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The Sars-Cov-2 Pandemic and the Brave New Digital World of Environmental Enrichment to Prevent Brain Aging and Cognitive Decline

H. Hampel, A. Vergallo
2020 The journal of prevention of Alzheimer's disease  
The evolving, highly contagious global viral spread has created a pressure test of unprecedented proportions for the existing brain health care infrastructure and related services for management, diagnosis  ...  Social distancing and lock-down measures are catalyzing and accelerating a technological paradigm shift, away from a traditional model of brain healthcare focused on late symptomatic disease stages and  ...  Acknowledgment: We thank Ricky Kurzman and Stephanie Cropper for their kind support in the critical revision of the article.  ... 
doi:10.14283/jpad.2020.39 pmid:32920634 pmcid:PMC7355512 fatcat:dik2tnxndfgjfnwoc7b2rbreia

The Perspectives Associated With the Computer-Based Diagnostic Method of Depressive Disorder

Elena Bartkiene, Vesta Steibliene, Virginija Adomaitiene, Vita Lele, Darius Cernauskas, Daiva Zadeike, Dovile Klupsaite, Grazina Juodeikiene
2018 Frontiers in Psychiatry  
The confirmation of this hypothesis can shed a new perspective on early contactless, computer-based psychiatric diagnostic strategies and early identification of DD symptoms, as DD is an important issue  ...  for diagnosis of DD.  ...  ACKNOWLEDGMENTS The authors gratefully acknowledge the Research Council of Lithuania for financial support (Project EMOPSYCHOSCREEN No. P-MIP-17-49).  ... 
doi:10.3389/fpsyt.2018.00687 pmid:30618867 pmcid:PMC6305725 fatcat:3lcjliu3kra2dfd65bjbvu7scy

A classifier fusion strategy to improve the early detection of neurodegenerative diseases

Shamaila Iram, Paul Fergus, Dhiya Al Jumeily, Abir Hussain, Martin Randles
2015 International Journal of Artificial Intelligence and Soft Computing  
Many believe that the early detection of neurodegenerative diseases will provide a much more sustainable framework for dealing with age-related diseases in the future.  ...  early detection of neurodegenerative diseases', Int.  ...  The goal is to provide a sophisticated and potentially powerful tool that improves the early detection, diagnosis and treatment of neurodegenerative diseases.  ... 
doi:10.1504/ijaisc.2015.067525 fatcat:kdj3zz2y2rekhdvwyxflmax454

Application of Precision Medicine in Neurodegenerative Diseases

Claudia Strafella, Valerio Caputo, Maria R. Galota, Stefania Zampatti, Gianluca Marella, Silvestro Mauriello, Raffaella Cascella, Emiliano Giardina
2018 Frontiers in Neurology  
One of the main challenges for healthcare systems is the increasing prevalence of neurodegenerative pathologies together with the rapidly aging populations.  ...  In fact, the availability of high technology and computational facilities for large-scale analysis enabled a deeper investigation of neurodegenerative disorders, providing a more comprehensive overview  ...  Currently, scientific research can rely on the availability of high-technology and computational tools for large-scale analysis.  ... 
doi:10.3389/fneur.2018.00701 pmid:30190701 pmcid:PMC6115491 fatcat:2vqbjhvpqjf3zeh5xpa4mu5qzu

A Precision Medicine Initiative for Alzheimer's disease: the road ahead to biomarker-guided integrative disease modeling

H. Hampel, S. E. O'Bryant, S. Durrleman, E. Younesi, K. Rojkova, V. Escott-Price, J-C. Corvol, K. Broich, B. Dubois, S. Lista
2017 Climacteric  
A patent in vitro procedure for diagnosis and early diagnosis of neurodegenerative diseases. FIGURE CAPTIONS Figure 1 .  ...  A patent In vitro Procedure for Diagnosis and Early Diagnosis of Neurodegenerative Diseases. Publication number: 20090263822 Issued.  ... 
doi:10.1080/13697137.2017.1287866 pmid:28286989 fatcat:5bdwpvg4jbej7ba3tkmrqw3keq

