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Personalised imaging and biomechanical modelling of large vessels

Rob Krams, Marcel Breeuwer, Frans van de Vosse
2008 Medical and Biological Engineering and Computing  
Furthermore, the development of invasive and non-invasive imaging enables imaging the 3D geometry of blood vessels and thereby to develop personalised and segmental calculations of the wall stress and  ...  The function of these blood vessels has successfully been studied in the framework of biology, physics, and imaging.  ...  Furthermore, the development of invasive and non-invasive imaging enables imaging the 3D geometry of blood vessels and thereby to develop personalised and segmental calculations of the wall stress and  ... 
doi:10.1007/s11517-008-0417-9 pmid:18987903 fatcat:3f35atki6rhbto2jgf45mic3bi

Three-dimensional cardiac computational modelling: methods, features and applications

Alejandro Lopez-Perez, Rafael Sebastian, Jose M Ferrero
2015 BioMedical Engineering OnLine  
Finally, we present examples of several specific applications, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling  ...  The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases  ...  TIN2012-37546-C03-01 and TIN2011-28067) and the European Commission (European Regional Development Funds -ERDF -FEDER) and by "eTorso project" (GVA/2013-001404) from the Generalitat Valenciana (Spain).  ... 
doi:10.1186/s12938-015-0033-5 pmid:25928297 pmcid:PMC4424572 fatcat:w3t3ewftebdf7hgnbd2fgli6he

Haemodynamic impact of stent–vessel (mal)apposition following carotid artery stenting: mind the gaps!

G. De Santis, M. Conti, B. Trachet, T. De Schryver, M. De Beule, J. Degroote, J. Vierendeels, F. Auricchio, P. Segers, P. Verdonck, B. Verhegghe
2013 Computer Methods in Biomechanics and Biomedical Engineering  
Starting from angiographic CT images of the vessel lumen and a micro-CT scan of the stent, a finite element analysis is carried out in order to deploy the stent in the vessel, reproducing CAS in silico  ...  Then, based on the post-stenting anatomy, the vessel is perfused using a set of boundary conditions: total pressure is applied at the inlet, and impedances that are assumed to be insensitive to the presence  ...  Joris Degroote gratefully acknowledges a postdoctoral fellowship of the Research Foundation Flanders (FWO).  ... 
doi:10.1080/10255842.2011.629997 pmid:22149183 fatcat:c5akeu4n3vh43apucqnwfdcaje

Blood flow in the cerebral venous system: modeling and simulation

Olivia Miraucourt, Stéphanie Salmon, Marcela Szopos, Marc Thiriet
2016 Computer Methods in Biomechanics and Biomedical Engineering  
The biomechanical modeling step is carefully analyzed and leads to the description of the flow governed by the dimensionless Navier-Stokes equations for an incompressible viscous fluid.  ...  The development of a software platform incorporating all aspects, from medical imaging data, through three-dimensional reconstruction and suitable meshing, up to simulation of blood flow in patient-specific  ...  of personalised parameter values, but also adequate 1D model of deformable (both distensible and collapsible) veins to avoid reflection artifacts of pressure waves.  ... 
doi:10.1080/10255842.2016.1247833 pmid:27802781 fatcat:2qhrmbzh3bh47idgrcdvqnj4wu

Highly integrated workflows for exploring cardiovascular conditions: Exemplars of precision medicine in Alzheimer's disease and aortic dissection

J.C. Vardakis, M. Bonfanti, G. Franzetti, L. Guo, T. Lassila, M. Mitolo, M. Hoz de Vila, J.P. Greenwood, G. Maritati, D. Chou, Z.A. Taylor, A. Venneri (+5 others)
2019 Morphologie  
imaging workflow and subject-specific blood flow variability model.  ...  The second workflow gives rise to the patient specific exploration of Aortic Dissections via a multi-scale and compliant model, harnessing imaging, computational fluid-dynamics (CFD) and dynamic boundary  ...  and image-based diagnosis and imaging quality assurance.  ... 
doi:10.1016/j.morpho.2019.10.045 pmid:31786098 fatcat:zz7co53zxzenxkmtbsy37tlot4

Biomechanical modelling of cancer: Agent‐based force‐based models of solid tumours within the context of the tumour microenvironment

Cicely K. Macnamara
2021 Computational and Systems Oncology  
In this review paper, key biomechanical relationships are discussed through a presentation of modelling efforts by the mathematical and computational oncology community.  ...  These forces are ones of repulsion and adhesion, and are typically modelled via either an extended Hertz model of contact mechanics or using Johnson-Kendal-Roberts theory, both of which are discussed here  ...  a large number of cells (macroscopic).  ... 
doi:10.1002/cso2.1018 fatcat:ln4jfr2f3fdzjiiempmaieys2a

Project presentation

Anna Rizzo
2021 Zenodo  
language and in the form of a high-level summary, to serve in project communication and dissemination.  ...  The project presentation is a document illustrating the project including its rationale, mission and objectives, consortium composition and role of partners, implementation and expected impacts, in a common  ...  models, and personalised simulations for device implantation and biomechanical interaction with human tissues, will greatly increase patients' safety and long-term outcomes.  ... 
doi:10.5281/zenodo.4644534 fatcat:6xojm3s2jbadto2deyao47gcgq

Computational modelling for congenital heart disease: how far are we from clinical translation?

