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Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge

Manfred Klöbl, Gregor Gryglewski, Lucas Rischka, Godber Mathis Godbersen, Jakob Unterholzner, Murray Bruce Reed, Paul Michenthaler, Thomas Vanicek, Edda Winkler-Pjrek, Andreas Hahn, Siegfried Kasper, Rupert Lanzenberger
2020 Frontiers in Computational Neuroscience  
Conclusion: It was shown that medication-specific antidepressant symptom improvements can be predicted using functional connectivity measured during acute pharmacological challenge as an easily assessable  ...  Hence, this study assessed the predictability of long-term antidepressant effects of escitalopram based on the short-term influence of citalopram on functional connectivity.  ...  Predictive Power of Escitalopram Treatment Response Models The overall aim of this work was to assess whether the response to antidepressant treatment (after a median of 10 weeks) with escitalopram can  ... 
doi:10.3389/fncom.2020.554186 pmid:33123000 pmcid:PMC7573155 fatcat:kya2426xlzgh7nie5dr7ygslnq

Ketamine Decreases Resting State Functional Network Connectivity in Healthy Subjects: Implications for Antidepressant Drug Action

Milan Scheidegger, Martin Walter, Mick Lehmann, Coraline Metzger, Simone Grimm, Heinz Boeker, Peter Boesiger, Anke Henning, Erich Seifritz, Stefano L. Sensi
2012 PLoS ONE  
processing and large-scale changes in functional brain connectivity underlying certain symptoms of major depressive disorder.  ...  Here, using a randomized, placebo-controlled, double-blind, crossover rsfMRI challenge in healthy subjects we demonstrate that ketamine decreases functional connectivity of the DMN to the DN and to the  ...  Reducing abnormally increased connectivities in those functional networks might represent a general response pattern to antidepressant drug treatment.  ... 
doi:10.1371/journal.pone.0044799 pmid:23049758 pmcid:PMC3461985 fatcat:crdtukdysjamhc2ro63rpyl3ve

Regional default mode network connectivity in major depressive disorder: modulation by acute intravenous citalopram

Arpan Dutta, Shane McKie, Darragh Downey, Emma Thomas, Gabriella Juhasz, Danilo Arnone, Rebecca Elliott, Steve Williams, J. F. William Deakin, Ian M. Anderson
2019 Translational Psychiatry  
Using intravenous citalopram and resting-state fMRI, we investigated DMN intra-network connectivity and serotonin function in 77 healthy controls and patients with MDD.  ...  That citalopram engaged the amygdala in the DMN in controls may relate to the paradoxical effects on aversive processing seen with acute SSRIs in healthy subjects.  ...  The present analysis sought to determine whether acute modulation of serotonin function using intravenous (i.v.) citalopram would modify ACC-DMN abnormalities in depression that are implicated in mechanisms  ... 
doi:10.1038/s41398-019-0447-0 pmid:30877271 pmcid:PMC6420575 fatcat:lmgqnkykhrblzgt5bmspchvuqq

The effects of serotonin manipulations on emotional information processing and mood

Wendelien Merens, A.J. Willem Van der Does, Philip Spinhoven
2007 Journal of Affective Disorders  
Treatment-efficiency may be greatly improved if early changes in emotional information processing are found to predict clinical outcome following antidepressant treatment.  ...  Conclusions: Serotonin function is related to several aspects of emotional information processing, but it is unknown whether these changes predict or have any relationship with clinical outcome.  ...  Cognitive effects of antidepressant treatment A recently proposed alternative explanation for the delay in therapeutic response following treatment with antidepressants is that cognitive changes, which  ... 
doi:10.1016/j.jad.2007.01.032 pmid:17363069 fatcat:fkul22yzjrecph2cjvpfsplz2u

Association Between Placebo-Activated Neural Systems and Antidepressant Responses

