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Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations

Debabani Ganguly, Jianhan Chen, Alexander MacKerell
<span title="2015-04-21">2015</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
Intrinsically disordered proteins (IDPs) are frequently associated with human diseases such as cancers, and about one-fourth of disease-associated missense mutations have been mapped into predicted disordered  ...  The calculated ensembles are in quantitative agreement with several types of existing NMR data on the wild-type protein and the K24N mutant.  ...  The correlation coefficient of the two contact maps is 0.91 and the RMSD is 0.016.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1004247">doi:10.1371/journal.pcbi.1004247</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25897952">pmid:25897952</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4405366/">pmcid:PMC4405366</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3oakznej4natfd5r6xi2tc3u54">fatcat:3oakznej4natfd5r6xi2tc3u54</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171015145642/http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004247&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5a/e6/5ae68c5c66f82386c08e53c0f1aacb538c743ea5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1004247"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405366" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

Susan Costantini, Ankush Sharma, Raffaele Raucci, Maria Costantini, Ida Autiero, Giovanni Colonna
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/frh6t5i3jveazlshhan2ekhgcq" style="color: black;">BMC Evolutionary Biology</a> </i> &nbsp;
While prokaryotic and archeal species usually have one or two sirtuin homologs, in humans as well as in eukaryotes we found multiple versions and in mammals this family is comprised of seven different  ...  We also suggest how a multisite phosphorylation provides a possible mechanism by which flexible and intrinsically disordered segments of a sirtuin supported by the presence of positively or negatively  ...  Disorder prediction The prediction of disordered regions in the protein sequences was made by ANCHOR server based on the assumption that disordered proteins have a specific amino acid composition that  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1471-2148-13-60">doi:10.1186/1471-2148-13-60</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23497088">pmid:23497088</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3599600/">pmcid:PMC3599600</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7val6iwgvfan3a7cuuf6vcjcoq">fatcat:7val6iwgvfan3a7cuuf6vcjcoq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830084213/https://bmcevolbiol.biomedcentral.com/track/pdf/10.1186/1471-2148-13-60?site=http://bmcevolbiol.biomedcentral.com" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fe/a1/fea17b00860b5b3d2e21f9fa4486992bb496b4e6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1471-2148-13-60"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599600" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

ABSTRACTS OF COMMUNICATIONS

J. FRANCE
<span title="">1997</span> <i title="Cambridge University Press (CUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kwgitwq7djenhpcdchli5a4jta" style="color: black;">Journal of Agricultural Science</a> </i> &nbsp;
The diurnal variations in the environmental variables are incorporated in this model by defining the coefficients of variation of radiation and temperature, and the correlation coefficient between radiation  ...  The original model is based on annual mass balance, assuming zero net flux of soil mineral N.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s0021859697004577">doi:10.1017/s0021859697004577</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wrovro6knnhirbp4yai7zz53em">fatcat:wrovro6knnhirbp4yai7zz53em</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190504195314/https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D4AA98DA36D81B494E8A98FA313F4461/S0021859697004577a.pdf/div-class-title-abstracts-of-communications-proceedings-of-the-twenty-ninth-meeting-of-the-agricultural-research-modellers-group-div.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7b/de/7bde0f442425f5ad516cdcf7809ea9ce38212056.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s0021859697004577"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> cambridge.org </button> </a>

The gene expression profiling of hepatocellular carcinoma by a network analysis approach shows a dominance of intrinsically disordered proteins (IDPs) between hub nodes

Sakshi Singh, Giovanni Colonna, Giovanni Di Bernardo, Francesca Bergantino, Marcella Cammarota, Giuseppe Castello, Susan Costantini
<span title="">2015</span> <i title="Royal Society of Chemistry (RSC)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zcnlz4nminfhjcp5esifetrr4u" style="color: black;">Molecular Biosystems</a> </i> &nbsp;
The results evidence a strong presence of intrinsically disordered proteins in key roles as hubs in HCC sub-networks.  ...  located in the same subcellular compartment.  ...  sub-areas.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1039/c5mb00434a">doi:10.1039/c5mb00434a</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26267014">pmid:26267014</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nbyzt5mj6nasxpmcmoz4rcnpo4">fatcat:nbyzt5mj6nasxpmcmoz4rcnpo4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223042242/http://pdfs.semanticscholar.org/41b9/251d6ad34a02e687c2b51f3de4cb75d16de3.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/41/b9/41b9251d6ad34a02e687c2b51f3de4cb75d16de3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1039/c5mb00434a"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation

