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Predicting the location of entorhinal cortex from MRI

Bruce Fischl, Allison A. Stevens, Niranjini Rajendran, B.T. Thomas Yeo, Douglas N. Greve, Koen Van Leemput, Jonathan R. Polimeni, Sita Kakunoori, Randy L. Buckner, Jennifer Pacheco, David H. Salat, Jennifer Melcher (+8 others)
2009 NeuroImage  
to quantify the variability of EC with respect to cortical geometry, and made predictions of its location on in vivo scans.  ...  Entorhinal cortex (EC) is a medial temporal lobe area critical to memory formation and spatial navigation that is among the earliest parts of the brain affected by Alzheimer's disease (AD).  ...  One of the authors (LLW) has obtained consulting income from Siemens Healthcare.  ... 
doi:10.1016/j.neuroimage.2009.04.033 pmid:19376238 pmcid:PMC2738987 fatcat:idjzay6c2faw7jwxecylko3wju

Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI

Jean C. Augustinack, Kristen E. Huber, Allison A. Stevens, Michelle Roy, Matthew P. Frosch, André J.W. van der Kouwe, Lawrence L. Wald, Koen Van Leemput, Ann C. McKee, Bruce Fischl
2013 NeuroImage  
Augustinack). 1 Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.ucla.edu).  ...  To test the accuracy of the probabilistic mapping, we measured the Hausdorff distance between the predicted and true labels and found that the median Hausdorff distance was 4.0 mm for the left hemispheres  ...  Imaging and Bioengineering (R01EB006758), the National Institute on Aging (AG022381) and (AG028521), the Massachusetts  ... 
doi:10.1016/j.neuroimage.2012.08.071 pmid:22960087 pmcid:PMC3508349 fatcat:dchqae66lfcqzf3usxnianl64q

Hippocampal Volume and Entorhinal Cortex Thickness in Alzheimer's Disease

2022 Indian Journal of Forensic Medicine & Toxicology  
This study aims to determine hippocampal volume and entorhinal cortex thickness in Alzheimer's disease obtained from a group of patients who underwent head MRI.  ...  The mean thickness of right, left, and total entorhinal cortex was 1.821±0.459 mm; 1.463±0.369 mm; and 3.285±0.791 mm, respectively.  ...  Acknowledgement We would like to thank Department of Radiology of Dr. Soetomo Hospital Surabaya, Indonesia in providing the data for analysing.  ... 
doi:10.37506/ijfmt.v16i1.17577 fatcat:mhpwgabxtfbkxfcjly4acjwzfu

Navigating the future of clinical assessments

2019 Brain  
This scientific commentary refers to 'Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation' by Howett et al. (  ...  Located in the medial temporal lobe, the entorhinal cortex (EC) is particularly vulnerable to accumulation of tau neurofibrillary tangles early in Alzheimer's disease.  ...  To examine the neural correlates of successful path integration, Howett et al. segmented structural MRI scans to assess the relationship between the integrity of different brain regions (including entorhinal  ... 
doi:10.1093/brain/awz121 pmid:31135046 fatcat:ph2p6mrjobemzh63bt7qdavsxe

MRI hippocampal and entorhinal cortex mapping in predicting conversion to Alzheimer's disease

D.P. Devanand, Ravi Bansal, Jun Liu, Xuejun Hao, Gnanavalli Pradhaban, Bradley S. Peterson
2012 NeuroImage  
Objective-Using MRI surface morphometry mapping, to evaluate local deformations of the hippocampus, parahippocampal gyrus, and entorhinal cortex in predicting conversion from mild cognitive impairment  ...  Methods-Baseline brain MRI with surface morphological analysis was performed in 130 outpatients with MCI, broadly defined, and 61 healthy controls followed for an average of 4 years in a single site study  ...  Acknowledgments Supported in part by grants AG17761 and P30 AG08051 from the National Institute of Aging.  ... 
doi:10.1016/j.neuroimage.2012.01.075 pmid:22289801 pmcid:PMC3320768 fatcat:kamwgivw5nbhbafaj7rxa5kghe

Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration

2020 Brain  
By contrast, smaller baseline entorhinal volumes predicted degeneration in the medial temporal cortex, recapitulating a prior influential staging model.  ...  cortex.  ...  and the Canada First Research Excellence Fund (T.W.S. and R.N.S.). S.F.C was supported by the Doctoral College "Imaging the Mind" (FWF-W1233) of the Austrian Science Fund.  ... 
doi:10.1093/brain/awaa012 pmid:32203580 pmcid:PMC7092749 fatcat:tcx4jdr3bbgv7ol45rsysypxoy

Brain imaging evidence of preclinical Alzheimer's disease in normal aging

William Jagust, Amy Gitcho, Felice Sun, Beth Kuczynski, Dan Mungas, Mary Haan
2006 Annals of Neurology  
The anatomical location of these findings suggests detection of preclinical Alzheimer's disease pathology.  ...  Both hippocampal (p ‫؍‬ 0.03) and entorhinal cortical volumes (p ‫؍‬ 0.01) predicted decline on delayed recall over time, and entorhinal cortical volumes remained significant when converters were excluded  ...  or hippocampus is the most sensitive location for the detection of early disease with MRI. 35, 36 However, the entorhinal cortex pathologically is the site that is affected earliest by neurofibrillary  ... 
doi:10.1002/ana.20799 pmid:16470518 fatcat:dhzhjehga5dvjeozg753kut3sq

MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys

Benjamin M. Basile, Chloe L. Karaskiewicz, Emily C. Fiuzat, Ludise Malkova, Elisabeth A. Murray
2017 Frontiers in Integrative Neuroscience  
For unintended damage, MRI estimates correlated with histological assessment for entorhinal cortex, perirhinal cortex and hippocampus, though MRI significantly overestimated the extent of that damage in  ...  The field will benefit from more research into in vivo lesion assessment techniques, and additional evaluation of the accuracy of MRI assessment in different brain areas.  ...  This work was supported by the Intramural Research Program of the National Institute of Mental Health (NIMH; ZIAMH0 02887).  ... 
doi:10.3389/fnint.2017.00012 pmid:28642691 pmcid:PMC5462941 fatcat:2nm4aoqmznb2rgvwqlxahcttha

MRI parcellation of ex vivo medial temporal lobe

Jean C. Augustinack, Caroline Magnain, Martin Reuter, André J.W. van der Kouwe, David Boas, Bruce Fischl
2014 NeuroImage  
We have identified several cytoarchitectonic features in the medial temporal lobe with high resolution ex vivo MRI, including gray matter structures such as the entorhinal layer II 'islands', perirhinal  ...  Localization of Brodmann areas 28 and 35 (entorhinal and perirhinal, respectively) demonstrates MRI based area boundaries validated with multiple methods and histological stains.  ...  Conflict of interest The authors have no conflict of interest to disclose regarding this work.  ... 
doi:10.1016/j.neuroimage.2013.05.053 pmid:23702414 pmcid:PMC3883990 fatcat:gtzhycjnzrgfdmioukf6ok646y

Medial temporal cortices in ex vivo magnetic resonance imaging

Jean C. Augustinack, André J.W. van der Kouwe, Bruce Fischl
2013 Journal of Comparative Neurology  
This review focuses on the ex vivo magnetic resonance imaging (MRI) modeling of medial temporal cortices and associated structures, the entorhinal verrucae and the perforant pathway.  ...  Neural information from multiple modalities converge in the entorhinal cortex and then project to the hippocampus via the perforant pathway (Van Hoesen et al., 1972; Van Hoesen and Pandya, 1975a,b).  ...  Acknowledgments The authors thank those who generously donated the brain and made this research possible.  ... 
doi:10.1002/cne.23432 pmid:23881818 pmcid:PMC6014627 fatcat:tq263igezfbr5ks2zqjwzjrdpa

