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Prediction Of Osteoporotic Hip Fracture In Postmenopausal Women Through Patient-Specific FE Analyses And Machine Learning

E. Villamor, C. Monserrat, L. Del Río, J.A. Romero-Martín, M.J. Rupérez
2020 Computer Methods and Programs in Biomedicine  
A great challenge in osteoporosis clinical assessment is identifying patients at higher risk of hip fracture.  ...  A total number of 137 postmenopausal women (81.4 ± 6.95 years) were included in the study and separated into a fracture group (n = 89) and a control group (n = 48).  ...  Acknowledgements This study was partially funded by two grants Cátedra UPV-Fundación Quaes, obtained by Eduardo Villamor Medina and Antonio Cutillas Pardines, and one FPI grant (FPI-SP20170111) from the  ... 
doi:10.1016/j.cmpb.2020.105484 pmid:32278980 fatcat:3topz3dy6rbytn3zu4lp3imzoa

Risk Assessment of Hip Fracture Based on Machine Learning

Alessio Galassi, José D. Martín-Guerrero, Eduardo Villamor, Carlos Monserrat, María José Rupérez, C. R. Torres-San Miguel
2020 Applied Bionics and Biomechanics  
Identifying patients with high risk of hip fracture is a great challenge in osteoporosis clinical assessment.  ...  This paper proposes the use of ML models to assess and predict hip fracture risk.  ...  Finally, although our study focused on prediction of hip fracture in postmenopausal women, hip fracture also happens in the male population [41] .  ... 
doi:10.1155/2020/8880786 pmid:33425008 pmcid:PMC7772022 fatcat:7w3543eaanacfggeknelx62gm4

Chronic obstructive pulmonary disease combined with vertebral compression fracture increases the risk of temporomandibular disorder

Kuei-Chen Lee, Yung-Tsan Wu, Liang-Cheng Chen, Chih-Hao Shen, Chi-Hsiang Chung, Wu-Chien Chien, Yi-Shing Shieh
2019 Medicine  
Multivariate Cox regression analysis was performed to determine the risk of TMD in COPD patients with and without VCF.  ...  Vertebral compression fracture (VCF) is a common comorbidity of chronic obstructive pulmonary disease (COPD), and the coexistence of COPD and temporomandibular disorder (TMD) has been clinically noted.  ...  Acknowledgements The Scientific Group thanks the following persons, who contributed to this report and edited the final version: Professor C. Cooper  ... 
doi:10.1097/md.0000000000017162 pmid:31517866 pmcid:PMC6750274 fatcat:67vo5zsplbduvaon2csktyspz4

Bone biosensors: knowing the present and predicting the future

Patricia Khashayar, Ghassem Amoabediny, Bagher Larijani, Jan Vanfleteren
2016 Journal of Micromechanics and Microengineering  
Conclusion: Impairment of bone MA predicts the risk of fracture in postmenopausal women.  ...  Conclusion: Our data provide first proof that specific circulating miRNA levels are indicative of fragility fractures in postmenopausal osteoporotic women and may be novel candidates for general fracture  ...  Low bone masses were noted up to 95 % in both of the control and patient groups. Conclusion: Most of hip fracture occurred in older postmenopausal women.  ... 
doi:10.1088/0960-1317/26/2/023002 fatcat:tuwbfvid5jdcfgku3aecotof2i

Opportunistic diagnosis of osteoporosis, fragile bone strength and vertebral fractures from routine CT scans; a review of approved technology systems and pathways to implementation