D. L. Bain, K. D. Connaghan, N. K. Maluf, Q. Yang, M. T. Miura, R. W. De Angelis, G. D. Degala, J. R. Lambert
<span title="2013-09-24">2013</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hfp6p6inqbdexbsu4r7usndpte" style="color: black;">Nucleic Acids Research</a> </i> &nbsp;
Here we discuss recent advances in placing receptorspecific transcriptional regulation on a more quantitative footing, specifically focusing on the role of macromolecular interaction energetics.  ...  Simple binding models predict non-linear affinity-function relationships Steroid receptors recognize an array of HREs, typically imperfect palindromes that vary by one or more base pairs.  ...  That is, based on the timescale argument, receptor-promoter equilibration rates must be faster than the rates at which receptor concentrations are changing-once more, a quantitatively testable prediction  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/nar/gkt859">doi:10.1093/nar/gkt859</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24064251">pmid:24064251</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3902896/">pmcid:PMC3902896</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2cxprtqpgbfvtidfcrf2br6dpy">fatcat:2cxprtqpgbfvtidfcrf2br6dpy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228184204/http://pdfs.semanticscholar.org/96c1/64ae645b15ff9265e995f328a8be1c2f3f10.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/96/c1/96c164ae645b15ff9265e995f328a8be1c2f3f10.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/nar/gkt859"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902896" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Prediction of Muscle Energy States at Low Metabolic Rates Requires Feedback Control of Mitochondrial Respiratory Chain Activity by Inorganic Phosphate

Joep P. J. Schmitz, Jeroen A. L. Jeneson, Joep W. M. van Oorschot, Jeanine J. Prompers, Klaas Nicolay, Peter A. J. Hilbers, Natal A. W. van Riel, François Blachier
<span title="2012-03-28">2012</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Ca 2+ signaling and protein phosphorylation) acting on a subset of model components.  ...  Model testing against independent data Based on predictions of physiological end-points (NADH/NAD, nY) it was not possible to discriminate between the model configurations.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0034118">doi:10.1371/journal.pone.0034118</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22470528">pmid:22470528</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3314597/">pmcid:PMC3314597</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/oqw7wptjrrc7decyln7uwnvqeu">fatcat:oqw7wptjrrc7decyln7uwnvqeu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171003113053/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034118&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b9/d9/b9d9e3a47ac4da8fb55177b37c393e03a6b22473.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0034118"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314597" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Core Microprocessor Component DiGeorge Syndrome Critical Region 8 (DGCR8) Is a Nonspecific RNA-binding Protein

Braden M. Roth, Daniella Ishimaru, Mirko Hennig
<span title="2013-07-26">2013</span> <i title="American Society for Biochemistry &amp; Molecular Biology (ASBMB)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a> </i> &nbsp;
DGCR8 (DiGeorge syndrome critical region protein 8).  ...  Double-stranded RNA-binding domain-containing proteins play key roles in microRNA biogenesis. Results: The Microprocessor protein DGCR8 binds RNA targets nonspecifically.  ...  Acknowledgments-We thank members of the Hennig laboratory for stimulating discussions and comments on the manuscript.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.m112.446880">doi:10.1074/jbc.m112.446880</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23893406">pmid:23893406</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3772224/">pmcid:PMC3772224</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/khkcx66lkzcmpfl22iosx6v6ii">fatcat:khkcx66lkzcmpfl22iosx6v6ii</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180723194047/http://www.jbc.org/content/288/37/26785.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c5/76/c576ecb9b8dc7c3cddb9f65e862bd4396549f68b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.m112.446880"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772224" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

CLEMSite, a software for automated phenotypic screens using light microscopy and FIB-SEM [article]

