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Pharmacological MRI with Simultaneous Measurement of Cerebral Perfusion and Blood-Cerebrospinal Fluid Barrier Function using Interleaved Echo-Time Arterial Spin Labelling

Charith Perera, Ian F. Harrison, Mark F. Lythgoe, David L. Thomas, Jack A. Wells
2021 NeuroImage  
Changes to brain perfusion and blood-cerebrospinal fluid barrier (BCSFB) function can be probed, non-invasively, by arterial spin labelling (ASL) and blood-cerebrospinal fluid barrier arterial spin labelling  ...  Here, we introduce a method for simultaneous recording of pharmacological perturbation of brain perfusion and BCSFB function using interleaved echo-time ASL, applied to the anesthetized mouse brain.  ...  L. receives funding from the EPSRC (EP/N034864/1); the King's College London and UCL Comprehensive Cancer Imaging Centre CR-UK and EP-SRC, in association with the MRC and DoH (England); UK Regenera-tive  ... 
doi:10.1016/j.neuroimage.2021.118270 pmid:34144160 fatcat:jm3zvshh5rfzjgns3rx3ecy57y

Increased 20-HETE Signaling Suppresses Capillary Neurovascular Coupling After Ischemic Stroke in Regions Beyond the Infarct

Zhenzhou Li, Heather L. McConnell, Teresa L. Stackhouse, Martin M. Pike, Wenri Zhang, Anusha Mishra
2021 Frontiers in Cellular Neuroscience  
Inhibition of ω-hydroxylases normalized 20-HETE levels in vivo and increased cerebral blood flow in the peri-infarct cortex.  ...  Using the middle cerebral artery occlusion (MCAO) model of stroke, we show that neuronal activity-evoked capillary dilation is reduced by ∼75% in the intact cortical tissue outside the infarct border.  ...  ACKNOWLEDGMENTS We thank David Attwell, Steve Sullivan, Ozama Ismail, and Evan Calkins for helpful comments on the manuscript.  ... 
doi:10.3389/fncel.2021.762843 pmid:34819839 pmcid:PMC8606525 fatcat:d3j7eilenvggjazombwwuyiori

The use of brain imaging to elucidate neural circuit changes in cocaine addiction

Colleen Hanlon, Canterberry
2012 Substance Abuse and Rehabilitation  
In this review, we will first describe several of the imaging methods that are actively being used to address functional and structural abnormalities in addiction.  ...  Through the use of these tools in both a basic science setting and as applied to treatment seeking individuals, we now have a greater understanding of the complex cortical and subcortical networks which  ...  [15] [16] [17] Arterial spin labeling (ASL)/cerebral blood flow measurement ASL is a noninvasive functional imaging method which uses the same properties of MR mentioned in the previous techniques to  ... 
doi:10.2147/sar.s35153 pmid:23162375 pmcid:PMC3499034 fatcat:unc6gafh6fcunbnqoqzh7llwka

Poster Viewing Session VI

2017 Journal of Cerebral Blood Flow and Metabolism  
Metabolic changes were assessed using Echo MRI and comprehensive lab animal monitoring system.  ...  Abstract Arterial networks coordinates blood flow delivery to the brain in accordance with metabolic demand.  ...  Cerebrospinal fluid (CSF) and blood samples were collected at days 1, 4 and 10 after ictus.  ... 
doi:10.1177/0271678x17695990 pmid:28366132 pmcid:PMC5441167 fatcat:6z42kszazjdxfgbi5avzlmphdu

Track I

2014 Biomedical Engineering  
We show that a properly designed and trained ESN is able to discriminate early and late granulopoietic cells in histopathological images of the human bone marrow with overall mean accuracy (±SD) of 0.846  ...  The main goal of this paper is to examine echo state networks (ESN) for quantitative cell recognition.  ...  This work has been supported Acknowledgement We thank the Ministry of Work, Social Integration and Welfare in collaboration with the Ministry of Economic Affairs, Energy and Industry and the Ministry  ... 
doi:10.1515/bmt-2014-5008 pmid:25385893 fatcat:4o7vqkhdmfgk5fjzqpeh74x5te

Combining Brain Perturbation and Neuroimaging in Non-human Primates

P. Christiaan Klink, Jean-François Aubry, Vincent P. Ferrera, Andrew S. Fox, Sean Froudist-Walsh, Bechir Jarraya, Elisa Konofagou, Richard Krauzlis, Adam Messinger, Anna S. Mitchell, Michael Ortiz-Rios, Hiroyuki Oya (+13 others)
2021 NeuroImage  
Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional  ...  This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging.  ...  All research discussed in this work was performed in accordance with institutional and nationally approved oversight, such as the NIH Guide for Care and Use of Laboratory Animals, the U.K.  ... 
doi:10.1016/j.neuroimage.2021.118017 pmid:33794355 fatcat:k2ezxzcgpncyxm7l7rch4btcru

Thirteenth meeting of the European Neurological Society 14–18June 2003,Istanbul, Turkey

