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Relationship between brain injury criteria and brain strain across different types of head impacts can be different [article]

Xianghao Zhan, Yiheng Li, Yuzhe Liu, August G. Domel, Hossein Vahid Alizadeh, Samuel J. Raymond, Jesse Ruan, Saeed Barbat, Stephen Tiernan, Olivier Gevaert, Michael Zeineh, Gerald Grant (+1 others)
2021 arXiv   pre-print
However, the accuracy of using the BIC on brain injury risk estimation across different types of head impacts has not been evaluated.  ...  Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts.  ...  This work is also supported by Stanford Department of Bioengineering.  ... 
arXiv:2012.10006v3 fatcat:n5kv3ao2bjfjxilcp7ehfmghfi

Functional Impairments and Caregiver Depressive Symptoms in the Context of Brain Tumour and Other Cancers: A Mediating Effect of Strain

Tamara Ownsworth, Laura Henderson, Suzanne Chambers, David Shum
2009 Brain Impairment  
T his study aimed to examine the associations among functional impairments, strain and depressive symptoms for caregivers of individuals with brain tumour and other cancers.  ...  For caregivers of individuals with brain tumour, strain was significantly related to depressive symptoms (r = .57) and the individual's functional impairments (r = -.58); however, level of depressive symptoms  ...  We would also like to acknowledge the coordinators and staff at the Apex Lodges, Prostate Cancer Foundation, Leukaemia Foundation Lodges, Head and Neck Cancer Support Group, Brain Tumour Support Service  ... 
doi:10.1375/brim.10.2.149 fatcat:qg53jcfvhvg6heii5udoa6ll5a

Clinical evidence of inflammation driving secondary brain injury

Holly E. Hinson, Susan Rowell, Martin Schreiber
2015 Journal of Trauma and Acute Care Surgery  
Background-Despite advances in both prevention and treatment, traumatic brain injury (TBI) remains one of the most burdensome diseases; 2% of the US population currently lives with disabilities resulting  ...  Study Eligibility Criteria-Studies were eligible if participants were adults and/or children who sustained moderate or severe TBI in the acute phase of injury, published in English.  ...  . 48 The complex protein termed the inflammasome may also prove to be a useful brain injury biomarker.  ... 
doi:10.1097/ta.0000000000000468 pmid:25539220 pmcid:PMC4297199 fatcat:mloxgwqqtvctfdbdbsk6nea7tq

Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review

Breton M. Asken, Gil D. Rabinovici
2021 Acta Neuropathologica Communications  
Background and Scope of Review Varying severities and frequencies of head trauma may result in dynamic acute and chronic pathophysiologic responses in the brain.  ...  Given the range of clinical syndromes and neurodegenerative pathologies observed in a subset of adults with prior repetitive head trauma, structural MRI and PET imaging may still be useful for differential  ...  Disease Brain Bank.  ... 
doi:10.1186/s40478-021-01197-4 pmid:34022959 pmcid:PMC8141132 fatcat:kfpmvznihfdvdjy2qo54d3cl2y

The Nanotheranostic Researcher's Guide for Use of Animal Models of Traumatic Brain Injury

Brandon Z. McDonald, Connor C. Gee, Forrest M. Kievit
2021 Journal of Nanotheranostics  
Traumatic brain injury (TBI) is currently the leading cause of injury-related morbidity and mortality worldwide, with an estimated global cost of USD 400 billion annually.  ...  Both clinical and preclinical behavioral outcomes associated with TBI are heterogeneous in nature and influenced by the mechanism and frequency of injury.  ...  Figure 18 . 18 Figure 18. Example of a T maze paradigm, the dual-solution T maze, used to measure both place and response learning.  ... 
doi:10.3390/jnt2040014 pmid:35655793 pmcid:PMC9159501 fatcat:wky2zcayxng6jeg6q5oafg4sc4

Scared or scarred: Could 'dissociogenic' lesions predispose to nonepileptic seizures after head trauma?

