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A Mechanistic Link from GABA to Cortical Architecture and Perception

James Kolasinski, John P. Logan, Emily L. Hinson, Daniel Manners, Amir P. Divanbeighi Zand, Tamar R. Makin, Uzay E. Emir, Charlotte J. Stagg
2017 Current Biology  
explain perceptual acuity via the underlying cellular and metabolic processes  ...  Graphical Abstract Highlights d GABAergic tone correlates with perceptual acuity in the human somatosensory system d This relationship is mediated by the tuning of activity in somatosensory cortex d We  ...  In Brief g-aminobutyric acid (GABA) is implicated in the tuning of activity in the primary sensory cortices. Kolasinski et al.  ... 
doi:10.1016/j.cub.2017.04.055 pmid:28552355 pmcid:PMC5462622 fatcat:uuvavdjacjcular46o4cjtyptq

The role of MRS-assessed GABA in human behavioral performance

Hong Li, Kirstin-Friederike Heise, Sima Chalavi, Nicolaas A.J. Puts, Richard A.E. Edden, Stephan P. Swinnen
2022 Progress in Neurobiology  
On the other hand, lower baseline GABA levels may support a reduction of inhibition, leading to higher cognitive flexibility. These effects are task-dependent and appear to be mediated by age.  ...  , motor and cognitive domains, with a particular focus on healthy participants across the lifespan.  ...  with GABA levels in the primary sensory cortices.  ... 
doi:10.1016/j.pneurobio.2022.102247 pmid:35149113 fatcat:3lcoaxvwkbe5lgw44dxf2s3qpq

Circuit Mechanisms of Sensorimotor Learning

Hiroshi Makino, Eun Jung Hwang, Nathan G. Hedrick, Takaki Komiyama
2016 Neuron  
Here we broadly define sensorimotor learning as an improvement in one's ability to interact with the environment by interpreting the sensory world and responding to it with the motor system.  ...  We divide the process in three hierarchical levels with distinct goals: 1) sensory perceptual learning, 2) sensorimotor associative learning, and 3) motor skill learning.  ...  ), New York Stem Cell Foundation, David & Lucile Packard Foundation, Pew Charitable Trusts and McKnight Foundation to T.K. and by the NARSAD  ... 
doi:10.1016/j.neuron.2016.10.029 pmid:27883902 pmcid:PMC5131723 fatcat:arc2dhec5vb5bbmuryz3jxjd7u

Absence of stimulus-driven synchronization effects on sensory perception in autism: Evidence for local underconnectivity?

Mark Tommerdahl, Vinay Tannan, Jameson K Holden, Grace T Baranek
2008 Behavioral and Brain Functions  
Methods: Recently, we reported a method for measuring the perceptual changes that are impacted by the presence of synchronized conditioning stimuli on the skin.  ...  Conclusion: It is speculated that the differences in sensory perceptual capacities in the presence of synchronized conditioning stimuli in autism are due to local under-connectivity in cortex at the minicolumnar  ...  We thank Abigail Carroll-Sharpe and the NDRC Subject Registry for assistance with ascertainment of the study participants.  ... 
doi:10.1186/1744-9081-4-19 pmid:18435849 pmcid:PMC2374789 fatcat:ozr4nafl3ngczbkiki7ckpra3a

Fluoxetine Does Not Enhance Visual Perceptual Learning and Triazolam Specifically Impairs Learning Transfer

Alice K. Lagas, Joanna M. Black, Winston D. Byblow, Melanie K. Fleming, Lucy K. Goodman, Robert R. Kydd, Bruce R. Russell, Cathy M. Stinear, Benjamin Thompson
2016 Frontiers in Human Neuroscience  
We also investigated (1) the effect of fluoxetine on visual and motor cortex excitability and (2) the impact of increased GABA mediated inhibition following a single dose of triazolam on post-training  ...  Motor and visual cortex excitability were measured using transcranial magnetic stimulation.  ...  There was no session by group interaction (F 4,43 = 2.0, p = 0.11).  ... 
doi:10.3389/fnhum.2016.00532 pmid:27807412 pmcid:PMC5069436 fatcat:6vjgljz7czelplnbgjyqisjdxm