José M Serra Lleti, Anna M Steyer, Nicole L Schieber, Beate Neumann, Christian Tischer, Volker Hilsenstein, Mike Holtstrom, David Unrau, Robert Kirmse, John M Lucocq, Rainer Pepperkok, Yannick Schwab
<span title="2021-03-19">2021</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Correlative light and electron microscopy (CLEM) combines two imaging modalities, balancing out the limits of one technique with the other.  ...  4a) were located based on their green/red fluorescence using a 10x lens.  ...  However, different paradigms are necessary to measure sub-cellular morphologies on heterogeneous cell cultures 4, 5 .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.03.19.436113">doi:10.1101/2021.03.19.436113</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uovcruhypvc5nhm7kap6fwm7mq">fatcat:uovcruhypvc5nhm7kap6fwm7mq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210717175822/https://www.biorxiv.org/content/biorxiv/early/2021/03/19/2021.03.19.436113.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a2/5d/a25df62ae9b7c193a7a79138eda7a2567daaa845.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.03.19.436113"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Aaron Arvey, Michael Rowe, Joseph Barten Legutki, Gang An, Anantha Gollapudi, Anna Lei, Bill Colston, Chaim Putterman, David Smith, Janelle Stiles, Theodore Tarasow, Preveen Ramamoorthy
<span title="2020-10-06">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vauxnes2mnbfrorwybrb45dczm" style="color: black;">Immunity &amp; Ageing</a> </i> &nbsp;
Peptide binding profiles were aggregated into an "immune age" by a machine learning regression model that was highly correlated with chronological age.  ...  Applying this regression model to previously-unobserved donors, we found that a donor's predicted immune age is longitudinally consistent over years, suggesting it could be a robust long-term biomarker  ...  , and about 4000 extra-cellular or secreted human proteins.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12979-020-00193-x">doi:10.1186/s12979-020-00193-x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33042204">pmid:33042204</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7539520/">pmcid:PMC7539520</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7qxyhnfm4zcufa7bpvflo77qpu">fatcat:7qxyhnfm4zcufa7bpvflo77qpu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201007163721/https://immunityageing.biomedcentral.com/track/pdf/10.1186/s12979-020-00193-x" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d7/a2/d7a2966b80dec98550609a3325b24a928e8d1bfd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12979-020-00193-x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539520" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Fungal X-Intrinsic Protein Aquaporin from Trichoderma atroviride: Structural and Functional Considerations

Maroua BEN AMIRA, Mohamed FAIZE, Magnus Karlsson, Mukesh DUBEY, Magdalena Frąc, Jacek PANEK, Boris FUMANAL, Aurélie Gousset-Dupont, Jean-Louis JULIEN, Hatem CHAAR, Daniel AUGUIN, Robin MOM (+2 others)
<span title="2021-02-23">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/clnmwghhxzd35jr6jihmkh3gju" style="color: black;">Biomolecules</a> </i> &nbsp;
The fungus-XIP clade, with one member (TriatXIP), is one of the three clades of MIPs that make up the diversity of T. atroviride MIPs, along with the AQPs (three members) and the AQGPs (three members).  ...  The fungal uncharacterized X-Intrinsic Protein (XIP) subfamily includes the full protein diversity of MIP. Their biological functions still remain fully hypothetical.  ...  IDs and AQP types are based on JGI assembly. b MW, Protein molecular weight; pI, protein isoelectric point.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biom11020338">doi:10.3390/biom11020338</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33672420">pmid:33672420</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7927018/">pmcid:PMC7927018</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/c7tqejdshve43knj36bz7qt3pa">fatcat:c7tqejdshve43knj36bz7qt3pa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210715094651/https://hal.inrae.fr/hal-03153574/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cd/3a/cd3a8af3365358787db5ad4b0cb1d499106d1b92.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biom11020338"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927018" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Francois-Xavier Theillet, Andres Binolfi, Tamara Frembgen-Kesner, Karan Hingorani, Mohona Sarkar, Ciara Kyne, Conggang Li, Peter B. Crowley, Lila Gierasch, Gary J. Pielak, Adrian H. Elcock, Anne Gershenson (+1 others)
<span title="2014-06-05">2014</span> <i title="American Chemical Society (ACS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3jiv5gamdrch7lswaebpzyrjmi" style="color: black;">Chemical Reviews</a> </i> &nbsp;
Therefore, it is difficult to predict how these parameters modulate cellular disorder-to-order transitions.  ...  One predicted outcome is that macromolecular crowding promotes protein compaction ( Figure 3B ), which may stabilize globular proteins ( Figure 3C ), or promote proteinprotein associations ( Figure  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1021/cr400695p">doi:10.1021/cr400695p</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24901537">pmid:24901537</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4095937/">pmcid:PMC4095937</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7v4q6t3bircyxpqfeyh7zzpo4a">fatcat:7v4q6t3bircyxpqfeyh7zzpo4a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170519105729/http://pubs.acs.org/doi/pdf/10.1021/cr400695p" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/aa/fe/aafebea21a9eb877e2907cb8fe2961f864d7f779.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1021/cr400695p"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> acs.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095937" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis [chapter]

