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Chiroptical Metamaterials and Their Use in Bio-Sensing [article]

Morten Slyngborg
2016 Ph.d.-serien for Det Teknisk-Naturvidenskabelige Fakultet, Aalborg Universitet  
It would also be interesting to produce two PCM samples with opposite handedness to probe how much the resulting CD response is affected by the random defects in the two samples. 29 Spin coating All  ...  Coarse-grained molecular dynamics simulations enabled very long timescales to monitor the self-assembly process.  ...  Paper C Langmuir, submitted May 2016 166 The Physical Properties and Self-Assembly Potential of the RFFFR Peptide  ... 
doi:10.5278/vbn.phd.engsci.00121 fatcat:bee6ylk3qzclxdaazuojxdoc3u

Minor Chemistry Changes Alter Surface Hydration to Control Fibronectin Adsorption and Assembly into Nanofibrils

Mateusz K. Bieniek, Virginia Llopis-Hernandez, Katie Douglas, Manuel Salmeron-Sanchez, Christian D. Lorenz
2019 Advanced Theory and Simulations  
Modelling Hub (MMM Hub) for computational resources, which is partially funded by EPSRC (EP/P020194/1) to carry out the MD simulations reported in this manuscript.  ...  Additionally, M.K.B. acknowledges the valuable conversations he had with Willie Taylor and Enrico Spiga at the Francis Crick Institute during the course of this study.  ...  Adsorption of FNIII 9 and 10 on EA and MA SAMs In order to gain a more detailed understanding of how fibronectin interacts with the self-assembled monolayer interfaces, we have analyzed our all-atom molecular  ... 
doi:10.1002/adts.201900169 fatcat:nhvcud3d7ngchocdycop263qly

Atomistic Simulations of Functionalized Nano-Materials for Biosensors Applications

Sutapa Dutta, Stefano Corni, Giorgia Brancolini
2022 International Journal of Molecular Sciences  
Nonetheless, the complex architecture of a biosensor, associated with the collective contribution from "substrate–receptor–analyte" conjugate in a solvent, often requires extensive atomistic simulations  ...  Due to experimental limitations at the microscopic level, integrated cross-disciplinary approaches that combine in silico design with experimental measurements have the potential to present a powerful  ...  Self-Assembled Monolayer-Based Biosensors Self-assembled monolayer (SAM) [49] plays a pivotal role in the definition of biosensor devices, specifically because of its miniature size and versatility in  ... 
doi:10.3390/ijms23031484 pmid:35163407 pmcid:PMC8835741 fatcat:rll4wtj5mrcspl4rb5seeykv4e

Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives

Paolo Pengo, Maria Şologan, Lucia Pasquato, Filomena Guida, Sabrina Pacor, Alessandro Tossi, Francesco Stellacci, Domenico Marson, Silvia Boccardo, Sabrina Pricl, Paola Posocco
2017 European Biophysics Journal  
This review aims to explore the current state of development of such patterned, self-assembled monolayerprotected gold nanoparticles, through step-by-step analysis of their conceptual design, synthetic  ...  procedures, predicted and determined surface characteristics, interactions with and performance in biological environments, and experimental and computational methods currently employed for their investigation  ...  Molecular probes have been employed in several methodologies to study phase-segregated domains in surface monolayers (Bonomi et al. 2011) .  ... 
doi:10.1007/s00249-017-1250-6 pmid:28865004 pmcid:PMC5693983 fatcat:zqtq7kuxpbhapj2rr32u5r6wz4

Molecular adsorption on graphene

Lingmei Kong, Axel Enders, Talat S Rahman, Peter A Dowben
2014 Journal of Physics: Condensed Matter  
with molecular adsorbates, but that this approach appears to be superior compared to these exploiting edge effects, local defects, or strain.  ...  In reviewing the studies of the effects of molecular adsorption on graphene, it is evident that the strong manipulation of graphene's electronic structure, including p-and n-doping, is not only possible  ...  Atomic-scale molecular dynamics simulations of alkylamine self-assembled monolayer (SAM) films on graphene [132] show that the SAM architecture can be tailored for use in emerging applications (e.g.  ... 
doi:10.1088/0953-8984/26/44/443001 pmid:25287516 fatcat:7ykjofxea5bqxam5a5y6ozpkai

