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Paul Terence Callaghan

Michael J. Kelly
2017 Figshare  
Callaghan, M.E.  ...  Callaghan, "Fluctuations in shear-banded flow seen by NMR velocimetry", Europhysics Letters, 64, 274-280 (2003) 178. E.-H. Liu, P.T. Callaghan, K.M.  ... 
doi:10.6084/m9.figshare.5315209 fatcat:xgdpgp2l6zbmrknothhtjbtypm

Sir Paul Terence Callaghan FRS PCNZM. 19 August 1947 — 24 March 2012

Michael J. Kelly
2017 Biographical Memoirs of Fellows of the Royal Society  
New Zealand Prime Minister's Science Prize 2011 New Zealander of the Year Figure 1 . 1 Mary, Paul, Jeanine and Jim Callaghan, circa 1953.  ...  (From Jim Callaghan) Figure 2 . 2 Paul tramping in rural New Zealand. (From the Beaglehole Room, the Victoria University archive, courtesy of Ms Sue Hirst.) (Online version in colour.)  ... 
doi:10.1098/rsbm.2017.0006 fatcat:bwqzwlmnpjewpjylezn3d235pi

Carolyn Callaghan—stop stepping down!

Paul Catling
2021 Canadian field-naturalist  
Carolyn Callaghan served "exceptionally" as Editor inChief of The Canadian Field-Naturalist (CFN) from 2011 (vol. 125 (1)) to 2016 (vol. 130 (2) ).  ...  Paul Catling OFNC Publications Committee ©The author. This work is freely available under the Creative Commons Attribution 4.0 International license (CC BY 4.0).  ... 
doi:10.22621/cfn.v134i4.2753 fatcat:zdgqoxm76raojpljrymoy563fy

The Adult Hip--Hip Preservation Surgery. Edited by John Clohisy, Paul Beaule, Craig Della Valle, John Callaghan, Aaron Rosenberg and Harry Rubash

A. J. Stubbs
2014 Journal of Hip Preservation Surgery  
doi:10.1093/jhps/hnu007 pmcid:PMC4765263 fatcat:mcaf7b6vc5djhbx4wc6gf3pptu

Beyond Poiseuille: Preservation Fluid Flow in an Experimental Model

Saurabh Singh, Lucy V. Randle, Paul T. Callaghan, Christopher J. E. Watson, Chris J. Callaghan
2013 Journal of Transplantation  
Poiseuille's equation describes the relationship between fluid viscosity, pressure, tubing diameter, and flow, yet it is not known if cold organ perfusion systems follow this equation. We investigated these relationships in anex vivomodel and aimed to offer some rationale for equipment selection. Increasing the cannula size from 14 to 20 Fr increased flow rate by a mean (SD) of 13 (12)%. Marshall's hyperosmolar citrate was three times less viscous than UW solution, but flows were only 45%
more » ... . Doubling the bag pressure led to a mean (SD) flow rate increase of only 19 (13)%, not twice the rate. When external pressure devices were used, 100 mmHg of continuous pressure increased flow by a mean (SD) of 43 (17)% when compared to the same pressure applied initially only. Poiseuille's equation was not followed; this is most likely due to "slipping" of preservation fluid within the plastic tubing. Cannula size made little difference over the ranges examined; flows are primarily determined by bag pressure and fluid viscosity. External infusor devices require continuous pressurisation to deliver high flow. Future studies examining the impact of perfusion variables on graft outcomes should include detailed equipment descriptions.
doi:10.1155/2013/605326 pmid:24062943 pmcid:PMC3770057 fatcat:ovu4scljxnbeda5zgk6dcbmwsy

The Imagined Space of Academic Life: Leacock, Callaghan, and English-Canadian Campus Fiction in Canada, 1914-1948

E. Lisa Panayotidis, Paul Stortz
2016 Historical Studies in Education  
La première se trouve dans le chapitre trois de l'œuvre de Stephen Leacock, Arcadian Adventures with the Idle Rich (1914) et l'autre provient du livre de Marley Callaghan intitulé The Varsity Story (1948  ...  Callaghan's adaptation -which also featured panel discussions by other notable students and professors from the University of Toronto -was prepared by Paul Fauteux, a third-year student at St.  ...  Paul Bennett, "It Takes a Village: Drawing on the Legacy of Jefferson, Campus Planners at the University of Virginia Plot a Future Based on the Past," Landscape Architecture 88, no. 10 (1998): 74, 7681  ... 
doi:10.32316/hse/rhe.v28i1.4461 fatcat:3nt3s6hk2nbvpahzs4tcn6tnci

Function of Resistance Conferring Plasmodium falciparum Chloroquine Resistance Transporter Isoforms

