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Predictive Modelling Strategies to Understand Heterogeneous Manifestations of Asthma in Early Life

Danielle Belgrave, Rachel Cassidy, Daniel Stamate, Adnan Custovic, Louise Fleming, Andrew Bush, Sejal Saglani
2017 2017 16th IEEE International Conference on Machine Learning and Applications (ICMLA)  
However, due to the heterogeneity of symptoms there are difficulties in treating and diagnosing these children.  ...  By performing feature selection algorithms and predictive modelling techniques, this study will attempt to determine if it is possible to robustly distinguish patient diagnostic categories among pre-school  ...  Diagnosing wheeze in pre-schoolers is fraught with difficulty due to the heterogeneity in the timing and manifestation of co-occurring symptoms.  ... 
doi:10.1109/icmla.2017.0-176 dblp:conf/icmla/BelgraveCSCFBS17 fatcat:4bcyb7qmmra6blbl5gtgv6bxqu

Atopic Dermatitis and Respiratory Allergy: What is the Link

Danielle C. M. Belgrave, Angela Simpson, Iain E. Buchan, Adnan Custovic
2015 Current Dermatology Reports  
Understanding the aetiology and progression of atopic dermatitis and respiratory allergy may elucidate early preventative and management strategies aimed towards reducing the global burden of asthma and  ...  Understanding the role of atopic dermatitis in the development of respiratory allergy may ultimately allow us to determine more effective treatment strategies, thus reducing the patient and economic burden  ...  increased risk of atopic dermatitis in early life.  ... 
doi:10.1007/s13671-015-0121-6 pmid:26566461 pmcid:PMC4635175 fatcat:cgl7w2wslzb5fmbt54h2wy2jge

Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management

Danielle CM Belgrave, Adnan Custovic, Angela Simpson
2013 Expert Review of Clinical Immunology  
One of the major challenges to treating asthma is understanding these different asthma phenotypes and their underlying biological mechanisms.  ...  This review gives an epidemiological perspective of our current understanding of the different phenotypes that develop from birth to childhood that come under the umbrella term "asthma".  ...  Defining wheeze phenotypes within a clinical setting Strategies for Predicting Asthma Development The first three years of life are important in childhood development and the later onset of respiratory  ... 
doi:10.1586/1744666x.2013.836450 pmid:24128156 fatcat:iy7o3whj3fh3flywe2v2atrlta

Future Research Directions in Asthma. An NHLBI Working Group Report

Bruce D. Levy, Patricia J. Noel, Michelle M. Freemer, Michelle M. Cloutier, Steve N. Georas, Nizar N. Jarjour, Carole Ober, Prescott G. Woodruff, Kathleen C. Barnes, Bruce G. Bender, Carlos A. Camargo, Geoff L. Chupp (+18 others)
2015 American Journal of Respiratory and Critical Care Medicine  
The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation  ...  This report summarizes the workshop and produces recommendations to guide future research in asthma.  ...  Test in utero or early-life strategies targeted to mitigate potential determinants of asthma onset (primary prevention). 5.  ... 
doi:10.1164/rccm.201505-0963ws pmid:26305520 pmcid:PMC4731702 fatcat:44vphls4evhpdg5fzrk6x7ulr4

Disaggregating asthma: Big investigation versus big data

Danielle Belgrave, John Henderson, Angela Simpson, Iain Buchan, Christopher Bishop, Adnan Custovic
2017 Journal of Allergy and Clinical Immunology  
the heterogeneity of asthma.  ...  Full terms of use are available: We are facing a major challenge in bridging the gap between identifying subtypes of asthma to understand causal mechanisms and translating this knowledge into personalized  ...  One initiative aimed at harnessing data from birth cohorts to understand the development of different endotypes of asthma and allergic diseases is the Study Team for Early Life Asthma Research (STELAR)  ... 
doi:10.1016/j.jaci.2016.11.003 pmid:27871876 pmcid:PMC5292995 fatcat:v4kxb7yrajdr3f4ptezhicbjlm

