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Pore Structure and Synergy in Antimicrobial Peptides of the Magainin Family
2016
PLoS Computational Biology
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Pore Structure and Synergy in Magainins PLOS Computational Biology | ...
Magainin 2 and PGLa are among the best-studied cationic antimicrobial peptides. ...
Acknowledgments Anton computer time was provided by the National Center for Multiscale Modeling of Biological Systems (MMBioS) through grant P41GM103712-S1 from the National Institutes of Health and the ...
doi:10.1371/journal.pcbi.1004570
pmid:26727376
pmcid:PMC4699650
fatcat:efasdudyzbgfna3yel2ekr4wwa
Synergy and duality in peptide antibiotic mechanisms
1999
Current Opinion in Chemical Biology
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and duality in peptide antibiotic mechanisms ...
EF elongation factor Lipid I undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide Lipid II undecaprenyl-pyrophosphoryl-MurNAc-(GlcNAc)pentapeptide PBP penicillin-binding protein PE phosphatidylethanolamine Synergy ...
Acknowledgements The authors wish to thank Scott Walsh and Carolina Monroy for their assistance in preparation of this manuscript. ...
doi:10.1016/s1367-5931(99)00025-3
pmid:10600730
fatcat:icver3bg3fbcrfpvifqgaqrnru
Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides
2020
Frontiers in Medical Technology
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The study of peptide-lipid and peptide-peptide interactions as well as their topology and dynamics using biophysical and structural approaches have changed our view how antimicrobial peptides work and ...
Interestingly, mixtures of two of those peptides namely magainin 2 and PGLa which occur naturally as a cocktail in the frog skin exhibit synergistic enhancement of antimicrobial activities when investigated ...
AUTHOR CONTRIBUTIONS EG and DJ performed experiments. BB wrote the manuscript. All authors contributed to writing the manuscript and in the preparation of Figures. ...
doi:10.3389/fmedt.2020.615494
pmid:35047895
pmcid:PMC8757784
fatcat:cg5bybebb5f6zfwpa4s7wpvdyy
Solution NMR studies of amphibian antimicrobial peptides: Linking structure to function?
2009
Biochimica et Biophysica Acta - Biomembranes
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In this work, we present the first NMR solution structure of a hybrid peptide composed of magainin 2 and PGLa bound to SDS and DPC micelles. ...
In some cases the amphipathic AAMP structures are directly membraneperturbing (e.g. magainin, aurein and the rana-box peptides), in other instances the peptide spontaneously passes through the membrane ...
Acknowledgements The Bio-NMR Centre at the University of Calgary received funding from the Canadian Institute of Health Research. ...
doi:10.1016/j.bbamem.2009.01.002
pmid:19272309
fatcat:eccr3vtbbrbqpefub6hcyd6ua4
Structure Activity Relationship for a Synergistic Pair of Antimicrobial Peptides from the Magainin Family
2014
Biophysical Journal
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a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S. ...
Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis. ...
doi:10.1016/j.bpj.2013.11.1716
fatcat:ye75a5jhwjayzp4cdbfzedae6i
Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR
2009
Biochimica et Biophysica Acta - Biomembranes
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The two antimicrobial peptides PGLa and magainin 2, isolated from the African frog Xenopus laevis, have been shown to act synergistically by permeabilizing the membranes of microorganisms. ...
The skin secretions of amphibians are a rich source of antimicrobial peptides. ...
Acknowledgements We thank all past and present members of the group of Anne Ulrich who has contributed to the work reviewed in this paper, and acknowledge the DFG-CFN (E1.2) for the NMR infrastructure. ...
doi:10.1016/j.bbamem.2008.12.018
pmid:19272296
fatcat:u3rplmchqrb6vn5wno7tbbdfc4
Antimicrobial Peptides: An Emerging Concept in Cutaneous Biology
1998
Journal of Investigative Dermatology
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Antimicrobial peptides are part of the host defense systems of plants, insects, fish, amphibia, birds, and mammals. ...
The presence of these peptides in the skin forms a barrier for innate host protection against microbial pathogenesis. Furthermore, antimicrobial peptides also act on animal cells by stimulating ...
The authors would like to acknowledge the assistance of Nitu Mahendru in preparation of this manuscript. ...
doi:10.1046/j.1523-1747.1998.00361.x
pmid:9804331
fatcat:ykpj4xbc3jcjhc7hvz3c3kqzmy
Computational studies of peptide-induced membrane pore formation
2017
Philosophical Transactions of the Royal Society of London. Biological Sciences
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Subject Areas: biophysics, computational biology A variety of peptides induce pores in biological membranes; the most common ones are naturally produced antimicrobial peptides (AMPs), which are small, ...