Pushpendra Mani Mishra, Navneet Chandra Verma, Chethana Rao, Vladimir N. Uversky, Chayan Kanti Nandi
<span title="2020-04-02">2020</span> <i title="Elsevier"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iiku6qaq6rd4lcpnbevlkv35ze" style="color: black;">Progress in Molecular Biology and Translational Science</a> </i> &nbsp;
The exploration of these dancing proteins in viruses has just started and crucial details such as correlation of rapid evolution, high rate of mutation and accumulation of disordered contents in viral  ...  Intrinsically disordered proteins (IDPs) possess the property of inherent flexibility and can be distinguished from other proteins in terms of lack of any fixed structure.  ...  The outcomes (particularly for influenza virus) demonstrated a correlation between the proximity to the RNA core of the virion and the levels of disorder in protein, where the closer protein is located  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/bs.pmbts.2020.03.001">doi:10.1016/bs.pmbts.2020.03.001</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32828463">pmid:32828463</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7129803/">pmcid:PMC7129803</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fzdkvurysffojcdp3ht425xdjy">fatcat:fzdkvurysffojcdp3ht425xdjy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200421081908/https://pdf.sciencedirectassets.com/278708/AIP/1-s2.0-S1877117320300363/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEAAaCXVzLWVhc3QtMSJHMEUCIG8i%2F%2BMdmVoTOSHaL%2BoUHOnPLOz2j7vKIwGSp5PtzljjAiEA9k%2FrQwqi8yagSSNtukFeBZiNH6VyMK8T1H79oedUaYQqtAMIKRADGgwwNTkwMDM1NDY4NjUiDAlmFq5i7cwupwZa%2BSqRA%2B0MuJr96CrIrNCBqKjm%2FU22p8TE1d6tp6UA3PZeSuiUZPpprJTiOtql0vHLeHbgSCxSIq6MY6CY2urhPHf1luFZ%2FYw9lTBUhAVOf%2Bb%2FV5aI0vODxvG%2FNh%2BEevSza%2Fo%2FGVhKvSqQkRuoSu9prSykaHUETThUb16qGicOhI%2BKXCJpO5TnuyBTLrDOqzBOmk1oNAaDpk%2BdyyfHw00sFNbjQ0%2FzpuejzmArK1jJCb0k8JFCofGZC%2FhF0IS4SK5Z5aRVKYVLVNwLNupJGWPuirPkwnZGCUrueeU7wL8XSPJ05SNhCM71mR1OiT7EiglQtZncha56kYWXujL9164oBwoFCfPOaBS9Q8RGH0wiOfy%2BZ1pfDjRjmAvBavod6S%2BEMngaQ2dQq9tub9jyzHE7fH08SWrRtuIjICF%2Bx9N6c93FD72oN7JceopNs0oA3OcoGf6MHm3D9m3%2B6F2HQ1v9w3xHzgnFVp3HOZ6XgVOKgHQftVye2hle3Q12vfbmhTLu0EfSXAzXoaH7Xp%2F1OPeoVcX4%2BhiQMMfE%2BvQFOusB3RuLh%2BN392JENOPfoO7R5GkqtXytXgaFQioH2oIN2y2%2FKhfSCgQMXp7lTZFLsw57sn6tKnqe2RC6AIBQHS41V3%2BKJ5r7I1knvhc2oSa3yHxw1Hw9QshF85BC%2BwhALMsczwdH83pjiF7yMNlA1yHL8P%2FgtI%2FMCk5mNspS4QSU0IhmsVmZDiqB4KgFOzAS7BkPNybMKI7%2FGIIi1vkyz6xCTHr0PrDOGSR1%2Fg4pCqqWQZuXnNIg6BqgOMWzkGSxkyVqtQc15F0cEn85YAjt7U8QCDm0ibDIwkfS959Zf3Y%2FD6K2q6zsaV5ZoMNqgA%3D%3D&amp;X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20200421T081850Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=300&amp;X-Amz-Credential=ASIAQ3PHCVTY5EN5TOWS%2F20200421%2Fus-east-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=c013bf75602b3ccb2e7279fe3403e130f21e77ec6b0c99261b41e9fa92f1c7dc&amp;hash=19a052a4c8074fd2a7cfdb5e67bec197ca1526eb4a988884f818586383358511&amp;host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&amp;pii=S1877117320300363&amp;tid=spdf-c8f74b66-1871-4506-8287-44ec80ec91eb&amp;sid=2cf067b33695874ba45ac124240367767680gxrqa&amp;type=client" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/56/97/5697f14aa4360ba3b3ef8336c6c8f9853b7bb4d4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/bs.pmbts.2020.03.001"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129803" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Mechanisms of statin-induced myalgia assessed by physiogenomic associations