New Directions in Understanding Atopic March Starting from Atopic Dermatitis

Nunzia Maiello, Pasquale Comberiati, Arianna Giannetti, Giampaolo Ricci, Rossella Carello, Elena Galli
2022 Children  
Indeed, multiple atopic trajectories are possible in addition to the classic atopic march. Nevertheless, atopic dermatitis is often the first manifestation of an atopic march.  ...  In this review, we outline the recent findings on the pathogenetic mechanisms leading to atopic dermatitis that could be targeted by intervention strategies for the prevention of atopic march.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/children9040450 pmid:35455494 pmcid:PMC9029734 fatcat:y5x2qhviivhgpj7yu2mrod7si4

The Natural History of Asthma [chapter]

Elizabeth Sapey, Duncan Wilso
2012 Bronchial Asthma - Emerging Therapeutic Strategies  
In all studies, severity and frequency of symptoms in early childhood predict outcomes in adulthood.  ...  Those that experience mild and infrequent symptoms in early life go on to experience no or mild asthma-related symptoms.  ...  The Natural History of Asthma, Bronchial Asthma -Emerging Therapeutic Strategies, Dr.  ... 
doi:10.5772/39095 fatcat:6ztpfu5kzjczxd3c5dbagfyy7a

Early identification of atopy in the prediction of persistent asthma in children

Peter D Sly, Attilio L Boner, Bengt Björksten, Andy Bush, Adnan Custovic, Philippe A Eigenmann, James E Gern, Jorrit Gerritsen, Eckard Hamelmann, Peter J Helms, Robert F Lemanske, Fernando Martinez (+6 others)
2008 The Lancet  
We contend that a lack of understanding of the role of atopy in early life in the development of persistent asthma in children exists amongst primary care physicians, paediatricians and specialists.  ...  Knowledge of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, as well as forming the basis for future preventative strategies.  ...  We contend that a lack of understanding of the role of atopy in early life in the development of persistent asthma in children exists amongst primary care physicians, paediatricians and specialists.  ... 
doi:10.1016/s0140-6736(08)61451-8 pmid:18805338 pmcid:PMC4440493 fatcat:v3ovgmnu2zd3df3x5nwvnmswcm

Phenotypes of allergic diseases in children and their application in clinical situations

Eun Lee, Soo-Jong Hong
2019 Korean Journal of Pediatrics  
result in the biased classification of phenotypes and limit the characterization of heterogeneous allergic diseases.  ...  treatment responses, and prediction of prognosis for each phenotype.  ...  Phenotypes of asthma and wheezing in children Phenotype studies of allergic diseases have been most commonly performed in asthma and wheezing in children due to the high prevalence in early life. 25)  ... 
doi:10.3345/kjp.2018.07395 pmid:31096745 pmcid:PMC6753312 fatcat:ilcz75zlkbcutfujan5p7jfesu

Asthma Microbiome Studies and the Potential for New Therapeutic Strategies

Yvonne J. Huang
2013 Current Allergy and Asthma Reports  
Perspectives are presented on how growing knowledge of relationships between the microbiome and asthma is likely to translate into improved understanding of asthma pathogenesis, its heterogeneity, and  ...  Although these studies are relatively new, current evidence suggests the possibility of new therapeutic strategies for the treatment or prevention of asthma.  ...  Huang has received grant support from the National Institutes of Health. Compliance with Ethics Guidelines Conflict of Interest Yvonne J. Huang has received grant support from Genentech.  ... 
doi:10.1007/s11882-013-0355-y pmid:23709178 pmcid:PMC3778058 fatcat:ilo22e4645dhbpegmwlns6vtfe

Chronic Obstructive Pulmonary Disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

