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Sachin S. Deshmukh, James J. Knierim
2012 Wiley Interdisciplinary Reviews: Cognitive Science  
Damage to the hippocampus and related brain regions causes a profound amnesic syndrome, in which patients are unable to form new memories about their experiences and about facts about the world.  ...  The theories that are currently most influential propose that the hippocampus is the substrate of declarative or episodic memory and that the hippocampus is the neural locus of a cognitive map.  ...  Thus, the long-term stabilization of new place fields was selectively affected by CPP, without hindering the formation of the place fields in new environments.  ... 
doi:10.1002/wcs.1164 pmid:26301397 fatcat:cvu5mv7qobbkhkfvdjpygipnjq

Place Cells, Grid Cells, and Memory

May-Britt Moser, David C. Rowland, Edvard I. Moser
2015 Cold Spring Harbor Perspectives in Biology  
mechanisms for long-term plasticity in the hippocampus, and that long-term spatiotemporal memory storage may depend on offline consolidation processes related to sharp-wave ripple activity in the hippocampus  ...  memory formation.  ...  Over the years, considerable evidence has accumulated to point to a role for sharp waves and ripples in the formation of hippocampus-dependent long-term memories.  ... 
doi:10.1101/cshperspect.a021808 pmid:25646382 pmcid:PMC4315928 fatcat:q7gka7lhprdlvcrcq3mmsbhaua

Hippocampal Memory Formation, Plasticity, and the Role of Sleep

M Wilson
2002 Neurobiology of Learning and Memory  
He termed these spatial receptive fields place fields and the cells place cells.  ...  Together these observations link the hippocampus to the cognitive aspects of memory and identify potential neural mechanisms that might be responsible for the formation and maintenance of memory.  ... 
doi:10.1006/nlme.2002.4098 pmid:12559835 fatcat:syiakfjhobd55kgxyklvnpvnq4

On the neural bases of the spatial mapping system: Hippocampus vs. hippocampal formation

Leonard E. Jarrard
1991 Hippocampus  
The term "hippocampus" is used to refer to the pyramidal cell fields of the hippocampus proper (CAI -CA3), together with the hilar cells and the dentate gyrus (see Gottlieb and Cowan, 1973) .  ...  The second circuit consists of direct projections from entorhinal cortex to the subiculunl and CA1 cell field, thus bypassing most of the hippocampus (Van Groen and Lopes da Silva, 1986; Witter et al.,  ...  ACKNOWLEDGMENTS T h e research described in this essay was supported by NSF grants BNS 85-07259 a n d 88-09208.  ... 
doi:10.1002/hipo.450010304 pmid:1669296 fatcat:xaihq47abfdrvikj3jhzw55c5e

Memory integration constructs maps of space, time, and concepts

Neal W Morton, Katherine R Sherrill, Alison R Preston
2017 Current Opinion in Behavioral Sciences  
Within the hippocampus and medial prefrontal cortex, related memories are represented by integrated codes that connect events experienced at different times and places.  ...  Recent evidence demonstrates that new events are learned in the context of their relationships to existing memories.  ...  Acknowledgments This work was supported by the National Institute of Mental Health (R01 MH100121 to A.R.P.), the National Institute of Child Health and Human Development (R21 HD083785 to A.R.P.), and the  ... 
doi:10.1016/j.cobeha.2017.08.007 pmid:28924579 pmcid:PMC5600494 fatcat:2i37iupma5bttbqn3jc2zznlre

Hippocampal and cortical place cell plasticity: Implications for episodic memory

Loren M. Frank, Emery N. Brown, Garrett B. Stanley
2006 Hippocampus  
In humans, the hippocampus is essential for storing episodic memories.  ...  We found that hippocampal place fields exhibited three phenomena that may have direct relevance to the encoding of episodic memories: (1) very rapid plasticity upon exposure to the new environment, (2)  ...  This finding may help explain why the hippocampus is essential for the formation of new episodic memories.  ... 
doi:10.1002/hipo.20200 pmid:16921502 fatcat:6vopxzhs4fffhgo7qmji22dzd4

Bridging the gap between spatial and mnemonic views of the hippocampal formation

Elizabeth A. Buffalo
2015 Hippocampus  
the form of place cells in the hippocampus and grid cells in the entorhinal cortex.  ...  While it has long been recognized that medial temporal lobe structures are important for memory formation, studies in rodents have also identified exquisite spatial representations in these regions in  ...  Acknowledgements This work was supported by National Institutes of Health Grants MH080007, MH 093807, and the Office of Infrastructure Programs (ORIP) Grant P51OD010425.  ... 
doi:10.1002/hipo.22444 pmid:25787704 pmcid:PMC4449301 fatcat:lkgekgazm5g4hawoezkii5mohq

Plasticity, Hippocampal Place Cells, and Cognitive Maps

Matthew Shapiro
2001 Archives of Neurology  
Lesions of the hippocampus profoundly impair memory for recent events in humans and rodents.  ...  step toward the formation of long-term memory.  ...  The same dose impairs spatial learning and long-term spatial working memory in the radial maze, and prevents the formation of stable place fields in new and unfamiliar environments ( Figure 2B ).  ... 
doi:10.1001/archneur.58.6.874 pmid:11405801 fatcat:ht5qq3kpafgc5gu3rvacxotqmq

