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NCUEE at MEDIQA 2019: Medical Text Inference Using Ensemble BERT-BiLSTM-Attention Model

Lung-Hao Lee, Yi Lu, Po-Han Chen, Po-Lei Lee, Kuo-Kai Shyu
2019 Proceedings of the 18th BioNLP Workshop and Shared Task  
We also used pre-trained weights of BioBERT (Lee et al., 2019) , a language representation model for the biomedical domain and publicly available at the GitHub site 2 .  ... 
doi:10.18653/v1/w19-5058 dblp:conf/bionlp/LeeLCLS19 fatcat:aoytojqr4remlflj4ux7i3xdsu

The perception of pain in others suppresses somatosensory oscillations: A magnetoencephalography study

Yawei Cheng, Chia-Yen Yang, Ching-Po Lin, Po-Lei Lee, Jean Decety
2008 NeuroImage  
oscillation can be related to an idling state of a system whereas reduced amplitudes can be associated with activation of the system (Hari and Salmelin, 1997; Niedermeyer, 1999; Pfurtscheller, 1999; Lee  ... 
doi:10.1016/j.neuroimage.2008.01.064 pmid:18353686 fatcat:botuh773p5hwndjiqyf7y7aw6e

Gender Differences in the Mu Rhythm of the Human Mirror-Neuron System

Yawei Cheng, Po-Lei Lee, Chia-Yen Yang, Ching-Po Lin, Daisy Hung, Jean Decety, Aldo Rustichini
2008 PLoS ONE  
Acknowledgments We thank Shin-Yi Lee for the help of data acquisition and Chi-Hsun Wu and Shyan-Shiou Chen for the help of the stimulus preparation. Author Contributions  ... 
doi:10.1371/journal.pone.0002113 pmid:18461176 pmcid:PMC2361218 fatcat:qu332tvyrnczlcyfp5gkdnfhn4

Taiwan's Ecological Footprint, 2012-2018

Yung-Jaan Lee, Po-Shu Wu, Lei Chai, R. Weerasinghe, C. Fang
2021 E3S Web of Conferences  
Taiwan's EF accounts are mainly conducted by Lee and his colleagues [3] [4] [5] 11] .  ...  Lee [3] adopted a local-scale approach to analyze Taiwan's EF at the county and city level.  ... 
doi:10.1051/e3sconf/202123704039 fatcat:qokratern5cc7jmplonfj5jfsm

Neuromagnetic Index of Hemispheric Asymmetry Prognosticating the Outcome of Sudden Hearing Loss

Lieber Po-Hung Li, An-Suey Shiao, Kuang-Chao Chen, Po-Lei Lee, David M. Niddam, Shyue-Yih Chang, Jen-Chuen Hsieh, Yu-Feng Zang
2012 PLoS ONE  
The longitudinal relationship between central plastic changes and clinical presentations of peripheral hearing impairment remains unknown. Previously, we reported a unique plastic pattern of "healthy-side dominance" in acute unilateral idiopathic sudden sensorineural hearing loss (ISSNHL). This study aimed to explore whether such hemispheric asymmetry bears any prognostic relevance to ISSNHL along the disease course. Using magnetoencephalography (MEG), interhemispheric differences in peak
more » ... amplitude and latency of N100m to monaural tones were evaluated in 21 controls and 21 ISSNHL patients at two stages: initial and fixed stage (1 month later). Dynamics/Prognostication of hemispheric asymmetry were assessed by the interplay between hearing level/hearing gain and ipsilateral/contralateral ratio (I/C) of N100m latency and amplitude. Healthy-side dominance of N100m amplitude was observed in ISSNHL initially. The pattern changed with disease process. There is a strong correlation between the hearing level at the fixed stage and initial I/ C amplitude on affected-ear stimulation in ISSNHL. The optimal cut-off value with the best prognostication effect for the hearing improvement at the fixed stage was an initial I/C latency on affected-ear stimulation of 1.34 (between subgroups of complete and partial recovery) and an initial I/C latency on healthy-ear stimulation of 0.76 (between subgroups of partial and no recovery), respectively. This study suggested that a dynamic process of central auditory plasticity can be induced by peripheral lesions. The hemispheric asymmetry at the initial stage bears an excellent prognostic potential for the treatment outcomes and hearing level at the fixed stage in ISSNHL. Our study demonstrated that such brain signature of central auditory plasticity in terms of both N100m latency and amplitude at defined time can serve as a prognostication predictor for ISSNHL. Further studies are needed to explore the long-term temporal scenario of auditory hemispheric asymmetry and to get better psychoacoustic correlates of pathological hemispheric asymmetry in ISSNHL.
doi:10.1371/journal.pone.0035055 pmid:22532839 pmcid:PMC3332152 fatcat:ezw6oqv7krgdbcpv74zajhj6qm