Gualberto Ruaño, Andreas Windemuth, Alan H.B. Wu, John P. Kane, Mary J. Malloy, Clive R. Pullinger, Mohan Kocherla, Kali Bogaard, Bruce R. Gordon, Theodore R. Holford, Ankur Gupta, Richard L. Seip (+1 others)
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sf6qazapd5b6nnonhcz7c5ism4" style="color: black;">Atherosclerosis</a> </i> &nbsp;
Objective-We investigated genetic variants predictive of muscular side effects in patients treated with statins.  ...  We utilized a physiogenomic approach to prototype a multi-gene panel correlated with statin-induced myalgia. Background-Statin induced myalgia occurs in ∼10% of lipid clinic outpatients.  ...  The panel on the right shows the SNP effect magnitude, as provided by the regression coefficient with 95% confidence intervals, in subgroups taking the three major statins.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.atherosclerosis.2011.07.007">doi:10.1016/j.atherosclerosis.2011.07.007</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21868014">pmid:21868014</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3224998/">pmcid:PMC3224998</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jh3gfwx7nrdqhmbdjuvn6ttwgu">fatcat:jh3gfwx7nrdqhmbdjuvn6ttwgu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200505231642/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3224998&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d8/8e/d88e1dc4387411a228f48550d3294d3f87c0e176.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.atherosclerosis.2011.07.007"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224998" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Conditional genetic screen in Physcomitrella patens reveals a novel microtubule depolymerizing-end-tracking protein

Xinxin Ding, Leah M. Pervere, Carl Bascom, Jeffrey P. Bibeau, Sakshi Khurana, Allison M. Butt, Robert G. Orr, Patrick J. Flaherty, Magdalena Bezanilla, Luis Vidali, Carolyn G. Rasmussen
<span title="2018-05-10">2018</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/j6fzfstrmzcj3aeps7bx6tpoy4" style="color: black;">PLoS Genetics</a> </i> &nbsp;
We selected one mutant with reduced cellular growth for detailed characterization and identified the mutation responsible for the TS phenotype.  ...  Localization studies of CLoG1 protein in living cells showed CLoG1 concentrates on microtubules and tracks depolymerizing ends.  ...  certain chromosome is positively correlated with the chromosome's length (based on the crossover landscape of F2 Arabidopsis) [34] ; 4) if there is only one crossover on a chromosome, the crossover point  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pgen.1007221">doi:10.1371/journal.pgen.1007221</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29746462">pmid:29746462</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5944918/">pmcid:PMC5944918</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3pwqjzk3qrbfjbaiak2ib552oa">fatcat:3pwqjzk3qrbfjbaiak2ib552oa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190427183814/https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=2291&amp;context=math_faculty_pubs" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1b/da/1bda994158aa82d16808b0a599ca7b0c9ef6e624.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pgen.1007221"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944918" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Single cell expression analysis of primate-specific retroviruses-derived HPAT lincRNAs in viable human blastocysts identifies embryonic cells co-expressing genetic markers of multiple lineages

Gennadi Glinsky, Jens Durruthy-Durruthy, Mark Wossidlo, Edward J. Grow, Jason L. Weirather, Kin Fai Au, Joanna Wysocka, Vittorio Sebastiano
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ifjemtdanzevfbtz3nv7p24qjm" style="color: black;">Heliyon</a> </i> &nbsp;
Classification of embryonic cells was performed solely based on expression patterns of human pluripotencyassociated transcripts (HPAT), which represent a family of primate-specific transposable element-derived  ...  This high frequency of cellular extinction events represents a significant experimental obstacle challenging analyses of individual cells isolated from human preimplantation embryos.  ...  S7F ; Table S1 ) based on the correlation scores of the 23-gene signature.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.heliyon.2018.e00667">doi:10.1016/j.heliyon.2018.e00667</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30003161">pmid:30003161</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6039856/">pmcid:PMC6039856</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/q7djtt57u5h4tftdsi24bqd2ha">fatcat:q7djtt57u5h4tftdsi24bqd2ha</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208111231/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6039856&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d9/12/d91226758332310214bbcb90a9ff811a8fc8139b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.heliyon.2018.e00667"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039856" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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