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Physiologically evoked neuronal current MRI in a bloodless turtle brain: Detectable or not?

Qingfei Luo, Huo Lu, Hanbing Lu, David Senseman, Keith Worsley, Yihong Yang, Jia-Hong Gao
2009 NeuroImage  
In this study, we used a bloodless turtle brain that eliminates hemodynamic effects, to explore the feasibility of detecting visual-evoked ncMRI signals at 9.4T.  ...  Contradictory results from the efforts for detecting evoked neuronal currents have left the feasibility of neuronal current MRI (ncMRI) an open question.  ...  Acknowledgments This work was supported by a NIH grant (RO1 EB004753 to JHG) and the Intramural Research Program of the NIH/NIDA.  ... 
doi:10.1016/j.neuroimage.2009.06.017 pmid:19539040 pmcid:PMC3860745 fatcat:442gtlh4kvfaviekb4qbzt5gei

Octopus visual system: A functional MRI model for detecting neuronal electric currents without a blood-oxygen-level-dependent confound

Xia Jiang, Hanbing Lu, Shuichi Shigeno, Li-Hai Tan, Yihong Yang, Clifton W. Ragsdale, Jia-Hong Gao
2013 Magnetic Resonance in Medicine  
Conclusion-These findings in a large hemoglobin-free nervous system suggest that sensory evoked neuronal magnetic fields are too weak for direct detection with current MRI technology.  ...  This study investigates the feasibility of detecting a physiologically induced nc-MRI signal in vivo in a BOLD-free environment.  ...  The results from the present study and those from our previous work on bloodless turtle brain model (27) suggest that sensory evoked potentials are too weak for direct nc-MRI detection.  ... 
doi:10.1002/mrm.25051 pmid:24301336 pmcid:PMC4041854 fatcat:niszpvajwnhkjehywoscx7qfcy

Direct neural current imaging in an intact cerebellum with magnetic resonance imaging

Padmavathi Sundaram, Aapo Nummenmaa, William Wells, Darren Orbach, Daniel Orringer, Robert Mulkern, Yoshio Okada
2016 NeuroImage  
The ability to detect neuronal currents with high spatiotemporal resolution using magnetic resonance imaging (MRI) is important for studying human brain function in both health and disease.  ...  Our results show that it is possible (1) to reliably detect an MR phase shift time course matching that of the concurrently measured LFP evoked by stimulation of a cerebellar peduncle, (2) to detect the  ...  In Luo et al. (2009) , the authors imaged a bloodless turtle brain/eye preparation with GE-EPI at 9.4 T but reported an inability to detect any significant MR signal changes (magnitude or phase) related  ... 
doi:10.1016/j.neuroimage.2016.01.059 pmid:26899788 pmcid:PMC4873157 fatcat:qpqqaxuicvaxdmyyjplvsc4hse

In vivo direct imaging of neuronal activity at high temporo-spatial resolution [article]

Phan Tan Toi, Hyun Jae Jang, Kyeongseon Min, Sung-Phil Kim, Seung-Kyun Lee, Jongho Lee, Jeehyun Kwag, Jang-Yeon Park
2021 bioRxiv   pre-print
There has been a longstanding demand for noninvasive neuroimaging methods capable of detecting neuronal activity at both high temporal and spatial resolution.  ...  Here, we propose a novel method that enables Direct Imaging of Neuronal Activity for functional MRI (termed DIANA-fMRI) that can dynamically image spiking activity in milliseconds precision, while retaining  ...  Gao, Physiologically evoked neuronal current MRI in a bloodless turtle brain: Detectable or not? NeuroImage. 47, 1268-1276 (2009), doi:10.1016/j.neuroimage.2009.06.017, pmid:19539040. 13. X.  ... 
doi:10.1101/2021.05.21.444581 fatcat:3fj6fvhayvfjbiyy2c5uhtbupu

Magnetic Resonance Imaging technology — bridging the gap between noninvasive human imaging and optical microscopy

Jonathan R Polimeni, Lawrence L Wald
2018 Current Opinion in Neurobiology  
Mounting evidence demonstrates that the hemodynamic changes utilized in functional MRI can be far more spatially and thus neuronally specific than previously believed.  ...  Technological advances in Magnetic Resonance Imaging (MRI) have provided substantial gains in the sensitivity and specificity of functional neuroimaging.  ...  This work was supported in part was supported in part by the NIH NIBIB (grants P41-EB015896, R01-EB023281, and R01-EB019437), by the NEI  ... 
doi:10.1016/j.conb.2018.04.026 pmid:29753942 pmcid:PMC6015259 fatcat:7msf5i7k5ja3tpavexhuzlw7wu