Nicholas K. Baro, Paul S. Callaghan, Paul D. Roepe
2013 Biochemistry  
The function of P. falciparum chloroquine resistance transporter (PfCRT) can be quantified using a S. cerevisiae model system (Baro, N. K., Pooput C and Roepe P.D. Biochemistry. 50, 6701 -6710). We further optimize this system to distinguish PfCRT isoforms found in P. falciparum strains and isolates from across the globe. We create and express 13 naturally occurring pfcrt alleles associated with a range of chloroquine resistant (CQR) phenotypes. Using galactose induction of PfCRT we quantify
more » ... RT and chloroquine (CQ) dependent yeast growth inhibition, and [ 3 H]-CQ transport specifically due to a given PfCRT isoform. Surprisingly, we find poor correlation between these parameters vs CQ IC 50 observed in strains of malaria harboring the same isoforms. This suggests that increased CQ transport due to PfCRT mutation is necessary, but not sufficient, for the range of CQ IC 50 observed in globally distributed CQR P. falciparum isolates. Mutation of the pfcrt gene causes cytostatic chloroquine resistance (CQR CS ) in P. falciparum malaria, typically characterized by a 7 -10 fold increase in CQ IC 50 [1] [2] [3] . The pfcrt mutations confer amino acid substitutions in the encoded PfCRT protein, which resides within the digestive vacuolar (DV) membrane of the intraerythrocytic parasite and which is believed to be a transporter [2, 3] . CQR phenotypes are further characterized by cross resistance patterns to other drugs that may be influenced by additional genes [4-6]. Our current model for how mutant PfCRT confers CQR envisions increased electrochemically downhill transport of CQ out of the DV [2,7-9], combined with DV osmolyte dysequilibria that perturbs CQ -heme binding via changes in DV volume and perhaps pH [2, 10, 11] .
doi:10.1021/bi400557x pmid:23688277 pmcid:PMC3703759 fatcat:4un7rgzdizbgflczeonboug7he

Automating agricultural vehicles

Victor Callaghan, Paul Chernett, Martin Colley, Tony Lawson, John Standeven, Malcolm Carr‐West, Malcolm Ragget
1997 Industrial robot  
Computational and Control Issues The work planned for this vehicle builds or R&D that originated from earlier laboratory based mobile robot work [Callaghan 95 ].  ...  Processors Vision CanBus Camera Camera GPS Steering Control Motion Sensor Engine Control ethernet Laptop PC VME RACK RF [Voudouris 95] Voudouris, C., Chernett, P., Wang, C.J. & Callaghan  ... 
doi:10.1108/01439919710177164 fatcat:dvdv45dcyjfzfh52xhxlchk2u4

Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology

Paul S. Callaghan, Amila Siriwardana, Matthew R. Hassett, Paul D. Roepe
2016 Malaria Journal  
Recent work has perfected yeast-based methods for measuring drug transport by the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT). Methods: The approach relies on inducible heterologous expression of PfCRT in Saccharomyces cerevisiae yeast. In these experiments selecting drug concentrations are not toxic to the yeast, nor is expression of PfCRT alone toxic. Only when PfCRT is expressed in the presence of CQ is the growth of yeast impaired, due to inward transport of
more » ... uine (CQ) via the transporter. Results: During analysis of all 53 known naturally occurring PfCRT isoforms, two isoforms (PH1 and PH2 PfCRT) were found to be intrinsically toxic to yeast, even in the absence of CQ. Additional analysis of six very recently identified PfCRT isoforms from Malaysia also showed some toxicity. In this paper the nature of this yeast toxicity is examined. Data also show that PH1 and PH2 isoforms of PfCRT transport CQ with an efficiency intermediate to that catalyzed by previously studied CQR conferring isoforms. Mutation of PfCRT at position 160 is found to perturb vacuolar physiology, suggesting a fitness cost to position 160 amino acid substitutions. Conclusion: These data further define the wide range of activities that exist for PfCRT isoforms found in P. falciparum isolates from around the globe.
doi:10.1186/s12936-016-1238-1 pmid:27036417 pmcid:PMC4815217 fatcat:nyaix4yn5vgwfjxiibbtqdxlka


Christos Voudouris, Paul Chernett, Chang J. Wang, Vic L. Callaghan
1995 Intelligent Autonomous Vehicles 1995  
The subject of this paper is the control of autonomous vehicles. A hierarchical approach is studied in the context of fuzzy systems and a programming language for the mid to low level control of autonomous vehicles is described. The language, called FDTL (Fuzzy Decision Tree Language), is based on a computational model that combines fuzzy rule based control with the hierarchical nature of decision trees.
doi:10.1016/b978-0-08-042366-1.50045-2 fatcat:lf4h3nx7dzcibmilpr2ucdmrie

