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Privacy-Preserving Randomized Controlled Trials: A Protocol for Industry Scale Deployment [article]

Mahnush Movahedi, Benjamin M. Case, Andrew Knox, James Honaker, Li Li, Yiming Paul Li, Sanjay Saravanan, Shubho Sengupta, Erik Taubeneck
2021 arXiv   pre-print
In this paper, we outline a way to deploy a privacy-preserving protocol for multiparty Randomized Controlled Trials on the scale of 500 million rows of data and more than a billion gates.  ...  A Randomized Controlled Trial is a scientifically rigorous method to measure the effectiveness of a treatment.  ...  We evaluated multiple general purpose Privacy-Preserving Randomized Controlled Trials: A Protocol for Industry Scale Deployment MPC frameworks for this step and concluded to build our solution based on  ... 
arXiv:2101.04766v2 fatcat:7qvkufa3jbft3lt6jvz7kgdbvu

In silico clinical trials: how computer simulation will transform the biomedical industry

Marco Viceconti, Adriano Henney, Edwin Morley-Fletcher
2016 International Journal of Clinical Trials  
The roadmap documents early examples of in silico clinical trials, identifies relevant use cases for in silico clinical trial technologies over the entire development and assessment cycle for both pharmaceuticals  ...  and medical devices, identifies open challenges and barriers to a wider adoption and puts forward 36 recommendations for all relevant stakeholders to consider<span lang="EN-US">.  ...  ACKNOWLEDGEMENTS The authors would like to thank Karen El-Arifi, Martina Contin, Anders Karlström, Mike Taylor, and Callum MCgregor for the support in running the Avicenna action, and all 577 experts listed  ... 
doi:10.18203/2349-3259.ijct20161408 fatcat:f2kosxh5zrg2boghgzabajr5ui

Ethical and regulatory issues of pragmatic cluster randomized trials in contemporary health systems

Monique L Anderson, Robert M Califf, Jeremy Sugarman
2015 Clinical Trials  
Cluster randomized trials (CRTs) randomly assign groups of individuals to examine research questions or test interventions and measure their effects on individuals.  ...  Attendees included experts in clinical trials, patient advocacy, research ethics, and research regulations from academia, industry, the NIH, and other federal agencies.  ...  Acknowledgments The authors thank the participants in the NIH HCS Collaboratory Workshop on Cluster Randomized Trials (listed in the Appendix), who reviewed an early draft of this manuscript and provided  ... 
doi:10.1177/1740774515571140 pmid:25733677 pmcid:PMC4498459 fatcat:ai4kltrvxngapa7jjboeyjcaxa

Cross-Border Trials for Cooperative, Connected and Automated Mobilty

Jesus Alonso-Zarate, Apostolos Kousaridas, Mmaciej Muehleisen
2019 Zenodo  
The possibility of providing CCAM services across different countries for vehicles driving across various national borders has a huge innovative business potential.  ...  industries have joined efforts to test and validate 5G technologies at a large scale in a crossborder setting.  ...  According to the paper, the deployment of a "5G digitized highway" is a main enabler, and it should be deployed only by private sector investments.  ... 
doi:10.5281/zenodo.3984691 fatcat:5wtnd6k37jf43apie3pwsh3x6u

TSCH Networks for Health IoT

Atis Elsts, Xenofon Fafoutis, George Oikonomou, Robert Piechocki, Ian Craddock
2020 ACM Transactions on Internet of Things  
Results from 29 long-term residential deployments confirm the suitability for the application and show that the system is able to adapt and avoid channels used by WiFi.  ...  Low-power wireless protocols for residential Health IoT applications are characterized by high reliability requirements, the need for energy-efficient operation, and the need to operate robustly in diverse  ...  A full list of SPHERE collaborators can be found at http://www.ircsphere.ac.uk. The authors acknowledge the valued contribution of the 50+ researchers and support personnel of the project.  ... 
doi:10.1145/3366617 dblp:journals/tiot/ElstsFOPC20 fatcat:4yxuqw2wnzhuhjpvnw4pro73ha

