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Just as in recent years many editors have paid insu cient (or inconsistent, or even contradictory) attention to the authority of the metre in editing early modem play-texts, so more recent editions have begun to discard even the rather basic assistance that has traditionally been supplied to the metrically unsophisticated reader: the Arden 3 editions, for example, no longer indicate the syllabic status of preterite su xes in the text (perhaps fearing that the occasional grave accent mightdoi:10.4000/variants.1002 fatcat:fsatapgmkzhg7dzn4an6mulu6a
more »... en the horses), and Jonathon Bates' recent RSC edition rejects the helpful practice, normal since Edmond Malone and George Steevens, of indicating the structure of shared lines by indentation, on the cogent grounds that the First Folio didn't do it. Ironically, this retreat from the authority of the metre has coincided with large advances, based in part upon linguistics, in our understanding of how metre works. But if metre is not some arid formality but rather a signifying system, this kind of negligence is doing that reader a disservice. This paper will explore some of the ways in which editors might discreetly assist the reader in grasping metrical and prosodic variation (where such variation seems relevant or important), and in exploring (without oppressing the reader with unnecessary detail) the kinds of editorial choices o ered by two equally but variously substantive witnesses, such as Q2 and FI Hamlet: one role of the editor here is to draw attention to meaningful variation while filtering out mere noise.
Standard-Nutzungsbedingungen: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesendoi:10.2139/ssrn.2970452 fatcat:svjsduxpirhtnc2k34sk3goxfu
more »... bedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Abstract We study the introduction of single-market liquidity provider incentives in fragmented securities markets. Specifically, we investigate whether fee rebates for liquidity providers enhance liquidity on the introducing market and thereby increase its competitiveness and market share. Further, we analyze whether single-market liquidity provider incentives increase overall market liquidity available for market participants. Therefore, we measure the specific liquidity contribution of individual markets to the aggregate liquidity in the fragmented market environment. While liquidity and market share of the venue introducing incentives increase, we find no significant effect for turnover and liquidity of the whole market. We would like to thank Karl Ludwig Keiber, Satchit Sagade and Christian Westheide for helpful comments and suggestions. We also greatly appreciate comments from conference participants at
Standard-Nutzungsbedingungen: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesendoi:10.2139/ssrn.3120370 fatcat:cmyag4yl35c3folwpwefw4t5zq
more »... bedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte.
Standard-Nutzungsbedingungen: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesendoi:10.2139/ssrn.2910977 fatcat:fg63dyuz65g3jdnmiugonx6cpm
more »... bedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Circuit breakers are volatility safeguards that shall protect markets from extreme price fluctuations, excessive volatility and overreactions. Especially in the context of today's highly automated trading and the large number of transactions conducted by algorithmic and highfrequency trading (HFT) firms, circuit breakers aim at ensuring market stability. Moreover, several flash crash type events, i.e., phases of high volatility and large price swings in very short time spans, have become an increasing phenomenon in recent years highlighting the importance of circuit breakers. Consequently, circuit breakers and their design gained public and regulatory attention, which also led to regulatory initiatives regarding the introduction and the configuration of these mechanisms. While the majority of trading venues has some kind of circuit breaker in place, these safeguards significantly differ in their design, which might be one of the reasons why academic studies come to different conclusions whether circuit breakers are beneficial or not. This paper adds to the literature on circuit breakers by analyzing how different design parameters influence the effectiveness of circuit breakers to calm securities markets during phases of high volatility. For our analysis, we compare volatility interruption mechanisms on two European venues, which differ in relevant design parameters. A volatility interruption is a specific type of circuit breaker that interrupts continuous trading with an unscheduled call auction. Our results show that a shorter duration and narrower price ranges support their effectiveness. The disclosure respectively non-disclosure of triggering thresholds, however, has no effect on the interruption's effectiveness, which might result from the possibility to approximate the thresholds based on tick-by-tick trade data. Furthermore, there is empirical evidence that volatility interruptions triggered by market-wide events are not as effective as interruptions triggered by single-stock events. With our empirical analysis, we show that circuit breakers in the form of volatility interruptions are able to reduce volatility but are also associated with a drop in liquidity. In particular, our results reveal how design parameters such as duration, width of triggering thresholds, and the publication of these thresholds influence the effectiveness of volatility interruptions in reducing volatility and preserving liquidity. These results may serve as a starting point for exchange operators and regulators to review existing circuit breaker designs or to start implementing them Abstract We investigate different designs of circuit breakers implemented on European trading venues and examine their effectiveness to manage excess volatility and to preserve liquidity. Specifically, we empirically analyze volatility and liquidity around volatility interruptions implemented on the German and Spanish stock market which differ regarding specific design parameters. We find that volatility interruptions in general significantly decrease volatility in the post interruption phase. Unfortunately, this decrease in volatility comes at the cost of decreased liquidity. Regarding design parameters, we find tighter price ranges and shorter durations to support volatility interruptions in achieving their goals.
