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Plaque characterization in ex vivo MRI evaluated by dense 3D correspondence with histology

Arna van Engelen, Marleen de Bruijne, Stefan Klein, Hence Verhagen, Harald Groen, Jolanda Wentzel, Aad van der Lugt, Wiro Niessen, Ronald M. Summers, Bram van Ginneken
2011 Medical Imaging 2011: Computer-Aided Diagnosis  
We present a new plaque classification method which uses 3D registration of histology data with ex vivo MRI data, using non-rigid registration, both for training and evaluation.  ...  Automatic quantification of carotid artery plaque composition is important in the development of methods that distinguish vulnerable from stable plaques.  ...  Harald Groen was financially supported by the Interuniversity Cardiology Institute of the Netherlands.  ... 
doi:10.1117/12.878007 dblp:conf/micad/EngelenB0VGWLN11 fatcat:zlmjs2oizbgizh376k5t73dkou

MRI of coronary artery atherosclerosis in rabbits: Histopathology-MRI correlation and atheroma characterization

Rakesh Sharma, Ram B Singh
2004 Thrombosis Journal  
Frequency of plaques, plaque height in aorta and coronary artery atheroma was also assessed by histology.  ...  CONCLUSION: The combination of in vivo MRI and comparison with histopathology images of rabbit coronary thrombus may be a research tool for understanding of the pathogenesis of acute coronary plaques.  ...  Acknowledgements Authors acknowledge the support for this imaging and histology data analysis at Heart Research Lab with R.B. Singh.  ... 
doi:10.1186/1477-9560-2-5 pmid:15144559 pmcid:PMC441413 fatcat:fv2cq52uq5hpjgl6cqe5arv52q

Quantitative Evaluation of Carotid Plaque Composition by In Vivo MRI

T. Saam
2004 Arteriosclerosis, Thrombosis and Vascular Biology  
Objective-This study evaluates the ability of MRI to quantify all major carotid atherosclerotic plaque components in vivo.  ...  For MRI and histology, area measurements of the major plaque components such as lipid-rich/necrotic core (LR/NC), calcification, loose matrix, and dense (fibrous) tissue were recorded as percentages of  ...  Acknowledgments This work is supported in part by grants from the National Institutes of Health R01HL56874 and R01HL072262 and from Pfizer, Inc.  ... 
doi:10.1161/01.atv.0000149867.61851.31 pmid:15528475 fatcat:cjzfjnsv2fdctlamzpqi6d7qwe

Ex vivo differential phase contrast and magnetic resonance imaging for characterization of human carotid atherosclerotic plaques

Romana Meletta, Nicole Borel, Paul Stolzmann, Alberto Astolfo, Jan Klohs, Marco Stampanoni, Markus Rudin, Roger Schibli, Stefanie D. Krämer, Adrienne Müller Herde
2015 The International Journal of Cardiovascular Imaging  
We aimed to evaluate the potential of ex vivo differential phase contrast X-ray tomography (DPC) to accurately characterize human carotid plaque components in comparison to high field multicontrast MRI  ...  Ex vivo DPC tomography allowed accurate identification of structures and components of atherosclerotic plaques at different lesion stages, in good correlation with histopathological findings.  ...  In a second step, both plaques were characterized by histological workup and, finally, the DPC and MR images were matched with the corresponding histological sections.  ... 
doi:10.1007/s10554-015-0706-y pmid:26179860 fatcat:bv56pwsoyreuvchcxj3xe4smva

Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer's disease brains

Clémence Dudeffant, Matthias Vandesquille, Kelly Herbert, Clément M. Garin, Sandro Alves, Véronique Blanchard, Emmanuel E. Comoy, Fanny Petit, Marc Dhenain
2017 Scientific Reports  
The brains were then evaluated by histology to investigate the impact of size, compactness, and iron load of amyloid plaques on their detection by MRI.  ...  Here, we investigated detection of amyloid plaques by Gd-stained MRI in five mouse models of amyloidosis (APP SL /PS1 M146L , APP/ PS1 dE9 , APP23, APP SwDI , and 3xTg) presenting with compact, diffuse  ...  Alzheimer and France Parkinson, with the support of Fondation Plan Alzheimer and IHU A-ICM for providing the brain samples used in this study.  ... 
doi:10.1038/s41598-017-05285-1 pmid:28694463 pmcid:PMC5504006 fatcat:qsk3bqczdfb5vfldzpewxqevz4

