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Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder

Giacomo Salvadore, Allison C. Nugent, Herve Lemaitre, David A. Luckenbaugh, Ruth Tinsley, Dara M. Cannon, Alexander Neumeister, Carlos A. Zarate, Wayne C. Drevets
2011 NeuroImage  
Previous neuromorphometric investigations of major depressive disorder (MDD) have reported abnormalities in gray matter in several regions, although the results have been inconsistent across studies.  ...  The aim of the present study was to investigate gray matter (GM) differences in unmedicated, currently-depressed participants (dMDD) and unmedicated, currently-remitted (rMDD) participants with MDD compared  ...  Regions where gray matter density was reduced in currently depressed (N=58) subjects with major depressive disorder compared to healthy controls (N=107) (a) and to currently remitted MDD subjects (N=27  ... 
doi:10.1016/j.neuroimage.2010.11.011 pmid:21073959 pmcid:PMC3020249 fatcat:cxfsm7ypzbdt7lou7xenq3af4y

Neuroimaging in bipolar disorder: A critical review of current findings

Matthew T. Keener, Mary L. Phillips
2007 Current Psychiatry Reports  
Also, the depression associated with bipolar disorder frequently continues to be treated as unipolar depression (UPD).  ...  These abnormalities in core domains represent potential endophenotypes of the illness.  ...  Emotion processing In remitted and depressed patients with bipolar disorder, decreased blood flow was shown in medial prefrontal cortex during sad mood induction relative to baseline [35] , with lateral  ... 
doi:10.1007/s11920-007-0070-2 pmid:18221633 pmcid:PMC2686113 fatcat:jk3cwnpm2nhmfbwgt53jmqwxyy

Amygdala activity and prefrontal cortex-amygdala effective connectivity to emerging emotional faces distinguish remitted and depressed mood states in bipolar disorder

Susan B Perlman, Jorge RC Almeida, Dina M Kronhaus, Amelia Versace, Edmund J LaBarbara, Crystal R Klein, Mary L Phillips
2012 Bipolar Disorders  
Methods-Thirty-one remitted adults with BD [(remitted BD), mean age = 32 years], 21 adults with BD in a depressed episode [(depressed BD), mean age = 33 years], and 25 healthy control participants [(HC  ...  Results-Our findings indicated patterns of abnormally elevated bilateral amygdala activity in response to emerging fearful, sad, and angry facial expressions in remitted-BD subjects versus HC, and abnormally  ...  Second, our previous FC data in individuals with remitted and depressed BD (12) allowed us to hypothesize that remitted-BD and depressed-BD patients versus HC would both show abnormal right-sided amydgala-prefrontal  ... 
doi:10.1111/j.1399-5618.2012.00999.x pmid:22420592 pmcid:PMC3703524 fatcat:qzjrhm2ujbgsnh6h3tt54ku2tu

Distinguishing between Unipolar Depression and Bipolar Depression: Current and Future Clinical and Neuroimaging Perspectives

Jorge Renner Cardoso de Almeida, Mary Louise Phillips
2013 Biological Psychiatry  
Differentiating bipolar disorder (BD) from recurrent unipolar depression (UD) is a major clinical challenge.  ...  , and differential patterns of functional abnormalities in emotion regulation and attentional control neural circuitry in the two depression types.  ...  Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry. 2004; 55:578-587.  ... 
doi:10.1016/j.biopsych.2012.06.010 pmid:22784485 pmcid:PMC3494754 fatcat:iipn3ugegbaw3jq7qk4l2j6hxi

Self-Referential Processing, Rumination, and Cortical Midline Structures in Major Depression

Ayna Baladi Nejad, Philippe Fossati, Cédric Lemogne
2013 Frontiers in Human Neuroscience  
Self-referential processing in major depression seems associated with abnormally increased activity of the anterior cortical midline structures.  ...  The role of the medial prefrontal cortex in self-referential processing has been previously emphasized in acute major depression.  ...  portion in particular, in the pathophysiology of major depressive disorder.  ... 
doi:10.3389/fnhum.2013.00666 pmid:24124416 pmcid:PMC3794427 fatcat:p7zj552t55a5jm2x6sggmmktga

