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Parcellation of the human substantia nigra based on anatomical connectivity to the striatum

Rumana Chowdhury, Christian Lambert, Raymond J. Dolan, Emrah Düzel
2013 NeuroImage  
We acquired diffusion tensor imaging (DTI) with probabilistic tractography in 30 healthy older adults to determine whether subregions of the SN/VTA could be delineated based on anatomical connectivity  ...  We found that a dorsomedial region of the SN/VTA preferentially connected to the ventral striatum whereas a more ventrolateral region connected to the dorsal striatum.  ...  Conflict of Interest The authors have no conflicts of interest to declare. Appendix A.  ... 
doi:10.1016/j.neuroimage.2013.05.043 pmid:23684858 pmcid:PMC3734352 fatcat:ea3ahtaji5ffbog4cgcv5yomgm

Anatomical and functional organization of the human substantia nigra and its connections

Yu Zhang, Kevin Michel-Herve Larcher, Bratislav Misic, Alain Dagher
2017 eLife  
We investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project.  ...  We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement.  ...  The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Additional information  ... 
doi:10.7554/elife.26653 pmid:28826495 pmcid:PMC5606848 fatcat:ibc4jj3gqzegziibb5zf6qols4

Anatomical And Functional Organization Of The Human Substantia Nigra And Its Connections [article]

Yu Zhang, Kevin Larcher, Bratislav Misic, Alain Dagher
2017 bioRxiv   pre-print
We investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project.  ...  We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive and motor arrangement.  ...  Figure 1 . 1 Connectivity-based brain parcellation procedure.5 Figure 2 .Figure 8 . 28 Parcellation of Substantia Nigra based on anatomical connectivity profiles.  ... 
doi:10.1101/120857 fatcat:jvvb3zrz5zhfxdqatm54pkxseq

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease

Flavia Niccolini, Salman Haider, Tiago Reis Marques, Nils Muhlert, Andri C. Tziortzi, Graham E. Searle, Sridhar Natesan, Paola Piccini, Shitij Kapur, Eugenii A. Rabiner, Roger N. Gunn, Sarah J. Tabrizi (+1 others)
2015 Brain  
Connectivity-based analysis revealed prominent PDE10A decreases confined in the sensorimotor-striatum and in striatonigral and striatopallidal projecting segments.  ...  PDE10A expression in early premanifest Huntington's disease was decreased in striatum and pallidum and increased in motor thalamic nuclei, compared to a group of matched healthy controls.  ...  to this study.  ... 
doi:10.1093/brain/awv214 pmid:26198591 fatcat:kkkzryn4bjecpfxrpujitpwray

Comprehensive in vivo Mapping of the Human Basal Ganglia and Thalamic Connectome in Individuals Using 7T MRI

Christophe Lenglet, Aviva Abosch, Essa Yacoub, Federico De Martino, Guillermo Sapiro, Noam Harel, Krystof Bankiewicz
2012 PLoS ONE  
Also described are subject-specific parcellations of the basal ganglia and thalamus into sub-territories based on their distinct connectivity patterns.  ...  Capitalizing on the enhanced signal-to-noise ratio (SNR) and enriched contrast obtained at high-field MRI, detailed structural and connectivity representations of the human basal ganglia and thalamus were  ...  It was also used to parcellate the basal ganglia and thalamus into distinct subdivisions based on their connectivity profiles. Pathway identification.  ... 
doi:10.1371/journal.pone.0029153 pmid:22235267 pmcid:PMC3250409 fatcat:l62inpzesjgglj5ojqylia3yfi

Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans

Stéphane Lehéricy, Mathieu Ducros, Pierre-François Van De Moortele, Chantal Francois, Lionel Thivard, Cyril Poupon, Nick Swindale, Kamil Ugurbil, Dae-Shik Kim
2004 Annals of Neurology  
Diffusion tensor imaging-based fiber tracking showed that the posterior (sensorimotor), anterior (associative), and ventral (limbic) compartments of the human striatum have specific connections with the  ...  These results provide the first direct demonstration of distinct corticostriatal connections in humans.  ...  This study was supported by grants from the NIH (National Center for Research Resources, BTRR P41-RR008079, K.U.), the Keck Foundation, the Human Frontiers Science Program (K.U., D.S.K.), and the Inciting  ... 
doi:10.1002/ana.20030 pmid:15048891 fatcat:xoouy5ecm5fhrgcacl2t7dwscm

Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease

Aline Delva, Donatienne Van Weehaeghe, Michel Koole, Koen Van Laere, Wim Vandenberghe
2020 Movement Disorders  
The main objective of this study was to assess the magnitude and anatomical extent of presynaptic terminal loss across the brain in early PD.  ...  This loss of presynaptic boutons in the substantia nigra may reflect an axonal response to target deprivation or could possibly point to a trans-synaptic mode of propagation of the disease process. © 2020  ...  Jef Van Loock for their contribution to the scanning and data handling, the positron emission tomography radiopharmacy team, and the medical physics team of University Hospitals Leuven for their skilled  ... 
doi:10.1002/mds.28216 pmid:32767618 fatcat:w5ym6ln44bh6xbhbevyqe2xmaa

Differences in neural connectivity between the substantia nigra and ventral tegmental area in the human brain

Hyeok Gyu Kwon, Sung Ho Jang
2014 Frontiers in Human Neuroscience  
ACKNOWLEDGMENTS This work was supported by the DGIST R&D Program of the Ministry of Education, Science and Technology of Korea (14-BD-0401).  ...  Recently, Chowdhury et al. (2013) investigated the connectivity between the SN and the striatum by parcellation of the SN based on the anatomical connectivity to the striatum (Chowdhury et al., 2013  ...  (A) The region of interest (ROI): a seed ROI for substantia nigra (SN, orange), is placed on the isolated SN of the upper midbrain on the B0 and color-coded map (dorsomedially next to the cerebral peduncle  ... 
doi:10.3389/fnhum.2014.00041 pmid:24567711 pmcid:PMC3915097 fatcat:5otqorkndzcztiqgqiktt63rym

Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients

Gianpaolo Antonio Basile, Alessia Bramanti, Salvatore Bertino, Giuseppina Cutroneo, Antonio Bruno, Adriana Tisano, Giuseppe Paladina, Demetrio Milardi, Giuseppe Anastasi
2020 Medicina  
Anatomical research on primates suggests that these regions may be subdivided into distinct, topographically organized functional territories according to their connectivity to the striatum.  ...  Materials and Methods: A hypothesis-driven connectivity-based parcellation derived from diffusion tractography was applied on 24 healthy subjects and 30 schizophrenic patients to identify distinct territories  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/medicina56120686 pmid:33322072 pmcid:PMC7764101 fatcat:rznais7m4natplbtc7w7gswpde

Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates

Aron Emmi, Angelo Antonini, Veronica Macchi, Andrea Porzionato, Raffaele De Caro
2020 Frontiers in Neuroanatomy  
However, most of the anatomical evidence available derives from non-human primate studies.  ...  We will also highlight the importance of additional research in humans focused on validating STh connectivity, cytoarchitectural organization, and its functional subdivision.  ...  Nigral Connections With the STh Subthalamo-Nigral Projections Non-human Primate Studies The substantia nigra represents one of the main targets of the STh (Carpenter et al., 1981b; Parent and Smith  ... 
doi:10.3389/fnana.2020.00013 pmid:32390807 pmcid:PMC7189217 fatcat:yai2lbtmcnd4dewvh4zomo4ar4

In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI

Marta Bianciardi, Nicola Toschi, Cornelius Eichner, Jonathan R. Polimeni, Kawin Setsompop, Emery N. Brown, Matti S. Hämäläinen, Bruce R. Rosen, Lawrence L. Wald
2016 Magnetic Resonance Materials in Physics, Biology and Medicine  
Object-To map the in vivo human functional connectivity of several brainstem nuclei with the rest of the brain by using seed-based correlation of ultra-high magnetic field functional magnetic resonance  ...  Results-The delineated Pearson's correlation-based functional connectivity diagrams (connectomes) of 11 brainstem nuclei of the ascending arousal, motor and autonomic systems from 12 controls are presented  ...  Acknowledgments This work was supported by these sources of funding: NIH NIBIB P41-RR014075, NIH NCRR S10-RR023043 and S10-RR023401.  ... 
doi:10.1007/s10334-016-0546-3 pmid:27126248 pmcid:PMC4892960 fatcat:a4qpgmc5v5emhpptlzyent5nym

