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Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome

Burkhard Pleger, Patrick Ragert, Peter Schwenkreis, Ann-Freya Förster, Claudia Wilimzig, Hubert Dinse, Volkmar Nicolas, Christoph Maier, Martin Tegenthoff
2006 NeuroImage  
We conclude that patterns of cortical reorganization in SI and SII seem to parallel impaired tactile discrimination.  ...  In the complex regional pain syndrome (CRPS), several theories proposed the existence of pathophysiological mechanisms of central origin.  ...  We thank Sonja Sellenmerten for data collection and Steve Langan for his skilful editing of the manuscript.  ... 
doi:10.1016/j.neuroimage.2006.03.045 pmid:16753306 fatcat:dwygqul6krfdxmrxh77dfyxdx4

Sensorimotor returning in complex regional pain syndrome parallels pain reduction

Burkhard Pleger, Martin Tegenthoff, Patrick Ragert, Ann-Freya Förster, Hubert R. Dinse, Peter Schwenkreis, Volkmar Nicolas, Christoph Maier
2005 Annals of Neurology  
This suggests that the reversal of tactile impairment and cortical reorganization in CRPS is associated with a decrease in pain.  ...  Patients with complex regional pain syndrome (CRPS) and intractable pain showed a shrinkage of cortical maps on primary (SI) and secondary somatosensory cortex (SII) contralateral to the affected limb.  ...  This research was supported by the Bundesministerium für Bildung und Forschung (Network "Neuropathic Pain" BMBF, 01EM0102). We thank Mr. Steve Langan for his skillful editing of this manuscript.  ... 
doi:10.1002/ana.20394 pmid:15732114 fatcat:bvqcvs6as5eerh7pk6wq4krcyy

Role of distorted body image in pain

Martin Lotze, G. Lorimer Moseley
2007 Current Rheumatology Reports  
In this review, we examine the literature relating to body image distortion in people with pain, and we discuss three themes: 1) evidence of distorted body image in people with pain; 2) evidence of distortion  ...  of the neural representations of body image held in primary sensory and primary motor cortex; and 3) clinical findings that correlate with distorted body image, distorted neural representation, or both  ...  This project was supported by a grant of the Ministry of Research and Education in Germany (BMBF), project number 01EM0505.  ... 
doi:10.1007/s11926-007-0079-x pmid:18177603 fatcat:h557nflj75egpgzb6xjtwghbji

Assessing tactile acuity in rheumatology and musculoskeletal medicine—how reliable are two-point discrimination tests at the neck, hand, back and foot?

Mark J. Catley, Abby Tabor, Benedict M. Wand, G. Lorimer Moseley
2013 Rheumatology  
Chronic pain from rheumatic and musculoskeletal conditions is associated with cortical changes and altered tactile acuity.  ...  Tactile acuity is considered a clinical signature of primary somatosensory representation. The two-point discrimination (TPD) threshold is increasingly used both clinically and in research.  ...  Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome. Neuroimage 2006;32:50310. 7 Pleger B, Tegenthoff M, Ragert P et al.  ... 
doi:10.1093/rheumatology/ket140 pmid:23611918 fatcat:yzubxfuzffflzj2cu4pvvas42y

Immobilization Impairs Tactile Perception and Shrinks Somatosensory Cortical Maps

Silke Lissek, Claudia Wilimzig, Philipp Stude, Burkhard Pleger, Tobias Kalisch, Christoph Maier, Sören A. Peters, Volkmar Nicolas, Martin Tegenthoff, Hubert R. Dinse
2009 Current Biology  
As demonstrated of blind Braille readers and musicians, long-lasting and exceptional usage of the fingers results in the development of outstanding sensorimotor skills and in expansions of the cortical  ...  reorganization of the somatosensory cortex in an otherwise intact nervous system.  ...  In patients with complex regional pain syndrome (CRPS) and intractable pain, cortical maps on the primary (SI) and secondary somatosensory cortex (SII) contralateral to the affected limb have been reported  ... 
doi:10.1016/j.cub.2009.03.065 pmid:19398335 fatcat:yc3nuf4oczcelfhqiarmpeceqe

