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Similarly, given the plurality of evolutionary histories among genes encoded in a given genome, there is a need for the combined analysis of genome-wide collections of phylogenetic trees (phylomes). ... Here, we introduce a new release of PhylomeDB (http://phylomedb.org), a public repository of phylomes. ... ACKNOWLEDGEMENTS The authors wish to thank members of Gabaldon's group, the quest for orthologs consortium and PhylomeDB users for their suggestions and feedback. ...doi:10.1093/nar/gkt1177 pmid:24275491 pmcid:PMC3964985 fatcat:mlzwnhm3mfeynb4h46c4hh7phu
We present an in silico characterization of the von Hippel-Lindau like protein (VLP), the only known human paralogue of the von Hippel-Lindau tumor suppressor protein (pVHL). ... In particular, conservation of elements at the protein interfaces suggests VLP to be a functional pVHL homolog potentially possessing multiple functions beyond HIF-1α-dependent binding activity. ... Acknowledgements The authors are grateful to members of the BioComputingUP group for insightful discussions. Conflict of interest and funding ...doi:10.1101/407353 fatcat:6poh6glfqvfzfa2kcrg6o7rejq
exception of the cerebellum. ... Only 48% of the candidate cytosolic tRNA modification enzymes have been experimentally validated in mammals (either directly or in a heterologous system). ... The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH and NINDS. ...doi:10.1093/nar/gkz011 pmid:30698754 pmcid:PMC6412123 fatcat:j7nj2nqoxvbmhm7ueirdqajyp4
High-throughput sequencing technology has provided us with a wealth of data. The analysis of these sequenced genomes is not possible without di erent bioinformatics methods and tools. ... Finally, we present a visualisation method that can be used to facilitate the study of large datasets by making it possible to look at the relationships in a network in a single image. ... PhylomeDB v4: zooming into the plurality of evolutionary histories of a genome. Nucleic Acids Research, 42(Database issue):D897-D902. [Hutchison et al., 1999] Hutchison, C. A., Peterson, S. ...doi:10.26021/7562 fatcat:hbqvdo2kwvbwphum3t37xfwkzm