Because it is not possible to observe these pores directly on a molecular scale, the structure of AMP-induced pores and the exact sequence of steps leading to their formation remain uncertain. ...
This work also provided insights into the synergy between these two magainin-family peptides: more transmembrane orientations, stronger interactions, and a larger and more ordered pore were seen in the ...
doi:10.1098/rstb.2016.0219
pmid:28630158
pmcid:PMC5483521
fatcat:4xasj6qbaba5fdr77fvuedbucy
Lycotoxins, Antimicrobial Peptides from Venom of the Wolf SpiderLycosa carolinensis
1998
Journal of Biological Chemistry
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The predicted secondary structures of the lycotoxins display amphipathic ␣-helix character typical of antimicrobial pore-forming peptides. ...
Two peptide toxins with antimicrobial activity, lycotoxins I and II, were identified from venom of the wolf spider Lycosa carolinensis (Araneae: Lycosidae) by virtue of their abilities to reduce ion and ...
Since magainin B belongs to a well established family of pore-forming peptides (41, 43) , we believe that the lycotoxins permeabilize cell membranes through similar mechanisms. ...
doi:10.1074/jbc.273.4.2059
pmid:9442044
fatcat:6pizi4mdf5h6tamihk5axjqnua
Screening the Insertion of Families of Bioactive Microbial Metabolites into Tethered Bilayer Lipid Membranes (TBLMS)
2014
Biophysical Journal
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a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S. ...
Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis. ...
doi:10.1016/j.bpj.2013.11.1714
fatcat:tcfwpijvzzgx7cqlnk52oo6dxy
Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo
2018
Biomolecules
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In this review, we discuss the diversity, history and the various mechanisms of action of AMPs. ...
Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance. ...
(NSERC) and Canadian Institutes of Health Research (CIHR), in the form of CHRP funding, Canada Foundation of Innovation (CFI) and the British Columbia Knowledge Development Fund (BCKDF). ...
doi:10.3390/biom8010004
pmid:29351202
pmcid:PMC5871973
fatcat:atczldzlnjcsxaqhvxujr4kb5q
Destabilization of α-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets
2016
Antimicrobial Agents and Chemotherapy
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We show here that the formulation of peptides LL37 and magainin-2B amide in polysorbate 20 (Tween 20) results in greater reductions in virus titer than formulation without detergent, and the effect is ...
ABSTRACTWe have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus. ...
ACKNOWLEDGMENTS We have no conflicts of interest with the contents of this article. Purchase of the CD instrument was partially funded by a BBSRC grant 75/REI18433. ...
doi:10.1128/aac.02146-15
pmid:26824944
pmcid:PMC4808201
fatcat:eiwcwoxa2vdlrkqgk5ujugpe4q
Synergistic Insertion of Antimicrobial Magainin-Family Peptides in Membranes Depends on the Lipid Spontaneous Curvature
2013
Biophysical Journal
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PGLa and magainin 2 (MAG2) are amphiphilic antimicrobial peptides from frog skin with known synergistic activity. ...
The orientation of the two helices in membranes was studied using solid-state 15 N-NMR, for each peptide alone and for a 1:1 mixture of the peptides, in a range of different lipid systems. ...
The two antimicrobial peptides PGLa and magainin 2 (MAG2) from the African frog Xenopus laevis, which are active against Gram-positive and Gram-negative bacteria, show intriguing synergistic effects that ...
doi:10.1016/j.bpj.2013.01.047
pmid:23528099
pmcid:PMC3602749
fatcat:6gbf7ajr7vdhjbbhfoxz2vvwzy
NMR Characterization of Spider Venom Neurotoxin Structure and Interactions with Lipid Bilayers
2014
Biophysical Journal
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a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S. ...
Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis. ...
doi:10.1016/j.bpj.2013.11.1715
fatcat:d5zwa7ywlbbj7nw3crrril5ab4
Redistribution of Cholesterol in Model Lipid Membranes in Response to Alamethicin
2014
Biophysical Journal
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a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S. ...
Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis. ...
doi:10.1016/j.bpj.2013.11.1713
fatcat:hyd26oyqsrcathlsecoj6etw7m
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