Structural brain networks in remitted psychotic depression

Nicholas H. Neufeld, Antonia N. Kaczkurkin, Aristeidis Sotiras, Benoit H. Mulsant, Erin W. Dickie, Alastair J. Flint, Barnett S. Meyers, George S. Alexopoulos, Anthony J. Rothschild, Ellen M. Whyte, Linda Mah, Jay Nierenberg (+4 others)
2020 Neuropsychopharmacology  
Major depressive disorder with psychotic features (psychotic depression) is a severe disorder.  ...  Overall, decreased cortical thickness was found in five structural brain networks in patients with remitted psychotic depression and brain-behavior relationships were observed, particularly between the  ...  INTRODUCTION Major depressive disorder (MDD) with psychotic features (psychotic depression) is a severe disorder with a lifetime prevalence of 0.35-1% [1] .  ... 
doi:10.1038/s41386-020-0646-7 pmid:32109935 fatcat:isf5mifztjd6pabvzcxnaafvtq

Bruijniks_Supplemental_materials_2 – Supplemental material for The Potential Role of Learning Capacity in Cognitive Behavior Therapy for Depression: A Systematic Review of the Evidence and Future Directions for Improving Therapeutic Learning

Sanne J. E. Bruijniks, Robert J. DeRubeis, Steven D. Hollon, Marcus J. H. Huibers
2019 Figshare  
Supplemental material, Bruijniks_Supplemental_materials_2 for The Potential Role of Learning Capacity in Cognitive Behavior Therapy for Depression: A Systematic Review of the Evidence and Future Directions  ...  Huibers in Clinical Psychological Science  ...  III Ruchsow et al., 2004 Case-control 16 patients with DSM-IV major depressive disorder in remission and 16 matched controls Current and previous CBT treatment unknown.  ... 
doi:10.25384/sage.7901714 fatcat:btd2nlxygvertbbx43j5skvace

Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder

Jorge R.C. Almeida, Andrea Mechelli, Stefanie Hassel, Amelia Versace, David J. Kupfer, Mary L. Phillips
2009 Psychiatry Research : Neuroimaging  
Forty-six individuals (age range: 18-56 years); 21 with a DSM-IV diagnosis of BD, type I currently remitted; 25 age-and gender-matched healthy controls (HC).  ...  Emotional liability and mood dysregulation characterize bipolar disorder (BD), yet no study has examined effective connectivity between parahippocampal gyrus and prefrontal cortical regions in ventromedial  ...  The research in this study was supported in part by a NARSAD Independent Investigator Award to MLP and 5R01 MH076971-01. MLP is the NARSAD Nellie Blumenthal Investigator.  ... 
doi:10.1016/j.pscychresns.2009.04.015 pmid:19910166 pmcid:PMC2787954 fatcat:2n7ftt45vja5hpk6ookvrxkcnm

State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge

Stephanie Krüger, David Seminowicz, Kim Goldapple, Sidney H Kennedy, Helen S Mayberg
2003 Biological Psychiatry  
Even in remission, patients with bipolar disorder (BD) remain sensitive to external stressors that can trigger new episodes.  ...  Unique to remitted subjects with BD were rCBF increases in dorsal anterior cingulate and in premotor cortex. Lateral prefrontal rCBF decreases were unique to depressed subjects with BD.  ...  We thank the Bipolar and Depression Clinics Staff at the Centre for Addiction and Mental Health, Clarke Site, for their support.  ... 
doi:10.1016/s0006-3223(03)00691-7 pmid:14643095 fatcat:wbgdc3wghne4fazfed6tsag4bu

A functional anatomical study of unipolar depression

WC Drevets, TO Videen, JL Price, SH Preskorn, ST Carmichael, ME Raichle
1992 Journal of Neuroscience  
Amaral DC, Price JL (1984) Amygdalocortical projections in the monkey.  ...  References Aggleton JP, Passingham RE (198 1) Syndrome produced by lesions of the amygdala in monkeys (Mucucu muluttu). J Comp Physiol Psychol 95~961-977.  ...  demarcated a prefrontal cortical abnormality in unipolar depression.  ... 
doi:10.1523/jneurosci.12-09-03628.1992 pmid:1527602 fatcat:c4alismv6bfmthocttvlvgzhge