Design of Surface Modifications for Nanoscale Sensor Applications

Erik Reimhult, Fredrik Höök
2015 Sensors  
We review in detail how patterning of molecular films designed to control interactions of biomolecules with nanoscale biosensor surfaces creates new possibilities as well as new challenges.  ...  This enables approaching single-molecule detection and new sensing modalities that probe molecular conformation.  ...  (Ai) Hybrid bilayer consisting of a self-assembled monolayer and a lipid monolayer which can be self-assembled on moth biosensors; (Aii) A solid-supported lipid bilayer suitable for cantilever (acoustic  ... 
doi:10.3390/s150101635 pmid:25594599 pmcid:PMC4327096 fatcat:fthj2de2lzd7jmaeqcbuewtaku

Simulations of inorganic–bioorganic interfaces to discover new materials: insights, comparisons to experiment, challenges, and opportunities

Hendrik Heinz, Hadi Ramezani-Dakhel
2016 Chemical Society Reviews  
This review covers biomolecular recognition mechanisms on inorganic surfaces at the 1 to 100 nm scale, predictions of materials performance in comparison to experiment, and computational methods.  ...  size including porosity and other defects. 82, [112] [113] [114] [115] Polymers and proteins assemble into nanoparticles with even less structural order due to reversible self-assembly or cross-linking  ...  View Article Online interactions with organic molecules, 104 self-assembled monolayers, 238, 291, 292 as well as polyelectrolytes. 237 The pK values of carbonic acid are pK 1 = 6.35 and pK 2 = 10.33  ... 
doi:10.1039/c5cs00890e pmid:26750724 fatcat:y2up4rb6njbjxie2rscjbg5twm

Adsorption and self-assembly of bio-organic molecules at model surfaces: A route towards increased complexity

Dominique Costa, Claire-Marie Pradier, Frederik Tielens, Letizia Savio
2015 Surface science reports  
Indeed an impressive number of studies exist (both experimental and -to a lesser extendtheoretical), which demonstrate the ability of molecular self-assembly to create different structural motifs in a  ...  Nowadays it is well demonstrated that a wide variety of different molecular assemblies can form upon adsorption of small biomolecules at surfaces.  ...  In this frame it is particularly interesting to see how the presence of the -potentially reactive-molecular tail affects the 3 adsorption configuration.  ... 
doi:10.1016/j.surfrep.2015.10.002 fatcat:lycdphcaybfnbi2thn4juvg4pu

Amplification of chirality in surface-confined supramolecular bilayers

Hai Cao, Steven De Feyter
2018 Nature Communications  
The nonlinear chiral amplification effect in bilayers of near-racemic mixtures involves the biased adsorption and organization of the majority enantiomer, and the compliance of the minority enantiomer  ...  One of the most dramatic effects of supramolecular assembly is the generation of homochirality in near-racemic systems. It is normally infeasible though to flip the absolute chirality of a molecule.  ...  In other words, these self-assembly processes of the less stable helix conformers are inactive (Fig. 4j) .  ... 
doi:10.1038/s41467-018-05962-3 pmid:30143623 pmcid:PMC6109073 fatcat:niz5sqg655awvp7rsvgiyoiiii

Atomic force microscopy to elucidate how peptides disrupt membranes

Katharine Hammond, Maxim G. Ryadnov, Bart W. Hoogenboom
2020 Biochimica et Biophysica Acta - Biomembranes  
This review describes how methodological advances in AFM facilitate new insights into membrane disruption mechanisms.  ...  Atomic force microscopy is an increasingly attractive tool to study how peptides disrupt membranes.  ...  (B) Fast scanning AFM topography images showing how self-assembled peptide capsids solubilise a SLB in under 5 min. Scale bar 1 µm. Reproduced from ref. [106], licensed under CC BY 4.0.  ... 
doi:10.1016/j.bbamem.2020.183447 pmid:32835656 fatcat:ekyghddrvrd7dlgropw76yrucm

Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer's disease

Elizabeth Drolle, Francis Hane, Brenda Lee, Zoya Leonenko
2014 Drug metabolism reviews (Softcover ed.)  
We review the current state of research, including applications of the latest nanotechnology approaches, on the interaction of lipid membranes with the amyloid-b (Ab) peptide in relation to amyloid toxicity  ...  We discuss the interactions of Ab with model lipid membranes with a focus to demonstrate that composition, charge and phase of the lipid membrane, as well as lipid domains and rafts, affect the binding  ...  This finding correlates with previous research on lipid monolayers showing that electrostatic interactions with negatively charged lipids increase peptide adsorption onto the monolayer at the air-water  ... 
doi:10.3109/03602532.2014.882354 pmid:24495298 fatcat:yzps3majjngo3dcuphptdxrqzy

Amphiphile nanoarchitectonics: from basic physical chemistry to advanced applications

Muruganathan Ramanathan, Lok Kumar Shrestha, Taizo Mori, Qingmin Ji, Jonathan P. Hill, Katsuhiko Ariga
2013 Physical Chemistry, Chemical Physics - PCCP  
Amphiphiles, either synthetic or natural, are structurally simple molecules with the unprecedented capacity to self-assemble into complex, hierarchical geometries in nanospace.  ...  amphiphiles in bulk phases, (iii) assembly on static surfaces, (iv) assembly at dynamic interfaces, and (v) advanced topics from simulation to application.  ...  affect the structure of the interface, and how does this structure affect interfacial tension?  ... 
doi:10.1039/c3cp50620g pmid:23639971 fatcat:64tzm6kb3jfi5d4wzxn4t2yy7m

Perspective on the Martini model

Siewert J. Marrink, D. Peter Tieleman
2013 Chemical Society Reviews  
The Martini model, a coarse-grained force field for biomolecular simulations, has found a broad range of applications since its release a decade ago.  ...  DPT is an Alberta Innovates Health Solutions Scientist and Alberta Innovates Technology Futures Strategic Chair in (Bio)Molecular Simulation. Notes and references  ...  Work in DPT's group is supported by the Canadian Institutes of Health Research (grant MOP-62690) and the Natural Sciences and Engineering Research Council.  ... 
doi:10.1039/c3cs60093a pmid:23708257 fatcat:yt7elpynnrcg3phev6oj6xd2l4

Biocompatible Materials Based on Self-Assembling Peptides on Ti25Nb10Zr Alloy: Molecular Structure and Organization Investigated by Synchrotron Radiation Induced Techniques

Valeria Secchi, Stefano Franchi, Marta Santi, Alina Vladescu, Mariana Braic, Tomáš Skála, Jaroslava Nováková, Monica Dettin, Annj Zamuner, Giovanna Iucci, Chiara Battocchio
2018 Nanomaterials  
be grafted on the surface in order to establish a molecular dialogue with host cells [47] .  ...  Among other bioactive molecules, self-assembling peptides (SAPs) are extremely promising candidates, since thanks to their on-purpose designed sequence they are able to self-assemble in a beta-sheet secondary  ...  The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.  ... 
doi:10.3390/nano8030148 pmid:29518968 pmcid:PMC5869639 fatcat:b6znr7ua2bewnflbhofiqn6c4y

Electrochemistry of redox-active self-assembled monolayers

Amanda L. Eckermann, Daniel J. Feld, Justine A. Shaw, Thomas J. Meade
2010 Coordination chemistry reviews  
Recent interest in surface (electrode) modification has led to the study of electron transfer using electrodes modified with self-assembled monolayers (SAMs) [1, [37] [38] [39] [40] [41] [42] [43] .  ...  Modeling of SAM structure Experimental preparation of monolayers on a metal surface by self-assembly was first reported by Zisman and coworkers in 1946 [407] .  ... 
doi:10.1016/j.ccr.2009.12.023 pmid:20563297 pmcid:PMC2885823 fatcat:qmflk4wcvnac3oag6thdi2fawq
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