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As evidenced by a multitude of studies, abnormalities in Theory of Mind (ToM) and its neural processing might constitute an intermediate phenotype of schizophrenia. If so, neural alterations during ToM should be observable in unaffected relatives of patients as well, since they share a considerable amount of genetic risk. While behaviorally, impaired ToM function is confirmed meta-analytically in relatives, evidence on aberrant function of the neural ToM network is sparse and inconclusive. Thedoi:10.1093/scan/nsv111 pmid:26341902 pmcid:PMC4733339 fatcat:cdfnk7hzwvgkzk4fj4vunvy6ci
more »... resent study therefore aimed to further explore the neural correlates of ToM in relatives of schizophrenia. 297 controls and 63 unaffected firstdegree relatives of patients with schizophrenia performed a ToM task during functional magnetic resonance imaging. Consistent with the literature relatives exhibited decreased activity of the medial prefrontal cortex. Additionally, increased recruitment of the right middle temporal gyrus and posterior cingulate cortex was found, which was related to subclinical paranoid symptoms in relatives. These results further support decreased medial prefrontal activation during ToM as an intermediate phenotype of genetic risk for schizophrenia. Enhanced recruitment of posterior ToM areas in relatives might indicate inefficiency mechanisms in the presence of genetic risk.
Acknowledgment We thank Josephine Klaembt, Claudia Schütz and Carolin Wackerhagen for help with data acquisition and Phöbe Schmierer for assistance in data analysis. ...doi:10.1016/j.nicl.2014.05.015 pmid:25003028 pmcid:PMC4081974 fatcat:mfvjobg6arczpdcqj6zo7uogve
ACKNOWLEDGEMENTS We thank Josephine Klaembt, Phöbe Schmierer, Carola Opitz von Boberfeld, Beate Newport, and Dagmar Gass for help with data acquisition and Torsten Wüstenberg for technical support. ...doi:10.1038/npp.2013.321 pmid:24247043 pmcid:PMC3957114 fatcat:kwi52wjjcne4nmters4n3xulfa
Schmierer, Björn Schott, Rosa Steimke, Christine Stelzel, Corinde Wiers, and Andrew Wold for valuable assistance and inspiring discussions. ... providing advice for the experimental procedure, and Sylvia Berndt, Judith Daniels, Susanne Erk, Michael Gaebler, Jimmy Jensen, Jan-Peter Lamke, Vera Ludwig, Sebastian Mohnke, Sabine Müller, Lena Paschke, Phöbe ...doi:10.3389/fpsyg.2012.00431 pmid:23133433 pmcid:PMC3490329 fatcat:hkn44b6745eljp7pxnyb7b6vtu