Functional imaging of the human dopaminergic midbrain

Emrah Düzel, Nico Bunzeck, Marc Guitart-Masip, Bianca Wittmann, Bjoern H. Schott, Philippe N. Tobler
2009 Trends in Neurosciences  
Invasive recording of dopamine neurons in the substantia nigra and ventral tegmental area (SN/VTA) of behaving animals suggests a role for these neurons in reward learning and novelty processing.  ...  We consider the anatomical and functional parcellation of the primate SN/VTA and find that its homogeneity suggests little variation in the regional specificity of fMRI signals for reward-related dopaminergic  ...  First, we focus on the functional-anatomical parcellation of the SN/VTA and the species differences of this parcellation.  ... 
doi:10.1016/j.tins.2009.02.005 pmid:19446348 fatcat:dnx2we2ut5ajdfuvsqzlhhknz4

Cerebral hemisphere regulation of motivated behavior11Published on the World Wide Web on 2 November 2000

Larry W. Swanson
2000 Brain Research  
paraventricular, ventromedial, and premammillary nuclei, the mammillary body, and finally the substantia nigra and ventral tegmental area.  ...  The goals of this article are to suggest a basic wiring diagram for the motor neural network that controls motivated behavior, and to provide a model for the organization of cerebral hemisphere inputs  ...  The oldest approach is based on the gross anatomy of lateral septal complex; MEA, medial nucleus amygdala; OT, olfactory the adult human brain, and it is easy to trace the first major tubercle; SI, substantia  ... 
doi:10.1016/s0006-8993(00)02905-x pmid:11119693 fatcat:7v6qom7zvvfrnoizhpxbux7ncm

Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography

Xiaoluan Xia, Lingzhong Fan, Bing Hou, Baogui Zhang, Dan Zhang, Chen Cheng, Hongxia Deng, Yunyun Dong, Xudong Zhao, Haifang Li, Tianzi Jiang
2019 Frontiers in Neuroscience  
In this study, high-resolution ex vivo macaque brain diffusion MRI data were acquired to investigate the tractography-based parcellation of the Acb.  ...  Furthermore, we characterized the specific anatomical and functional connectivity profiles of these Acb subregions and generalized their specialized functions to establish a fine-grained macaque Acb brainnetome  ...  AUTHOR CONTRIBUTIONS TJ and HL conceived and designed the study. BH, BZ, DZ, and XZ acquired and checked the data. XX, LF, CC, HD, and YD performed research and analyzed the data.  ... 
doi:10.3389/fnins.2019.00709 pmid:31354418 pmcid:PMC6635473 fatcat:qph3tbo2urbrpecvkgdfagstyy

Fronto-striatal organization: Defining functional and microstructural substrates of behavioural flexibility

Laurel S. Morris, Prantik Kundu, Nicholas Dowell, Daisy J. Mechelmans, Pauline Favre, Michael A. Irvine, Trevor W. Robbins, Nathaniel Daw, Edward T. Bullmore, Neil A. Harrison, Valerie Voon
2016 Cortex  
to the striatum and striatal projections through the direct and indirect basal ganglia circuit.  ...  We demonstrate distinct limbic (ventromedial prefrontal regions, ventral striatum e VS, ventral tegmental area e VTA), motor (supplementary motor areas e SMAs, putamen, substantia nigra) and cognitive  ...  He is or has been in receipt of research grants from Lundbeck, Eli Lilly and GSK and is an editor for Springer-Verlag (Psychopharmacology).  ... 
doi:10.1016/j.cortex.2015.11.004 pmid:26673945 pmcid:PMC4729321 fatcat:4fgr3vxtr5hehifsde47xfgiwy
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