imaging, which allows quantitative characterization of white matter fiber integrity in health and disease, has served to strengthen Geschwind's proposal.  ...  Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.  ...  Acknowledgments All authors were involved in drafting the article or revising it critically, and they read and approved the final version of the manuscript.  ... 
doi:10.1007/s11065-010-9129-7 pmid:20422451 pmcid:PMC2910550 fatcat:pkx5s4lrmngwxliz5vujlptcna

Fiber tracking functionally distinct components of the internal capsule

Edith V. Sullivan, Natalie M. Zahr, Torsten Rohlfing, Adolf Pfefferbaum
2010 Neuropsychologia  
Quantitative fiber tracking combined with assessment of cognitive and motor functions enabled the identification of selective brain structure-function relations in healthy adults without lesions that were  ...  Identification of a triple dissociation indicated selective correlations between anterior FA and Set Shifting, genu FA and Motor Skills, and posterior FA and Fluency.  ...  Acknowledgments This work was funded by grants from the National Institute on Aging (AG019717), the National Institute on Alcohol Abuse and Alcoholism (AA010723, AA012388, AA017168), and the National Institute  ... 
doi:10.1016/j.neuropsychologia.2010.10.023 pmid:20974161 pmcid:PMC2993875 fatcat:mggsfftcabfudle46vlbovmyfe

Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Sandra Chanraud, Michel Reynaud, Michèle Wessa, Jani Penttilä, Nikoleta Kostogianni, Arnaud Cachia, Eric Artiges, Françoise Delain, Murielle Perrin, Henri-Jean Aubin, Yann Cointepas, Catherine Martelli (+1 others)
2008 Neuropsychopharmacology  
In addition, the normalized number of these fibers correlated with the performance in the Trail-Making Test part-B.  ...  Bundles connecting two regions of interest were analyzed using a fiber-tracking quantitative approach, which provided estimates of the fractional anisotropy and the apparent diffusion coefficient, as well  ...  The authors have no financial interests or potential conflicts of interest. FINANCIAL DISCLOSURES  ... 
doi:10.1038/npp.2008.101 pmid:18615012 fatcat:mipc43zwkba5pd643h2znh66ka

The Fornix in Health and Disease: An Imaging Review

Adam G. Thomas, Panos Koumellis, Robert A. Dineen
2011 Radiographics  
Quantitative fiber tracking in healthy subjects has demonstrated significant inverse correlations between fractional anisotropy and working memory (r = 0.63, P < .001) and between fractional anisotropy  ...  By using quantitative fiber tracking, an age-dependent reduction in forniceal integrity has been demonstrated in healthy aging (13) .  ...  As part of this extended hippocampal-diencephalic system, the fornices are thought to contribute to the efficient encoding and normal recall of new episodic information (15) .  ... 
doi:10.1148/rg.314105729 pmid:21768242 fatcat:5xnpmfutmrb4zof2vbvrecmf7y

The relation of structural integrity and task-related functional connectivity in the aging brain

Hana Burianová, Lars Marstaller, Jeiran Choupan, Farshid Sepehrband, Maryam Ziaei, David Reutens
2015 Neurobiology of Aging  
These findings demonstrate the importance of structural integrity and functional connectivity in working memory performance associated with healthy ageing.  ...  Our results are twofold, showing (i) agerelated differences in functional connectivity of the working memory network and (ii) agerelated recruitment of a compensatory network associated with better accuracy  ...  Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: A quantitative fiber tracking study. NeuroImage, 44, 1050-1062.  ... 
doi:10.1016/j.neurobiolaging.2015.07.006 pmid:26234754 fatcat:iirfjn7a6zdwzn5gcziq6gc4bq

Focus on the brain: HIV infection and alcoholism: comorbidity effects on brain structure and function

Margaret J Rosenbloom, Edith V Sullivan, Adolf Pfefferbaum
2010 Alcohol Research and Health  
Finally, neuropsychological studies have revealed impairment in selective functions involving working memory, visuospatial abilities, and movement speed that are especially likely to occur in people with  ...  individuals singly affected and a compounding of effects in individuals with both HIV infection and alcoholism.  ...  , a procedure known as quantitative fiber tracking (Gerig et al. 2005) .  ... 
pmid:23584066 pmcid:PMC3860510 fatcat:smbqvkanzfhu3ny44sbvsbsgiy

Clinical and Pathophysiological Considerations of Gait Limitations and High Prevalence of Falls, in Elderly with Most Common, Disabling Neurological Diseases

Aurelian Anghelescu
2017 International Journal of Neurorehabilitation  
cognitive abasement, functional compromise in problem solving, declining of working memory, gait impairments, motor dyspraxia and increased risk for the development of neurodegenerative diseases [9,  ...  Quantitative fiber tracking studies (DTI) illustrated WM destructuration in parallel with the functional degradation, and permitted longitudinal evaluation of the myeloarchitectonics in MS [43] .  ... 
doi:10.4172/2376-0281.1000262 fatcat:3n7fx3xd5jfndbjbvho5tme5i4

Plasticity of left perisylvian white-matter tracts is associated with individual differences in math learning

Dietsje Jolles, Demian Wassermann, Ritika Chokhani, Jennifer Richardson, Caitlin Tenison, Roland Bammer, Lynn Fuchs, Kaustubh Supekar, Vinod Menon
2015 Brain Structure and Function  
More generally, our quantitative approach will be useful for future studies examining longitudinal changes in white matter integrity associated with cognitive skill development.  ...  Here, we examine learning-related changes of white matter tracts innervating inferior parietal, prefrontal and extend previous findings of individual differences in white matter integrity, and provide  ...  Acknowledgments This research was supported by grants from the National Institutes of Health (HD047520, HD059205, HD057610, MH074794) and the Netherlands Organization for Scientific Research (NWO) (446  ... 
doi:10.1007/s00429-014-0975-6 pmid:25604464 pmcid:PMC4819785 fatcat:g2odg6sidfacbpupakfxsojavy

The Superior Longitudinal Fasciculus in Typically Developing Children and Adolescents

Sacide E. Urger, Michael D. De Bellis, Stephen R. Hooper, Donald P. Woolley, Steven D. Chen, James Provenzale
2014 Journal of Child Neurology  
After adjusting for age and gender, fractional anisotropy and axial diffusivity values in the superior longitudinal fasciculus were positively correlated with executive functions of set-shifting; while  ...  In the left arcuate fasciculus, fractional anisotropy correlated with IQ and attention; while radial diffusivity values negatively correlated with IQ, fine-motor skills, and expressive language.  ...  Acknowledgements The authors thank the staff of the Duke Healthy Childhood Brain Development Developmental Traumatology Research Program and the participants and their families for making this work possible  ... 
doi:10.1177/0883073813520503 pmid:24556549 pmcid:PMC4138302 fatcat:mo2do4zomfbcflb7y2df7hasma
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