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Relationship between brain injury criteria and brain strain across different types of head impacts can be different
[article]
2021
arXiv
pre-print
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However, the accuracy of using the BIC on brain injury risk estimation across different types of head impacts has not been evaluated. ...
Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts. ...
This work is also supported by Stanford Department of Bioengineering. ...
arXiv:2012.10006v3
fatcat:n5kv3ao2bjfjxilcp7ehfmghfi
Functional Impairments and Caregiver Depressive Symptoms in the Context of Brain Tumour and Other Cancers: A Mediating Effect of Strain
2009
Brain Impairment
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T his study aimed to examine the associations among functional impairments, strain and depressive symptoms for caregivers of individuals with brain tumour and other cancers. ...
For caregivers of individuals with brain tumour, strain was significantly related to depressive symptoms (r = .57) and the individual's functional impairments (r = -.58); however, level of depressive symptoms ...
We would also like to acknowledge the coordinators and staff at the Apex Lodges, Prostate Cancer Foundation, Leukaemia Foundation Lodges, Head and Neck Cancer Support Group, Brain Tumour Support Service ...
doi:10.1375/brim.10.2.149
fatcat:qg53jcfvhvg6heii5udoa6ll5a
Clinical evidence of inflammation driving secondary brain injury
2015
Journal of Trauma and Acute Care Surgery
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Background-Despite advances in both prevention and treatment, traumatic brain injury (TBI) remains one of the most burdensome diseases; 2% of the US population currently lives with disabilities resulting ...
Study Eligibility Criteria-Studies were eligible if participants were adults and/or children who sustained moderate or severe TBI in the acute phase of injury, published in English. ...
. 48 The complex protein termed the inflammasome may also prove to be a useful brain injury biomarker. ...
doi:10.1097/ta.0000000000000468
pmid:25539220
pmcid:PMC4297199
fatcat:mloxgwqqtvctfdbdbsk6nea7tq
Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review
2021
Acta Neuropathologica Communications
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Background and Scope of Review Varying severities and frequencies of head trauma may result in dynamic acute and chronic pathophysiologic responses in the brain. ...
Given the range of clinical syndromes and neurodegenerative pathologies observed in a subset of adults with prior repetitive head trauma, structural MRI and PET imaging may still be useful for differential ...
Disease Brain Bank. ...
doi:10.1186/s40478-021-01197-4
pmid:34022959
pmcid:PMC8141132
fatcat:kfpmvznihfdvdjy2qo54d3cl2y
The Nanotheranostic Researcher's Guide for Use of Animal Models of Traumatic Brain Injury
2021
Journal of Nanotheranostics
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Traumatic brain injury (TBI) is currently the leading cause of injury-related morbidity and mortality worldwide, with an estimated global cost of USD 400 billion annually. ...
Both clinical and preclinical behavioral outcomes associated with TBI are heterogeneous in nature and influenced by the mechanism and frequency of injury. ...
Figure 18 . 18 Figure 18. Example of a T maze paradigm, the dual-solution T maze, used to measure both place and response learning. ...
doi:10.3390/jnt2040014
pmid:35655793
pmcid:PMC9159501
fatcat:wky2zcayxng6jeg6q5oafg4sc4
Scared or scarred: Could 'dissociogenic' lesions predispose to nonepileptic seizures after head trauma?
2018
Seizure
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Furthermore, the emotional impact of head injury could induce long-term changes in stress responsivity. ...
Lesional effects of head injury, on the other hand, remain unexplored in the context of PNES. ...
injury; TBI-Hx, positive history of head injury; mTBI, mild traumatic brain injury; y, years; mo, months; SD, standard deviation affective stressor can induce long-term changes in stressresponsivity and ...
doi:10.1016/j.seizure.2018.04.009
pmid:29702410
fatcat:rllor253djggdibupoxd54xf74
In Vitro Models for Biomechanical Studies of Neural Tissues
[chapter]
2011
Neural Tissue Biomechanics
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In the context of biomechanics, culture models that accurately mimic specific brain features can be used to determine tissue properties and tolerances to mechanical loading. ...
In this review, we present design criteria for ideal cultures, the current state of the art in neural cell and tissue culturing methods, and the advantages and limitations to using culture mimics. ...
However, these definitions may be too insensitive to identify the onset of injury for the brain, i.e. tolerance criteria. ...
doi:10.1007/8415_2011_79
fatcat:pli43ekcajcirkvtgdsqbkzfue
Frequency and Predictors of Traumatic Encephalopathy Syndrome in a Prospective Cohort of Retired Professional Athletes
2021
Frontiers in Neurology
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Traumatic encephalopathy syndrome (TES) is proposed to represent the long-term impact of repetitive head-injury exposure and the clinical manifestation of chronic traumatic encephalopathy (CTE). ...
