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Performance study of active tracking in a cellular network using a modular signaling platform

Michal Ficek, Tomáš Pop, Petr Vláčil, Kateřina Dufková, Lukáš Kencl, Martin Tomek
2010 Proceedings of the 8th international conference on Mobile systems, applications, and services - MobiSys '10  
We present the SS7Box modular signaling platform, a tool for rapid application prototyping in a cellular mobile network, and examine in detail its performance limits for the application of active network-based  ...  We present performance studies of real deployment in an existing cellular network and document the measured as well as simulated performance limits such as platform interconnection utilization.  ...  We thank to Srinivasan Keshav for his attentive shepherding of this paper and many valuable comments.  ... 
doi:10.1145/1814433.1814458 dblp:conf/mobisys/FicekPVDKT10 fatcat:nk2xxiuuxjhr5dx6mtgn46m3qy

Rewiring Cells: Synthetic Biology as a Tool to Interrogate the Organizational Principles of Living Systems

Caleb J. Bashor, Andrew A. Horwitz, Sergio G. Peisajovich, Wendell A. Lim
2010 Annual Review of Biophysics  
Here, we outline recent work that uses synthetic biology approaches to investigate the organization and function of cellular networks, and describe a vision for a synthetic biology toolkit that could be  ...  By rearranging the parts that comprise existing networks, we can gain valuable insight into the hierarchical logic of the networks and identify the modular building blocks that evolution uses to generate  ...  ACKNOWLEDGMENTS We thank Angie Chau, Jesse Zalatan, Reid Williams, Maria Borovinskaya, Wilson Wong, Russell Gordley, and other members of the Lim lab for their comments. LITERATURE CITED  ... 
doi:10.1146/annurev.biophys.050708.133652 pmid:20192780 pmcid:PMC2965450 fatcat:je4bki77pfbtvadcq73lhxh3li

Benefits of a Reconfigurable Software GNSS Receiver in Multipath Environment

Fabio Dovis, Marco Pini, Massimiliano Spelat, Paolo Mulassano
2004 Journal of Global Positioning Systems  
In this paper, the implementation of a reconfigurable user terminal integrating both navigation and communication capabilities will be discussed.  ...  The realization of civil GPS applications, the advent of the European navigation system Galileo, and the integration of localization services in communication network make the reconfigurability an indispensable  ...  In particular, all simulations and tests have been performed in the Navigation Lab within the Services and Applications Lab of ISMB.  ... 
doi:10.5081/jgps.3.1.49 fatcat:mclzopw57jg2le6latdn3w7zde

Engineered, harnessed, and hijacked: synthetic uses for cytoskeletal systems

Brian S. Goodman, Nathan D. Derr, Samara L. Reck-Peterson
2012 Trends in Cell Biology  
Next, we highlight how engineering molecular motors is providing a modular toolbox for synthetic in vitro transport [6] [7] [8] .  ...  In the arena of cytoskeletal-based transport, synthetic approaches are currently used in two broad ways. First, molecular motors are harnessed for nonphysiological functions in cells.  ...  Track and motor design offers the potential to create many track-motor combinations or dynamically programmable routes through a network of tracks.  ... 
doi:10.1016/j.tcb.2012.09.005 pmid:23059001 pmcid:PMC3505249 fatcat:ar6wztbm6jgnfbm6gxq6wsxgfi

The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms

Sushil Tripathi, Åsmund Flobak, Konika Chawla, Anaïs Baudot, Torunn Bruland, Liv Thommesen, Martin Kuiper, Astrid Lægreid
2015 BMC Systems Biology  
Results: We performed a detailed analysis of the literature reporting experimental evidence on signaling pathways triggered by CCK1R and CCK2R, in order to create a comprehensive map of gastrin and cholecystokinin-mediated  ...  The decomposition of the signaling map into sub-networks revealed 18 modules that represent higher-level structures of the signaling map.  ...  Chapple for sharing his protein-protein interaction network and Enrico Glaab for "a la carte" PathExpand analyses.  ... 
doi:10.1186/s12918-015-0181-z pmid:26205660 pmcid:PMC4513977 fatcat:b5eybe2wtvcjtlb5rbs4okuykm

