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Serotonin receptors involved in antidepressant effects

Francesc Artigas
2013 Pharmacology and Therapeutics  
The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the pathophysiology and treatment of major depression since the serendipitous discovery of antidepressant drugs in the 1950s  ...  Presynaptic 5-HT 1A and 5-HT 1B autoreceptors play a major detrimental role in antidepressant treatments, as their activation by the excess of the active (extracellular) 5-HT fraction produced by serotonin  ...  and Roth, 2001) , which is predicted to be of benefit in the treatment of depression.  ... 
doi:10.1016/j.pharmthera.2012.09.006 pmid:23022360 fatcat:dljc4rzpgfbjfblmxoinh7qfsy

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

M A Lebow, A Chen
2016 Molecular Psychiatry  
In this review, we will look in-depth at the anatomy and projections of the BNST, and provide an overview of the current literature on the relevance of BNST dysregulation in psychiatric diseases.  ...  Most research on stress and psychiatric diseases has focused on the amygdala, which regulates immediate responses to fear.  ...  We would like to give a special thanks to all those who read and re-read versions of the manuscript through the years and commented and brainstormed on each version: Dr Yair Shemesh, Dr Orit Furman and  ... 
doi:10.1038/mp.2016.1 pmid:26878891 pmcid:PMC4804181 fatcat:upihkt3zlzdllnjwvjmidxwvyq

Global decrease of serotonin-1A receptor binding after electroconvulsive therapy in major depression measured by PET

R Lanzenberger, P Baldinger, A Hahn, J Ungersboeck, M Mitterhauser, D Winkler, Z Micskei, P Stein, G Karanikas, W Wadsak, S Kasper, R Frey
2012 Molecular Psychiatry  
This includes associations between treatment response and changes in 5-HT 1A function and density by antidepressants.  ...  Results from preclinical and clinical studies emphasize a crucial involvement of the serotonin-1A receptor (5-HT 1A ) in the mode of action of antidepressant treatment.  ...  A Hahn is recipient of a DOC-fellowship of the Austrian Academy of Sciences (OeAW) at the Department of Psychiatry and Psychotherapy.  ... 
doi:10.1038/mp.2012.93 pmid:22751491 pmcid:PMC3526726 fatcat:iksynowklngklhn6w4r3gzpb2a

Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome

Mary Gemmel, Eszter Bögi, Christina Ragan, Mariah Hazlett, Michal Dubovicky, Daniel L. van den Hove, Tim F. Oberlander, Thierry D. Charlier, Jodi L. Pawluski
2018 Neuroscience and Biobehavioral Reviews  
been raised about the benefits and risks of SSRI exposure on the developing child.  ...  Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome.  ...  Targeted lesioning of serotonergic neurons in the median raphe nucleus severely impairs pup retrieval and nursing (Barofsky et al., 1983) .  ... 
doi:10.1016/j.neubiorev.2017.04.023 pmid:28472631 fatcat:pfncq7f6vjfqfov6jgrbwunh3q

Functional neuroanatomy in panic disorder: Status quo of the research

Thomas Sobanski, Gerd Wagner
2017 World Journal of Psychiatry  
Thereby, the main focus was laid on recent neurofunctional, neurostructural, and neurochemical studies (from the period between January 2012 and April 2016).  ...  Gorman et al (1989; 2000) proposed a comprehensive neuroanatomical model of PD, which suggested that fear-and anxiety-related responses are mediated by a so-called "fear network" which is centered in the  ...  of the DRN, and the dorsal hippocampus in the case of the median raphe nucleus.  ... 
doi:10.5498/wjp.v7.i1.12 pmid:28401046 pmcid:PMC5371170 fatcat:evxkv5x2ozhnfakw4jcwdxyjo4

Circuit mechanisms of reward, anhedonia and depression

Anna Höflich, Paul Michenthaler, Siegfried Kasper, Rupert Lanzenberger
2018 International Journal of Neuropsychopharmacology  
Intact hedonic capacity requires an undisturbed interplay between a number of different brain regions and transmitter systems.  ...  For this purpose, definition of anhedonia and the involved reward components are described first, then current data on reward networks in healthy individuals and in depressed patients are summarized, and  ...  Willmar Schwabe GmbH, Orphan Pharmaceuticals AG, Janssen-Cilag Pharma GmbH, and Roche Austria GmbH. The other authors declared no conflicts of interest.  ... 
doi:10.1093/ijnp/pyy081 pmid:30239748 pmcid:PMC6368373 fatcat:ja4xqu2s5vcqzd7ak74zgedwxu

Paroxetine for Somatic Pain Associated With Physical Illness

Prakash S. Masand, Meera Narasimhan, Ashwin A. Patkar
2006 The Primary Care Companion to the Journal Clinical Psychiatry  
The review looks at evidence for the efficacy of the selective serotonin reuptake inhibitor paroxetine on pain in physical illness with and without depression and the mechanisms for the relief of pain  ...  Data Synthesis: Nearly two thirds of patients with major depressive disorder suffer from a physical illness, and about one fifth of patients with chronic physical illness are depressed.  ...  In addition to the ascending serotonergic and noradrenergic pathways, neurons in the raphe nucleus and locus ceruleus project to the spinal cord. 67 These descending pathways can inhibit input from the  ... 
doi:10.4088/pcc.v08n0301 pmid:16912814 pmcid:PMC1540386 fatcat:n62iwdky5fbndhypo3fzsxedwu

Serotonin in Aging, Late-Life Depression, and Alzheimer's Disease: The Emerging Role of Functional Imaging