In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent

Clifford R. Jack, Michael Garwood, Thomas M. Wengenack, Bret Borowski, Geoffrey L. Curran, Joseph Lin, Gregor Adriany, Olli H. J. Gröhn, Roger Grimm, Joseph F. Poduslo
2004 Magnetic Resonance in Medicine  
In vivo MRI -ex vivo MRI -in vitro histological correlations are provided. Histologically verified plaques as small as 50 μm in diameter were visualized in the living animal.  ...  Imaging of labeled plaques has been accomplished with other modalities, but only MRI has sufficient spatial and contrast resolution to visualize individual plaques non-invasively.  ...  Results Variable slice thickness was evaluated with ex vivo MRI using a fixed transgenic mouse brain.  ... 
doi:10.1002/mrm.20266 pmid:15562496 pmcid:PMC2744889 fatcat:3p4uzoczivdphfwmucli4cb4u4

Preliminary ex vivo 3D microscopy of coronary arteries using a standard 1.5 T MRI scanner and a superconducting RF coil

M. Poirier-Quinot, J.-C. Ginefri, F. Ledru, P. Fornes, L. Darrasse
2005 Magnetic Resonance Materials in Physics, Biology and Medicine  
Preliminary ex vivo 3D microscopy of coronary arteries using a standard 1.5 T MRI scanner and a superconducting RF coil.  ...  Local microscopy at the surface of an explanted, entire heart was achieved by a 3D spoiled gradient echo sequence and assessed by comparison with conventional histology.  ...  Acknowledgements This work has been supported by a grant from the French Ministry of Research.  ... 
doi:10.1007/s10334-004-0097-x pmid:15711851 fatcat:bbuscqowu5fy5dbfhvnn7nywyq

Carotid Magnetic Resonance Imaging

Minako Oikawa, Hideki Ota, Norihide Takaya, Zach Miller, Thomas S Hatsukami, Chun Yuan
2009 Circulation Journal  
A reliable, in vivo, imaging method capable of identifying plaque characteristics associated with high-risk plaque will be immensely useful for evaluating plaque status and predicting future events.  ...  This review will cover the current state-of-the-art and new developments in carotid MRI to characterize atherosclerosis and its use in clinical diagnoses and longitudinal studies to understand mechanisms  ...  vivo black blood MRI and ex vivo MRI.  ... 
doi:10.1253/circj.cj-09-0617 pmid:19755748 fatcat:34wtw5ke3bcjbdoqh2i4vcffzq

Automated segmentation of atherosclerotic histology based on pattern classification

Arna van Engelen, WiroJ Niessen, Stefan Klein, HaraldC Groen, Kim van Gaalen, HenceJ Verhagen, JolandaJ Wentzel, Aad van der Lugt, Marleen de Bruijne
2013 Journal of Pathology Informatics  
We evaluate the results on segmentation accuracy in histology, and we use the obtained histology segmentations to train plaque component classification methods in ex vivo Magnetic resonance imaging (MRI  ...  Using the obtained histology segmentations to train plaque component classification methods in ex vivo MRI and in vivo MRI and CT resulted in similar image segmentations for training on the automated histology  ...  WN, SK, and MdB were financially supported by the Netherlands Organization for Scientific Research (NWO). HG was financially supported by the Interuniversity Cardiology Institute of the Netherlands.  ... 
doi:10.4103/2153-3539.109844 pmid:23766939 pmcid:PMC3678743 fatcat:tfqot24klrbrlbfk4ldcuikbia

Classification of Human Carotid Atherosclerotic Lesions With In Vivo Multicontrast Magnetic Resonance Imaging

J.-M. Cai
2002 Circulation  
Background-Recent studies demonstrated that in vivo and ex vivo MRI can characterize the components of the carotid atherosclerotic plaque, such as fibrous tissue, lipid/necrotic core, calcium, hemorrhage  ...  Overall, the classification obtained by MRI and the American Heart Association classifications showed good agreement, with Cohen's (95% CI) of 0.74 (0.67 to 0.82) and weighted of 0.79.  ...  Kerwin for preparing the manuscript and Geraldo Ortiz for his help in acquiring the highresolution MR images.  ... 
doi:10.1161/01.cir.0000028591.44554.f9 pmid:12221054 fatcat:tucrq3gwr5hezbyrbem4xkr67m