Play it again: reactivation of waking experience and memory

Joseph O'Neill, Barty Pleydell-Bouverie, David Dupret, Jozsef Csicsvari
2010 Trends in Neurosciences  
Ben Micklem for help with artwork and design.  ...  Acknowledgements We would like to thank Andrew Sharott, Collin Lever, Mark Cunningham and Jack Mellor for their helpful comments on this manuscript as well as Timothy Senior for helpful discussions and  ...  Hippocampus-dependent memory formation is likely to take place in two main stages. First, the hippocampus rapidly encodes memories during alert wakefulness.  ... 
doi:10.1016/j.tins.2010.01.006 pmid:20207025 fatcat:n7h6jrna6bhh5ejj7eodiw36z4

What is remembered? Role of attention on the encoding and retrieval of hippocampal representations

Isabel A. Muzzio, Clifford Kentros, Eric Kandel
2009 Journal of Physiology  
The hippocampus is critically involved in storing explicit memory such as memory for space.  ...  Whereas, a great deal is now known about the mechanisms of storage, the mechanisms whereby attention modulates the encoding and retrieval of space and other hippocampus-dependent memory representations  ...  for place field stability and memory consolidation.  ... 
doi:10.1113/jphysiol.2009.172445 pmid:19525568 fatcat:p2ijsdmcivgu3da5srlgc64hbq

The Hippocampal Engram as a Memory Index

Kazumasa Z Tanaka, Thomas J McHugh
2018 Journal of Experimental Neuroscience  
These two distinct ensembles of hippocampal neurons suggest heterogeneous roles for subsets of hippocampus neurons in memory.  ...  The hippocampus encodes memories for past events, but the nature of the hippocampal code subserving this function remains unclear.  ...  example, pharmacological blockade of N-methyl-D-aspartate (NMDA) receptors in the hippocampus impairs stable formation of place fields. 15 Together, these findings support the idea that the hippocampus  ... 
doi:10.1177/1179069518815942 pmid:30546263 pmcid:PMC6287299 fatcat:uav2i3y2drffll3vhus6uezvrm

Page 3105 of The Journal of Neuroscience Vol. 10, Issue 9 [page]

1990 The Journal of Neuroscience  
Sutherland RJ, Rudy JW (1989) Configural association theory: the role of the hippocampal formation in learning, memory, and amnesia. Psychobiology 17:129-144.  ...  O’Keefe J (1976) Place units in the hippocampus of the freely moving rat. Exp Neurol 51:78-109.  ... 

c-Rel, an NF- B family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation

H. J. Ahn, C. M. Hernandez, J. M. Levenson, F. D. Lubin, H.-C. Liou, J. D. Sweatt
2008 Learning & memory (Cold Spring Harbor, N.Y.)  
Together, our results demonstrate that c-Rel is necessary for long-term synaptic potentiation in vitro and hippocampus-dependent memory formation in vivo. 5 Present address: Galnea, Corp., 300 Technology  ...  These results indicate that c-rel −/− mice have impaired hippocampus-dependent memory formation.  ...  Paylor for help with statistical analysis of the novel object recognition test. Grant support was from MH57014, NS13546, P30 NS047466, and P30 NS057098, Mc-Knight Brain Research Foundation.  ... 
doi:10.1101/lm.866408 pmid:18626097 pmcid:PMC2505322 fatcat:3tkiekreibgthnab53i3tnfznm

Simulation of Human Episodic Memory by Using a Computational Model of the Hippocampus

Naoyuki Sato, Yoko Yamaguchi
2010 Advances in Artificial Intelligence  
Neuroscience evidence has shown that the hippocampus, a part of the limbic system, plays an important role in the encoding and the retrieval of the episodic memory.  ...  Results from computer simulations demonstrate that our model provides advantage for instantaneous memory formation and selective retrieval enabling memory search.  ...  Acknowledgment This study was supported by the MEXT KAKENHI (20220003).  ... 
doi:10.1155/2010/392868 fatcat:3yjns45xhnhc7c23hkaswytrmy

Hippocampus at 25

Howard Eichenbaum, David G. Amaral, Elizabeth A. Buffalo, György Buzsáki, Neal Cohen, Lila Davachi, Loren Frank, Stephan Heckers, Richard G. M. Morris, Edvard I. Moser, Lynn Nadel, John O'Keefe (+4 others)
2016 Hippocampus  
organization in spatial and memory processing by the hippocampus, and (4) understanding how the hippocampus integrates related events into networks of memories.  ...  a review of progress and highlights of current research on the hippocampus and memory.  ...  Page 33 of 41 John Wiley & Sons Hippocampus This article is protected by copyright. All rights reserved.  ... 
doi:10.1002/hipo.22616 pmid:27399159 pmcid:PMC5367855 fatcat:tq2knecikzfsrel6sqvkjbw2se
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