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Patterns of use, effectiveness and safety of gadolinium contrast agents: a European prospective cross-sectional multicentre observational study

Jarl Åsbjørn Jakobsen, Carlo Cosimo Quattrocchi, Frank H. H. Müller, Olivier Outteryck, Andrés Alcázar, Wolfgang Reith, Patricia Fraga, Valeria Panebianco, Alexis Sampedro, Radoslaw Pietura
2021 BMC Medical Imaging  
Methods Prospective, cross-sectional, multicentre, observational study in patients undergoing contrast-enhanced magnetic resonance.  ...  The study aims to understand the patterns of (GBCA) use, and to study the effectiveness and safety of GBCA in routine practice across Europe.  ...  Emilio Moreno and Jeannette Rautenbach of GE Healthcare contributed to study manuscript.  ... 
doi:10.1186/s12880-021-00600-9 pmid:33879075 pmcid:PMC8056663 fatcat:rrnzo3peuzhatjlfhxpmbsmahe

The TRUTH confirmed: validation of an intraindividual comparison of gadobutrol and gadoteridol for imaging of glioblastoma using quantitative enhancement analysis

Matthew J. Kuhn, Julia W. Patriarche, Douglas Patriarche, Miles A. Kirchin, Massimo Bona, Gianpaolo Pirovano
2021 European Radiology Experimental  
Conclusions The enhancement of glioblastoma achieved with gadoteridol and gadobutrol at 0.1 mmol/kg bodyweight is similar indicating that these agents have similar contrast efficacy and can be used interchangeably  ...  , confirming the results of a prior double-blind, randomised, intraindividual, crossover study.  ...  Whereas prospective multicentre studies of gadobutrol and gadoteridol reveal no differences in terms of immediate contrast reactions [31] [32] [33] [34] , animal studies of gadolinium (Gd) retention suggest  ... 
doi:10.1186/s41747-021-00240-2 pmid:34635965 pmcid:PMC8505590 fatcat:fxilcxacwnfqpckaamwhqejgka

Cardiovascular magnetic resonance imaging: what the general cardiologist should know

D P Ripley, T A Musa, L E Dobson, S Plein, J P Greenwood
2016 Heart  
Acknowledgments: We thank David Broadbent for providing critical review of the MR physics, methodology & safety section. H. Figures & Legends  ...  [25] Access to this area is restricted to trained staff, CMR Contrast Agents: Indications and Safety Intravenously administered gadolinium chelate-based contrast agents (GBCA)(0.1-0.2mmol/Kg), are  ...  CMR is a versatile cross-sectional imaging modality for the functional and anatomical assessment of a wide range of cardiovascular diseases 2.  ... 
doi:10.1136/heartjnl-2015-307896 pmid:27559093 fatcat:6pqpjki775bitllarleevwgb7i

Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR)

Nandita M. deSouza, European Society of Radiology, Eric Achten, Angel Alberich-Bayarri, Fabian Bamberg, Ronald Boellaard, Olivier Clément, Laure Fournier, Ferdia Gallagher, Xavier Golay, Claus Peter Heussel, Edward F. Jackson (+9 others)
2019 Insights into Imaging  
Observer-driven pattern recognition is the standard for interpretation of medical images.  ...  Despite this, the quantitative potential of imaging remains under-exploited because of variability of the measurement, lack of harmonised systems for data acquisition and analysis, and crucially, a paucity  ...  Authors' information All authors are either past or current members of the European Biomarkers Alliance subcommittee.  ... 
doi:10.1186/s13244-019-0764-0 pmid:31468205 pmcid:PMC6715762 fatcat:kwj6lkjwgrgjxhow67mlnxza3i

Risk of Hypersensitivity Reactions to Iopromide After Intra-Arterial Versus Intravenous Administration

Jan Endrikat, Alexander Michel, Ralf Kölbach, Philipp Lengsfeld, Kai Vogtländer
2019 Investigative Radiology  
The aim of this study was to compare the risk of hypersensitivity reactions to iopromide after intra-arterial (IA) administration and intravenous (IV) administration.  ...  hypersensitivity reactions: A multicentre retrospective cohort study.  ...  Additional Specific Recommendations for Specific Groups of Patients Patients with end-stage renal disease on chronic dialysis If a contrast-enhanced cross-sectional imaging study is required in an anuric  ... 
doi:10.1097/rli.0000000000000611 pmid:31524764 pmcid:PMC6903317 fatcat:omldtaiv2zgtfg7c2bfbh66rsq

What is the appropriate management of non‐functioning pancreatic neuroendocrine tumours disclosed on screening in adult patients with multiple endocrine neoplasia type 1?