Orthographic and phonological processing of Chinese characters: an fMRI study

Wen-Jui Kuo, Tzu-Chen Yeh, Jun-Ren Lee, Li-Fen Chen, Po-Lei Lee, Shyan-Shiou Chen, Low-Tone Ho, Daisy L Hung, Ovid J.-L Tzeng, Jen-Chuen Hsieh
2004 NeuroImage  
The present study used functional magnetic resonance imaging (fMRI) to investigate the neural mechanisms underlying the orthographic and phonological processing of Chinese characters. Four tasks were devised, including one homophone judgment and three physical judgments of characters, pseudo-characters, and Korean-like nonsense figures. While the left occipitotemporal region, left dorsal processing stream, and right middle frontal gyrus constitute a network for orthographic processing, the left
more » ... premotor gyrus, left middle/inferior frontal gyrus, supplementary motor area (SMA), and the left temporoparietal region work in concert for phonological processing. The ventral part of the left inferior frontal cortex responds specifically to the character stimuli, suggesting a general lexical processing role for this region for linguistic material. The stronger activation of the dorsal visual stream by Chinese homophone judgment pinpoints a tight coupling between phonological representation of Chinese characters and corresponding orthographic percepts. The concomitant engagement of sets of regions for different levels of Chinese orthographic and phonological processing is consistent with the notion of distributed parallel processing. D
doi:10.1016/j.neuroimage.2003.12.007 pmid:15050593 fatcat:4phkzhgc3zajre5nikvfxvgyfe

Is deck B a disadvantageous deck in the Iowa Gambling Task?

Ching-Hung Lin, Yao-Chu Chiu, Po-Lei Lee, Jen-Chuen Hsieh
2007 Behavioral and Brain Functions  
The Iowa gambling task is a popular test for examining monetary decision behavior under uncertainty. According to Dunn et al. review article, the difficult-to-explain phenomenon of "prominent deck B" was revealed, namely that normal decision makers prefer bad final-outcome deck B to good final-outcome decks C or D. This phenomenon was demonstrated especially clearly by Wilder et al. and Toplak et al. The "prominent deck B" phenomenon is inconsistent with the basic assumption in the IGT;
more » ... most IGT-related studies utilized the "summation" of bad decks A and B when presenting their data, thereby avoiding the problems associated with deck B. Methods: To verify the "prominent deck B" phenomenon, this study launched a two-stage simple version IGT, namely, an AACC and BBDD version, which possesses a balanced gain-loss structure between advantageous and disadvantageous decks and facilitates monitoring of participant preferences after the first 100 trials. Results: The experimental results suggested that the "prominent deck B" phenomenon exists in the IGT. Moreover, participants cannot suppress their preference for deck B under the uncertain condition, even during the second stage of the game. Although this result is incongruent with the basic assumption in IGT, an increasing number of studies are finding similar results. The results of the AACC and BBDD versions can be congruent with the decision literatures in terms of gain-loss frequency. Conclusion: Based on the experimental findings, participants can apply the "gain-stay, loss-shift" strategy to overcome situations involving uncertainty. This investigation found that the largest loss in the IGT did not inspire decision makers to avoid choosing bad deck B.
doi:10.1186/1744-9081-3-16 pmid:17362508 pmcid:PMC1839101 fatcat:enj2mvsapjb25bpp7joejiztoy