In Vivo Accuracy of Multispectral Magnetic Resonance Imaging for Identifying Lipid-Rich Necrotic Cores and Intraplaque Hemorrhage in Advanced Human Carotid Plaques

C. Yuan, L. M. Mitsumori, M. S. Ferguson, N. L. Polissar, D. Echelard, G. Ortiz, R. Small, J. W. Davies, W. S. Kerwin, T. S. Hatsukami
2001 Circulation  
Conclusions-Multispectral MRI can identify the lipid-rich necrotic core in human carotid atherosclerosis in vivo with high sensitivity and specificity.  ...  There was good agreement between MRI and histological findings, with a value of ϭ0.69 (0.53 to 0.85).  ...  Acknowledgments This research was funded by grants from the NIH (RO1-HL-61851, HL-56874, and RO1-HL-60213).  ... 
doi:10.1161/hc4201.097839 pmid:11673345 fatcat:akwq3hunxjccxinipbfqltp424

Recent Advances in Visualizing Alzheimers Plaques by Magnetic Resonance Imaging

Niels Braakman, Mark van Buchem, Reinhard Schliebs, Huub de Groot, A. Alia
2009 Current Medical Imaging Reviews  
of these plaques with age in the same animals.  ...  The presence of amyloid plaques in the brain is one of prominent histological features of Alzheimer's disease. However, imaging of amyloid plaques in vivo in humans is not yet feasible.  ...  ACKNOWLEDGEMENTS This work was supported in part by funds from Internationale Stichting Alzheimer Onderzoek (ISAO), CYTTRON within the Bsik program (Besluit subsidies investeringen kennisinfrastructuur  ... 
doi:10.2174/157340509787354741 fatcat:ki5xn34f3ffxnihrucvx62y4aa

Advanced Techniques for MRI of Atherosclerotic Plaque

William S. Kerwin, Gador Canton
2009 Topics in Magnetic Resonance Imaging (TMRI)  
This review examines the state of the art in vessel wall imaging by MRI with an emphasis on the biomechanical assessment of atherosclerotic plaque. Three areas of advanced techniques are discussed.  ...  The paper closes with a discussion of the extent to which these techniques have been applied to different arteries commonly targeted by vessel wall MRI.  ...  In histological comparisons, in vivo measurements of v p and K trans in carotid arteries have been shown to correlate with plaque inflammatory features including neovascularity and macrophage content  ... 
doi:10.1097/rmr.0b013e3181ea2853 pmid:20805732 pmcid:PMC3074299 fatcat:zudseujb2nhopn5qh6apzipgbi

Detection of High-Risk Atherosclerotic Plaques by Magnetic Resonance Imaging

Teruo Noguchi, Naoaki Yamada, Tomohiro Kawasaki, Atsushi Tanaka, Satoshi Yasuda
2013 Circulation Journal  
In contrast, high-resolu-tion MRI has emerged as the leading noninvasive in vivo imaging modality for the characterization of atherosclerotic carotid plaques ( Table 1) .  ...  MRI of Atherosclerosis Atherosclerotic plaque characterization by MRI is based on the signal intensity and morphologic appearance of the plaque on multiple contrast weightings.  ...  types of images, MRI can characterize plaque compo- nents such as fibrous tissue, hemorrhagic tissue, and dense calcification. 2,14 Because the advantage of carotid plaque imag- ing using MRI lies in  ... 
doi:10.1253/circj.cj-13-0651 pmid:23877708 fatcat:24f6ey5qebbpdbwkivlfig4zca

Regions of Low Endothelial Shear Stress Colocalize With Positive Vascular Remodeling and Atherosclerotic Plaque Disruption: An In Vivo Magnetic Resonance Imaging Study

A. Phinikaridou, N. Hua, T. Pham, J. A. Hamilton
2013 Circulation Cardiovascular Imaging  
Disrupted plaques were histologically characterized by a thin, inflamed fibrous cap, a dense lipid core, and mural thrombus.  ...  We used in vivo MRI to investigate the role of the magnitude of ESS on vascular remodeling, plaque burden, and disruption using a rabbit model of controlled atherothrombosis.  ...  Sources of Funding This project was supported by National Institustes of Health Grant 5P50HL083801 (Dr Hamilton).  ... 
doi:10.1161/circimaging.112.000176 pmid:23357244 fatcat:zg4qkdqxvbes7a4mk7lfehutzu
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