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Top quark properties [article]

Petra Van Mulders
2018 arXiv   pre-print
The multi-purpose experiments at CERN's Large Hadron Collider have a very rich programme in top quark physics. The large amount of data allows for measuring the top quark properties with an unprecedented precision. This document presents some of the properties that have been measured using top quark pair events produced in proton-proton collisions with a centre-of-mass energy of 13 TeV. The focus lies on the measurements of the colour flow, the charge asymmetry and spin correlations in top quark pair events.
arXiv:1812.05819v1 fatcat:tvl4y42vwjhdpbsg3o2bpailba

Searches for new fermions and new bosons [article]

Petra Van Mulders, for the CMS Collaboration, for the ATLAS Collaboration
2012 arXiv   pre-print
The high center-of-mass energy at the LHC provides the opportunity to test the predictions of some of the beyond the standard model theories. We provide an overview of a selected number of searches for new fermions and new bosons with the ATLAS and CMS experiments. No evidence for the existence of new particles was found and therefore limits are obtained on the parameters of the models under consideration.
arXiv:1212.2339v2 fatcat:zsbpw53ntbgqpcazoqi6swf4ie

How robust is the language architecture? The case of mood

Jos J. A. Van Berkum, Dieuwke De Goede, Petra M. Van Alphen, Emma R. Mulder, José H. Kerstholt
2013 Frontiers in Psychology  
Combining this with the Van Berkum et al.  ...  ., 2008; Davis, 2009) , and reduces the degree of conflict-driven control (Van Steenbergen et al., 2010) .  ...  Citation: Van Berkum JJA, De Goede D, Van Alphen PM, Mulder ER and Kerstholt JH (2013)  ... 
doi:10.3389/fpsyg.2013.00505 pmid:23986725 pmcid:PMC3749370 fatcat:jju5rxvo3vb3jmj7ri2xezbfra

ReSyst: a novel technique to Reduce the Systematic uncertainty for precision measurements [article]

Petra Van Mulders
2018 arXiv   pre-print
We are in an era of precision measurements at the Large Hadron Collider. The precision that can be achieved on some of the measurements is limited however due to large systematic uncertainties. This paper introduces a new technique to reduce the systematic uncertainty by quantifying the systematic impact of single events and correlating it with event observables to identify parts of the phase space that are more sensitive to systematic effects. A proof of concept is presented by means of a
more » ... ified top quark mass estimator applied on simulated events. Even without a thorough optimization, it is shown that the total systematic uncertainty can be reduced by a factor of at least two.
arXiv:1809.07700v1 fatcat:2jl3rg65zrfllnnzvnony3wgw4

Crucial factors preceding compulsory psychiatric admission: a qualitative patient-record study

Mark H. de Jong, Margreet Oorschot, Astrid M. Kamperman, Petra E. Brussaard, Esther M. Knijff, Roland van de Sande, Arthur R. Van Gool, Cornelis L. Mulder
2017 BMC Psychiatry  
Compulsory admissions have a strong effect on psychiatric patients and represent a deprivation of personal liberty. Although the rate of such admissions is tending to rise in several Western countries, there is little qualitative research on the mental health-care process preceding compulsory admission. The objective of the study was to identify crucial factors in the mental health-care process preceding compulsory admission of adult psychiatric patients. Methods: This retrospective,
more » ... multiple-case study was based on the patient records of patients with severe mental illness, mainly schizophrenia and other psychotic disorders. Twenty two patient records were analyzed. Patients' demographic and clinical characteristics were heterogeneous. All were treated by Flexible Assertive Community Treatment teams (FACT teams) at two mental health institutions in the greater Rotterdam area in the Netherlands and had a compulsory admission in a predefined inclusion period. The data were analyzed according to the Prevention and Recovery System for Monitoring and Analysis (PRISMA) method, assessing acts, events, conditions, and circumstances, failing protective barriers and protective recovery factors. Results: The most important patient factors in the process preceding compulsory admission were psychosis, aggression, lack of insight, care avoidance, and unauthorized reduction or cessation of medication. Neither were health-care professionals as assertive as they could be in managing early signs of relapse and care avoidance of these particular patients. Conclusion: The health-care process preceding compulsory admission is complex, being influenced by acts, events, conditions and circumstances, failing barriers, and protective factors. The most crucial factors are patients' lack of insight and cessation of medication, and health-care professionals' lack of assertiveness.
doi:10.1186/s12888-017-1512-y pmid:29065870 pmcid:PMC5655985 fatcat:2vzi4nowlzakbf5hnjpnyozeie

Syntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture [article]

Marije Kat, Ellie Karampini, Arie Johan Hoogendijk, Petra Bürgisser, Aat A. Mulder, Floris van Alphen, Jenny Olins, Dirk Geerts, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings
2021 bioRxiv   pre-print
AbstractVon Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongated WPB morphology is correlated to longer VWF strings with better adhesive properties. We previously identified the SNARE SEC22B, which is involved in anterograde ER-to-Golgi transport, as a novel
more » ... lator of WPB elongation. To elucidate novel determinants of WPB morphology we explored endothelial SEC22B interaction partners in a mass spectrometrybased approach, identifying the Golgi SNARE Syntaxin 5 (STX5). We established STX5 knockdown in ECs using shRNA-dependent silencing and analyzed WPB and Golgi morphology, using confocal and electron microscopy. STX5-depleted ECs exhibited extensive Golgi fragmentation and decreased WPB length, which was associated with reduced intracellular VWF levels, and impaired stimulated VWF secretion. However, the secretion-incompetent organelles in shSTX5 cells maintained WPB markers such as Angiopoietin 2, P-selectin, Rab27A, and CD63. Taken together, our study has identified SNARE protein STX5 as a novel regulator of WPB biogenesis.
doi:10.1101/2021.12.10.472050 fatcat:hcfnrluj2nbw7hx2r6qf6anrpa

The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis

Petra Mulder, Anita M. van den Hoek, Robert Kleemann, Manlio Vinciguerra
2017 PLoS ONE  
Acknowledgments The authors thank Wim van Duyvenvoorde, Anita van Straalen-van Nieuwkoop and Annemarie Maas for excellent technical assistance. Author Contributions Conceptualization: PM AMvdH RK.  ... 
doi:10.1371/journal.pone.0169740 pmid:28076416 pmcid:PMC5226841 fatcat:b52cbadvivdpjafbgrtwhczy6y

Development of muscle ultrasound density in healthy fetuses and infants

Renate J. Verbeek, Petra B. Mulder, Krystyna M. Sollie, Johannes H. van der Hoeven, Wilfred F. A. den Dunnen, Natalia M. Maurits, Deborah A. Sival, Antonio Gonzalez-Bulnes
2020 PLoS ONE  
Muscle ultrasound density (MUD) is a non-invasive parameter to indicate neuromuscular integrity in both children and adults. In healthy fetuses and infants, physiologic MUD values during development are still lacking. We therefore aimed to determine the physiologic, age-related MUD trend of biceps, quadriceps, tibialis anterior, hamstrings, gluteal and calf muscles, from pre- to the first year of postnatal life. To avoid a bias by pregnancy-related signal disturbances, we expressed fetal MUD as
more » ... a ratio against bone ultrasound density. We used the full-term prenatal MUD ratio and the newborn postnatal MUD value as reference points, so that MUD development could be quantified from early pre- into postnatal life. Results: During the prenatal period, the total muscle group revealed a developmental MUD trend concerning a fetal increase in MUD-ratio from the 2nd trimester up to the end of the 3rd trimester [median increase: 27% (range 16-45), p < .001]. After birth, MUD-values increased up to the sixth month [median increase: 11% (range -7-27), p = 0.025] and stabilized thereafter. Additionally, there were also individual MUD characteristics per muscle group and developmental stage, such as relatively low MUD values of fetal hamstrings and high values of the paediatric gluteus muscles. These MUD trends are likely to concur with analogous developmentally, maturation-related alterations in the muscle water to peptide content ratios.
doi:10.1371/journal.pone.0235836 pmid:32649730 fatcat:xtov2wj6h5ez3gzgbyhxdoirhe