Temporomandibular Disorder Modifies Cortical Response to Tactile Stimulation

Mary Beth Nebel, Stephen Folger, Mark Tommerdahl, Mark Hollins, Francis McGlone, Gregory Essick
2010 Journal of Pain  
Understanding the complexity of sensory disruption in chronic pain could lead to improved methods for assessing cerebral cortical function in these patients.  ...  Activation of the amygdala in our TMD group could reflect the establishment of aversive associations with tactile stimulation due to the persistence of pain.  ...  Monbureau and Mike Young for technical assistance.  ... 
doi:10.1016/j.jpain.2010.02.021 pmid:20462805 pmcid:PMC2943972 fatcat:32pctrddwnaw7d7oad7iet2fsm

最近話題の疼痛に関する診断機器と治療機器 機能的脳画像診断機器
Functional Brain Imaging Device of Pain

Mikio Fukui, Narihito Iwashita
2010 Iryou kikigaku (The Japanese journal of medical instrumentation)  
Patterns of cortical reorganization parallel impaired tactile discrimination and pain inten-sity in complex regional pain syndrome, Neuroimage. 2006, Vol. 32, No. 2, p. 503-510. 11)Fukui S.; Matsuno M.  ...  Evaluation of brain metabolite in patients with complex regional pain syndrome by MR spectroscopy, Pain Research. 2010, Vol. 25, No. 1, p. 37-43. 21)Sprenger T.; Valet M.; Boecker H. et al.  ... 
doi:10.4286/jjmi.80.217 fatcat:hcqec2tqi5fjhfe6g2drbdygqa

Clinical evidence of parietal cortex dysfunction and correlation with extent of allodynia in CRPS type 1

H. Cohen, C. McCabe, N. Harris, J. Hall, J. Lewis, D.R. Blake
2012 European Journal of Pain  
Unusual symptoms such as digit misidentification and neglect-like phenomena have been reported in complex regional pain syndrome (CRPS), which we hypothesized could be explained by parietal lobe dysfunction  ...  Six (27%) subjects failed six or more test categories and demonstrated new clinical signs consistent with their parietal testing impairments, which were impacting significantly on activities of daily living  ...  Acknowledgements We would like to thank and acknowledge all our patients and healthy volunteers who gave up their time so freely.  ... 
doi:10.1002/j.1532-2149.2012.00213.x pmid:23132624 fatcat:ng3opbmw5jdeznme3o6kzz767u

Tactile acuity is disrupted in osteoarthritis but is unrelated to disruptions in motor imagery performance

T. R. Stanton, C.-W. C. Lin, H. Bray, R. J. E. M. Smeets, D. Taylor, R. Y. W. Law, G. L. Moseley
2013 Rheumatology  
In painful knee OA, tactile acuity at the knee is decreased, implying disrupted representation of the knee in primary sensory cortex.  ...  To determine whether tactile acuity is disrupted in people with knee OA and to determine whether tactile acuity, a clinical signature of primary sensory cortex representation, is related to motor imagery  ...  Acknowledgements We thank Ruby Tsang for assisting with data collection and Barbara Toson, medical biostatistician, for her assistance with the statistical analysis. T.R.  ... 
doi:10.1093/rheumatology/ket139 pmid:23661429 fatcat:2xhbxug3u5ckjondwhqoxk7jca

An Update on the Pathophysiology of Complex Regional Pain Syndrome

Stephen Bruehl
2010 Anesthesiology  
Complex regional pain syndrome (CRPS) is a neuropathic pain disorder with significant autonomic features.  ...  url=/data/journals/jasa/931099/ on 10/18/2018 CGRP ϭ calcitonin gene-related peptide; CRPS ϭ complex regional pain syndrome; SNS ϭ sympathetic nervous system; TNF ϭ tumor necrosis factor.  ...  ., Professor of Radiology and Radiologic Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, for his comments regarding the brain imaging portion of this review.  ... 
doi:10.1097/aln.0b013e3181e3db38 pmid:20693883 fatcat:dlhxz2jag5dyxarfclun5woftq