Stoyan Popkirov, Alan J. Carson, Jon Stone
2018 Seizure  
Furthermore, the emotional impact of head injury could induce long-term changes in stress responsivity.  ...  Lesional effects of head injury, on the other hand, remain unexplored in the context of PNES.  ...  injury; TBI-Hx, positive history of head injury; mTBI, mild traumatic brain injury; y, years; mo, months; SD, standard deviation affective stressor can induce long-term changes in stressresponsivity and  ... 
doi:10.1016/j.seizure.2018.04.009 pmid:29702410 fatcat:rllor253djggdibupoxd54xf74

In Vitro Models for Biomechanical Studies of Neural Tissues [chapter]

Barclay Morrison, D. Kacy Cullen, Michelle LaPlaca
2011 Neural Tissue Biomechanics  
In the context of biomechanics, culture models that accurately mimic specific brain features can be used to determine tissue properties and tolerances to mechanical loading.  ...  In this review, we present design criteria for ideal cultures, the current state of the art in neural cell and tissue culturing methods, and the advantages and limitations to using culture mimics.  ...  However, these definitions may be too insensitive to identify the onset of injury for the brain, i.e. tolerance criteria.  ... 
doi:10.1007/8415_2011_79 fatcat:pli43ekcajcirkvtgdsqbkzfue

Frequency and Predictors of Traumatic Encephalopathy Syndrome in a Prospective Cohort of Retired Professional Athletes

Jeff Schaffert, Nyaz Didehbani, Christian LoBue, John Hart, Heidi Rossetti, Laura Lacritz, C. Munro Cullum
2021 Frontiers in Neurology  
Traumatic encephalopathy syndrome (TES) is proposed to represent the long-term impact of repetitive head-injury exposure and the clinical manifestation of chronic traumatic encephalopathy (CTE).  ...  TES and head-injury exposure.  ...  of Texas at Dallas (UTD) which aimed to investigate the neurocognitive impact of repetitive head-injury exposure.  ... 
doi:10.3389/fneur.2021.617526 pmid:33708171 pmcid:PMC7940833 fatcat:hzanywiv55bknbauxprbpqplle

Structural brain disconnectivity mapping of post-stroke fatigue

Kristine M. Ulrichsen, Knut K. Kolskår, Geneviève Richard, Dag Alnæs, Erlend S. Dørum, Anne-Marthe Sanders, Sveinung Tornås, Jennifer Monereo Sánchez, Andreas Engvig, Hege Ihle Hansen, Michel Thiebaut de Schotten, Jan E. Nordvik (+1 others)
2021 NeuroImage: Clinical  
Despite a general consensus that brain perturbations constitute a precipitating event in the multifactorial etiology of PSF, the specific predictive value of conventional lesion characteristics such as  ...  a structural disconnectivity approach with regards to the brain correlates of PSF.  ...  Psychology, University of Oslo.  ... 
doi:10.1016/j.nicl.2021.102635 pmid:33799271 fatcat:g6pz3khdorbxfpyhlekqjmc3ha

Translational Intracerebral Hemorrhage Research: Has Current Neuroprotection Research ARRIVEd at a Standard for Experimental Design and Reporting?

Lane J. Liddle, Shivani Ralhan, Daniel L. Ward, Frederick Colbourne
2020 Translational Stroke Research  
Reporting of group sizes, blinding, and randomization are almost unanimous, but group size calculations, mortality and exclusion criteria, and animal model characteristics are infrequently reported.  ...  Contemporary ICH research predominantly uses young, healthy male rodents. The collagenase model is the most commonly used.  ...  hemorrhage OR traumatic brain injury OR middle cerebral artery occlusion model)" compared treatment efficacy across a range in hemorrhage volumes.  ... 
doi:10.1007/s12975-020-00824-x pmid:32504197 fatcat:2ieaacy5kbc5xa65a45k74qu2m

Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development

Stuart P. McCluskey, Christophe Plisson, Eugenii A. Rabiner, Oliver Howes
2019 European Journal of Nuclear Medicine and Molecular Imaging  
We provide an overview of the criteria used to evaluate PET tracers. We then used the National Institute of Mental Health Research Priorities list to identify the key CNS targets.  ...  We conducted a PubMed search (search period 1st of January 2013 to 31st of December 2018), which yielded 40 new PET tracers across 16 CNS targets which met our selectivity criteria.  ...  Direct head-to-head studies on larger cohorts are required; however, this is a very promising initial study into the use of 11 C-UCB-J in epilepsy.  ... 
doi:10.1007/s00259-019-04488-0 pmid:31541283 pmcid:PMC6974496 fatcat:f427ljt5ajfnjeq7wo4pekmbbi

Altered Amygdala Connectivity in Individuals with Chronic Traumatic Brain Injury and Comorbid Depressive Symptoms

Kihwan Han, Sandra B. Chapman, Daniel C. Krawczyk
2015 Frontiers in Neurology  
Depression is one of the most common psychiatric conditions in individuals with chronic traumatic brain injury (TBI).  ...  Further analysis revealed that spatially dissociable patterns of correlation between amygdala connectivity and symptom severity according to subtypes (Cognitive and Affective) of depressive symptoms (pvoxel  ...  participant using the same head coil  ... 
doi:10.3389/fneur.2015.00231 pmid:26581959 pmcid:PMC4631949 fatcat:6jxmdzyycfhlpfutfv7fj3dz2m

Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity

Robert H. Paul, Sarah Phillips, Jacqueline Hoare, David H. Laidlaw, Ryan Cabeen, Gayla R. Olbricht, Yuqing Su, Dan J. Stein, Susan Engelbrecht, Soraya Seedat, Lauren E. Salminen, Laurie M. Baker (+2 others)
2016 Journal of Neurovirology  
Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (  ...  Inclusion criteria included (1) Xhosa as the primary language and (2) Age 18 to 50 years.  ...  Future studies are needed across clade subtypes to the key triggers of downstream immunological responses, seeding of viral reservoirs harbored in brain tissue or circulating monocytes, and plasma markers  ... 
doi:10.1007/s13365-016-0503-y pmid:27913960 pmcid:PMC5334278 fatcat:2yem57ooyzgurlnyxv66hgfjnq

Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature

Ariel Walker, Ben Chapin, Jose Abisambra, Steven T. DeKosky
2022 Acta Neuropathologica Communications  
Background The initiation, anatomic pattern, and extent of tau spread in traumatic brain injury (TBI), and the mechanism by which TBI leads to long-term tau pathology, remain controversial.  ...  Interpretation Results indicate that a single moderate to severe TBI leads to greater chronic development of tauopathy compared to no history of head injury.  ...  Thomas Denagamage for providing guidance on how to construct a systematic review using PRISMA guidelines.  ... 
doi:10.1186/s40478-022-01311-0 pmid:35101132 pmcid:PMC8805270 fatcat:r2kbjc3xyjg2flrhevik4si4he

Advanced Neuroimaging in Traumatic Brain Injury

Ona Wu, Brian Edlow
2013 Seminars in neurology  
with traumatic brain injury (TBI), while also providing biomarkers to guide the development of new therapies.  ...  In this review, we examine recent advances in structural and functional neuroimaging and the potential applications of these techniques to the clinical care of patients with TBI.  ...  Acknowledgments This work was supported by the National Institutes of Health (R25NS065743 and P41RR14075) and the Center for Integration of Medicine & Innovative Technology (Boston, MA).  ... 
doi:10.1055/s-0032-1331810 pmid:23361483 pmcid:PMC3779469 fatcat:ecxuxhf3obefngigwjg6ebjrd4
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