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As-One-Goes Blood Pressure and Heart Rate Monitoring: A Chronobiology Approach with Applications in Clinical Practice and Basic Science

Germaine Cornelissen, Yoshihiko Watanabe, Larry A Beaty, Chase Turner A, Robert Sothern, Jarmila Siegelova, Tamara Breus, Denis Gubin, Abdullah A al-Abdulgader, Rollin McCraty, Kuniaki Otsuka
2021 Cardiology & Vascular Research  
than 15 years, as was the case for Wolf numbers in the absence of a second harmonic term. © Halberg Chronobiology Center.  ...  Using a similar model (10-year trial period, with added second harmonic) for the SBP data from Ladakh, the period estimate is about 9.95 years, but the 95 % CIs of the amplitude of both the fundamental  ...  Based on these chronobiologic reference values, abnormal patterns of BP and HR variability were associated with increases in cardiovascular disease risk, beyond an elevated BP itself, as illustrated in  ... 
doi:10.33425/2639-8486.s1-1003 fatcat:iacl2uzp3bfk7p4iux5sli5u24

A normal ambulatory blood pressure poorly predicts normalization of clinic pressure in hypertension

R Fagard
2001 American Journal of Hypertension  
Cox proportional hazard regression analysis was used to estimate the relative risk of a subsequent incident CV event (myocardial infarction, stroke, CABG/PTCA, or CV death) as a function of baseline ABP  ...  The risk of a first CV event was greater for males, and increased as a function of age, total cholesterol, and number of packs of cigarettes smoked.  ... 
doi:10.1016/s0895-7061(01)01364-4 fatcat:bldtgryeinhdpofvh3jwr7zmaa

Perspectives of Human Development: Time, Space, and Chrononutrition

D. W. Wilson
2012 The Open Nutraceuticals Journal  
Great challenges to reduce poverty and hunger lie ahead: people need to be fed but safely, the risk of inflammatory diseases such as gastrointestinal and cardiovascular disorders needs to be reduced: and  ...  Already about 1 out of 3 billion people go hungry [2] (and currently in overall decline) and by 2050 the estimated population is about 9 billion [3].  ...  Suzanne Sanders, School of Medicine and Health, Durham University, gave secretarial assistance in the preparation of this manuscript. Any shortcomings are due to DWW (Mea culpa).  ... 
doi:10.2174/1876396001205010066 fatcat:rgmxmlmywndv3pej4s27fadxba

Identification of earlier predictors of pregnancy complications through wearable technologies in a Brazilian multicentre cohort: Maternal Actigraphy Exploratory Study I (MAES-I) study protocol

Renato T Souza, Jose Guilherme Cecatti, Jussara Mayrink, Rafael Bessa Galvão, Maria Laura Costa, Francisco Feitosa, Edilberto Rocha Filho, Debora F Leite, Janete Vettorazzi, Ricardo P Tedesco, Danielly S Santana, Joao Paulo Souza
2019 BMJ Open  
The plan is to design a predictive model using actigraphy data for screening pregnant women at risk of developing specific adverse maternal and perinatal outcomes.Ethics and disseminationMAES-I has been  ...  IntroductionNon-invasive tools capable of identifying predictors of maternal complications would be a step forward for improving maternal and perinatal health.  ...  Finally, we will develop a predictive model for screening pregnant women at risk of specific adverse maternal and perinatal outcomes using PA and sleep-wake data estimated by actigraphy technology.  ... 
doi:10.1136/bmjopen-2018-023101 pmid:31005906 pmcid:PMC6500316 fatcat:jzpgplumsjejlpscei26wgu7e4

Decadal Cycles in the Human Cardiovascular System

Franz Halberg, Germaine Cornelissen, Robert B Sothern, Dewayne Hillman, Yoshihiko Watanabe, Erhard Haus, Othild Schwartzkopff, William R Best
2012 World Heart Journal  
of severe cardiovascular events, greater than that of a high BP.  ...  Some of the other VVAs, such as a circadian overswing, i.e., CHAT (Circadian Hyper-Aplitude-Tension), or an excessive pulse pressure, based on repeated 7-day around-the-clock records, can represent a risk  ...  In them, the risk of cardiovascular disease associated with CHAT exceeds that of high BP. © Halberg.  ... 
pmid:24860279 pmcid:PMC4028693 fatcat:7snrh4r4ybgwvhx7c3c4vnillq