Veena Aggarwal, Christina Maslen, Richard L. Abel, Pinaki Bhattacharya, Paul A Bromiley, Emma M. Clark, Juliet E. Compston, Nicola Crabtree, Jennifer S. Gregory, Eleni P. Kariki, Nicholas C. Harvey, Kate A. Ward (+1 others)
2021 Therapeutic Advances in Musculoskeletal Disease  
One way to improve both vertebral fracture identification and the diagnosis of osteoporosis is to assess a patient's spine or hips during routine computed tomography (CT) scans.  ...  Patients often suffer further spine or other fractures, deformity, height loss and pain before diagnosis.  ...  These spinal fractures are the most common of all osteoporotic fragility fractures, occurring in 25% of men and postmenopausal women. 4 Under-diagnosis is a particular issue for vertebral fractures as  ... 
doi:10.1177/1759720x211024029 pmid:34290831 pmcid:PMC8274099 fatcat:2jjrnyra2nfkxguorejbkbzhii

Bones, Fractures, Antiretroviral Therapy and HIV

Linda A. Battalora, Benjamin Young, Edgar T. Overton
2014 Current Infectious Disease Reports  
In a separate analysis, FRAX ® score of >3% was also independently predictive of new fracture.  ...  In multivariable analyses, only osteoporosis and increasing age remained associated with incident fracture.  ...  Acknowledgements The authors thank the many SUN and HOPS patients for their participation in the studies and for the HOPS patients for their ongoing participation.  ... 
doi:10.1007/s11908-014-0393-1 pmid:24535243 pmcid:PMC4240510 fatcat:y57zcqvtmbbxvasigiiltohc6q

Delivering computationally-intensive Digital Patient applications to the clinic: an exemplar solution to predict femoral bone strength from CT data

I. Benemerito, W. Griffiths, J. Allsopp, W. Furnass, P. Bhattacharya, X. Li, A. Marzo, S. Wood, M. Viceconti, A. Narracott
2021 Computer Methods and Programs in Biomedicine  
Clinicians request the analysis of CT scans of a patient through the website.  ...  Whilst fragility hip fractures commonly affect elderly people, often causing permanent disability or death, they are rarely addressed in advance through preventive techniques.  ...  and treatment of osteoporotic fracture in the future.  ... 
doi:10.1016/j.cmpb.2021.106200 pmid:34107372 fatcat:v424sjqm5fh4bpwln2ennrtnde

Functional health literacy and health-promoting behaviour in a national sample of British adults

C. v. Wagner, K. Knight, A. Steptoe, J. Wardle
2007 Journal of Epidemiology and Community Health  
Epidemiological evidence suggests that, compared with a sedentary lifestyle, over three hours targeted exercise each week can halve the risk of osteoporosis, falls-related injuries and hip fracture.  ...  But we know some forms of exercise, in certain groups of older people, can actually increase the risk of a fall or fracture.  ...  The purpose of the present study is to analyze the effects of aerobic and strength-based training programs on functional fitness and mood states in older adults, and to assess the relationship between  ... 
doi:10.1136/jech.2006.053967 pmid:18000132 pmcid:PMC2465677 fatcat:6wt4pkden5fqjm3f2vi3agcp4m

Improved prediction of femoral fracture toughness in mice by combining standard medical imaging with Raman spectroscopy [article]

Christine Massie, Emma Knapp, Keren Chen, Andrew J Berger, Hani A Awad
2020 bioRxiv   pre-print
A leave one out cross-validated (LOOCV) partial least squares regression (PLSR) model based only on the combination of aBMD and cortical thickness showed no significant predictive correlations with fracture  ...  Here, we explored how femoral midshaft measurements from DXA, micro-computed tomography (micro-CT), and Raman spectroscopy could predict fracture toughness.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. (which was not certified by peer review) is the author/funder.  ... 
doi:10.1101/2020.11.20.391383 fatcat:frlpbmxaljbynogagudd5lqwsu

Extended Oral Antibiotic Prophylaxis in High-Risk Patients Substantially Reduces Primary Total Hip and Knee Arthroplasty 90-Day Infection Rate

