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Top quark properties
[article]
2018
arXiv
pre-print
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The multi-purpose experiments at CERN's Large Hadron Collider have a very rich programme in top quark physics. The large amount of data allows for measuring the top quark properties with an unprecedented precision. This document presents some of the properties that have been measured using top quark pair events produced in proton-proton collisions with a centre-of-mass energy of 13 TeV. The focus lies on the measurements of the colour flow, the charge asymmetry and spin correlations in top quark pair events.
arXiv:1812.05819v1
fatcat:tvl4y42vwjhdpbsg3o2bpailba
Searches for new fermions and new bosons
[article]
2012
arXiv
pre-print
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The high center-of-mass energy at the LHC provides the opportunity to test the predictions of some of the beyond the standard model theories. We provide an overview of a selected number of searches for new fermions and new bosons with the ATLAS and CMS experiments. No evidence for the existence of new particles was found and therefore limits are obtained on the parameters of the models under consideration.
arXiv:1212.2339v2
fatcat:zsbpw53ntbgqpcazoqi6swf4ie
How robust is the language architecture? The case of mood
2013
Frontiers in Psychology
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Combining this with the Van Berkum et al. ...
., 2008; Davis, 2009) , and reduces the degree of conflict-driven control (Van Steenbergen et al., 2010) . ...
Citation: Van Berkum JJA, De Goede D, Van Alphen PM, Mulder ER and Kerstholt JH (2013) ...
doi:10.3389/fpsyg.2013.00505
pmid:23986725
pmcid:PMC3749370
fatcat:jju5rxvo3vb3jmj7ri2xezbfra
ReSyst: a novel technique to Reduce the Systematic uncertainty for precision measurements
[article]
2018
arXiv
pre-print
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We are in an era of precision measurements at the Large Hadron Collider. The precision that can be achieved on some of the measurements is limited however due to large systematic uncertainties. This paper introduces a new technique to reduce the systematic uncertainty by quantifying the systematic impact of single events and correlating it with event observables to identify parts of the phase space that are more sensitive to systematic effects. A proof of concept is presented by means of a
arXiv:1809.07700v1
fatcat:2jl3rg65zrfllnnzvnony3wgw4
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... ified top quark mass estimator applied on simulated events. Even without a thorough optimization, it is shown that the total systematic uncertainty can be reduced by a factor of at least two.
Crucial factors preceding compulsory psychiatric admission: a qualitative patient-record study
2017
BMC Psychiatry
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Compulsory admissions have a strong effect on psychiatric patients and represent a deprivation of personal liberty. Although the rate of such admissions is tending to rise in several Western countries, there is little qualitative research on the mental health-care process preceding compulsory admission. The objective of the study was to identify crucial factors in the mental health-care process preceding compulsory admission of adult psychiatric patients. Methods: This retrospective,
doi:10.1186/s12888-017-1512-y
pmid:29065870
pmcid:PMC5655985
fatcat:2vzi4nowlzakbf5hnjpnyozeie
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... multiple-case study was based on the patient records of patients with severe mental illness, mainly schizophrenia and other psychotic disorders. Twenty two patient records were analyzed. Patients' demographic and clinical characteristics were heterogeneous. All were treated by Flexible Assertive Community Treatment teams (FACT teams) at two mental health institutions in the greater Rotterdam area in the Netherlands and had a compulsory admission in a predefined inclusion period. The data were analyzed according to the Prevention and Recovery System for Monitoring and Analysis (PRISMA) method, assessing acts, events, conditions, and circumstances, failing protective barriers and protective recovery factors. Results: The most important patient factors in the process preceding compulsory admission were psychosis, aggression, lack of insight, care avoidance, and unauthorized reduction or cessation of medication. Neither were health-care professionals as assertive as they could be in managing early signs of relapse and care avoidance of these particular patients. Conclusion: The health-care process preceding compulsory admission is complex, being influenced by acts, events, conditions and circumstances, failing barriers, and protective factors. The most crucial factors are patients' lack of insight and cessation of medication, and health-care professionals' lack of assertiveness.
Syntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture
[article]
2021
bioRxiv
pre-print
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AbstractVon Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongated WPB morphology is correlated to longer VWF strings with better adhesive properties. We previously identified the SNARE SEC22B, which is involved in anterograde ER-to-Golgi transport, as a novel
doi:10.1101/2021.12.10.472050
fatcat:hcfnrluj2nbw7hx2r6qf6anrpa
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... lator of WPB elongation. To elucidate novel determinants of WPB morphology we explored endothelial SEC22B interaction partners in a mass spectrometrybased approach, identifying the Golgi SNARE Syntaxin 5 (STX5). We established STX5 knockdown in ECs using shRNA-dependent silencing and analyzed WPB and Golgi morphology, using confocal and electron microscopy. STX5-depleted ECs exhibited extensive Golgi fragmentation and decreased WPB length, which was associated with reduced intracellular VWF levels, and impaired stimulated VWF secretion. However, the secretion-incompetent organelles in shSTX5 cells maintained WPB markers such as Angiopoietin 2, P-selectin, Rab27A, and CD63. Taken together, our study has identified SNARE protein STX5 as a novel regulator of WPB biogenesis.
The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis
2017
PLoS ONE
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Acknowledgments The authors thank Wim van Duyvenvoorde, Anita van Straalen-van Nieuwkoop and Annemarie Maas for excellent technical assistance.
Author Contributions Conceptualization: PM AMvdH RK. ...
doi:10.1371/journal.pone.0169740
pmid:28076416
pmcid:PMC5226841
fatcat:b52cbadvivdpjafbgrtwhczy6y
Development of muscle ultrasound density in healthy fetuses and infants
2020
PLoS ONE
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Muscle ultrasound density (MUD) is a non-invasive parameter to indicate neuromuscular integrity in both children and adults. In healthy fetuses and infants, physiologic MUD values during development are still lacking. We therefore aimed to determine the physiologic, age-related MUD trend of biceps, quadriceps, tibialis anterior, hamstrings, gluteal and calf muscles, from pre- to the first year of postnatal life. To avoid a bias by pregnancy-related signal disturbances, we expressed fetal MUD as
doi:10.1371/journal.pone.0235836
pmid:32649730
fatcat:xtov2wj6h5ez3gzgbyhxdoirhe
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... a ratio against bone ultrasound density. We used the full-term prenatal MUD ratio and the newborn postnatal MUD value as reference points, so that MUD development could be quantified from early pre- into postnatal life. Results: During the prenatal period, the total muscle group revealed a developmental MUD trend concerning a fetal increase in MUD-ratio from the 2nd trimester up to the end of the 3rd trimester [median increase: 27% (range 16-45), p < .001]. After birth, MUD-values increased up to the sixth month [median increase: 11% (range -7-27), p = 0.025] and stabilized thereafter. Additionally, there were also individual MUD characteristics per muscle group and developmental stage, such as relatively low MUD values of fetal hamstrings and high values of the paediatric gluteus muscles. These MUD trends are likely to concur with analogous developmentally, maturation-related alterations in the muscle water to peptide content ratios.
Coordinated and Interactive Expression of Genes of Lipid Metabolism and Inflammation in Adipose Tissue and Liver during Metabolic Overload
2013
PLoS ONE
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Citation: Liang W, Tonini G, Mulder P, Kelder T, van Erk M, et al. (2013) Coordinated and Interactive Expression of Genes of Lipid Metabolism and Inflammation in Adipose Tissue and Liver during Metabolic ...
Offerman, Wim van Duyvenvoorde and Karin Toet for technical assistance. (XLS)
PLOS ONE | www.plosone.org
September 2013 | Volume 8 | Issue 9 | e75290 ...
doi:10.1371/journal.pone.0075290
pmid:24086498
pmcid:PMC3783477
fatcat:pp6o5u43e5empgddpncnoweii4
Early in vivo assessment of angiostatic therapy efficacy by molecular MRI
2007
The FASEB Journal
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-Mulder, W. J. M., van der Schaft, Early in vivo assessment of angiostatic therapy efficacy by molecular MRI. FASEB J. 21, 000 -000 (2007) ...
Vol. 21 February 2007
Vol. 21 February 2007 MULDER ET AL. The FASEB Journal ...
doi:10.1096/fj.06-6791com
pmid:17202248
fatcat:f2jgvpcrtbbx3curt7nnf4x3i4
Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study
2012
BMC Gastroenterology
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Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD. Methods: We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy associated T-cell lymphoma (EATL). Results: In both active CD and RCDI-II elevated levels of the proinflammatory IL-8,
doi:10.1186/1471-230x-12-159
pmid:23145841
pmcid:PMC3579729
fatcat:6zx3arobevas3leua3m5ix3fi4
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... L-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups. Conclusions: A series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.