2003 Journal of Neurology  
All 3 inhibitors bind NgR with similar mechanisms involved in the onset of migraine attacks and the interaction with migraine trigger factors.  ...  Because of the many clinical and pathophysiological similarities, other episodic disorders such as ataxia, epilepsy, and trauma-triggered cerebral oedema may profit as well from these developments.  ...  Patients and methods: Thirty-six patients with neurologic manifestation ofWD were examined using fast-spin-echo T2/PD-weighted sequence in axial plain and T1-weighted sequence in sagittal plain with 1.5T  ... 
doi:10.1007/bf03160427 fatcat:dra3sin345hullyy7lbyrzyjsa

31st Meeting of the Canadian Congress of Neurological Sciences

1996 Canadian Journal of Neurological Sciences  
The pulse sequence used was a conventional ECG gated 2D phase contrast gradient echo sequence with interleaved flow sensitive and flow compensated components.  ...  The primary outcome was the change in the Gross Motor Function Measure (GMFM), a quantitative and validated measure for use in children with spastic cerebral palsy.  ...  At the time of craniotomy infarcted tissue was encountered. Subsequent investigations revealed a mural based thrombus in the cervical internal carotid artery with a degree of stenosis.  ... 
doi:10.1017/s0317167100020849 fatcat:rueh6t47qzb55abv7q46jgctl4

Poster Session II

2005 Neuropsychopharmacology  
Methods: Eighteen cocaine dependent subjects and 18 healthy controls underwent full brain Diffusion tensor imaging (DTI) acquired with a diffusion sensitized dual spin echo prepared echoplanar imaging  ...  Fast spin echo proton density and T2 weighted images were acquired from the same location as DTI. DTI post processing was performed using the Automated Image Registration (AIR) package.  ...  Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S Kegeles, Gordon W Frankle, Raj Narendran, Roberto Gil,  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi

Poster Session I

2013 Neuropsychopharmacology  
Results: Thirty-five subjects with a mean age of 50±9 years and 70% Caucasian.  ...  We examined how folate supplementation would affect metabolic measures and endothelial functioning (RHI) in AAP treated schizophrenia subjects meeting NCEP-ATP-III metabolic syndrome criteria.  ...  Abi-Dargham, and S. Kapur, Arch Gen Psychiatry 69, 776 (2012). 2  ... 
doi:10.1038/npp.2013.279 fatcat:54ipecxjarcvljrvn5fgtgif5u

Poster Session III

2010 Neuropsychopharmacology  
Brains and blood serum were collected and processed for analysis.  ...  model the neuroadaptive processes in humans that lead to abnormal brain function and psychosis.  ...  GM1 ganglosides are components of lipid rafts that can be visualized through labeling with GFP-tagged cholera toxin (CTX) subunit B.  ... 
doi:10.1038/npp.2010.218 fatcat:i5knteqsgveybffza7g6b4iqei

Computer-Assisted Analysis of Biomedical Images [article]

Leonardo Rundo
2021 arXiv   pre-print
In conclusion, the ultimate goal of these research studies is to gain clinically and biologically useful insights that can guide differential diagnosis and therapies, leading towards biomedical data integration  ...  Therefore, the computational analysis of medical and biological images plays a key role in radiology and laboratory applications.  ...  In T1w images, the cerebrospinal fluid is dark while the fat is bright; • T2-weighted (T2w) images: the spin-spin (i.e., transverse) relaxation time is a measurement of the time taken by the spin of protons  ... 
arXiv:2106.04381v1 fatcat:osqiyd3sbja3zgrby7bf4eljfm

Poster Session I

2010 Neuropsychopharmacology  
One measure of impulsive choice is delayed discounting and occurs in 26.8% of children with ADHD.  ...  Since our results of differentially expressed genes culminated in mitochondrial function, we used the oxidative phosphorylation inhibitor rotenone to evaluate behavioral reversal of Lithium effects.  ...  Discussion: Depression is associated with increased susceptibility of T-cells to the HIV virus ex-vivo.  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee

Poster Session II

2012 Neuropsychopharmacology  
Unlike the most commonly used blood-oxygenation-level-dependent (BOLD) contrast, the imaging modality of arterial spin labeling (ASL) provides absolute quantification of cerebral blood perfusion as a proxy  ...  continuous arterial spin labeling (pCASL) to measure rCBF.  ...  Methods: Twenty patients who met DSM-IV criteria for schizophrenia and seventeen demographically-matched healthy subjects underwent Pavlovian fear conditioning while functional MRI data were simultaneously  ... 
doi:10.1038/npp.2012.220 fatcat:coblfrtlujc6hdycjbnrdwzslm

ACNP 58th Annual Meeting: Poster Session III

2019 Neuropsychopharmacology  
All subjects participated in a magnetic resonance imaging (MRI) study and one [11C]PBR28 PET scan with arterial blood sampling to measure the metabolite-corrected parent input function. [11C]PBR28 binds  ...  Background: Preclinical and clinical studies of peripheral, cerebrospinal fluid, and brain transcription levels of immune markers indicate that innate immunity and inflammatory responses are dysregulated  ...  Diffusion tensor images (DTI) were acquired using single-shot spin-echo echo-planar imaging sequence (field of view: 240 mm; voxel size: 0.83 × 0.83 × 2.2 mm; TR/TE: 6,994/71 ms; flip angle: 90 degrees  ... 
doi:10.1038/s41386-019-0547-9 pmid:31801974 pmcid:PMC6957926 fatcat:dd7d43ysfvc5bbbstfl73szya4
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