Can Team-Based Care Improve Patient Satisfaction? A Systematic Review of Randomized Controlled Trials

Jin Wen, Kevin A. Schulman, Susanne Hempel
2014 PLoS ONE  
However, considering the pooling result of continuous data, along with the suboptimal quality of included trials, further large-scale and high-quality randomized controlled trials comparing team-based  ...  Articles with different settings between intervention and control were excluded, as were trial protocols. The reference lists of retrieved papers were also evaluated for inclusion.  ...  'routine care,'' ''standard care,'' ''conventional care,'' or similar terms as a control group mentioned in randomized controlled trials.  ... 
doi:10.1371/journal.pone.0100603 pmid:25014674 pmcid:PMC4094385 fatcat:yw6fw5iaejfrrkss43hzrrd7s4

Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials

2017 Trials  
Acknowledgements Funded by the MRC North West Hub in Trials Methodological Research (MR/K025635/1) and the NIHR Health Technology Assessment programme (08/14/39).  ...  National Institutes of Health, or NIH) initiative created to conduct studies of treatments for neurological diseases through partnerships with academia, private foundations, and industry.  ...  We conducted a randomized controlled trial of 10,000 pregnant women across 16 clinical centers.  ... 
doi:10.1186/s13063-017-1902-y fatcat:yt477zyq4vbi7cm6f3sozyl42u

Design of a multi-site multi-state clinical trial of home monitoring of chronic disease in the community in Australia

Branko G Celler, Ross Sparks, Surya Nepal, Leila Alem, Marlien Varnfield, Jane Li, Julian Jang-Jaccard, Simon J McBride, Rajiv Jayasena
2014 BMC Public Health  
organisational change management that will impact on large scale national deployment of telehealth services.  ...  The Trial Design is an Intervention control study based on the Before-After-Control-Impact (BACI) design.  ...  In-kind support from participating health service organizations and industry partners was also provided.  ... 
doi:10.1186/1471-2458-14-1270 pmid:25511206 pmcid:PMC4320478 fatcat:oa7ayryfrza7vhjgjnscdsagm4

Paraplegia prevention in aortic aneurysm repair by thoracoabdominal staging with 'minimally invasive staged segmental artery coil embolisation' (MIS²ACE): trial protocol for a randomised controlled multicentre trial

David Petroff, Martin Czerny, Tilo Kölbel, Germano Melissano, Lars Lonn, Josephina Haunschild, Konstantin von Aspern, Petra Neuhaus, Johann Pelz, David Mark Epstein, Nuria Romo-Avilés, Katja Piotrowski (+1 others)
2019 BMJ Open  
Risk Evaluation (euroSCORE) II as fixed effects and the centre as a random effect.  ...  Minimally invasive staged segmental artery coil embolisation (MIS2ACE) has been proved recently to be a feasible enhanced approach to staged repair.Methods and analysisThis randomised controlled trial  ...  to the intervention and control arms with a random number generator.  ... 
doi:10.1136/bmjopen-2018-025488 pmid:30837256 pmcid:PMC6429943 fatcat:yxavca4hvzecjhk6coegwpsjiy

Developing a Robust Clinical Trials Workforce

Ann Bonham, Robert Califf, Elaine Gallin, Michael Lauer
2012 NAM Perspectives  
Of course, effective deployment of EHRs with standardized data elements would allow randomized controlled trials (RCTs) to be done at a much lower cost by reducing or eliminating redundant data collection  ...  A smaller number work at government agencies such as NIH, the Centers for Disease Control and Prevention, and FDA; others work with public-private partnerships such as the Medicines for Malaria Initiative  ... 
doi:10.31478/201204e fatcat:chcjhmbucjaojj7uyoxyog57jq