Post-routing redundant via insertion with wire spreading capability

Cheok-Kei Lei, Po-Yi Chiang, Yu-Min Lee
2009 2009 Asia and South Pacific Design Automation Conference  
Lee et. al. [7] formulated the redundant via insertion problem as a maximum independent set (MIS) problem in the post-routing stage.  ... 
doi:10.1109/aspdac.2009.4796524 dblp:conf/aspdac/LeiCL09 fatcat:uhqukozqlfg3rg3f4yh4uts7dm

Supplementary – Supplemental material for β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke

Chih-Wei Tang, Fu-Jung Hsiao, Po-Lei Lee, Yun-An Tsai, Ya-Fang Hsu, Wei-Ta Chen, Yung-Yang Lin, Charlotte J. Stagg, I-Hui Lee
2020 Figshare  
Supplemental material, Supplementary for β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke by Chih-Wei Tang, Fu-Jung Hsiao, Po-Lei Lee, Yun-An Tsai, Ya-Fang Hsu, Wei-Ta Chen,  ...  Stagg and I-Hui Lee in Neurorehabilitation and Neural Repair  ... 
doi:10.25384/sage.12191379.v1 fatcat:oiqml5nxy5c3pphgdycd4xg4tm

Study of Repetitive Movements Induced Oscillatory Activities in Healthy Subjects and Chronic Stroke Patients

Chuan-Chih Hsu, Wai-Keung Lee, Kuo-Kai Shyu, Hsiao-Huang Chang, Ting-Kuang Yeh, Hao-Teng Hsu, Chun-Yen Chang, Gong-Yau Lan, Po-Lei Lee
2016 Scientific Reports  
Repetitive movements at a constant rate require the integration of internal time counting and motor neural networks. Previous studies have proved that humans can follow short durations automatically (automatic timing) but require more cognitive efforts to track or estimate long durations. In this study, we studied sensorimotor oscillatory activities in healthy subjects and chronic stroke patients when subjects were performing repetitive finger movements. We found the movement-modulated changes
more » ... n alpha and beta oscillatory activities were decreased with the increase of movement rates in finger lifting of healthy subjects and the non-paretic hands in stroke patients, whereas no difference was found in the paretic-hand movements at different movement rates in stroke patients. The significant difference in oscillatory activities between movements of non-paretic hands and paretic hands could imply the requirement of higher cognitive efforts to perform fast repetitive movements in paretic hands. The sensorimotor oscillatory response in fast repetitive movements could be a possible indicator to probe the recovery of motor function in stroke patients. Timing in the brain has its important role in many aspects, such as speech perception, speech production, reading, attention, memory, cognitive processing, decision-making, and motor coordination 1 . Especially, internal time counting is crucial for motor control in our daily life activities. The processing of time estimation for movements has been studied in many literatures 2 . Morillon et al. postulated the time estimation in human motor system as a dual system, which can track a short duration automatically (automatic timing) but requires more cognitive demands to track a long duration by a so-called default mode network (DMN) 3 . Poppel E. studied the capability of time estimation in a stimulus reproduction task from 0.5 s to 7 s, and found movements become temporally irregular for inter-movement interval (IMI) above 3 s which indicated precisely control of movements with IMIs longer than 3 s is not possible 4 . Though these literatures have shown great difference between movements in short and long durations in healthy subjects, nevertheless, the study of brain responses induced by rapid movements in patients with motor neurological disorder was seldom reported. Several imaging modalities have been developed to quantify motor response in human brain, including EEG, MEG, fMRI, TMS, etc. 5,6 . The EEG, which is the tool used most widely, has the advantages of low-cost, easy preparation, and its superiority of high temporal resolution to measure fast changes of neural oscillatory activities. Neural oscillatory activities in human brain can be either phase-locked or non-phase-locked reactive to external or internal stimuli. These oscillatory activities usually exist in specific frequency bands and spatial locations. Event-related non-phase-locked neural activities represent power changes, either enhanced or suppressed relative to baseline activities. The power changes in event-related activities can be caused by the decrease or increase in synchrony of the underlying activated neuronal populations. Pfurtscheller et al. 7 studied the Mu-rhythm changes in discrete voluntary finger movements, and found oscillatory activities were suppressed, started about
doi:10.1038/srep39046 pmid:27976723 pmcid:PMC5157038 fatcat:xxvaygggkzdzhkm5p3t6m6hgte