Avinash Inabathula, Julian E. Dilley, Mary Ziemba-Davis, Lucian C. Warth, Khalid A. Azzam, Philip H. Ireland, R. Michael Meneghini
2018 Journal of Bone and Joint Surgery. American volume  
Less than half of patients with isolated, full-thickness tears are reconstructed, and repair of the PCL is rarely attempted.  ...  There is variability in rehabilitation, but most surgeons lock the postoperative brace in extension. Assessment of Elbow Torque in Youth and Adolescent Baseball Pitchers: Fastballs vs.  ...  The machinelearning algorithms achieved acceptable risk prediction for 30-day SAEs CONCLUSION: Machine-learning techniques achieve moderate predictive accuracy for short-term complications and readmission  ... 
doi:10.2106/jbjs.17.01485 fatcat:2sfka3hjgfadjbcybn6rbmmn2a

10th International Conference on Frailty, Sarcopenia Research Geroscience (ICFSR), March 11-13, 2020, Toulouse, France

I. Posters
2020 The Journal of frailty & aging  
Methods: New cases visited to center of comprehensive care and research for memory disorders in National Center for Geriatrics and Gerontology were enrolled to the study.  ...  Conclusion: Nurse's clinical classification of fall risks by visually obtained information predict frailty on the basis of integrated impression such as muscle strength, gait speed and balance.  ...  P257-AGE-RELATED REDUCTIONS IN THE ABILITY OF THE CNS TO RAPIDLY ACTIVATE MUSCLES IS A KEY CONTRIBUTOR TO MOBILITY LIMITATIONS. Simon Moskowitz 1 , David W.  ... 
doi:10.14283/jfa.2020.9 pmid:32150217 fatcat:3enkjl24cff3fe6o6fcxrffas4

RISING TREND IN THE INCIDENCE OF HIP FRACTURES IN LITHUANIA FROM 2006 TO 2010

M. Tamulaitiene, V. Alekna, A. Mastaviciute, R. Martinaityte
2017 Innovation in aging  
of sarcopenia in patients older than 80, hospitalized for the treatment of a hip fracture.  ...  No patients expressed fear to fall through FES but 63% of subjects showed increased risk for falling through TUG test.  ...  Outcomes for patients undergoing surgery for hip fracture in the UK are well established through the National Hip Fracture database [3] .  ... 
doi:10.1093/geroni/igx004.4105 fatcat:a3qfulyzgjcg5kqprf2miejsxe

Poster presentations

2016 European Geriatric Medicine  
of sarcopenia in patients older than 80, hospitalized for the treatment of a hip fracture.  ...  No patients expressed fear to fall through FES but 63% of subjects showed increased risk for falling through TUG test.  ...  Outcomes for patients undergoing surgery for hip fracture in the UK are well established through the National Hip Fracture database [3] .  ... 
doi:10.1016/s1878-7649(16)30149-8 fatcat:hufxrwbiencbtf4qe5t7aokn6q

Supplementum 236: swiss orthopaedics, 79th annual meeting

2019 Swiss Medical Weekly  
P032 From medical images to patient specific biomechanical analysisa machine learning based pipeline Sebastiano Caprara¹; Prof. Dr. Jess Gerrit Snedeker¹; Prof. Dr. Mazda Farshad²; Dr.  ...  Influence of timing was analysed through meta-analyses in terms of PROMs, risk of complications, ROM limitation, risk of re-tears, and residual laxity.  ...  As secondary outcome Kujala, and IKDC score were analysed through a meta-analysis. Furthermore, the complication rate was analysed.  ... 
doi:10.4414/smw.2019.20438 fatcat:fruhdz3hwre5td4osxvycvey5a

The Kronos Early Estrogen Prevention Study

JoAnn E Manson
2013 Women's Health  
osteoporotic hip fractures 11 contribute about as much to morbidity and mortality as does breast cancer in women over 70 12 [6] . 13 Interpretation of epidemiological and observational studies has  ...  [11] [12] [13] [14] and osteoporotic fractures [15] [16] [17] .  ... 
doi:10.2217/whe.12.69 pmid:23241151 fatcat:6oxd6exil5eitiknrgrhva6h6q
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