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High precision magnetically driven microtools with ultrasonic vibration for enucleation of oocytes

Masaya Hagiwara, Tomohiro Kawahara, Lin Feng, Yoko Yamanishi, Fumihito Arai
2010 2010 International Symposium on Micro-NanoMechatronics and Human Science  
This paper presents innovative driving method for the magnetically driven microtools (MMT) which is micrometer positioning accuracy by horizontally arranged permanent magnets.  ...  A piezoelectric ceramic is used to induce nanoscale vibration to the microfluidic chip to reduce the friction on the MMT. The enucleation process has been conducted by the dual arm MMTs.  ...  ACKNOWLEDGEMENT This work is partially supported by JST-SENTAN and the Nagoya University Global COE program for Education and Research of Micro-Nano Mechatronics.  ... 
doi:10.1109/mhs.2010.5669580 fatcat:nqwmrgu2bbcmzehlzwxpfvipq4

On-Chip Enucleation of Bovine Oocytes using Microrobot-Assisted Flow-Speed Control

Lin Feng, Masaya Hagiwara, Akihiko Ichikawa, Fumihito Arai
2013 Micromachines  
In this study, we developed a microfluidic chip with a magnetically driven microrobot for oocyte enucleation.  ...  A microfluidic system was specially designed for enucleation, and the microrobot actively controls the local flow-speed distribution in the microfluidic chip.  ...  Acknowledgements This work is partially supported by SENTAN, JST; the Nagoya University Global COE program for Education and Research of Micro-Nano Mechatronics; and Scientific Research from the Ministry  ... 
doi:10.3390/mi4020272 fatcat:nyvx5qqjcrbsxh6rnyndvuztii

High-Speed Magnetic Microrobot Actuation in a Microfluidic Chip by a Fine V-Groove Surface

Masaya Hagiwara, Tomohiro Kawahara, Toru Iijima, Fumihito Arai
2013 IEEE Transactions on robotics  
This paper presents high-speed microrobotic actuation driven by permanent magnets in a microfluidic chip.  ...  Index Terms-Friction reduction, high speed, lab on a chip, magnetically driven microtool (MMT), microfluidics, microrobot.  ...  FABRICATION OF THE SI-NI COMPOSITE MAGNETICALLY DRIVEN MICROTOOL WITH AN OPTIMUM RIBLET SURFACE In order to produce the optimum riblet shape, precise 3-D fabrication is required.  ... 
doi:10.1109/tro.2012.2228310 fatcat:wzrg4qvienapxaezbxahdulqnm

Magnetically Driven Bionic Millirobots with a Low-Delay Automated Actuation System for Bioparticles Manipulation

Xue Bai, Dixiao Chen, Wei Zhang, Heulin Ossian, Yuanyuan Chen, Yanmin Feng, Lin Feng, Fumihito Arai
2020 Micromachines  
This paper presents a semi-automatic actuation system which can achieve bio-particles tracking, transportation, and high-precision motion control of robots in a microfluidic chip.  ...  In biotechnology, precise transportation of cells is used for the enucleation, microinjection, and investigation of the characteristics of a single cell.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/mi11020231 pmid:32102365 pmcid:PMC7074837 fatcat:bj3qmd5twvd25javylsowjwthq

Cell Injection Millirobot Development and Evaluation in Microfluidic Chip

Lin Feng, Qiang Zhou, Bin Song, Yanmin Feng, Jun Cai, Yonggang Jiang, Deyuan Zhang
2018 Micromachines  
We propose an innovative design of millirobot, which can achieve donor cell suction, delivery, and injection in a mammalian oocyte on a microfluidic chip.  ...  We demonstrate the effectiveness of the proposed millirobot through an experiment of the absorption and ejection of 20-µm particles from the nozzle using magnetic control in a microfluidic chip.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/mi9110590 pmid:30428554 pmcid:PMC6266326 fatcat:56tsba7qq5evnpguple3wqiv7q

Biomedical Applications of Untethered Mobile Milli/Microrobots

Metin Sitti, Hakan Ceylan, Wenqi Hu, Joshua Giltinan, Mehmet Turan, Sehyuk Yim, Eric Diller
2015 Proceedings of the IEEE  
As the robot size goes down to the order of a single cell, previously inaccessible body sites would become available for high-resolution in situ and in vivo manipulations.  ...  We put a special emphasis on the potential impacts of biomedical microrobots in the near future.  ...  Furthermore, Hagiwara et al. proposed a magnetically driven microtools that was able to orient, position and cut single cell [126] . These functions were used to enucleate the oocyte [127] .  ... 
doi:10.1109/jproc.2014.2385105 pmid:27746484 pmcid:PMC5063027 fatcat:lsvefsokvnhu3mjnf7576t3fyq

Analysis and suppression of residual vibration in microhand for high-speed single-cell manipulation

Ebubekir Avci, Chanh Nghiem Nguyen, Kenichi Ohara, Yasushi Mae, Tatsuo Arai
2013 International Journal of Mechatronics and Automation  
Second, precise motion throughout a large workspace for the transportation of microobjects in the limited space of a microscope is another arduous task.  ...  In this study, we propose multiscalability concept, i.e., a large workspace with precise positioning for the grasping and transportation of multisized microobjects.  ...  Magnetic driven microtools (MMT) were developed to provide many microfluidic functions, such as those of manipulation, sorting, dispensing, etc. [21, 22] .  ... 
doi:10.1504/ijma.2013.053402 fatcat:xgqdqjntkvgq3nqe5mp3i4fwbi

Micro-scale Instruments Applied to a Bovine Nuclear Transfer System [article]

Andrew Leif Clow, University Of Canterbury
2010
Tools were developed for two areas of cell handling: cell fusion and cell transportation. Designs suitable for implementation in microscale lab-on-chip systems were evaluated.  ...  Many miniaturised lab-on-chip systems rely on cell transportation. One illustration in the baseline procedure is the on-chip transport of cells to the cell fusion device.  ...  [133] developed a microfluidic device specifically for separation of the oocyte from surrounding cumulus cells.  ... 
doi:10.26021/2780 fatcat:dda3sr73orgkbjthmcqfadvhje