Coordinated and Interactive Expression of Genes of Lipid Metabolism and Inflammation in Adipose Tissue and Liver during Metabolic Overload

Wen Liang, Giulia Tonini, Petra Mulder, Thomas Kelder, Marjan van Erk, Anita M. van den Hoek, Rob Mariman, Peter Y. Wielinga, Michela Baccini, Teake Kooistra, Annibale Biggeri, Robert Kleemann (+1 others)
2013 PLoS ONE  
Citation: Liang W, Tonini G, Mulder P, Kelder T, van Erk M, et al. (2013) Coordinated and Interactive Expression of Genes of Lipid Metabolism and Inflammation in Adipose Tissue and Liver during Metabolic  ...  Offerman, Wim van Duyvenvoorde and Karin Toet for technical assistance. (XLS) PLOS ONE | www.plosone.org September 2013 | Volume 8 | Issue 9 | e75290  ... 
doi:10.1371/journal.pone.0075290 pmid:24086498 pmcid:PMC3783477 fatcat:pp6o5u43e5empgddpncnoweii4

Early in vivo assessment of angiostatic therapy efficacy by molecular MRI

Willem J. M. Mulder, Daisy W. J. van der Schaft, Petra A. I. Hautvast, Gustav J. Strijkers, Gerben A. Koning, Gert Storm, Kevin H. Mayo, Arjan W. Griffioen, Klaas Nicolay
2007 The FASEB Journal  
-Mulder, W. J. M., van der Schaft, Early in vivo assessment of angiostatic therapy efficacy by molecular MRI. FASEB J. 21, 000 -000 (2007)  ...  Vol. 21 February 2007 Vol. 21 February 2007 MULDER ET AL. The FASEB Journal  ... 
doi:10.1096/fj.06-6791com pmid:17202248 fatcat:f2jgvpcrtbbx3curt7nnf4x3i4

Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study

Greetje J Tack, Roy L J van Wanrooij, B Mary E Von Blomberg, Hedayat Amini, Veerle M H Coupe, Petra Bonnet, Chris J J Mulder, Marco W J Schreurs
2012 BMC Gastroenterology  
Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD. Methods: We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy associated T-cell lymphoma (EATL). Results: In both active CD and RCDI-II elevated levels of the proinflammatory IL-8,
more » ... L-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups. Conclusions: A series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.
doi:10.1186/1471-230x-12-159 pmid:23145841 pmcid:PMC3579729 fatcat:6zx3arobevas3leua3m5ix3fi4

Evaluation of the IRF-2 Gene as a Candidate for PSORS3

John Foerster, Ilja Nolte, Susann Schweiger, Claudia Ehlert, Marcel Bruinenberg, Katja Spaar, Gerrit van der Steege, Marcel Mulder, Vera Kalscheuer, Bettina Moser, Zofia Kijas, Petra Seeman (+3 others)
2004 Journal of Investigative Dermatology  
Levinson et al, 2001; te Meerman and Van der Meulen, 1997; Beckmann et al, 2001; Nolte and Te Meerman, 2002b) .  ...  Recently, IRF2 was reported to be aberrantly expressed in suprabasal psoriatic lesional epidermis (van der Fits et al, 2003) .  ... 
doi:10.1046/j.0022-202x.2003.22104.x pmid:14962090 fatcat:uudnju2whzey3oaabasnscddum

Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice

Petra Mulder, Martine C. Morrison, Lars Verschuren, Wen Liang, J. Hajo van Bockel, Teake Kooistra, Peter Y. Wielinga, Robert Kleemann
2016 Scientific Reports  
Acknowledgements The authors would like to thank Erik Offerman, Wim van Duyvenvoorde, Karin Toet. Elvira Fluitsma and Anne Schwerk for their excellent technical assistance.  ... 
doi:10.1038/srep31542 pmid:27545964 pmcid:PMC4992869 fatcat:raae4zy5gramnb4qvll4yg42xu

