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Pore Structure and Synergy in Antimicrobial Peptides of the Magainin Family

Almudena Pino-Angeles, John M. Leveritt, Themis Lazaridis, Emad Tajkhorshid
2016 PLoS Computational Biology  
Pore Structure and Synergy in Magainins PLOS Computational Biology |  ...  Magainin 2 and PGLa are among the best-studied cationic antimicrobial peptides.  ...  Acknowledgments Anton computer time was provided by the National Center for Multiscale Modeling of Biological Systems (MMBioS) through grant P41GM103712-S1 from the National Institutes of Health and the  ... 
doi:10.1371/journal.pcbi.1004570 pmid:26727376 pmcid:PMC4699650 fatcat:efasdudyzbgfna3yel2ekr4wwa

Synergy and duality in peptide antibiotic mechanisms

Dewey G McCafferty, Predrag Cudic, Michael K Yu, Douglas C Behenna, Ryan Kruger
1999 Current Opinion in Chemical Biology  
and duality in peptide antibiotic mechanisms  ...  EF elongation factor Lipid I undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide Lipid II undecaprenyl-pyrophosphoryl-MurNAc-(GlcNAc)pentapeptide PBP penicillin-binding protein PE phosphatidylethanolamine Synergy  ...  Acknowledgements The authors wish to thank Scott Walsh and Carolina Monroy for their assistance in preparation of this manuscript.  ... 
doi:10.1016/s1367-5931(99)00025-3 pmid:10600730 fatcat:icver3bg3fbcrfpvifqgaqrnru

Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides

Burkhard Bechinger, Dennis Wilkens Juhl, Elise Glattard, Christopher Aisenbrey
2020 Frontiers in Medical Technology  
The study of peptide-lipid and peptide-peptide interactions as well as their topology and dynamics using biophysical and structural approaches have changed our view how antimicrobial peptides work and  ...  Interestingly, mixtures of two of those peptides namely magainin 2 and PGLa which occur naturally as a cocktail in the frog skin exhibit synergistic enhancement of antimicrobial activities when investigated  ...  AUTHOR CONTRIBUTIONS EG and DJ performed experiments. BB wrote the manuscript. All authors contributed to writing the manuscript and in the preparation of Figures.  ... 
doi:10.3389/fmedt.2020.615494 pmid:35047895 pmcid:PMC8757784 fatcat:cg5bybebb5f6zfwpa4s7wpvdyy

Solution NMR studies of amphibian antimicrobial peptides: Linking structure to function?

Evan F. Haney, Howard N. Hunter, Katsumi Matsuzaki, Hans J. Vogel
2009 Biochimica et Biophysica Acta - Biomembranes  
In this work, we present the first NMR solution structure of a hybrid peptide composed of magainin 2 and PGLa bound to SDS and DPC micelles.  ...  In some cases the amphipathic AAMP structures are directly membraneperturbing (e.g. magainin, aurein and the rana-box peptides), in other instances the peptide spontaneously passes through the membrane  ...  Acknowledgements The Bio-NMR Centre at the University of Calgary received funding from the Canadian Institute of Health Research.  ... 
doi:10.1016/j.bbamem.2009.01.002 pmid:19272309 fatcat:eccr3vtbbrbqpefub6hcyd6ua4

Structure Activity Relationship for a Synergistic Pair of Antimicrobial Peptides from the Magainin Family

Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S. Ulrich
2014 Biophysical Journal  
a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S.  ...  Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis.  ... 
doi:10.1016/j.bpj.2013.11.1716 fatcat:ye75a5jhwjayzp4cdbfzedae6i

Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR

Erik Strandberg, Pierre Tremouilhac, Parvesh Wadhwani, Anne S. Ulrich
2009 Biochimica et Biophysica Acta - Biomembranes  
The two antimicrobial peptides PGLa and magainin 2, isolated from the African frog Xenopus laevis, have been shown to act synergistically by permeabilizing the membranes of microorganisms.  ...  The skin secretions of amphibians are a rich source of antimicrobial peptides.  ...  Acknowledgements We thank all past and present members of the group of Anne Ulrich who has contributed to the work reviewed in this paper, and acknowledge the DFG-CFN (E1.2) for the NMR infrastructure.  ... 
doi:10.1016/j.bbamem.2008.12.018 pmid:19272296 fatcat:u3rplmchqrb6vn5wno7tbbdfc4

Antimicrobial Peptides: An Emerging Concept in Cutaneous Biology

Richard L. Gallo, Kenneth M. Huttner
1998 Journal of Investigative Dermatology  
Antimicrobial peptides are part of the host defense systems of plants, insects, fish, amphibia, birds, and mammals.  ...  The presence of these peptides in the skin forms a barrier for innate host protection against microbial pathogenesis. Furthermore, antimicrobial peptides also act on animal cells by stimulating  ...  The authors would like to acknowledge the assistance of Nitu Mahendru in preparation of this manuscript.  ... 
doi:10.1046/j.1523-1747.1998.00361.x pmid:9804331 fatcat:ykpj4xbc3jcjhc7hvz3c3kqzmy