Giovanni Biglino, Claudio Capelli, Jan Bruse, Giorgia M Bosi, Andrew M Taylor, Silvia Schievano
2016 Heart  
of computational models in the field of CHD, that is, large validation studies, cost-effectiveness evaluation and establishing possible improvements in patient outcomes. 98  ...  While their potential to aid understanding of CHD, surgical/ procedural decision-making and personalisation of treatments is undeniable, important elements are still lacking prior to clinical translation  ...  Contributors GB, CC, JB, GMB, AMT and SS contributed to drafting the manuscript and approve of its contents.  ... 
doi:10.1136/heartjnl-2016-310423 pmid:27798056 pmcid:PMC5284484 fatcat:ovbrhag5gfggpgd2a4hvqiudqu

From the wave propagation model to a transfer function: A possibility for personalisation

Bernhard Hametner, Stephanie Parragh, Anita Gerstenmayer, Thomas Weber, Siegfried Wassertheurer
2015 Artery Research  
levels, and lipids profile were measured. Ambulatory blood pressure measurements and echocardiography were performed. Results: LVH was detected in 34 out of 71 children.  ...  Conclusions: Hypertension, a decreased HDL cholesterol level and overhydration have significant impact on the development of LVH in CKD children.  ...  The transfer function based on an arterial tree model and wave propagation theory can be personalised by optimising model parameters to fit a specific patient.  ... 
doi:10.1016/j.artres.2015.10.267 fatcat:ztk4vo5qkbf5dprt4mbhc2kdim

Towards real-time finite-strain anisotropic thermo-visco-elastodynamic analysis of soft tissues for thermal ablative therapy [article]

Jinao Zhang, Remi Jacob Lay, Stuart K. Roberts, Sunita Chauhan
2020 arXiv   pre-print
It can be used to predict tissue temperatures and ablation volumes for personalised treatment planning and image-guided intervention.  ...  Numerically, it requires full nonlinear modelling of the coupled computational bioheat transfer and biomechanics, and efficient solution procedures; however, existing studies considered the bioheat analysis  ...  Bioheat and biomechanics models Computational thermo-visco-elastodynamic analysis of soft tissues requires the definition of bioheat and biomechanics models.  ... 
arXiv:2009.10400v1 fatcat:s7fcyzysr5gazg6z2girx5hqfa

PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers

Luis Martí-Bonmatí, Ángel Alberich-Bayarri, Ruth Ladenstein, Ignacio Blanquer, J. Damian Segrelles, Leonor Cerdá-Alberich, Polyxeni Gkontra, Barbara Hero, J. M. García-Aznar, Daniel Keim, Wolfgang Jentner, Karine Seymour (+22 others)
2020 European Radiology Experimental  
PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children.  ...  The project is constructed as an observational in silico study involving high-quality anonymised datasets (imaging, clinical, molecular, and genetics) for the training and validation of machine learning  ...  Acknowledgements PRIMAGE (PRedictive In-silico Multiscale Analytics to support cancer personalised diaGnosis and prognosis, empowered by imaging biomarkers) Business Place is a Horizon 2020 | RIA (Topic  ... 
doi:10.1186/s41747-020-00150-9 pmid:32246291 fatcat:qujua7cvcnbvvelwuolpaygduu

Methods in Mechanical Testing of Arterial Tissue: A Review

R. A. Macrae, K. Miller, B. J. Doyle
2016 Strain  
With the increasing precision and versatility of optical measuring systems, and the rising interest in the mechanical behaviour of vessels with complex geometries and material properties, we also discuss  ...  The analysis and characterisation provided by advanced mechanical testing techniques can produce and inform more accurate surgical simulations, as well aid in the risk prediction and modelling of pathological  ...  Acknowledgements The authors would like to gratefully acknowledge funding from the National Health and Medical Research Council (Grants APP1063986 and APP1083572).  ... 
doi:10.1111/str.12183 fatcat:bpdul6qjwjc3pmyl5nnr3gyzc4

Current status and progress of digital orthopaedics in China

Guo-Xian Pei, Ya-Bo Yan
2014 Journal of Orthopaedic Translation  
The most striking feature of digital orthopaedics is the combination of basic and clinical orthopaedic knowledge with digital technology.  ...  Based on the development of digital medicine and digital anatomy, the concept of "digital orthopaedics" was raised by Pei Guo-Xian in China in 2006.  ...  Acknowledgements The authors acknowledge the Ministry of Science and Technology for their financial support (grant no. 2012AA02A603).  ... 
doi:10.1016/ fatcat:hczurkmyzfh3pjewirvx2ozzou

Towards enabling a cardiovascular digital twin for human systemic circulation using inverse analysis

Neeraj Kavan Chakshu, Igor Sazonov, Perumal Nithiarasu
2020 Biomechanics and Modeling in Mechanobiology  
blood vessels (carotid, femoral and brachial arteries).  ...  Blood pressure waveforms in various vessels of the body are inversely calculated with the help of long short-term memory (LSTM) cells by inputting pressure waveforms from three non-invasively accessible  ...  Jason Carson, Swansea University, for providing access to the onedimensional haemodynamic model, a crucial component of this research.  ... 
doi:10.1007/s10237-020-01393-6 pmid:33064221 fatcat:nvlc4xdrozda5ajsp4vcg75og4

Oncological image analysis

Sir Michael Brady, Ralph Highnam, Benjamin Irving, Julia A. Schnabel
2016 Medical Image Analysis  
Abstract Cancer is one of the world's major healthcare challenges and, as such, an important application of medical image analysis.  ...  Highlights  Medical image analysis applied to cancer has to date only addressed a very small subset of the "hallmarks of cancer".  A number of opportunities and challenges for research over the next  ...  Wessel, Schnabel and Brady [2012] have begun the development of a biomechanical model of a spiculated tumour that includes such stiffening of normal tissue; but much remains to be done.  ... 
doi:10.1016/ pmid:27364431 fatcat:4qvkuszzfjannpadlziibmfg3m
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