Marta Peciña, Amy S. B. Bohnert, Magdalena Sikora, Erich T. Avery, Scott A. Langenecker, Brian J. Mickey, Jon-Kar Zubieta
2015 JAMA psychiatry  
Placebo-induced endogenous opioid release in these regions was associated with better antidepressant treatment response, predicting 43% of the variance in symptom improvement at the end of the antidepressant  ...  MAIN OUTCOMES AND MEASURES Changes in depressive symptoms in response to active placebo and antidepressant. Baseline and activation measures of μ-opioid receptor binding.  ...  stress and emotion regulatory regions (ie, sgACC, THA, NAc, and AMYG) 42-46 predicted 43% of the variance in the response to antidepressant treatment after 10 weeks.  ... 
doi:10.1001/jamapsychiatry.2015.1335 pmid:26421634 pmcid:PMC4758856 fatcat:6l5o6pxnonezlphqmpas5r7j7e

Modulation of Emotional Faces Processing and Its Implication for Depression and Anxiety [chapter]

Cristina Marta, Frederico Guilherme
2010 Neuroimaging  
The superior temporal sulcus connects with the intraparietal sulcus, responsible for analyzing the spatial direction, related to head movement and direction of the eyes, and the auditory cortex responsible  ...  The orbitofrontal cortex is crucially involved in this kind of function and activations in this region to expressions of anger are reported (Sprengelmeyer et al., 1998) .  ...  Taken together, these data suggest an increase in serotonin function immediately after the acute administration of citalopram.  ... 
doi:10.5772/9880 fatcat:lnsmxpanp5apflrqbelxc6lzv4

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

David J Kupfer, Ellen Frank, Mary L Phillips
2012 The Lancet  
We address two treatment-related issues: suicide risk with selective serotonin reuptake inhibitors, and the safety of antidepressants in pregnancy.  ...  Further studies of depression-specific psychotherapies, the continued application of antidepressants, the development of new treatment compounds, and the status of new somatic treatments are also discussed  ...  We thank Tanya Fabian, Jessica Levenson, and Meredith Lotz for their assistance with the literature search for the section about advances in treatment.  ... 
doi:10.1016/s0140-6736(11)60602-8 pmid:22189047 pmcid:PMC3397431 fatcat:5zqv5r3g3jg6xgcv7ajndl6kc4

Role of the Serotonergic System in Reduced Pulmonary Function after Exposure to Methamphetamine

Sandra M. Wells, Mary C. Buford, Virginia M. Porter, Heather L. Brunell, Melisa Bunderson-Schelvan, Andrew B. Nevin, Fernando Cardozo-Pelaez, Andrij Holian
2010 American Journal of Respiratory Cell and Molecular Biology  
Together, these data demonstrate that low-dose exposure to MA results in reduced pulmonary function mediated via SERT and subsequent perturbation of 5-HT metabolism in the lung.  ...  Pretreatment of mice with a selective 5-HT reuptake inhibitor completely ablated the MA-induced changes in pulmonary function, confirming a key role for the 5-HT transporter (serotonin transporter [SERT  ...  None of the other authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript. Acknowledgments: The authors thank R.  ... 
doi:10.1165/rcmb.2009-0121oc pmid:19541843 pmcid:PMC2874440 fatcat:r3n4hwyxkndofhqy6dain7gphq

Lasting effects of chronic fluoxetine treatment on the late developing rat brain: Age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI

A. Klomp, J.L. Tremoleda, M. Wylezinska, A.J. Nederveen, M. Feenstra, W. Gsell, L. Reneman
2012 NeuroImage  
Results: We observed a diminished brain response to the acute challenge in adult treated animals when compared to control animals, whereas this response was increased in juvenile treated rats.  ...  Conclusion: An opposite effect of chronic fluoxetine treatment was seen in the developing brain compared to that in matured brain, as assessed non-invasively using phMRI.  ...  Adolescence is a particularly critical period for such 'imprinting' effects, due to changes in neurotransmitter function, and changes in functional connectivity.  ... 
doi:10.1016/j.neuroimage.2011.07.082 pmid:21840402 fatcat:knrqyi3ivraybfme3k27eu3z5q