Evaluation of the IRF-2 Gene as a Candidate for PSORS3
2004
Journal of Investigative Dermatology
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Levinson et al, 2001; te Meerman and Van der Meulen, 1997; Beckmann et al, 2001; Nolte and Te Meerman, 2002b) . ...
Recently, IRF2 was reported to be aberrantly expressed in suprabasal psoriatic lesional epidermis (van der Fits et al, 2003) . ...
doi:10.1046/j.0022-202x.2003.22104.x
pmid:14962090
fatcat:uudnju2whzey3oaabasnscddum
Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice
2016
Scientific Reports
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Acknowledgements The authors would like to thank Erik Offerman, Wim van Duyvenvoorde, Karin Toet. Elvira Fluitsma and Anne Schwerk for their excellent technical assistance. ...
doi:10.1038/srep31542
pmid:27545964
pmcid:PMC4992869
fatcat:raae4zy5gramnb4qvll4yg42xu
BRCA1 -Mutated Estrogen Receptor–Positive Breast Cancer Shows BRCAness, Suggesting Sensitivity to Drugs Targeting Homologous Recombination Deficiency
2016
Clinical Cancer Research
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Purpose: As estrogen receptor-positive (ER þ ) breast cancer in BRCA1 mutation carriers arises at an older age with less aggressive tumor characteristics than ER-negative (ER À ) BRCA1-mutated breast cancer, it has been suggested that these tumors are "sporadic" and not BRCA1 driven. With the introduction of targeted treatments specific for tumors with a nonfunctioning BRCA1 or BRCA2 gene, the question whether the BRCA genes are impaired in the tumor is highly relevant. Therefore, we performed
doi:10.1158/1078-0432.ccr-16-0198
pmid:27620280
fatcat:qe2pipvpg5gedhhz2k6xopntgq
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... enomic profiling of BRCA1-mutated ER þ tumors. Experimental Design: Genomic profiling, BRCA1 promoter methylation assessment, and loss of heterozygosity analysis were done on 16 BRCA1-mutated ER þ tumors. Results were compared with 57 BRCA1-mutated ER À tumors, 36 BRCA2-mutated ER þ -associated tumors, and 182 sporadic ER þ tumors. Results: The genomic profile of BRCA1-mutated ER þ tumors was different from BRCA1-mutated ER À breast tumors, but highly similar to BRCA2-mutated ER þ tumors. In 83% of the BRCA1mutated ER þ tumors, loss of the wild-type BRCA1 allele was observed. In addition, clinicopathologic variables in BRCA1mutated ER þ cancer were also more similar to BRCA2-mutated ER þ and sporadic ER þ breast cancer than to BRCA1-mutated ER À cancers. Conclusions: As BRCA1-mutated ER þ tumors show a BRCAness copy number profile and LOH, it is likely that the loss of a functional BRCA1 protein plays a role in tumorigenesis in BRCA1mutated ER þ tumors. Therefore, we hypothesize that these tumors are sensitive to drugs targeting the BRCA1 gene defect, providing new targeted treatment modalities for advanced BRCA-deficient, ER þ breast cancer. a P value for comparison of BRCA1-mutated ER þ tumors with BRCA1-mutated ER À tumors, BRCA2-mutated ER þ tumors, and sporadic ER þ tumors, respectively.
Haplotype Sharing Analysis Identifies a Retroviral dUTPase as Candidate Susceptibility Gene for Psoriasis
2005
Journal of Investigative Dermatology
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The psoriasis susceptibility locus 1 (PSORS1) mutation is assumed to reside within a region around human leukocyte antigen-C spanning 250 kb, termed risk haplotype (RH) 1/2. By re-analyzing a published data set with a previously developed method, the haplotype sharing statistic, we confirm localization of PSORS1 to the RH1 region and refine its location to marker M6S168. We replicate this result in an independent patient sample. The target region harbors fragments of a human endogenous
doi:10.1111/j.0022-202x.2004.23504.x
pmid:15654959
fatcat:6zymterwo5eqlejzma5idhbykm
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... s K (HERV-K) endogenous retrovirus. Two singlenucleotide polymorphisms with alleles differing between high-and low-risk haplotypes are located within the HERV-K dUTPase. One of these encodes a predicted non-conserved Glu-Arg exchange. The HERV-K dUTPase is expressed in peripheral blood and in normal as well as lesional psoriatic skin. Our results indicate that an endogenous retroviral dUTPase constitutes a candidate gene for the PSORS1 mutation.
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