An integrated image analysis platform to quantify signal transduction in single cells

Serge Pelet, Reinhard Dechant, Sung Sik Lee, Frank van Drogen, Matthias Peter
2012 Integrative Biology  
First, we quantified the expression of fluorescent reporters induced by osmotic stress to study noise in gene expression.  ...  First, we 15 quantified the expression of fluorescent reporters induced by osmotic stress to study noise in gene expression.  ...  Horvath and members of the Peter laboratory for helpful discussions, and A. Smith for critical reading of the manuscript.  ... 
doi:10.1039/c2ib20139a pmid:22976484 fatcat:fovdgi77pjampb6brn7jqlnley

The Berkeley Tricorder

Reza Naima, John F. Canny
2010 Wireless Health 2010 on - WH '10  
Along these lines, we have developed a small wireless health monitoring device, named The Berkeley Tricorder, capable of monitoring a wide range of health-related signals, and have vetted it in a number  ...  We will present a number of different real-time visualization tools that have been developed, and discuss some relevant applications for the Tricorder as a platform.  ...  The Tricorder has been successfully used in four sets of human trials, and is planned on being used in a number of future studies.  ... 
doi:10.1145/1921081.1921117 dblp:conf/wh/NaimaC10 fatcat:qmdqefjglnahfai42yd7cl5xoy

Understanding Biological Regulation Through Synthetic Biology

Caleb J. Bashor, James J. Collins
2018 Annual Review of Biophysics  
As differences in designed and experimentally observed circuit behavior are inevitably encountered, investigated, and resolved, each turn of the engineering cycle can force a re-synthesis in understanding  ...  of natural network function.  ...  A number of pioneering studies have demonstrated that domain recombination can be used as a design principle for creating new connections in signaling networks, in much the same way that modular promoter  ... 
doi:10.1146/annurev-biophys-070816-033903 pmid:29547341 fatcat:tj6bjg7nirebjkfppjdkzhtjku

Oncoimmunology Meets Organs-on-Chip

Fabrizio Mattei, Sara Andreone, Arianna Mencattini, Adele De Ninno, Luca Businaro, Eugenio Martinelli, Giovanna Schiavoni
2021 Frontiers in Molecular Biosciences  
However, the use of animals represents a challenge due to ethical issues and long duration of experiments.  ...  Oncoimmunology represents a biomedical research discipline coined to study the roles of immune system in cancer progression with the aim of discovering novel strategies to arm it against the malignancy  ...  GAN uses a Generator Network and a Discriminator Network to develop the predicted tracks from Real and Random tracks, extrapolated from each frame of the time-lapse.  ... 
doi:10.3389/fmolb.2021.627454 pmid:33842539 pmcid:PMC8032996 fatcat:ffviktdub5b5jp6v5zqaimw4ma

Next-generation synthetic gene networks

Timothy K Lu, Ahmad S Khalil, James J Collins
2009 Nature Biotechnology  
Accelerated, large-scale diversification 34 and the use of characterized component libraries in conjunction with in silico models for a priori design 22 are proving useful in helping to fine-tune network  ...  testing platforms-tools that are largely lacking in the engineering of biology.  ...  ACKNOWLEDGMENTS We would like to thank the Howard Hughes Medical Institute and the National Institutes of Health Director's Pioneer Award Program for their financial support.  ... 
doi:10.1038/nbt.1591 pmid:20010597 pmcid:PMC2796205 fatcat:ydulznd2nneofhi2hlg5epswku