Nociceptive Processing in the Cerebral Cortex [chapter]

R.D. Treede, A.V. Apkarian
2008 The Senses: A Comprehensive Reference  
As an example, we discuss one study which attempted to identify brain activity in complex regional pain syndrome (CRPS) patients using fMRI (Apkarian, A. V. et al., 2001a; 2001b) .  ...  cortical activation pattern in each and every healthy subject.  ... 
doi:10.1016/b978-012370880-9.00188-2 fatcat:lcynngvpnrg3hlgtkuqgzxtxyu

The Stochastic Entanglement and Phantom Motor Execution Hypotheses: A Theoretical Framework for the Origin and Treatment of Phantom Limb Pain

Max Ortiz-Catalan
2018 Frontiers in Neurology  
Stochastic entanglement of the pain neurosignature, or connectome, with impaired sensorimotor circuitry is proposed as an alternative hypothesis for the genesis of PLP, and the implications and predictions  ...  The proposed stochastic entanglement hypothesis of PLP can be generalized to neuropathic pain due to sensorimotor impairment, and can be used to design suitable therapeutic treatments.  ...  In addition, somatosensory cortical reorganization has been observed in other conditions such as complex regional pain syndrome (CRPS) (34) , and carpal tunnel syndrome (35) .  ... 
doi:10.3389/fneur.2018.00748 pmid:30237784 pmcid:PMC6135916 fatcat:x4kjflfgvvbxldys654cowkwsi

Sub-Optimal Learning of Tactile-Spatial Predictions in Patients with Complex Regional Pain Syndrome [article]

Christopher A Brown, Ingrid Scholtes, Nicholas Shenker, Michael C Lee
2019 biorxiv/medrxiv   pre-print
In Complex Regional Pain Syndrome (CRPS), tactile sensory deficits have motivated the therapeutic use of sensory discrimination training.  ...  It is unknown whether the learning of such statistical regularities is impaired in CRPS.  ...  ACKNOWLEDGEMENTS 21 The authors would like to thank the participants in this study. We acknowledge the support 22  ... 
doi:10.1101/775676 fatcat:kqxzlqig75fwjfiearezimsmxa

Towards a theory of chronic pain

A. Vania Apkarian, Marwan N. Baliki, Paul Y. Geha
2009 Progress in Neurobiology  
We also thank Elle Parks for commenting on earlier versions of this manuscript. This work was supported by NIH NINDS grants NS35115, NS53602, and NS57704.  ...  Acknowledgements The authors thank all the patients and volunteers who have contributed to the science we have generated over the last decade or so.  ...  changes in tactile sensations, tactile and postural hallucinations and increases in sensations of pain, tickle, warmth and cold.  ... 
doi:10.1016/j.pneurobio.2008.09.018 pmid:18952143 pmcid:PMC2650821 fatcat:dipjvabye5bmzcwakt6kjuz7ju

Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity

Liam Carroll, Sven Braeutigam, John M. Dawes, Zeljka Krsnik, Ivica Kostovic, Ester Coutinho, Jennifer M. Dewing, Christopher A. Horton, Diego Gomez-Nicola, David A. Menassa
2020 The Neuroscientist  
Some ASD cases are syndromic: associated with clinically defined patterns of somatic abnormalities and a neurobehavioral phenotype (e.g., Fragile X syndrome).  ...  ASDs manifest by deficits in social communication and interaction, restricted and repetitive patterns of behavior across multiple contexts, sensory abnormalities across multiple modalities and comorbidities  ...  For instance, genetic mutations in Mecp2, Frm1, and Shank3 all result in impairment of discriminate touch and hypersensitivity to tactile stimuli (Orefice and others 2016) .  ... 
doi:10.1177/1073858420921378 pmid:32441222 pmcid:PMC7804368 fatcat:q5brkhvga5ddhpf4yaouzxuuqu
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