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PockDrug-Server: a new web server for predicting pocket druggability on holo and apo proteins

Hiba Abi Hussein, Alexandre Borrel, Colette Geneix, Michel Petitjean, Leslie Regad, Anne-Claude Camproux
2015 Nucleic Acids Research  
Currently computational druggability prediction models are attached to one unique pocket estimation method despite pocket estimation uncertainties.  ...  It clearly distinguishes druggable from less druggable pockets using different estimation methods and outperformed recent druggability models for apo pockets.  ...  This confirms PockDrug model ability to overcome the pocket estimation uncertainties to predict pocket druggability.  ... 
doi:10.1093/nar/gkv462 pmid:25956651 pmcid:PMC4489252 fatcat:36ovg3id5jdptafmu4eshjmbay