A Reliability Model for Low-Temperature Polycrystalline Silicon Thin-Film Transistors

Chih-Yang Chen, Jam-Wem Lee, Po-Hao Lee, Wei-Cheng Chen, Hsiao-Yi Lin, Kuan-Lin Yeh, Ming-Wen Ma, Shen-De Wang, Tan-Fu Lei
2007 IEEE Electron Device Letters  
We proposed here a reliability model that successfully introduces both the physical mechanisms of negative bias temperature instability (NBTI) and hot carrier stress (HCS) for p-channel low-temperature polycrystalline silicon thin-film transistors (LTPS TFTs). The proposed model is highly matched with the experimental results, in which the NBTI dominates the device reliability at small negative drain bias while the HCS dominates the degradation at large negative drain bias. In summary, the
more » ... sed model provides a comprehensive way to predict the lifetime of the p-channel LTPS TFTs, which is especially necessary for the system-on-panel circuitry design. Index Terms-Hot carrier stress (HCS), low-temperature polycrystalline silicon thin-film transistors (LTPS TFTs), negative bias temperature instability (NBTI), reliability.
doi:10.1109/led.2007.895454 fatcat:phqc52g6lbgwjf23hmxrqmpryy

Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling

Chao Yuan Yu, Kang-Yi Su, Po-Lei Lee, Jie-Yu Jhan, Po-Hung Tsao, De-Chuan Chan, Yi-Lin Sophia Chen
2013 Evidence-Based Complementary and Alternative Medicine  
Gastric cancer is one of the most common malignant cancers due to poor prognoses and high mortality rates worldwide. However, an effective chemotherapeutic drug without side effects remains lacking.Saussurea involucrata(SI) Kar. et Kir., also known as snow lotus, grows in mountainous rocky habitats at 2600 m elevation in the Tian Shan and A'er Tai regions of China. The ethyl acetate extract of SI had been shown to inhibit proliferation and induce apoptosis in various tumor cells. In this study,
more » ... we demonstrated that Hispidulin, active ingredients in SI, inhibits the growth of AGS gastric cancer cells. After Hispidulin treatment, NAG-1 remained highly expressed, whereas COX-2 expression was downregulated. Flow cytometric analysis indicated that Hispidulin induces G1/S phase arrest and apoptosis in time- and concentration-dependent manners. G1/S arrest correlated with upregulated p21/WAF1 and p16 and downregulated cyclin D1 and cyclin E, independent of p53 pathway. In addition, Hispidulin can elevate Egr-1 expression and ERK1/2 activity, whereas ERK1/2 inhibitor markedly attenuated NAG-1 mediated apoptosis. Taken together, Hispidulin can efficiently activate ERK1/2 signaling followed by NAG-1 constitutive expression and trigger cell cycle arrest as well as apoptosis in cancer cell. It can be a potential compound for combination therapy of gastric cancer in the future.
doi:10.1155/2013/518301 pmid:24159347 pmcid:PMC3789485 fatcat:cellx25l3vbodgbsssesr6rjha

TSA-CRAFT: A Free Software for Automatic and Robust Thermal Shift Assay Data Analysis