BRCA1 -Mutated Estrogen Receptor–Positive Breast Cancer Shows BRCAness, Suggesting Sensitivity to Drugs Targeting Homologous Recombination Deficiency

Esther H. Lips, Rashmie D. Debipersad, Caroline E. Scheerman, Lennart Mulder, Gabe S. Sonke, Lizet E. van der Kolk, Jelle Wesseling, Frans B.L. Hogervorst, Petra M. Nederlof
2016 Clinical Cancer Research  
Purpose: As estrogen receptor-positive (ER þ ) breast cancer in BRCA1 mutation carriers arises at an older age with less aggressive tumor characteristics than ER-negative (ER À ) BRCA1-mutated breast cancer, it has been suggested that these tumors are "sporadic" and not BRCA1 driven. With the introduction of targeted treatments specific for tumors with a nonfunctioning BRCA1 or BRCA2 gene, the question whether the BRCA genes are impaired in the tumor is highly relevant. Therefore, we performed
more » ... enomic profiling of BRCA1-mutated ER þ tumors. Experimental Design: Genomic profiling, BRCA1 promoter methylation assessment, and loss of heterozygosity analysis were done on 16 BRCA1-mutated ER þ tumors. Results were compared with 57 BRCA1-mutated ER À tumors, 36 BRCA2-mutated ER þ -associated tumors, and 182 sporadic ER þ tumors. Results: The genomic profile of BRCA1-mutated ER þ tumors was different from BRCA1-mutated ER À breast tumors, but highly similar to BRCA2-mutated ER þ tumors. In 83% of the BRCA1mutated ER þ tumors, loss of the wild-type BRCA1 allele was observed. In addition, clinicopathologic variables in BRCA1mutated ER þ cancer were also more similar to BRCA2-mutated ER þ and sporadic ER þ breast cancer than to BRCA1-mutated ER À cancers. Conclusions: As BRCA1-mutated ER þ tumors show a BRCAness copy number profile and LOH, it is likely that the loss of a functional BRCA1 protein plays a role in tumorigenesis in BRCA1mutated ER þ tumors. Therefore, we hypothesize that these tumors are sensitive to drugs targeting the BRCA1 gene defect, providing new targeted treatment modalities for advanced BRCA-deficient, ER þ breast cancer. a P value for comparison of BRCA1-mutated ER þ tumors with BRCA1-mutated ER À tumors, BRCA2-mutated ER þ tumors, and sporadic ER þ tumors, respectively.
doi:10.1158/1078-0432.ccr-16-0198 pmid:27620280 fatcat:qe2pipvpg5gedhhz2k6xopntgq

Haplotype Sharing Analysis Identifies a Retroviral dUTPase as Candidate Susceptibility Gene for Psoriasis

John Foerster, Ilja Nolte, Judith Junge, Marcel Bruinenberg, Susann Schweiger, Katja Spaar, Gerrit van der Steege, Claudia Ehlert, Marcel Mulder, Vera Kalscheuer, Elisa Blumenthal-Barby, Jennifer Winter (+4 others)
2005 Journal of Investigative Dermatology  
The psoriasis susceptibility locus 1 (PSORS1) mutation is assumed to reside within a region around human leukocyte antigen-C spanning 250 kb, termed risk haplotype (RH) 1/2. By re-analyzing a published data set with a previously developed method, the haplotype sharing statistic, we confirm localization of PSORS1 to the RH1 region and refine its location to marker M6S168. We replicate this result in an independent patient sample. The target region harbors fragments of a human endogenous
more » ... s K (HERV-K) endogenous retrovirus. Two singlenucleotide polymorphisms with alleles differing between high-and low-risk haplotypes are located within the HERV-K dUTPase. One of these encodes a predicted non-conserved Glu-Arg exchange. The HERV-K dUTPase is expressed in peripheral blood and in normal as well as lesional psoriatic skin. Our results indicate that an endogenous retroviral dUTPase constitutes a candidate gene for the PSORS1 mutation.
doi:10.1111/j.0022-202x.2004.23504.x pmid:15654959 fatcat:6zymterwo5eqlejzma5idhbykm
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