Differential Circuit Mechanisms of Young and Aged Visual Cortex in the Mammalian Brain

Chand Parvez Danka Mohammed
2021 NeuroSci  
It is particularly interesting to note that the visual perceptual processing of certain visual behavior functions does not change with age.  ...  It is well known that aging significantly modulates both the structural and physiological properties of visual cortical neurons in V1 and other visual cortical areas in various species.  ...  Functional behavioral tasks such as perception of sensory input and controlled motor output regulate the lifelong process of learning and memory function via the systematic interconnectivity of neurons  ... 
doi:10.3390/neurosci2010001 fatcat:sgxend5rirc7nf2klxzjib6lce

Continuous theta-burst stimulation modulates tactile synchronization

Kevin GH Lee, Mark F Jacobs, Michael J Asmussen, Christopher M Zapallow, Mark Tommerdahl, Aimee J Nelson
2013 BMC Neuroscience  
cause perceptual binding across the two skin sites.  ...  CTBS offers one method to suppress cortical excitability in the cortex and potentially benefit clinical populations with altered inhibitory cortical circuits.  ...  The mechanisms that underpin TOJ and TOJ-S are not fully understood although GABAergic activity via lateral inhibition across cortical columns and in-field inhibition within cortical columns likely mediates  ... 
doi:10.1186/1471-2202-14-89 pmid:23968301 pmcid:PMC3844444 fatcat:zwetqmauufbyxhi3of4ndqo54y

Molecular and cellular aspects of plasticity after neural injury

K.K. L. Yunge, D.K. Y. Shum, L. W. Chen, Y. S. Chan
2009 Journal of Medical Sciences  
of motor functions.  ...  After severance of sensory input from one inner ear, topographic representations of spacecentered coordinates in the brain undergo plastic changes.  ...  This work was supported by grants from the Hong Kong Research Grants Council (HKU 7294/01M, 7270/02M, 7380/03M, N_ HKBU 202/02).  ... 
doi:10.2174/1996327000801020033 fatcat:msbxuyovz5gz7a6sqyquuf2ix4

Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications

Martin Bareš, Richard Apps, Laura Avanzino, Assaf Breska, Egidio D'Angelo, Pavel Filip, Marcus Gerwig, Richard B. Ivry, Charlotte L. Lawrenson, Elan D. Louis, Nicholas A. Lusk, Mario Manto (+3 others)
2018 Cerebellum  
Additionally, sensory information such as an unexpected stimulus can be forwarded to the cerebellum via the climbing fiber system, providing a temporally constrained mechanism to adjust ongoing behavior  ...  However, supra-second timing seems to require cortical and basal ganglia networks, perhaps operating in concert with cerebellum.  ...  Acknowledgments: This work was supported by a grant from the EU H2020 Marie Skłodowska RISE project #691110 (MICROBRADAM); National Institute of Health (NS092079); European Union grant Human Brain Project  ... 
doi:10.1007/s12311-018-0979-5 pmid:30259343 fatcat:3epqchvpjfhcfeulc2gawpohqy

Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS

Claire J. Hanley, Mark Tommerdahl, David J. McGonigle
2015 Frontiers in Cellular Neuroscience  
The neuromodulation technique transcranial direct current stimulation (tDCS) is thought to produce its effects on behavior by altering cortical excitability.  ...  The failure of DC stimulation to alter vibrotactile adaptation thresholds is discussed in the context of several factors that may have confounded the induction of changes in cortical plasticity.  ...  Acknowledgments The authors would like to thank Jameson Holden (North Carolina) for assistance with implementing the vibrotactile tasks, Christopher Allen (Cardiff) for providing guidance with regard to  ... 
doi:10.3389/fncel.2015.00400 pmid:26500499 pmcid:PMC4595660 fatcat:cw7yhlhsnfa4bf4msazljshkk4