Benjamin G. Challis, Ruth T. Casey, Ashley Grossman, John Newell‐Price, Paul Newey, Rajesh V. Thakker
2019 Clinical Endocrinology  
Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumour syndrome characterised by a predisposition to the development of endocrine tumours of the parathyroid glands, pituitary and pancreas: 30%  ...  It is therefore critical that future MEN1 research initiatives include: (a) the discovery of biomarkers that better predict tumour behaviour; (b) the evaluation of medical therapies that may delay, or  ...  Of note, emerging evidence has implicated repeated administration of gadolinium-based contrast agents, during contrast enhanced MRI examinations with gadolinium, to be associated with deposition of gadolinium  ... 
doi:10.1111/cen.14094 pmid:31505044 fatcat:kr5ebribsjhjvk7vlamoubynwq

Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease

Clement Lo, Tadashi Toyama, Ying Wang, Jin Lin, Yoichiro Hirakawa, Min Jun, Alan Cass, Carmel M Hawley, Helen Pilmore, Sunil V Badve, Vlado Perkovic, Sophia Zoungas
2018 Cochrane Database of Systematic Reviews  
Evidence concerning the efficacy and safety of glucose-lowering agents in diabetes and CKD is limited.  ...  Most studies had a high risk of bias due to funding and attrition bias, and an unclear risk of detection bias.Compared to placebo, SGLT2 inhibitors probably reduce HbA1c (7 studies, 1092 participants:  ...  Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease. European Heart Journal 2010; 31(23):2888-96.  ... 
doi:10.1002/14651858.cd011798.pub2 pmid:30246878 pmcid:PMC6513625 fatcat:kxnobw3qyrdtdlhojn4mexppjm

Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications

2018 European Heart Journal-Cardiovascular Imaging  
Myocardial fibrosis as detected by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is a powerful prognostic marker in hypertrophic cardiomyopathy (HCM) and may be progressive.  ...  We sought to assess the extent of LGE progression in HCM and explore potential causal mechanisms and clinical implications.  ...  Acknowledgements We would like to acknowledge Ms Judith Delos Santos, Ms Roser Farras-Araya, and Ms Joanne Selwood for their invaluable assistance with patient recruitment.  ... 
doi:10.1093/ehjci/jey135 pmid:30358845 pmcid:PMC6343081 fatcat:udijuvidkbgczcnegyl5bkznba

Herceptin-Mediated Cardiotoxicity: Assessment by Cardiovascular Magnetic Resonance

Jin Jiang, Boyang Liu, Sandeep S Hothi, Francesco Paciullo
2022 Cardiology Research and Practice  
Herceptin (trastuzumab) is a recombinant, humanized, monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and is used in the treatment of HER2-positive breast and gastric  ...  However, due to limited availability, it is not routinely used in the serial assessment of cardiac function in patients receiving trastuzumab.  ...  motherapy: a prospective study using novel cardiac imaging [57] E. A. Perez, C. Barrios, W.  ... 
doi:10.1155/2022/1910841 pmid:35265371 pmcid:PMC8898877 fatcat:xqhiu6hxlrhbvak4wv4efao5hy

New and developing therapies for AL amyloidosis

Giulia Zumbo, Omid Sadeghi-Alavijeh, Philip N. Hawkins, Marianna Fontana
2016 Expert Opinion on Pharmacotherapy  
It has become clear that the best prospects of survival and preservation or improvement in amyloid related organ function require as near complete suppression as possible of the underlying hematological  ...  Diagnosis requires demonstration of amyloid deposition and confirmation of the fibril protein type.  ...  CMR, after the administration of contrast, shows a characteristic pattern of global subendocardial late gadolinium enhancement (LGE) coupled with abnormal myocardial and blood-pool gadolinium kinetics  ... 
doi:10.1080/14656566.2016.1274971 pmid:28002971 fatcat:4cms3icokjgqvkpheqjdxz4mlu