Interrogating cellular perception and decision making with optogenetic tools

Lukasz J. Bugaj, Geoff P. O'Donoghue, Wendell A. Lim
2016 Journal of Cell Biology  
In this study, we present our vision for how these nascent tools may transform our view of fundamental cell biological processes.  ...  Optogenetics promises to deepen our understanding of how cells perceive and respond to complex and dynamic signals and how this perception regulates normal and abnormal function.  ...  On a molecular level, optogenetics can be used to perform essentially any biochemical experiment in the biochemical context of a living cell.  ... 
doi:10.1083/jcb.201612094 pmid:28003330 pmcid:PMC5223619 fatcat:ny4lyu3egfc5zkz434ofn4m3ce

Topological and system-level protein interaction network (PIN) analyses to deduce molecular mechanism of curcumin

Anupam Dhasmana, Swati Uniyal, Anukriti, Vivek Kumar Kashyap, Pallavi Somvanshi, Meenu Gupta, Uma Bhardwaj, Meena Jaggi, Murali M. Yallapu, Shafiul Haque, Subhash C. Chauhan
2020 Scientific Reports  
The precise mode of action of curcumin and its impact on system level protein networks are still not well studied.  ...  MCODE plug-in was used for sub-modulization analysis, wherein we identified 25 modules; ClueGo plug-in was used for the pathway's enrichment analysis, wherein 37 enriched signalling pathways were obtained  ...  Olaf Wolkenhauer from University of Rostock, Germany for providing the motivation and guidance for this study. The author, Dr.  ... 
doi:10.1038/s41598-020-69011-0 pmid:32694520 fatcat:jlv336lvajctfogxbeqrrich7u

Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins

Ren Sheng, Yong Chen, Heon Yung Gee, Ewa Stec, Heather R. Melowic, Nichole R. Blatner, Moe P. Tun, Yonjung Kim, Morten Källberg, Takahiro K. Fujiwara, Ji Hye Hong, Kwang Pyo Kim (+4 others)
2012 Nature Communications  
Cholesterol is known to modulate the physical properties of cell membranes but its direct involvement in cellular signaling has not been thoroughly investigated.  ...  This modular domain has a cholesterol-binding site topologically distinct from its canonical protein-binding site and serves as a dual specificity domain that bridges the membrane and juxta-membrane signaling  ...  Alejandro Heuck for a generous gift of the PFO expression vector.  ... 
doi:10.1038/ncomms2221 pmid:23212378 pmcid:PMC3526836 fatcat:2llsdlfrmzaftaiu2esz5uzxia

A Survey on Cellular-connected UAVs: Design Challenges, Enabling 5G/B5G Innovations, and Experimental Advancements [article]

Debashisha Mishra, Enrico Natalizio
2020 arXiv   pre-print
cellular networks.  ...  In this integration, the UAVs perform the role of flying users within cellular coverage, thus they are termed as cellular-connected UAVs (a.k.a. UAV-UE, drone-UE, 5G-connected drone, or aerial user).  ...  The authors in [45] demonstrated a UAV-based IoT framework for crowd surveillance application which collects the data and performs facial recognition to track and identify suspicious activities in a  ... 
arXiv:2005.00781v1 fatcat:gnjjupum7zh25kwaetdtxzidja

Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics

Dirk R. Albrecht, Gregory H. Underhill, Joshua Resnikoff, Avital Mendelson, Sangeeta N. Bhatia, Jagesh V. Shah
2010 Integrative Biology  
Overall, these studies illustrate the capacity to probe cellular functions and yield dynamic information in time and space through the integration of a simple, modular, microfluidics-based imaging platform  ...  This modular, medium-throughput platform enables the long-term imaging of living cells at high numerical aperture (via oil immersion) by using a conserved 96-well, B6 Â 5 mm 2 imaging area with a variable  ...  This work was supported in part by a Seed Grant from the Harvard Stem Cell Institute to SNB and an NIH U54/R21 grant from the NIH SysCODE consortium (5RL2EB008541) to JVS.  ... 
doi:10.1039/b923699f pmid:20532320 pmcid:PMC4040291 fatcat:ahy6s52e5zcq5fi3wx2ss7yn5q
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