Po-Hsien Lee, Xi Xiao Huang, Bin Tean Teh, Ley-Moy Ng
2019 SALAS Discovery  
Thermal shift assay (TSA) is an increasingly popular technique used for identifying protein stabilizing conditions or interacting ligands in X-ray crystallography and drug discovery applications. Although the setting up and running of TSA reactions is a relatively simple process, the subsequent analysis of TSA data, especially in high-throughput format, requires substantial amount of effort if conducted manually. We therefore developed the Thermal Shift Assay-Curve Rapid and Automatic Fitting
more » ... ol (TSA-CRAFT), a freely available software that enable automatic analysis of TSA data of any throughput. TSA-CRAFT directly reads real-time PCR instrument data files and displays the analyzed results in a web browser. This software features streamlined data processing and Boltzmann equation fitting, which is demonstrated in this study to provide more accurate data analysis than the commonly used first-derivative method. TSA-CRAFT is freely available as a cross-operating system-compatible standalone tool ( https://sourceforge.net/projects/tsa-craft/ ) and also as a freely accessible web server ( http://tbtlab.org/tsacraft.html ).
doi:10.1177/2472555218823547 pmid:30744467 pmcid:PMC6537141 fatcat:tijciwabezgd7kpphmuwatbewa

Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells

Huai-Ching Tai, Tzong-Huei Lee, Chih-Hsin Tang, Lei-Po Chen, Wei-Cheng Chen, Ming-Shian Lee, Pei-Chi Chen, Chih-Yang Lin, Chih-Wen Chi, Yu-Jen Chen, Cheng-Ta Lai, Shiou-Sheng Chen (+3 others)
2019 Marine Drugs  
Lymphangiogenesis is an important biological process associated with cancer metastasis. The development of new drugs that block lymphangiogenesis represents a promising therapeutic strategy. Marine fungus-derived compound phomaketide A, isolated from the fermented broth of Phoma sp. NTOU4195, has been reported to exhibit anti-angiogenic and anti-inflammatory effects. However, its anti-lymphangiogenic activity has not been clarified to date. In this study, we showed that phomaketide A inhibited
more » ... ell growth, migration, and tube formation of lymphatic endothelial cells (LECs) without an evidence of cytotoxicity. Mechanistic investigations revealed that phomaketide A reduced LECs-induced lymphangiogenesis via vascular endothelial growth factor receptor-3 (VEGFR-3), protein kinase Cδ (PKCδ), and endothelial nitric oxide synthase (eNOS) signalings. Furthermore, human proteome array analysis indicated that phomaketide A significantly enhanced the protein levels of various protease inhibitors, including cystatin A, serpin B6, tissue factor pathway inhibitor (TFPI), and tissue inhibitor matrix metalloproteinase 1 (TIMP-1). Importantly, phomaketide A impeded tumor growth and lymphangiogenesis by decreasing the expression of LYVE-1, a specific marker for lymphatic vessels, in tumor xenograft animal model. These results suggest that phomaketide A may impair lymphangiogenesis by suppressing VEGFR-3, PKCδ, and eNOS signaling cascades, while simultaneously activating protease inhibitors in human LECs. We document for the first time that phomaketide A inhibits lymphangiogenesis both in vitro and in vivo, which suggests that this natural product could potentially treat cancer metastasis.
doi:10.3390/md17040215 fatcat:lu7npjs4brci3bngawnjjndnie

TCTAP A-175 Catheter-Based Renal Denervation Could Lower Blood Pressure As Early As One Month

Chuan Lei Chao, Po-Lin Lin, Tsung Yeh Yang, Chun-Wei Lee, Ying-Hsiang Lee
2015 Journal of the American College of Cardiology  
TCTAP A-175 Catheter-Based Renal Denervation Could Lower Blood Pressure As Early As One Month Chuan Lei Chao, 1 Po-Lin Lin, 2 Tsung Yeh Yang, 1 Chun-Wei Lee, 1 Ying-Hsiang Lee 1 1 MacKay Memorial Hospital  ... 
doi:10.1016/j.jacc.2015.03.258 fatcat:ny56d5gjrbfrxaxq4hrt7zajnu
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