This observation is in line with Clapham and Zimmermann (2016) , where the authors observe a significant decline of trading activity on alternative venues during mid-day auctions on Xetra. ...doi:10.2139/ssrn.2906719 fatcat:pr4xgbh7p5fddkbj7oodn5wpga
In qualitative methods, yarning has been developed as a decolonising methodology in the work of Bessarab and others (Bessarab Australasian Journal of Information Systems Clapham et al. 2021, Vol 25 ... Technologies literature on social media and Aboriginal youth in Australia Australasian Journal of Information Systems Clapham et al. 2021, Vol 25, Research on Indigenous Use of Digital Support ... Australasian Journal of Information Systems Clapham et al. 2021, Vol 25 ...doi:10.3127/ajis.v25i0.2885 fatcat:ych52pq2hjcm3jyojpiszox3ny
in Hervey Bay, singers are heard, and competitive groups are observed in the bay (Corkeron 1993 , Corkeron et al. 1994 ; the latter involve intrasexual competition among males for access to females (Clapham ... Mothers of humpback calves exclusively provide maternal care in the form of food, protection, and preparation for their calves' first migration to high-latitude feeding areas (Clapham 2000) . ...doi:10.1111/j.1748-7692.2010.00430.x fatcat:uof46fumkrevndjoilk4cvy7im
Journal of Mammalogy
of Mammalogists Humpback whales (Megaptera novaeangliae) undertake extensive seasonal migrations from summer feeding areas in high latitudes to winter mating and calving grounds in tropical waters (Clapham ...doi:10.1644/09-mamm-a-033r.1. fatcat:ibg6fvr3vvaoziqobijtqe3gka
Peter Panagiotis (Peter Pan) was the designer of the wet suits and owner of the Peter Pan Surf Academy. ... We piloted an eight week surfing program for children with disabilities that included many individuals with Down syndrome (Clapham, Armitano, Lamont, & Audette, in press ). ...doi:10.25035/ijare.08.01.09 fatcat:27l2gu6eyrhcll2wpizfhyfqfu
custom-designed Delrin chamber (adapted for use with either mouse or rat preparations) is commercially available from the workshop of the Department of Physiology, University of Erlangen-Nuremberg, through Peter ...doi:10.1038/nprot.2008.223 pmid:19180088 pmcid:PMC4082318 fatcat:yr4y7d54r5gvlgakaxwzocxroy
and Payne, 2011; Payne and Clapham, 2012) . ... eruption of the Emeishan Large Igneous Province (LIP) and thus potentially was triggered by the same ecological-disruption mechanism seen in other LIP eruptions: global warming and oceanic acidification (Clapham ...doi:10.1016/j.palaeo.2012.12.019 fatcat:er6cdyqkibbwrl3ng7van53ata
Clapham et al. It is important to recognize that while a median index offers a more stable index, a quality-controlled index is required for these types of instruments. ... Clapham et al. The repeat-sales index appears to perform worse with hedonic information included. This may reflect the maintained assumption of constant implicit prices. ...doi:10.1111/j.1540-6229.2006.00167.x fatcat:ehetlnngabccjk5a6barffige4
Increasingly large amounts of DNA sequencing data are being generated within the Wellcome Trust Sanger Institute (WTSI). The traditional file system struggles to handle these increasing amounts of sequence data. A good data management system therefore needs to be implemented and integrated into the current WTSI infrastructure. Such a system enables good management of the IT infrastructure of the sequencing pipeline and allows biologists to track their data. Results: We have chosen a data griddoi:10.1186/1471-2105-12-361 pmid:21906284 pmcid:PMC3228552 fatcat:rdfqtr57o5avliqamsysybjqga