Gerard W. Ostheimer "What's New in Obstetric Anesthesia" Lecture

Roshan Fernando
2007 Anesthesiology  
Preeclampsia Predicting Preeclampsia Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and neonatal morbidity and mortality ( fig. 1 ).  ...  Removing fentanyl from epidural infusions would increase local anesthetic concentrations and the risk of instrumental delivery. 38 Instead, they suggest the need for a greater awareness of potential  ... 
doi:10.1097/00000542-200703000-00025 pmid:17325519 fatcat:3qfm4ovvunfybgbp7uxbeyze3e

The significance of circadian rhythms and dysrhythmias in critical illness

Helen T McKenna, Irwin KM Reiss, Daniel S Martin
2017 Journal of the Intensive Care Society  
These circadian rhythms underlie 'permissive homeostasis', whereby anticipation of periods of increased energy demand or stress may enhance the function of individual cells, organ systems or whole organisms  ...  Harnessing these important biological phenomena to match metabolic supply to demand and bolster cell defenses at the apposite time may be a future therapeutic strategy in the intensive care unit.  ...  Acknowledgements HM thanks the London Clinic for its support.  ... 
doi:10.1177/1751143717692603 pmid:28979558 pmcid:PMC5606425 fatcat:sf6fwumy2zeijhc4cgelnnjlle

Aspirin for Prevention of Preeclampsia

A. Atallah, E. Lecarpentier, F. Goffinet, M. Doret-Dion, P. Gaucherand, V. Tsatsaris
2017 Drugs  
Key points Indications for aspirin during pregnancy are a great matter of debate and there is a recent trend to a wide prescription of aspirin in pregnancy.  ...  Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications.  ...  The estimated area under the curve of the test was 0.907, with 89% sensitivity, and a 10% false-positive rate in the prediction of early preeclampsia [78] .  ... 
doi:10.1007/s40265-017-0823-0 pmid:29039130 pmcid:PMC5681618 fatcat:kte4hst22jgqxgjs5iav5psyf4

Transdisciplinary unifying implications of circadian findings in the 1950s

Franz Halberg, Germaine Cornélissen, George Katinas, Elena V Syutkina, Robert B Sothern, Rina Zaslavskaya, Francine Halberg, Yoshihiko Watanabe, Othild Schwartzkopff, Kuniaki Otsuka, Roberto Tarquini, Perfetto Frederico (+1 others)
2003 Journal of Circadian Rhythms  
Chronomics (mapping time structures) with the major aim of quantifying normalcy by dynamic reference values for detecting earliest risk elevation, also yields the dividend of allowing molecular biology  ...  of the normal and for an individualized detection of the abnormal.  ...  Bakken, of "free-running" fame, and to Henry Nash Smith for circadiana; and to four masters in indispensable time-  ... 
doi:10.1186/1740-3391-1-2 pmid:14728726 pmcid:PMC317388 fatcat:stjwejwjlfcv5p54s5huif6r6m

Non-photic solar associations of heart rate variability and myocardial infarction

Germaine Cornélissen, Franz Halberg, Tamara Breus, Elena V. Syutkina, Roman Baevsky, Andi Weydahl, Yoshihiko Watanabe, Kuniaki Otsuka, Jarmila Siegelova, Bohumil Fiser, Earl E. Bakken
2002 Journal of Atmospheric and Solar-Terrestrial Physics  
within the physiological range, for detecting environmental e ects and for recognizing endogenous as well as exogenous disease-risk syndromes.  ...  Coordinated physiological and physical monitoring, the scope of an international project on the Biosphere and the Cosmos, seeks reference values for a better understanding of environmental e ects on human  ...  Weihe, MD, for a critical discussion of the concept of the chronome. Thanks are also addressed to Dr. Yamauchi and to Dr. Dorman for their invaluable help with this manuscript.  ... 
doi:10.1016/s1364-6826(02)00032-9 fatcat:vtrlqkbw2fdtndxhehena5hnwy