The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

David N. Hager, Michael H. Hooper, Gordon R. Bernard, Laurence W. Busse, E. Wesley Ely, Alpha A. Fowler, David F. Gaieski, Alex Hall, Jeremiah S. Hinson, James C. Jackson, Gabor D. Kelen, Mark Levine (+8 others)
2019 Trials  
The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled trial.  ...  VICTAS is a large, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled trial that will test the efficacy of vitamin C, thiamine, and hydrocortisone as a combined therapy in  ...  Acknowledgments The authors are deeply indebted to the following individuals for their administrative and scientific support of the VICTAS trial: Lindsay Eyzaguirre, Jessica S.  ... 
doi:10.1186/s13063-019-3254-2 pmid:30953543 pmcid:PMC6451231 fatcat:dqxs65h565by3gjky3wk34rl6q

Design of a randomized trial testing a multi-level weight-control intervention to reduce obesity and related health conditions in low-income workers

Richard I. Stein, Jaime R. Strickland, Rachel G. Tabak, Ann Marie Dale, Graham A. Colditz, Bradley A. Evanoff
2019 Contemporary Clinical Trials  
Weight-control is a major public health focus for preventing multiple obesity-related health conditions.  ...  These nested interventions are being tested in a group-randomized trial among 22 work groups (~1000 total workers, ~300 workers with obesity).  ...  We thank Bridget Kirk, BS, Sam Biver, MPH, and Skye Buckner-Petty, MPH, for their assistance with this manuscript.  ... 
doi:10.1016/j.cct.2019.01.011 pmid:30664943 pmcid:PMC6521952 fatcat:7bekvs45zray3ge2z4rv7i6664

Quantitative Imaging in Cancer Clinical Trials

T. E. Yankeelov, D. A. Mankoff, L. H. Schwartz, F. S. Lieberman, J. M. Buatti, J. M. Mountz, B. J. Erickson, F. M. M. Fennessy, W. Huang, J. Kalpathy-Cramer, R. L. Wahl, H. M. Linden (+7 others)
2016 Clinical Cancer Research  
Our goal is to encourage and guide the oncology community to deploy standardized quantitative imaging techniques in clinical trials to further personalize care for cancer patients and to provide a more  ...  We then describe the tools and methods required to apply quantitative imaging and provide concrete examples of work making these advances practically available for routine application in clinical trials  ...  Heather Jacene and Annick van den Abbeele for constructive criticism and informative discussions. Grant Support  ... 
doi:10.1158/1078-0432.ccr-14-3336 pmid:26773162 pmcid:PMC4717912 fatcat:k5cvc6qmrraphbqoqjsqrlvo7u

The Elusive Path Toward Measuring Health Outcomes: Lessons Learned From a Pseudo-Randomized Controlled Trial of a Large-Scale Mobile Health Initiative

Patricia Mechael, Nadi Nina Kaonga, Subhashini Chandrasekharan, Muthu Perumal Prakash, Joanne Peter, Aakash Ganju, Nirmala Murthy
2019 JMIR mHealth and uHealth  
controlled trial to evaluate the impact of mMitra, a stage-based voice messaging program to improve maternal, newborn, and child health outcomes in urban slums in India.  ...  This commentary shares lessons and important considerations based on the experience of applying new research frameworks and incorporating maternal and child health records data into a pseudo-randomized  ...  Lester et al. describe a protocol for evaluating effectiveness of the WelTelKenya randomized controlled trial for SMS-supported HIV management in a population receiving antiretroviral therapy in Nairobi  ... 
doi:10.2196/14668 pmid:31436165 pmcid:PMC6724498 fatcat:ihhrlwyylbejpmrqgcsb35eipu

Towards an Architecture to Guarantee Both Data Privacy and Utility in the First Phases of Digital Clinical Trials

Fabio Angeletti, Ioannis Chatzigiannakis, Andrea Vitaletti
2018 Sensors  
Current approaches in digital trials entail that private user data are provisioned to the trial investigator that is considered a trusted party.  ...  The proposed architecture will let the individuals keep their data private during these phases while providing a useful sketch of their data to the investigator.  ...  More formally, given a randomized algorithm A and two datasets D1 and D2 that differ in exactly one record (i.e., the data of one person), A is -differential private if for any S ⊆ Range(A) Pr[A(D1)  ... 
doi:10.3390/s18124175 pmid:30487435 fatcat:6s3bgzgthjctdekupawvxp2x4m
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