more »... stem, iRODS (Rule-Oriented Data management systems), to act as the data management system for the WTSI. iRODS provides a rule-based system management approach which makes data replication much easier and provides extra data protection. Unlike the metadata provided by traditional file systems, the metadata system of iRODS is comprehensive and allows users to customize their own application level metadata. Users and IT experts in the WTSI can then query the metadata to find and track data. The aim of this paper is to describe how we designed and used (from both system and user viewpoints) iRODS as a data management system. Details are given about the problems faced and the solutions found when iRODS was implemented. A simple use case describing how users within the WTSI use iRODS is also introduced. Conclusions: iRODS has been implemented and works as the production system for the sequencing pipeline of the WTSI. Both biologists and IT experts can now track and manage data, which could not previously be achieved. This novel approach allows biologists to define their own metadata and query the genomic data using those metadata.
The Polycystic Kidney Disease 2 (pkd2) gene is mutated in autosomal dominant polycystic kidney disease (ADPKD), one of the most common human monogenic disorders. Here, we present the cryo-EM structure of PKD2 in lipid bilayers at 3.0 Å resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into potential mechanisms for its activation. The PKD2 voltage-sensor domain retains two of four gating charges commonly found in those of voltage-gated ion channels. The PKD2doi:10.1016/j.cell.2016.09.048 pmid:27768895 pmcid:PMC6055481 fatcat:4e23eqlkt5dyjp2mjlqnmp7yse
more »... ion permeation pathway is constricted at the selectivity filter and near the cytoplasmic end of S6, suggesting that two gates regulate ion conduction. The extracellular domain of PKD2, a hotspot for ADPKD pathogenic mutations, contributes to channel assembly and strategically interacts with the transmembrane core, likely serving as a physical substrate for extracellular stimuli to allosterically gate the channel. Finally, our structure establishes the molecular basis for the majority of pathogenic mutations in pkd2-related ADPKD.
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca 2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have been assigned to this class of ion channels. Despite their physiological relevance, few selective pharmacological tools are available to study TRPC channel function. We, therefore, screened a selection of pharmacologically active compounds fordoi:10.1371/journal.pone.0035393 pmid:22530015 pmcid:PMC3328449 fatcat:spajvfc6efhbndylon7hcdgkcm
more »... C modulating activity. We found that the synthetic gestagen norgestimate inhibited diacylglycerol-sensitive TRPC3 and TRPC6 with IC 50 s of 3-5 mM, while half-maximal inhibition of TRPC5 required significantly higher compound concentrations (.10 mM). Norgestimate blocked TRPC-mediated vasopressin-induced cation currents in A7r5 smooth muscle cells and caused vasorelaxation of isolated rat aorta, indicating that norgestimate could be an interesting tool for the investigation of TRP channel function in native cells and tissues. The steroid hormone progesterone, which is structurally related to norgestimate, also inhibited TRPC channel activity with IC 50 s ranging from 6 to 18 mM but showed little subtype selectivity. Thus, TRPC channel inhibition by high gestational levels of progesterone may contribute to the physiological decrease of uterine contractility and immunosuppression during pregnancy.
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