TRF1: It Was the Best of Time(s)…

Anne Giersch, Jennifer T. Coull
2018 Timing & Time Perception  
The Timing Research Forum (TRF; is an international ( Fig. 1) , gender-inclusive, and open academic society for timing research, founded in 2016 by Argiro Vatakis and Sundeep Teki  ...  Kononowicz has been supported by ERC-YSt-263584 to Virginie van Wassenhove. References Ouellet, M., Santiago, J., Israeli, Z., & Gabay, S. (2010)  ...  Contemporary research has mainly concentrated on enhancing relevant sensory, perceptual and motor capacities, assuming short-term and nearly momentary interaction between the two ends.  ... 
doi:10.1163/22134468-00603001 fatcat:u3eej7wjhrdnphz7u6nozppiwm

Vision Science and Schizophrenia Research: Toward a Re-view of the Disorder Editors' Introduction to Special Section

S. M. Silverstein, B. P. Keane
2011 Schizophrenia Bulletin  
These include reviews of abnormal form perception (perceptual organization and backward masking) and motion processing, and an article on reduced size contrast illusions experienced by hearing but not  ...  This theme section on vision science and schizophrenia research demonstrates that our understanding of the disorder could be significantly accelerated by a greater adoption of the methods of vision science  ...  In short, the evidence from vision research highlights that much coordination of perceptual and cognitive activity emerges via self-organization in local populations of neurons, which is a general property  ... 
doi:10.1093/schbul/sbr053 pmid:21700588 pmcid:PMC3122283 fatcat:rs5t4fk7fnhyffrci3y66l2kky

Incorporation of feedback during beat synchronization is an index of neural maturation and reading skills

Kali Woodruff Carr, Ahren B. Fitzroy, Adam Tierney, Travis White-Schwoch, Nina Kraus
2017 Brain and Language  
Speech communication involves integration and coordination of sensory perception and motor production, requiring precise temporal coupling.  ...  Precision of temporal coding across modalities is important for speech processing and downstream literacy skills that rely on dynamic interactions with sound.  ...  This work was supported by National Institutes of Health R01 HD069414 (to N.K.), the Knowles Hearing Center of Northwestern University (N.K.), and Interactive Metronome®.  ... 
doi:10.1016/j.bandl.2016.09.005 pmid:27701006 fatcat:gho5bysexbbulmkshbx7ni57p4

Autism-Specific Covariation in Perceptual Performances: "g" or "p" Factor?

Andrée-Anne S. Meilleur, Claude Berthiaume, Armando Bertone, Laurent Mottron, Leonardo Chelazzi
2014 PLoS ONE  
Results: In typically developing individuals, most perceptual tasks were associated with intelligence measured either by RPM or Wechsler FSIQ.  ...  The residual covariation between unimodal tasks, i.e. covariation not explained by intelligence, could be explained by a modality-specific factor.  ...  Kate Plaisted and HRDP autism research team members for comments on the manuscript, as well as our research assistant Chloé Paquin-Hodge for testing the participants. Author Contributions  ... 
doi:10.1371/journal.pone.0103781 pmid:25117450 pmcid:PMC4130524 fatcat:xekiltdd3jfvldscqq2whsoqqa

Environmental Enrichment Increases Response Strength And Paired‐Pulse Depression Of Auditory Cortex Neurons

Cherie R. Percaccio, Autumn L. Pruette, Shilpa T. Mistry, Yeting H. Chen, Daniel L. Rathbun, Michael P. Kilgard
2008 Journal of the Acoustical Society of America  
Cortical plasticity underlying perceptual, motor, and cognitive skill development: implications for neurorehabilitation. Cold Spring Harb Symp Quant Biol, 61: 1-8.  ...  Monkeys exposed to sensory inputs without behavioral meaning do not exhibit the cortical map plasticity observed in monkeys who use stimuli to make behavioral judgments (Recanzone et al., 1993) .  ... 
doi:10.1121/1.2935202 fatcat:xswkwaqixnehhhnwi2iumlh63i
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