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Theory of mind network activity is altered in subjects with familial liability for schizophrenia

Sebastian Mohnke, Susanne Erk, Knut Schnell, Nina Romanczuk-Seiferth, Phöbe Schmierer, Lydia Romund, Maria Garbusow, Carolin Wackerhagen, Stephan Ripke, Oliver Grimm, Leila Haller, Stephanie H. Witt (+5 others)
2015 Social Cognitive and Affective Neuroscience  
As evidenced by a multitude of studies, abnormalities in Theory of Mind (ToM) and its neural processing might constitute an intermediate phenotype of schizophrenia. If so, neural alterations during ToM should be observable in unaffected relatives of patients as well, since they share a considerable amount of genetic risk. While behaviorally, impaired ToM function is confirmed meta-analytically in relatives, evidence on aberrant function of the neural ToM network is sparse and inconclusive. The
more » ... resent study therefore aimed to further explore the neural correlates of ToM in relatives of schizophrenia. 297 controls and 63 unaffected firstdegree relatives of patients with schizophrenia performed a ToM task during functional magnetic resonance imaging. Consistent with the literature relatives exhibited decreased activity of the medial prefrontal cortex. Additionally, increased recruitment of the right middle temporal gyrus and posterior cingulate cortex was found, which was related to subclinical paranoid symptoms in relatives. These results further support decreased medial prefrontal activation during ToM as an intermediate phenotype of genetic risk for schizophrenia. Enhanced recruitment of posterior ToM areas in relatives might indicate inefficiency mechanisms in the presence of genetic risk.
doi:10.1093/scan/nsv111 pmid:26341902 pmcid:PMC4733339 fatcat:cdfnk7hzwvgkzk4fj4vunvy6ci

Larger amygdala volume in first-degree relatives of patients with major depression

Nina Romanczuk-Seiferth, Lydia Pöhland, Sebastian Mohnke, Maria Garbusow, Susanne Erk, Leila Haddad, Oliver Grimm, Heike Tost, Andreas Meyer-Lindenberg, Henrik Walter, Torsten Wüstenberg, Andreas Heinz
2014 NeuroImage: Clinical  
Acknowledgment We thank Josephine Klaembt, Claudia Schütz and Carolin Wackerhagen for help with data acquisition and Phöbe Schmierer for assistance in data analysis.  ... 
doi:10.1016/j.nicl.2014.05.015 pmid:25003028 pmcid:PMC4081974 fatcat:mfvjobg6arczpdcqj6zo7uogve

Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network

Sebastian Mohnke, Susanne Erk, Knut Schnell, Claudia Schütz, Nina Romanczuk-Seiferth, Oliver Grimm, Leila Haddad, Lydia Pöhland, Maria Garbusow, Mike M Schmitgen, Peter Kirsch, Christine Esslinger (+12 others)
2013 Neuropsychopharmacology  
ACKNOWLEDGEMENTS We thank Josephine Klaembt, Phöbe Schmierer, Carola Opitz von Boberfeld, Beate Newport, and Dagmar Gass for help with data acquisition and Torsten Wüstenberg for technical support.  ... 
doi:10.1038/npp.2013.321 pmid:24247043 pmcid:PMC3957114 fatcat:kwi52wjjcne4nmters4n3xulfa

An Experimental Decision-Making Paradigm to Distinguish Guilt and Regret and Their Self-Regulating Function via Loss Averse Choice Behavior

Ullrich Wagner, Lisa Handke, Denise Dörfel, Henrik Walter
2012 Frontiers in Psychology  
Schmierer, Björn Schott, Rosa Steimke, Christine Stelzel, Corinde Wiers, and Andrew Wold for valuable assistance and inspiring discussions.  ...  providing advice for the experimental procedure, and Sylvia Berndt, Judith Daniels, Susanne Erk, Michael Gaebler, Jimmy Jensen, Jan-Peter Lamke, Vera Ludwig, Sebastian Mohnke, Sabine Müller, Lena Paschke, Phöbe  ... 
doi:10.3389/fpsyg.2012.00431 pmid:23133433 pmcid:PMC3490329 fatcat:hkn44b6745eljp7pxnyb7b6vtu