M. Bradley Drummond, A. Sonia Buist, James D. Crapo, Robert A. Wise, Stephen I. Rennard
2014 Annals of the American Thoracic Society  
Understanding risk factors early in life, whether specific to COPD or not, allows for study of interventions to optimize lung function at birth and to prolong the lung function plateau, potentially reducing  ...  It is necessary to identify noninvasive ways to screen for early COPD in those at risk before progression to clinically significant disease.  ...  COPD Is a Heterogeneous Disease Primary prevention of COPD necessitates an understanding of the risk factors, pathological findings, and clinical manifestation of disease.  ... 
doi:10.1513/annalsats.201312-432ld pmid:24754824 pmcid:PMC5473655 fatcat:6p7lhg7udvblhhqfl3pribqpnm

Personalised medicine in asthma: from curative to preventive medicine

Laurent Guilleminault, Hakima Ouksel, Chantal Belleguic, Yannick Le Guen, Patrick Germaud, Emilie Desfleurs, Christophe Leroyer, Antoine Magnan
2017 European Respiratory Review  
The concept of asthma has changed substantially in recent years. Asthma is now recognised as a heterogeneous entity that is complex to treat.  ...  This personalised approach to curative medicine should make way in the coming years for personalised preventive and predictive medicine, focused on subjects at risk who are not yet ill, with the aim of  ...  The pathophysiology will be studied in biological models and in silico models to identify therapies (or management) targeting defined groups (strata) of subjects and to propose preventive, predictive,  ... 
doi:10.1183/16000617.0010-2016 pmid:28049124 fatcat:bqms3zkmrngnvoitdicxuk77ja

Asthma phenotypes in childhood

Matea Deliu, Danielle Belgrave, Matthew Sperrin, Iain Buchan, Adnan Custovic
2016 Expert Review of Clinical Immunology  
Areas Covered: This review provides an overview of our current understanding of the asthma phenotype concept in childhood and describes key findings from both conventional and data-driven methods.  ...  One of the ongoing challenges is understanding the underlying pathophysiological mechanisms that may be responsible for the varying responses to treatment.  ...  Our understanding of asthma heterogeneity is constantly evolving. In this review, we present our current knowledge of the subtypes in childhood asthma.  ... 
doi:10.1080/1744666x.2017.1257940 pmid:27817211 fatcat:56u2owtepzgkvjcwlpecuohmzq

The puzzle of immune phenotypes of childhood asthma

Katja Landgraf-Rauf, Bettina Anselm, Bianca Schaub
2016 Molecular and Cellular Pediatrics  
This review summarizes recent key findings on the complex mechanisms of the development and manifestation of childhood asthma.  ...  Whereas preschool children present with wheezing triggered by different factors (multitrigger and viral wheeze), clinical asthma manifestation in school children has previously been classified as allergic  ...  Course of different phenotypes There are several tools to diagnose asthma early in life, such as the International Study of Asthma and Allergy in Childhood (ISAAC) criteria or the modified asthma predictive  ... 
doi:10.1186/s40348-016-0057-3 pmid:27468754 pmcid:PMC4965363 fatcat:ewlmqmmutjg75bxfsukvraigwq

Effects of Physical Exercises on Pulmonary Rehabilitation, Exercise Capacity, and Quality of Life in Children with Asthma: A Meta-Analysis

YiRan Liu, Yan Zhao, Fang Liu, Lin Liu, Sabina Barrios-Ferrandez
2021 Evidence-Based Complementary and Alternative Medicine  
This study aimed to systematically evaluate the effect of exercise on pulmonary function, exercise capacity, and quality of life in children with bronchial asthma. Methods.  ...  The results of the meta-analysis showed that exercise had significant advantages in improving lung function and exercising capacity and quality of life in children with asthma compared with conventional  ...  of life of children with asthma from 7 to 17 years old.  ... 
doi:10.1155/2021/5104102 pmid:34976094 pmcid:PMC8718301 fatcat:imrjow6klvdk5oielww6yyijtm
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