C Meltzer, M.D.
1998 Neuropsychopharmacology  
Neuropharmacology 23:1561-1569 Curcio C, Kemper T (1984): Nucleus raphe dorsalis in dementia of the Alzheimer type: Neurofibrillary changes and neuronal packing density.  ...  in the brains of patients with Alzheimer-type dementia and depression, and suicides.  ...  ACKNOWLEDGMENTS This work was supported in part by PHS grants MH52247, AG05133, MH01210, MH00295, MH37869, MH49936, NS22899, and MH49815, and the Radiological Society of North America Research and Education  ... 
doi:10.1016/s0893-133x(97)00194-2 pmid:9571651 fatcat:wntzfpasjvbxnhn4r36czekneu

An Update on the Role of Serotonin and its Interplay with Dopamine for Reward

Adrian G. Fischer, Markus Ullsperger
2017 Frontiers in Human Neuroscience  
The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward guided behavior as well as drug dependance, still remains elusive.  ...  It appears that the additive effect of serotonin and DA conveys significant reward related information and is subjectively highly euphorizing. Neither DA nor serotonin alone have such an effect.  ...  ACKNOWLEDGMENTS We thank Gerhard Jocham for comments on the manuscript.  ... 
doi:10.3389/fnhum.2017.00484 pmid:29075184 pmcid:PMC5641585 fatcat:6cpyyn3u2va7fde3kpzpzaiqke

Supplementary_materials_for – Supplemental material for Locations for noninvasive brain stimulation in treating depressive disorders: A combination of meta-analysis and resting-state functional connectivity analysis

Binlong Zhang, Jiao Liu, Tuya Bao, Georgia Wilson, Joel Park, Bingcong Zhao, Jian Kong
2020 Figshare  
Supplemental material, Supplementary_materials_for for Locations for noninvasive brain stimulation in treating depressive disorders: A combination of meta-analysis and resting-state functional connectivity  ...  analysis by Binlong Zhang, Jiao Liu, Tuya Bao, Georgia Wilson, Joel Park, Bingcong Zhao and Jian Kong in Australian & New Zealand Journal of Psychiatry  ...  response in major depression based on serotonin Year First Author PMID Journal Title transporter interplay between median raphe nucleus and projection areas. 2012 Zeng LL 22957005 PloS one  ... 
doi:10.25384/sage.12327524.v1 fatcat:ntuqeyzyozfebjwsn625chesce

Neurochemical and Behavioural Changes in Rat Models of Depression

Ivan Skelin, Tomislav Kovačević, Mirko Diksic
2011 Croatica Chemica Acta  
In this review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and Flinders Sensitive Line (FSL) of rats.  ...  /biological changes occurring during depression and the subsequent treatment of its symptoms.  ...  Acknowledgements: The research reported here was supported in part by grants from the Croatian Ministry of Science, Education and Sports (219-1081970-2032).  ... 
doi:10.5562/cca1817 fatcat:5zrskc36w5cwrdhtel5lug6g34

Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: What depression has in common with impulsive aggression

Charles S. Carver, Sheri L. Johnson, Jutta Joormann
2008 Psychological bulletin  
Substantial differences between depression and other phenomena reviewed are interpreted by proposing that depression reflects both low serotonergic function and low reward sensitivity.  ...  Literatures reviewed include work on two-mode models; studies of brain function supporting the biological plausibility of the two-mode view and the involvement of serotonergic pathways in functions pertaining  ...  Serotonergic projections originate primarily in the dorsal and median raphe nuclei. Neurons within these nuclei have different but overlapping projection patterns.  ... 
doi:10.1037/a0013740 pmid:18954161 pmcid:PMC2847478 fatcat:hyy63trqfnf5jjjbnm4ctyjycu

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Rainald Mössner, Olya Mikova, Eleni Koutsilieri, Mohamed Saoud, Ann-Christince Ehlis, Norbert Müller, Andreas J. Fallgatter, Peter Riederer
2007 World Journal of Biological Psychiatry  
Biological markers for depression are of great interest to aid in elucidating the causes of major depression.  ...  We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression.  ...  The authors have no conflict of interest with any commercial or other associations in connection with the submitted article.  ... 
doi:10.1080/15622970701263303 pmid:17654407 fatcat:edorzisvsjfvhixwyj4zmgfxaa

A systematic review of prevalence studies of depression in Parkinson's disease

Jennifer S.A.M. Reijnders, Uwe Ehrt, Wim E.J. Weber, Dag Aarsland, Albert F.G. Leentjens
2007 Movement Disorders  
However, a positron emission tomography study using 123I-beta-CIT SPECT failed to show a relationship between serotonergic median raphe HT1A binding or brainstem serotonin transporter (SERT) binding and  ...  Using postmortem immunohistochemical analysis, Halliday et al. reported the first chemically identified loss of serotonin neurons in the median raphe nucleus of the pons and of substance P-containing preganglionic  ... 
doi:10.1002/mds.21803 pmid:17987654 fatcat:2rx6xiz6afcyrnblwhjfb5tj4m

Serotonin, Amygdala and Fear: Assembling the Puzzle

Marco Bocchio, Stephen B. McHugh, David M. Bannerman, Trevor Sharp, Marco Capogna
2016 Frontiers in Neural Circuits  
The amygdala is a key player in the processing of fear. This brain area is prominently modulated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).  ...  The 5-HT input to the amygdala has drawn particular interest because genetic and pharmacological alterations of the 5-HT transporter (5-HTT) affect amygdala activation in response to emotional stimuli.  ...  ACKNOWLEDGMENTS We thank Ayesha Sengupta for helpful discussions and comments.  ... 
doi:10.3389/fncir.2016.00024 pmid:27092057 pmcid:PMC4820447 fatcat:se7nwoebvjaw7cuw5fpm3qhiby
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