An early diagnosis is not the same as a timely diagnosis of Parkinson's disease

Richard Nathaniel Rees, Anita Prema Acharya, Anette Schrag, Alastair John Noyce
2018 F1000Research  
Benefits of early diagnosis and treatment would affect not only the individual (and their families) but also the wider society and the research community.  ...  However, picking the right point for a "timely" diagnosis will vary depending on the preferences of the individual patient, efficacy (or existence) of disease-modifying treatment, and the ability for health  ...  From a scientific perspective, "early" is easy to comprehend within the framework of disease pathology and its manifestations.  ... 
doi:10.12688/f1000research.14528.1 pmid:30079229 pmcid:PMC6053699 fatcat:tirhtpwhsjdwbb42uu364hb5aq

Gait analysis for early neurodegenerative diseases classification through the Kinematic Theory of Rapid Human Movements

Vincenzo Dentamaro, Donato Impedovo, Giuseppe Pirlo
2020 IEEE Access  
Up to now, some Computer Aided Diagnosis (CAD) tools for neurodegenerative assessment, have shown to be effective. Those tools are based on behavioral biometrics [1] .  ...  NEURODEGENERATIVE DISEASES MOTOR PATTERNS Neurodegenerative diseases affect long neuronal cells. The affected cells create physical disorder during the walk.  ...  Conflict of interest: The authors declare no conflict of interest.  ... 
doi:10.1109/access.2020.3032202 fatcat:pysqtp3q6zcapkpcsccpdtfhzq

Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment

Zahinoor Ismail, Eric E. Smith, Yonas Geda, David Sultzer, Henry Brodaty, Gwenn Smith, Luis Agüera-Ortiz, Rob Sweet, David Miller, Constantine G. Lyketsos
2016 Alzheimer's & Dementia  
NPS in MCI confer a greater risk for conversion to dementia  ...  Acknowledgments The authors acknowledge The Alzheimer's Association ISTAART group for reading and supporting these criteria.  ...  Interpretation: Neuropsychiatric symptoms (NPS) can manifest early in the course of neurodegenerative illness. Currently, diagnosis of neurodegenerative disease is predicated on cognitive impairment.  ... 
doi:10.1016/j.jalz.2015.05.017 pmid:26096665 pmcid:PMC4684483 fatcat:t4om6lzegvf4zodluauyrpzmlu

A report from the 8th Kuopio Alzheimer Symposium

Annakaisa Haapasalo, Mikko Hiltunen
2018 Neurodegenerative Disease Management  
and comorbidities and novel approaches 25 for diagnosis, prediction, prevention and therapies of Alzheimer s disease (AD) and other 26 neurodegenerative diseases.  ...  21 The international Kuopio Alzheimer Symposium was organized by the University of Eastern Finland 22 in Kuopio, Finland on June 6-8, 2018 for the 8 th time.  ...  for 333 diagnosis of MCI and AD, e.g. by using the PredictND clinical decision support system, and taking 334 into account patients' perspective and wishes on their use.  ... 
doi:10.2217/nmt-2018-0029 pmid:30112972 fatcat:qrbw2lppgvevrlpbhcnszvd6fq

When dementia progresses quickly: a practical approach to the diagnosis and management of rapidly progressive dementia

Gregory S Day, David F Tang-Wai
2014 Neurodegenerative Disease Management  
The causes of RPD are diverse, spanning the spectrum of primary and secondary neurological diseases.  ...  Causes of rapidly progressive dementia (RPD) are distinguished by the evolution of symptoms and signs over a number of days, weeks or months.  ...  rate of disease of progression on the differential diagnosis, and the possibility that symptoms may represent limbic encephalitis.  ... 
doi:10.2217/nmt.13.75 pmid:24640978 fatcat:riiyjtndzfhrjeino5cz35pm2e

Perspectives on the modeling of the neuromusculoskeletal system to investigate the influence of neurodegenerative diseases on sensorimotor control

