A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Filters
Power Estimates for Voxel-Based Genetic Association Studies Using Diffusion Imaging
[chapter]
2013
Mathematics and Visualization
Preserved Fulltext
We computed voxel-wise heritability estimates for fractional anisotropy in over 1100 DTI scans, and used the results to threshold FA images from new studies. ...
Here, we developed a method to compute and boost power to detect genetic associations in brain images. ...
Here, we show that meta-analyzed heritability estimates are useful for genetic studies on the entire image space. ...
doi:10.1007/978-3-319-02475-2_21
fatcat:4enknzpfizddxi5q7cwbn3uxxa
Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling
2014
NeuroImage
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. ...
There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. ...
Data collection for the Bipolar Family Study was supported by an Academy of Medical Sciences/Health Foundation Clinician Scientist Fellowship to AMM. ...
doi:10.1016/j.neuroimage.2014.03.033
pmid:24657781
pmcid:PMC4043878
fatcat:mxe7lkp2hfdyrdmcgzzhdbh3zm
Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group
2013
NeuroImage
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2016; you can also visit the original URL.
The file type is application/pdf.
DTI measures, such as the fractional anisotropy (FA) of water diffusion, may be useful for identifying genetic variants that influence brain microstructure. ...
Diffusion tensor imaging (DTI) yields quantitative measures sensitive to brain development and degeneration, and some common genetic variants may be associated with white matter integrity or connectivity ...
large genome-wide association studies (GWAS)especially metaanalyses of multiple studiesto uncover genetic loci associated with MRI-based phenotypes including hippocampal volumes Stein et al., 2012) , ...
doi:10.1016/j.neuroimage.2013.04.061
pmid:23629049
pmcid:PMC3729717
fatcat:j4q3mc76wzbazexgmsz7xybx3a
Extending Genetic Linkage Analysis to Diffusion Tensor Images to Map Single Gene Effects on Brain Fiber Architecture
[chapter]
2009
Lecture Notes in Computer Science
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
We extended genetic linkage analysis -an analysis widely used in quantitati ve genetics -to 3D images to analyze single gene effects on brain fiber architecture. ...
After highdimensional fluid registration, at each voxel we estimated the genetic linkage between the single nucleotide polymorphism (SNP), Val66Met (dbSNP number rs6265), of the BDNF gene (brain-derived ...
We used the FMRIB software library (FSL, http://www.fmrib.ox. ac.uk/fsl/) for initial pre-processing of the diffusion images. ...
doi:10.1007/978-3-642-04271-3_62
fatcat:xycyxdhakjao7mjdybywwm6ryu
Heritability of brain network topology in 853 twins and siblings
2015
2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2016; you can also visit the original URL.
The file type is application/pdf.
Some global network measures (probtrackx-derived GLOB and ST) showed significant genetic effects, making them attractive targets for genome-wide association studies. ...
Genetic analysis of these networks may help identify processes giving rise to heritable brain disorders, but we do not yet know which network measures are promising for genetic analyses. ...
Bedpostx stands for Bayesian Estimation of Diffusion Parameters Obtained using Sampling Techniques [15] . In our study, up to 3 fibers were modeled per voxel. ...
doi:10.1109/isbi.2015.7163908
pmid:26413204
pmcid:PMC4578220
dblp:conf/isbi/ZhanJFZPMZMWT15
fatcat:4jmwwba7svbn3fz5mx7hhi6zya
Hierarchical clustering of the genetic connectivity matrix reveals the network topology of gene action on brain microstructure: An N=531 twin study
2011
2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2012; you can also visit the original URL.
The file type is application/pdf.
In an analysis of 4 Tesla diffusion tensor images (DTI) from 531 healthy young adult twins and their siblings, we generalized the concept of genetic correlation to determine common genetic influences on ...
We applied genome-wide association (GWA) to assess associations between 529,497 SNPs and FA in clusters defined by hubs of the clustered genetic correlation matrix. ...
Recently, voxel-based searches have been performed, for genetic markers that correlate with image-derived measures at each voxel in the brain (e.g., vGWAS [1] ). ...
doi:10.1109/isbi.2011.5872533
dblp:conf/isbi/ChiangBMZJMTWT11
fatcat:76ocferydza6hgozvhl6ewvria
Scalar connectivity measures from fast-marching tractography reveal heritability of white matter architecture
2010
2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2011; you can also visit the original URL.
The file type is application/pdf.
Recent advances in diffusion-weighted MRI (DWI) have enabled studies of complex white matter tissue architecture in vivo. ...
We then calculate connectivity maps for a DTI dataset from 92 healthy adult twins and decompose the genetic and environmental contributions to the variance in these metrics using structural equation models ...