Coercive Subtyping via Mappings of Reduction Behaviour

Paul Callaghan
2008 Electronical Notes in Theoretical Computer Science  
This paper reports preliminary work on a novel approach to Coercive Subtyping that is based on relationships between reduction behaviour of source and target types in coerced terms. Coercive Subtyping is a superset of record-based subtyping, allowing so-called coercion functions to carry the subtyping. This allows many novel and powerful forms of subtyping and abbreviation, with applications including interfaces to theorem provers and programming with dependent type systems. However, the use of
more » ... coercion functions introduces non-trivial overheads, and requires difficult proof of properties such as coherence in order to guarantee sensible results. These points restrict the practicality of coercive subtyping. We begin from the idea that coercing a value v from type U to a type T intuitively means that we wish to compute with v as if it was a value in T, not that v must be converted into a value in T. Instead, we explore how to compute on U in terms of computation on T, and develop a framework for mapping computations on some T to computations on some U via a simple extension of the elimination rule of T. By exposing how computations on different types are related, we gain insight on and make progress with several aspects of coercive subtyping, including (a) distinguishing classes of coercion and finding reasons to deprecate use of some classes; (b) alternative techniques for proving key properties of coercions; (c) greater efficiency from implementations of coercions.
doi:10.1016/j.entcs.2007.09.017 fatcat:u5jew5ytzfffzm5pcpvmbfsvoq

gwverse: a template for a new generic Geographically Weighted Rpackage [article]

Alexis Comber, Chris Brunsdon, Martin Callaghan, Paul Harris, Binbin Lu, Nick Malleson
2021 arXiv   pre-print
GWR is a popular approach for investigating the spatial variation in relationships between response and predictor variables, and critically for investigating and understanding process spatial heterogeneity. The geographically weighted (GW) framework is increasingly used to accommodate different types of models and analyses reflecting a wider desire to explore spatial variation in model parameters or components. However the growth in the use of GWR and different GW models has only been partially
more » ... supported by package development in both R and Python, the major coding environments for spatial analysis. The result is that refinements have been inconsistently included (if at all) within GWR and GW functions in any given package. This paper outlines the structure of a new 'gwverse' package, that will over time replace 'GWmodel', that takes advantage of recent developments in the composition of complex, integrated packages. It conceptualises 'gwverse' as having a modular structure, that separates core GW functionality and applications such as GWR. It adopts a function factory approach, in which bespoke functions are created and returned to the user based on user-defined parameters. The paper introduces two demonstrator modules that can be used to undertake GWR and identifies a number of key considerations and next steps.
arXiv:2109.14542v1 fatcat:okg74gnqyfdn3fapjo6zssjdda

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)

Paul S. Callaghan, Matthew R. Hassett, Paul D. Roepe
2015 Biochemistry  
Callaghan PS, Siriwardana A, Hassett MR, Roepe PD.  ...  Callaghan, P. D. Roepe, and D. A. Fidock, manuscript in preparation).  ... 
doi:10.1021/acs.biochem.5b00412 pmid:26208441 pmcid:PMC5070608 fatcat:ilpe6apdhbbqfmxxhgysgbz42m

Hierarchical Behavioural Control for Autonomous Vehicles

Christos Voudouris, Paul Chernett, Chang J. Wang, Vic L. Callaghan
1995 IFAC Proceedings Volumes  
The subject of this paper is the control of autonomous vehicles. A hierarchical approach is studied in the context of fuzzy systems and a programming language for the mid to low level control of autonomous vehicles is described. The language, called FDTL (Fuzzy Decision Tree Language), is based on a computational model that combines fuzzy rule based control with the hierarchical nature of decision trees.
doi:10.1016/s1474-6670(17)46981-3 fatcat:yyjnq5chm5fe7fvaxz2sotsv5u

Two-Phase Shear Band Structures at Uniform Stress

Melanie M. Britton, Paul T. Callaghan
1997 Physical Review Letters  
Using NMR microscopy we measure the velocity distribution for a wormlike surfactant solution in the gap of a small angle cone-and-plate rheometer. This system, cetylpyridinium chloride͞sodium salicylate 100 mM͞60 mM, exhibits biphasic shear band structure when the applied shear rate exceeds the critical rate of strain beyond which a plateau is observed in the shear stress. The structure is characterized by two low/high shear interfaces and the region of high shear evolves by increasing width as
more » ... the average gap shear is increased. [S0031-9007(97)03449-2]
doi:10.1103/physrevlett.78.4930 fatcat:twvl3kvqwvexthy7qrqlat26ui
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