Leonardo Abdala Elias, Débora Elisa da Costa Matoso, Renato Naville Watanabe, André Fabio Kohn
2018 Research on Biomedical Engineering  
that they can be useful in the future to discover early predictors of neurodegenerative diseases, as well as to propose new quantitative clinical neurophysiology approaches to follow the course of improvements  ...  Albeit some efforts have been made to investigate how neurodegenerative diseases alter the dynamics of individual elements of the neuromuscular system, such diseases have not been analyzed from a systems  ...  RNW was funded by FAPESP and CAPES (Coordination for the Improvement of Higher Education Personnel, proc. no. 2015/21819-3). AFK was funded by CNPq (proc. no. 303809/2016-7).  ... 
doi:10.1590/2446-4740.00118 fatcat:jmnn6fcoinbudow3wr5tlge5sy

Psychological and Cognitive Markers of Behavioral Variant Frontotemporal Dementia–A Clinical Neuropsychologist's View on Diagnostic Criteria and Beyond

Andreas Johnen, Maxime Bertoux
2019 Frontiers in Neurology  
Since the histopathology of the disease is heterogeneous and identified genetic mutations only account for ~30% of cases, there are no reliable biomarkers for the diagnosis of bvFTD available in clinical  ...  Early detection of bvFTD thus relies on correct application of clinical diagnostic criteria.  ...  FUNDING We acknowledge support from the Open Access Publication Fund of the University of Muenster.  ... 
doi:10.3389/fneur.2019.00594 pmid:31231305 pmcid:PMC6568027 fatcat:bu65bvxpkzenrgifwqiiphq2ye

Clinical impact and diagnostic accuracy of 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography/computed tomography (PET/CT) brain imaging in patients with cognitive impairment: a tertiary centre experience in the UK

H. Motara, T. Olusoga, G. Russell, S. Jamieson, S. Ahmed, N. Brindle, A. Pillai, A.F. Scarsbrook, C.N. Patel, F.U. Chowdhury
2017 Clinical Radiology  
, small reductions in metabolic activity in the hippocampus are not usually 201 demonstrable on FDG PET in the early stages of the AD [13]. 202 203 brain perfusion single-photon emission computed tomography  ...  Discussion 162 The diagnosis of dementia can be challenging, especially in the early stages of the disease, in 163 younger patients (<65 years), in those with atypical presentations, and in patients  ... 
doi:10.1016/j.crad.2016.08.003 pmid:27637430 fatcat:wuvcuhqnmbenpbiu6et4medasu

Global Current Trends in Drug Designing for Management of Type-2 Diabetes and Neurodegenerative Disorders

Alam Q Alam MZ
2013 Drug Designing: Open Access  
Neurodegenerative diseases (NDs) and Type 2 diabetes (T2D) are progressive disorder often advances with age.  ...  Since conventional drugs fail to surpass the natural CNS protective barriers, therefore, in order to overcome these hurdles, targeted drug delivery is of foremost significance for the treatment of AD and  ...  Gazdar, Librarian, and KFMRC for providing assistance in retrieving research articles from journals available in the library and as well from different web resources.  ... 
doi:10.4172/2169-0138.1000e120 fatcat:um4hqmpndvarjht5jtatcmleam

Mild Behavioral Impairment: presentation of the diagnostic criteria and the Italian version of the MBI-Checklist

Camilla Elefante, Lorenzo Lattanzi, Zahinoor Ismail, Pierpaolo Medda, Silvia Bacciardi, Cecilia Mainardi, Giulio Perugi
2019 Rivista di psichiatria  
For some, MBI may be the initial manifestation of neurodegenerative disease, observed before cognitive impairment is apparent.  ...  The need to identify, in the early stages of the disease, the population at risk of cognitive decline has led to the formulation of the concept of Mild Behavioral Impairment (MBI).  ...  The identification of a population at risk for neurodegenerative disease has important implications on the therapeutic management of affective, psychotic and behavioral symptoms and on the prevention of  ... 
doi:10.1708/3142.31246 pmid:30985830 fatcat:ls7hiunx2jgyplak237ro4tafy
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