Subject index

2003 Journal of the American College of Cardiology  
the Thrombolysls in Myocardial Infarction Risk Index for Early Acute Coronary Syndrome in the National Registry of Myocardial Infarctloo: A Simple Risk Index Predicts Mortality in Both ST and Non-ST  ...  in Awake Patients With Heart Failure Predicts Prognosis 1062-88.161A A Robust Prediction Model for All Forms of Acute Coronary Syndromes: Estimating the Risk of In-Hospital Death and Myocardial Infarction  ... 
doi:10.1016/s0735-1097(03)82907-8 fatcat:d4qz6ksv7nhoxguu4isczjd7du

Chronobiology's progress. Part I, season's appreciations 2004-2005: time-, frequency-, phase-, variable-, individual-, age- and site-specific chronomics

Franz Halberg, Germaine Cornélissen, George Katinas, Levan Tvildiani, Marina Gigolashvili, Ketevan Janashia, Tim Toba, Miguel Revilla, Philip Regal, Robert B. Sothern, Hans W. Wendt, Zhengrong Wang (+15 others)
2006 Journal of Applied Biomedicine  
Abnormalities in the variability of blood pressure and heart rate, impossible to find during a conventional office visit (the latter aiming at the fiction of a "true" blood pressure), can raise cardiovascular  ...  May a marker-guided preventive chronotherapy of elevations of the risks of diseases not only of individuals but also of societies and nations eventually evolve.  ...  for a thousand or a few hundred years such as the aurora or the sunspot or for hardly more than 100 years, such as a geomagnetic index and for much shorter spans in the case of physical "newcomers" to  ... 
doi:10.32725/jab.2006.001 fatcat:ucyarz6chbhl7eshggbyo6pmza

Assessing circadian rhythms during prolonged midazolam infusion in the pediatric intensive care unit (PICU) children

Agnieszka Bienert, Alicja Bartkowska-Śniatkowska, Paweł Wiczling, Jowita Rosada-Kurasińska, Małgorzata Grześkowiak, Czesław Żaba, Artur Teżyk, Anna Sokołowska, Roman Kaliszan, Edmund Grześkowiak
2013 Pharmacological Reports  
Results: A two-compartment model for midazolam pharmacokinetics and a one-compartment model for midazolam metabolite adequately described the data.  ...  Methods: Blood samples for midazolam and 1-OH-midazolam assay were collected throughout the infusion at different times of the day.  ...  Acknowledgments: One of the authors (Pawe³ Wiczling) was supported by a grant from Iceland, Liechtenstein, and Norway through the EEA Financial Mechanism via Homing Program from the Foundation for Polish  ... 
doi:10.1016/s1734-1140(13)70969-1 pmid:23563029 fatcat:j2ihhx27ongmzlfpbmr6u75fzq

The role of the vagus nerve during fetal development and its relationship with the environment [article]

Francesco Cerritelli, Martin G. Frasch, Marta C. Antonelli, Chiara Viglione, Stefano Vecchi, Marco Chiera, Andrea Manzotti
2021 arXiv   pre-print
This analysis could help clinicians and stakeholders define precise guidelines for improving the management of fetuses and newborns, particularly to reduce the potential adverse environmental impacts on  ...  pathway, which may affect the functioning of each organ, to the production of hormones involved in bioenergetic metabolism.  ...  The development during labor Brith, as the transition from fetal to neonatal physiology, is a major challenge for the fetus and requires an ANS able to efficiently adapt the cardiovascular, respiratory  ... 
arXiv:2106.01756v1 fatcat:mhfuklofb5gwrlzxdcbhvvg73q

A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows

Francesco Cerritelli, Martin G. Frasch, Marta C. Antonelli, Chiara Viglione, Stefano Vecchi, Marco Chiera, Andrea Manzotti
2021 Frontiers in Neuroscience  
This analysis could help clinicians and stakeholders define precise guidelines for improving the management of fetuses and newborns, particularly to reduce the potential adverse environmental impacts on  ...  In fact, fHRV is a non-invasive marker whose changes have been associated with ANS development, vagal modulation, systemic and neurological inflammatory reactions, and even fetal distress during labor.  ...  The Development During Labor Birth, as the transition from fetal to neonatal physiology, is a major challenge for the fetus and requires an ANS able to efficiently adapt the cardiovascular, respiratory  ... 
doi:10.3389/fnins.2021.721605 pmid:34616274 pmcid:PMC8488382 fatcat:u3e4nbnbanfg3ftgsd5oj53syy
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