The diffusion tensor (DT) model estimates a single Gaussian diffusion profile at each voxel [1] . ...
doi:10.1109/isbi.2010.5490187
dblp:conf/isbi/PatelCTMZMWT10
fatcat:urz2yvtlenhuroxes7i7rxtk2u
Genetics of Path Lengths in Brain Connectivity Networks: HARDI-Based Maps in 457 Adults
[chapter]
2012
Lecture Notes in Computer Science
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
We defined a new measure, based on Dijkstra's algorithm, to compute path lengths for tracts connecting pairs of cortical regions. ...
Brain connectivity analyses are increasingly popular for investigating organization. ...
Additional support for algorithm development was provided by NIH R01 grants EB008432, EB008281, and EB007813. ...
doi:10.1007/978-3-642-33530-3_3
pmid:25584366
pmcid:PMC4288784
fatcat:tk4hg5uzjzh2zf46jprizdsxfm
Voxelwise gene-wide association study (vGeneWAS): Multivariate gene-based association testing in 731 elderly subjects
2011
NeuroImage
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Imaging traits provide a powerful and biologically relevant substrate to examine the influence of genetics on the brain. ...
This multivariate, gene-based voxelwise association study offers a novel framework to detect genetic influences on the brain. ...
Acknowledgments Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904, 3U01AG024904-03S5). ...
doi:10.1016/j.neuroimage.2011.03.077
pmid:21497199
pmcid:PMC3366726
fatcat:plqqxysutvgbjn3ue3prfgk7gi
Whole-genome analyses of whole-brain data: working within an expanded search space
2014
Nature Neuroscience
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
With the advent of global neuroimaging consortia, imaging studies are now well powered to discover genetic variants that reliably affect the brain. ...
Meanwhile, brain imaging studies are increasing in size and scope, revealing disease and genetic effects on brain structure and function, and implicating neural pathways and causal mechanisms. ...
The power to identify a given genetic effect, at a given voxel, can be determined if we can estimate the proportion of variance in the signal at that voxel due to the variant. ...
doi:10.1038/nn.3718
pmid:24866045
pmcid:PMC4300949
fatcat:ililaltty5d2rmtzgxsnlryuzi
Comparison of fractional and geodesic anisotropy in diffusion tensor images of 90 monozygotic and dizygotic twins
2008
2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
We used diffusion tensor magnetic resonance imaging (DTI) to reveal the extent of genetic effects on brain fiber microstructure, based on tensor-derived measures, in 22 pairs of monozygotic (MZ) twins ...
While maps were relatively noisy, the CDFs showed promise for detecting genetic influences on brain fiber integrity as the current sample expands. ...
Figure 4 4 shows non-parametric permutation based p-values at each voxel, based on r values for tGA and FA for MZ and DZ groups. ...
doi:10.1109/isbi.2008.4541153
pmid:30546820
pmcid:PMC6289524
fatcat:h2oxnppaxnguhk3snfkddyswg4
Genetics of the connectome
2013
NeuroImage
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Here we review a variety of genetic analysis methods--such as genome-wide association studies (GWAS), linkage and candidate gene studies--that have been fruitfully adapted to imaging data to implicate ...
We also review some consortium efforts, such as ENIGMA, that offer the power to detect robust common genetic associations using phenotypic harmonization procedures and meta-analysis. ...
By grouping SNPs based on gene membership, a voxel-wise gene-wide association study (vGeneWAS) was carried out, using the same imaging and genetic data as in vGWAS Stein et al., 2010a) showed increased ...
doi:10.1016/j.neuroimage.2013.05.013
pmid:23707675
pmcid:PMC3905600
fatcat:dv26qigaovc4vdpm6jkealvoly
A multivariate to multivariate approach for voxel-wise genome-wide association analysis
[article]
2021
bioRxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
., a set of SNPs highly correlated with a cluster of voxels) for the systematic association pattern. ...
We attempt to identify underlying organized association patterns of SNP-voxel pairs and understand the polygenic and pleiotropic networks on brain imaging traits. ...
We tested the imaging-genetic associations between SNPs across 22 chromosomes and voxel-level imaging traits using our proposed method. ...
doi:10.1101/2021.11.02.467021
fatcat:nj232szeq5cfvbvh3oylkutare
Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
2015
NeuroImage
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis ...
We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, ...
The HCP diffusion imaging data differs from those used in previous ENIGMA-DTI studies in several important ways, including higher spatial resolution (1.25 mm isotropic voxels vs. 2-3 mm for ENIGMA-DTI ...
doi:10.1016/j.neuroimage.2015.02.050
pmid:25747917
pmcid:PMC4387079
fatcat:s4lpvm3wozd27fdqjc36aewfoe
Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data
2019
Frontiers in Neuroinformatics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable to additive genetic factors. ...
We tested the agreement between heritability estimates provided by four methods that are used for heritability estimates in neuroimaging traits. ...
Imaging genetic studies combine methods from both imaging and genetic disciplines. ...
doi:10.3389/fninf.2019.00016
pmid:30914942
pmcid:PMC6422938
fatcat:zo5ci45nwra7jcwcvthim5xury
« Previous
Showing results 1 — 15 out of 7,644 results