Mechanisms of antidepressant resistance

Wissam El-Hage, Samuel Leman, Vincent Camus, Catherine Belzung
2013 Frontiers in Pharmacology  
Here, we will first review markers that can be used to predict response to pharmacotherapy, such as markers of drug metabolism or blood-brain barrier (BBB) function, the activity of specific brain areas  ...  Since the discovery of antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds, several classes of psychotropic drugs have shown be effective in treating major depressive  ...  genes known to be implicated in AD non-response, and the use of brain imaging or EEG to identify brain changes known to predict poor response to ADs are among the most promising.  ... 
doi:10.3389/fphar.2013.00146 pmid:24319431 pmcid:PMC3837246 fatcat:7agqxmyvcvhdbhlhqlydua5jn4

The miRNome of Depression

Dariusz Żurawek, Gustavo Turecki
2021 International Journal of Molecular Sciences  
We focused on studies investigating post-mortem brain tissue of individuals with depression, as well as research aiming to elucidate the biomarker potential of miRNAs in depression and antidepressant response  ...  It is well established that stress responses are associated with multiple modest and often dynamic molecular changes in the homeostatic balance, rather than with a single genetic factor that has a strong  ...  Right panel represents directions of changes in the expression of miRNAs found in brain and periphery in depressed patients after different antidepressant treatments.  ... 
doi:10.3390/ijms222111312 pmid:34768740 pmcid:PMC8582693 fatcat:2vorydg4gfdhde5qk3fs24yb2q

Advances in the Management of Treatment-Resistant Depression

Paul E. Holtzheimer
2010 FOCUS The Journal of Lifelong Learning in Psychiatry  
focal brain stimulation techniques.  ...  Treatment-resistant depression (TRD) is a prevalent, disabling, and costly condition affecting 1%-4% of the U.S. population.  ...  In STAR*D, lithium was added after two failed treatment attempts that included bupropion, citalopram plus bupropion, citalopram plus buspirone, sertraline, or venlafaxine (27).  ... 
doi:10.1176/foc.8.4.foc488 pmid:25960694 pmcid:PMC4423609 fatcat:ur24xucdczhctglni7dgonhdly

Psychedelics and Other Psychoplastogens for Treating Mental Illness

Maxemiliano V. Vargas, Retsina Meyer, Arabo A. Avanes, Mark Rus, David E. Olson
2021 Frontiers in Psychiatry  
Psychedelics belong to a more general class of compounds known as psychoplastogens, which robustly promote structural and functional neural plasticity in key circuits relevant to brain health.  ...  Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike any treatments currently available.  ...  Moreover, the current standard of care treatments suffer from slow onset (e.g., 7 week average response time with citalopram) (259), low efficacy (only 27% of depressed patients achieved remission after  ... 
doi:10.3389/fpsyt.2021.727117 pmid:34671279 pmcid:PMC8520991 fatcat:lxvdrefrurfjjnwgjf3u7k744y

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

Ronald S Duman, George K Aghajanian, Gerard Sanacora, John H Krystal
2016 Nature Medicine  
This critical brain function plays a key role in both short-and long-term memory, and the mechanisms underlying these changes have been linked to the pathophysiology and treatment of multiple neurobiological  ...  Although current antidepressants such as serotonin reuptake inhibitors produce subtle changes that take effect in weeks or months, new agents have recently shown improvement in mood ratings within hours  ...  Rapid responses in treatment resistant depressed patients suggest a mechanism that results in fast changes in synaptic function and plasticity.  ... 
doi:10.1038/nm.4050 pmid:26937618 pmcid:PMC5405628 fatcat:kz3bazlfifctdfxfhkzdjlli7u

Monoaminergic Antidepressants in the Relief of Pain: Potential Therapeutic Utility of Triple Reuptake Inhibitors (TRIs)

Guillaume Hache, François Coudore, Alain M. Gardier, Bruno P. Guiard
2011 Pharmaceuticals  
Imaging, anatomical and functional studies have demonstrated the existence of common brain structures, neuronal pathways and neurotransmitters in depression and pain.  ...  therapeutic tools in the treatment of painful symptoms with depression.  ...  Changes in 5-HT receptor function in the amygdala were observed under a chronic pain-like state [102] .  ... 
doi:10.3390/ph4020285 fatcat:ao7rolrcafal5dvkmvcuzxenve
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