Detection of entorhinal layer II using Tesla magnetic resonance imaging

Jean C. Augustinack, Andre J. W. van der Kouwe, Megan L. Blackwell, David H. Salat, Christopher J. Wiggins, Matthew P. Frosch, Graham C. Wiggins, Andreas Potthast, Lawrence L. Wald, Bruce R. Fischl
2005 Annals of Neurology  
The entorhinal cortex receives vast sensory association input, and its major output arises from the layer II and III neurons that form the perforant pathway.  ...  In 70 and 100m isotropic data, the entorhinal islands were clearly visible throughout the anterior-posterior extent of entorhinal cortex.  ...  Fig 2 . 2 Corresponding high-resolution magnetic resonance image (MRI) and histological Nissl section of the entorhinal cortex.  ... 
doi:10.1002/ana.20426 pmid:15786476 pmcid:PMC3857582 fatcat:adzmrgvl5jbhdgokfwdfmznose

MRI based volumetric analysis of entorhinal cortex in elderly subjects with mild cognitive impairment and in subjects with normal cognition to see effects of aging on volume of ERC

Sarita Jilowa, Hitesh Kumar, Yashvant Singh, K. S. Anand
2020 International Journal of Research in Medical Sciences  
Aim of the study was to evaluate the volume of entorhinal cortex in patients of MCI and to compared the volume with patients of normal cognition.  ...  Volume of entorhinal cortex was measured on 1 mm thick T1 coronal oblique MR scans by manually tracing the boundaries defined by two widely used methods i.e.  ...  . 16 Changes in the ERC in elderly individuals seemed to be predictive of the transition from normal cognition to MCI. 17 The volume of the entorhinal cortex differentiated the subjects from those  ... 
doi:10.18203/2320-6012.ijrms20202884 fatcat:fs2yvuwygrg3pd2k4ja4zxlt5q

Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease

T. R. Stoub, L. deToledo-Morrell, G. T. Stebbins, S. Leurgans, D. A. Bennett, R. C. Shah
2006 Proceedings of the National Academy of Sciences of the United States of America  
Table 2 shows the Talairach coordinates (29) and cluster size for all statistically significant areas in white  ...  Entorhinal Cortex and Hippocampal Volumes. Predicting Memory Performance from MRI Measures.  ...  from the entorhinal cortex.  ... 
doi:10.1073/pnas.0603414103 pmid:16785436 pmcid:PMC1479867 fatcat:ih3agsjpdvbpfp4umacc5ah2na

Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease

Ronald J. Killiany, Teresa Gomez-Isla, Mark Moss, Ron Kikinis, Tamas Sandor, Ferenc Jolesz, Rudolph Tanzi, Kenneth Jones, Bradley T. Hyman, Marilyn S. Albert
2000 Annals of Neurology  
Baseline MRI measures of the entorhinal cortex, the banks of the superior temporal sulcus, and the anterior cingulate were most useful in discriminating the status of the subjects on follow-up examination  ...  One hundred percent (100%) of normal subjects and patients with mild AD could be discriminated from one another based on these MRI measures.  ...  This study was supported by the National Institutes of Health (grants P01-AG04953, P01-CA67165, R01-AG08487, and P50-AG05236, and contract N01-NS-0-2397).  ... 
doi:10.1002/1531-8249(200004)47:4<430::aid-ana5>3.0.co;2-i pmid:10762153 fatcat:mx3quuqel5fkrdigyfdnbyfxum

Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease

Ronald J. Killiany, Teresa Gomez‐Isla, Mark Moss, Ron Kikinis, Tamas Sandor, Ferenc Jolesz, Rudolph Tanzi, Kenneth Jones, Bradley T. Hyman, Marilyn S. Albert
2000 Annals of Neurology  
Baseline MRI measures of the entorhinal cortex, the banks of the superior temporal sulcus, and the anterior cingulate were most useful in discriminating the status of the subjects on follow-up examination  ...  One hundred percent (100%) of normal subjects and patients with mild AD could be discriminated from one another based on these MRI measures.  ...  This study was supported by the National Institutes of Health (grants P01-AG04953, P01-CA67165, R01-AG08487, and P50-AG05236, and contract N01-NS-0-2397).  ... 
doi:10.1002/1531-8249(200004)47:4<430::aid-ana5>3.3.co;2-9 pmid:10762153 fatcat:ux7uuw25w5gklhrcxs2dwafoz4
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