Computational studies of peptide-induced membrane pore formation

Richard Lipkin, Themis Lazaridis
2017 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Subject Areas: biophysics, computational biology A variety of peptides induce pores in biological membranes; the most common ones are naturally produced antimicrobial peptides (AMPs), which are small,  ...  Because it is not possible to observe these pores directly on a molecular scale, the structure of AMP-induced pores and the exact sequence of steps leading to their formation remain uncertain.  ...  This work also provided insights into the synergy between these two magainin-family peptides: more transmembrane orientations, stronger interactions, and a larger and more ordered pore were seen in the  ... 
doi:10.1098/rstb.2016.0219 pmid:28630158 pmcid:PMC5483521 fatcat:4xasj6qbaba5fdr77fvuedbucy

Lycotoxins, Antimicrobial Peptides from Venom of the Wolf SpiderLycosa carolinensis

Lizhen Yan, Michael E. Adams
1998 Journal of Biological Chemistry  
The predicted secondary structures of the lycotoxins display amphipathic ␣-helix character typical of antimicrobial pore-forming peptides.  ...  Two peptide toxins with antimicrobial activity, lycotoxins I and II, were identified from venom of the wolf spider Lycosa carolinensis (Araneae: Lycosidae) by virtue of their abilities to reduce ion and  ...  Since magainin B belongs to a well established family of pore-forming peptides (41, 43) , we believe that the lycotoxins permeabilize cell membranes through similar mechanisms.  ... 
doi:10.1074/jbc.273.4.2059 pmid:9442044 fatcat:6pizi4mdf5h6tamihk5axjqnua

Screening the Insertion of Families of Bioactive Microbial Metabolites into Tethered Bilayer Lipid Membranes (TBLMS)

Charles G. Cranfield, Sonia Carne, Heba Alkhamici, Paul Duckworth, Ernest Lacey, Boris Martinac, Bruce Cornell
2014 Biophysical Journal  
a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S.  ...  Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis.  ... 
doi:10.1016/j.bpj.2013.11.1714 fatcat:tcfwpijvzzgx7cqlnk52oo6dxy

Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo

Prashant Kumar, Jayachandran Kizhakkedathu, Suzana Straus
2018 Biomolecules  
In this review, we discuss the diversity, history and the various mechanisms of action of AMPs.  ...  Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance.  ...  (NSERC) and Canadian Institutes of Health Research (CIHR), in the form of CHRP funding, Canada Foundation of Innovation (CFI) and the British Columbia Knowledge Development Fund (BCKDF).  ... 
doi:10.3390/biom8010004 pmid:29351202 pmcid:PMC5871973 fatcat:atczldzlnjcsxaqhvxujr4kb5q

Destabilization of α-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets

David O. Ulaeto, Christopher J. Morris, Marc A. Fox, Mark Gumbleton, Konrad Beck
2016 Antimicrobial Agents and Chemotherapy  
We show here that the formulation of peptides LL37 and magainin-2B amide in polysorbate 20 (Tween 20) results in greater reductions in virus titer than formulation without detergent, and the effect is  ...  ABSTRACTWe have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus.  ...  ACKNOWLEDGMENTS We have no conflicts of interest with the contents of this article. Purchase of the CD instrument was partially funded by a BBSRC grant 75/REI18433.  ... 
doi:10.1128/aac.02146-15 pmid:26824944 pmcid:PMC4808201 fatcat:eiwcwoxa2vdlrkqgk5ujugpe4q

Synergistic Insertion of Antimicrobial Magainin-Family Peptides in Membranes Depends on the Lipid Spontaneous Curvature

Erik Strandberg, Jonathan Zerweck, Parvesh Wadhwani, Anne S. Ulrich
2013 Biophysical Journal  
PGLa and magainin 2 (MAG2) are amphiphilic antimicrobial peptides from frog skin with known synergistic activity.  ...  The orientation of the two helices in membranes was studied using solid-state 15 N-NMR, for each peptide alone and for a 1:1 mixture of the peptides, in a range of different lipid systems.  ...  The two antimicrobial peptides PGLa and magainin 2 (MAG2) from the African frog Xenopus laevis, which are active against Gram-positive and Gram-negative bacteria, show intriguing synergistic effects that  ... 
doi:10.1016/j.bpj.2013.01.047 pmid:23528099 pmcid:PMC3602749 fatcat:6gbf7ajr7vdhjbbhfoxz2vvwzy

NMR Characterization of Spider Venom Neurotoxin Structure and Interactions with Lipid Bilayers

Xiangyan Shi, Chengchen Guo, Gregory P. Holland
2014 Biophysical Journal  
a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S.  ...  Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis.  ... 
doi:10.1016/j.bpj.2013.11.1715 fatcat:d5zwa7ywlbbj7nw3crrril5ab4

Redistribution of Cholesterol in Model Lipid Membranes in Response to Alamethicin

Shuo Qian, William T. Heller
2014 Biophysical Journal  
a Synergistic Pair of Antimicrobial Peptides from the Magainin Family Jonathan Zerweck, Erik Strandberg, Parvesh Wadhwani, Anne S.  ...  Karlsruhe Institute of Technology, Karlsruhe, Germany. The antimicrobial peptides Magainin 2 (Mag2) and PGLa are both found in the skin of the African frog Xenopus laevis.  ... 
doi:10.1016/j.bpj.2013.11.1713 fatcat:hyd26oyqsrcathlsecoj6etw7m
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