TES and head-injury exposure. ...
of Texas at Dallas (UTD) which aimed to investigate the neurocognitive impact of repetitive head-injury exposure. ...
doi:10.3389/fneur.2021.617526
pmid:33708171
pmcid:PMC7940833
fatcat:hzanywiv55bknbauxprbpqplle
Structural brain disconnectivity mapping of post-stroke fatigue
2021
NeuroImage: Clinical
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Despite a general consensus that brain perturbations constitute a precipitating event in the multifactorial etiology of PSF, the specific predictive value of conventional lesion characteristics such as ...
a structural disconnectivity approach with regards to the brain correlates of PSF. ...
Psychology, University of Oslo. ...
doi:10.1016/j.nicl.2021.102635
pmid:33799271
fatcat:g6pz3khdorbxfpyhlekqjmc3ha
Translational Intracerebral Hemorrhage Research: Has Current Neuroprotection Research ARRIVEd at a Standard for Experimental Design and Reporting?
2020
Translational Stroke Research
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Reporting of group sizes, blinding, and randomization are almost unanimous, but group size calculations, mortality and exclusion criteria, and animal model characteristics are infrequently reported. ...
Contemporary ICH research predominantly uses young, healthy male rodents. The collagenase model is the most commonly used. ...
hemorrhage OR traumatic brain injury OR middle cerebral artery occlusion model)" compared treatment efficacy across a range in hemorrhage volumes. ...
doi:10.1007/s12975-020-00824-x
pmid:32504197
fatcat:2ieaacy5kbc5xa65a45k74qu2m
Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
2019
European Journal of Nuclear Medicine and Molecular Imaging
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We provide an overview of the criteria used to evaluate PET tracers. We then used the National Institute of Mental Health Research Priorities list to identify the key CNS targets. ...
We conducted a PubMed search (search period 1st of January 2013 to 31st of December 2018), which yielded 40 new PET tracers across 16 CNS targets which met our selectivity criteria. ...
Direct head-to-head studies on larger cohorts are required; however, this is a very promising initial study into the use of 11 C-UCB-J in epilepsy. ...
doi:10.1007/s00259-019-04488-0
pmid:31541283
pmcid:PMC6974496
fatcat:f427ljt5ajfnjeq7wo4pekmbbi
Altered Amygdala Connectivity in Individuals with Chronic Traumatic Brain Injury and Comorbid Depressive Symptoms
2015
Frontiers in Neurology
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Depression is one of the most common psychiatric conditions in individuals with chronic traumatic brain injury (TBI). ...
Further analysis revealed that spatially dissociable patterns of correlation between amygdala connectivity and symptom severity according to subtypes (Cognitive and Affective) of depressive symptoms (pvoxel ...
participant using the same head coil ...
doi:10.3389/fneur.2015.00231
pmid:26581959
pmcid:PMC4631949
fatcat:6jxmdzyycfhlpfutfv7fj3dz2m
Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity
2016
Journal of Neurovirology
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Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus ( ...
Inclusion criteria included (1) Xhosa as the primary language and (2) Age 18 to 50 years. ...
Future studies are needed across clade subtypes to the key triggers of downstream immunological responses, seeding of viral reservoirs harbored in brain tissue or circulating monocytes, and plasma markers ...
doi:10.1007/s13365-016-0503-y
pmid:27913960
pmcid:PMC5334278
fatcat:2yem57ooyzgurlnyxv66hgfjnq
Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature
2022
Acta Neuropathologica Communications
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Background The initiation, anatomic pattern, and extent of tau spread in traumatic brain injury (TBI), and the mechanism by which TBI leads to long-term tau pathology, remain controversial. ...
Interpretation Results indicate that a single moderate to severe TBI leads to greater chronic development of tauopathy compared to no history of head injury. ...
Thomas Denagamage for providing guidance on how to construct a systematic review using PRISMA guidelines. ...
doi:10.1186/s40478-022-01311-0
pmid:35101132
pmcid:PMC8805270
fatcat:r2kbjc3xyjg2flrhevik4si4he
Advanced Neuroimaging in Traumatic Brain Injury
2013
Seminars in neurology
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with traumatic brain injury (TBI), while also providing biomarkers to guide the development of new therapies. ...
In this review, we examine recent advances in structural and functional neuroimaging and the potential applications of these techniques to the clinical care of patients with TBI. ...
Acknowledgments This work was supported by the National Institutes of Health (R25NS065743 and P41RR14075) and the Center for Integration of Medicine & Innovative Technology (Boston, MA). ...
doi:10.1055/s-0032-1331810
pmid:23361483
pmcid:PMC3779469
fatcat:ecxuxhf3obefngigwjg6ebjrd4
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