Neural circuits underlying the pathophysiology of mood disorders

Joseph L. Price, Wayne C. Drevets
2012 Trends in Cognitive Sciences  
, physiology, and neurochemistry in human subjects with mood disorders have enabled significant advances towards elucidating the pathophysiology of major depressive disorder (MDD) and bipolar disorder  ...  Animal and human studies of mood disorders Major depressive disorder (MDD) and bipolar disorder (BD) constitute the first and fifth leading causes of years lived with disability, respectively [1].  ...  patients before versus after treatment and from remitted patients scanned before versus during depressive relapse [56, 57] .  ... 
doi:10.1016/j.tics.2011.12.011 pmid:22197477 fatcat:btjyfiyfyrbq3plck75rgnkzwu

Bruijniks_Supplemental_Material – Supplemental material for The Potential Role of Learning Capacity in Cognitive Behavior Therapy for Depression: A Systematic Review of the Evidence and Future Directions for Improving Therapeutic Learning

Sanne J. E. Bruijniks, Robert J. DeRubeis, Steven D. Hollon, Marcus J. H. Huibers
2019 Figshare  
Supplemental material, Bruijniks_Supplemental_Material for The Potential Role of Learning Capacity in Cognitive Behavior Therapy for Depression: A Systematic Review of the Evidence and Future Directions  ...  Huibers in Clinical Psychological Science  ...  III Ruchsow et al., 2004 Case-control 16 patients with DSM-IV major depressive disorder in remission and 16 matched controls Current and previous CBT treatment unknown.  ... 
doi:10.25384/sage.7901711.v2 fatcat:vequel76uvev3hb5oasp52oxme

Bruijniks_Supplemental_Material – Supplemental material for The Potential Role of Learning Capacity in Cognitive Behavior Therapy for Depression: A Systematic Review of the Evidence and Future Directions for Improving Therapeutic Learning

Sanne J. E. Bruijniks, Robert J. DeRubeis, Steven D. Hollon, Marcus J. H. Huibers
2019 Figshare  
Supplemental material, Bruijniks_Supplemental_Material for The Potential Role of Learning Capacity in Cognitive Behavior Therapy for Depression: A Systematic Review of the Evidence and Future Directions  ...  Huibers in Clinical Psychological Science  ...  III Ruchsow et al., 2004 Case-control 16 patients with DSM-IV major depressive disorder in remission and 16 matched controls Current and previous CBT treatment unknown.  ... 
doi:10.25384/sage.7901711.v1 fatcat:cpjge2qierfj7izgezz2vdfrsm

Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters

R. Kerestes, C. D. Ladouceur, S. Meda, P. J. Nathan, H. P. Blumberg, K. Maloney, B. Ruf, A. Saricicek, G. D. Pearlson, Z. Bhagwagar, M. L. Phillips
2011 Psychological Medicine  
Patients with major depressive disorder (MDD) show deficits in processing of facial emotions that persist beyond recovery and cessation of treatment.  ...  Abnormalities in neural areas supporting attentional control and emotion processing in remitted depressed (rMDD) patients suggests that there may be enduring, trait-like abnormalities in key neural circuits  ...  Acknowledgments We thank all of the patients who participated in this study, R.  ... 
doi:10.1017/s0033291711001097 pmid:21733287 fatcat:7hkav63tcba4flv5vv2kstgzcu

Reduced volume of orbitofrontal cortex in major depression

J.Douglas Bremner, Meena Vythilingam, Eric Vermetten, Ahsan Nazeer, Jahangir Adil, Sarfraz Khan, Lawrence H Staib, Dennis S Charney
2002 Biological Psychiatry  
The purpose of this study was to measure volume of orbitofrontal cortex and other frontal cortical subregions in patients with major depression.  ...  Methods: Magnetic resonance imaging was used to measure volume of the orbitofrontal cortex and other frontal cortical regions in patients with major depression in remission (n ϭ 15) and comparison subjects  ...  The authors thank Kathy Colonese, Jacque Piscitelli, and Lisa Roach for assistance in patient assessments and data management; Hedy Sarofin for expert assistance in MRI acquisition; and Helen Sayward for  ... 
doi:10.1016/s0006-3223(01)01336-1 pmid:11958777 fatcat:yiagm57b5zb2ndnryulr6jym7u
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