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

Roger Stupp, Monika E Hegi, Thierry Gorlia, Sara C Erridge, James Perry, Yong-Kil Hong, Kenneth D Aldape, Benoit Lhermitte, Torsten Pietsch, Danica Grujicic, Joachim Peter Steinbach, Wolfgang Wick (+25 others)
2014 The Lancet Oncology  
METHODS In this multicentre, open-label, phase 3 study, we investigated the efficacy of cilengitide in patients from 146 study sites in 25 countries.  ...  None of the predefined clinical subgroups showed a benefit from cilengitide. We noted no overall additional toxic effects with cilengitide treatment.  ...  Acknowledgements The authors would like to thank patients for their trust and participation, and their family members for the provided support and care.  ... 
doi:10.1016/s1470-2045(14)70379-1 pmid:25163906 fatcat:wq5bz4lhsvgtbcoforyge4etae

ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detections of complications

Christian Maaser, Andreas Sturm, Stephan R Vavricka, Torsten Kucharzik, Gionata Fiorino, Vito Annese, Emma Calabrese, Daniel C Baumgart, Dominik Bettenworth, Paula Borralho Nunes, Johan Burisch, Fabiana Castiglione (+18 others)
2018 Journal of Crohn's & Colitis  
The diagnosis of CD or UC is based on a combination of clinical, biochemical, stool, endoscopic, cross-sectional imaging, and histological investigations [EL5]  ...  A single reference standard for the diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) does not exist.  ...  The use of luminal contrast and anti-peristaltic agents is recommended for CT enterography and MR enterography [347] .  ... 
doi:10.1093/ecco-jcc/jjy113 pmid:30137275 fatcat:lw2suuka5ratpkadxsr7yyeilm

Utility of Non-invasive Cardiac Imaging Assessment in Coronavirus Disease 2019

Sandeep S. Hothi, Jin Jiang, Richard P. Steeds, William E. Moody
2021 Frontiers in Cardiovascular Medicine  
Non-invasive cardiac imaging has a well-established role in assessing cardiac structure and function in a wide range of cardiac diseases.  ...  Coronavirus disease 2019 (COVID-19) was initially regarded as a disease of the lungs, which manifests as an acute respiratory illness and pneumonia, although more recently cardiac complications have been  ...  In a multicentre, prospective, observational study of 79 adults hospitalised with COVID-19 pneumonia, echo was performed during admission and at 3 months follow-up (52) .  ... 
doi:10.3389/fcvm.2021.663864 pmid:34095253 pmcid:PMC8175983 fatcat:425um35s2vgc5gd77555u2tuom

Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis [article]

Einar August Høgestøl, Gro Owren Nygaard, Petter Espeseth Emhjellen, Tobias Kaufmann, Mona Kristiansen Beyer, Piotr Sowa, Ole Andreas Andreassen, Elisabeth Gulowsen Celius, Nils Inge Landrø, Lars Tjelta Westlye, Hanne Flinstad Harbo
2019 biorxiv/medrxiv   pre-print
Associations between brain age gap and cognitive performance were assessed using linear mixed effects (LME) models and corrected for multiple testing.  ...  Methods: A group of 76 MS patients (mean age 34 years, 71% females, 96% relapsing-remitting) was examined 1, 2 and 5 years after diagnosis.  ...  We acknowledge the collaboration with members of the Multiple Sclerosis Research Group at the University of Oslo and Oslo University hospital, especially Professor Elisabeth G. Celius.  ... 
doi:10.1101/651521 fatcat:h46va3z6r5cwdicg4daues7odm

Machine learning and glioma imaging biomarkers

T.C. Booth, M. Williams, A. Luis, J. Cardosa, A. Keyoumars, H. Shuaib
2019 Clinical Radiology  
Differentiating a treatment response from a post-treatment-related effect using imaging is clinically important and also an area of active study (described here in one of two Special Issue publications  ...  Using carefully chosen image features, ML is frequently used to allow accurate classification in a variety of scenarios.  ...  Indeed, when the maximal perpendicular cross-sectional dimensions of Figure 1 The phases of radiomics are shown using explicit feature engineering.  ... 
doi:10.1016/j.crad.2019.07.001 pmid:31371027 pmcid:PMC6927796 fatcat:l2epcua3rrdgdowqupwd4cegz4
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