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Clinical Clues of Pre-Symptomatic Pancreatic Ductal Adenocarcinoma Prior to Its Diagnosis: A Retrospective Review of CT Scans and Laboratory Tests

Hwe Hoon Chung, Kyung Sook Lim, Joo Kyung Park
2022 Clinics and Practice  
We tried to find out useful clinical clues of pre-symptomatic area prior to pancreatic cancer diagnosis compared to normal controls.  ...  Most pancreatic ductal adenocarcinoma cases are unresectable at the time of diagnosis. Only early diagnosis and curative resection can help prolong survival.  ...  The study patients were evaluated for clinical changes and CT scans 36, 24, 12 and 6 months prior to pancreatic cancer diagnosis.  ... 
doi:10.3390/clinpract12010008 pmid:35076498 pmcid:PMC8788273 fatcat:wbogzhbrxbgkvagnoacfagzabu

Prognostic Predicting Role of Contrast-Enhanced Computed Tomography for Locally Advanced Pancreatic Adenocarcinoma

Chien-shan Cheng, Wei Liu, Liangping Zhou, Wei Tang, Ailing Zhong, Zhiqiang Meng, Lianyu Chen, Zhen Chen
2019 BioMed Research International  
However, the value of semiquantitative and quantitative assessments of CECT parameters used to predict survival in PAC remains unknown.  ...  Our results showed that TER can be used to predict survival in LAPAC, and we developed a nomogram for determining the prognosis of patients with LAPAC.  ...  Our results suggest that pretreatment CECT scans can be used to predict survival in advance pancreatic cancer.  ... 
doi:10.1155/2019/1356264 pmid:31886169 pmcid:PMC6899328 fatcat:zaeoygycgjgu7h3tyjbcjzuwwe

A Bio-Imaging Signature as a Predictor of Clinical Outcomes in Locally Advanced Pancreatic Cancer

Michele Fiore, Silvia Taralli, Pasquale Trecca, Valentina Scolozzi, Luca Marinelli, Elizabeth K. A. Triumbari, Damiano Caputo, Silvia Angeletti, Massimo Ciccozzi, Alessandro Coppola, Carlo Greco, Edy Ippolito (+3 others)
2020 Cancers  
Purpose: To evaluate the predictive value of 18F-FDG PET/CT semiquantitative parameters of the primary tumour and CA 19-9 levels assessed before treatment in patients with locally advanced pancreatic cancer  ...  (LP) and overall survival (OS).  ...  mainly polarised on the association between PET/CT variables and survival.  ... 
doi:10.3390/cancers12082016 pmid:32717967 fatcat:3vptbaflarhjjayol4btsn2j5a

Prognostic value of SUVmax measured by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography in Patients with Pancreatic Cancer

Jae Pil Hwang, Ilhan Lim, Kyoung Jin Chang, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
2012 Nuclear medicine and molecular imaging  
factors in patients with pancreatic cancer.  ...  The relationship between FDG uptake and survival was analyzed using the Kaplan-Meier with log-Rank test and Cox's proportionalhazard regression methods.  ...  Schellenberg et. al. evaluated 55 locally advanced pancreatic cancer patients undergoing radiotherapy, and also showed that clinical SUVmax independently predicts overall survival and progression-free  ... 
doi:10.1007/s13139-012-0151-y pmid:24900062 pmcid:PMC4043042 fatcat:4dno67jo75ds3opouxzntjh3ya

Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18F-FDG PET/CT in patients with pancreatic cancer

Jeong Won Lee, Chang Moo Kang, Sang Mi Lee, Jae-Hoon Lee, Jong Doo Lee
2014 Journal of Clinical Oncology  
Conclusion: MTV and TLG are independent prognostic factors for predicting RFS and OS in patients with pancreatic cancer.  ...  Thus, 18 F-FDG PET/CT can provide useful prognostic information for patients undergoing resection of pancreatic cancer with curative intent irrespective of neoadjuvant treatment.  ...  be used to predict clinical outcomes before surgery.  ... 
doi:10.1200/jco.2014.32.3_suppl.190 fatcat:foeqfdmx3jh53emxixvccqtgfy

Maximum Standard Uptake Value as a Clinical Biomarker for Detecting Loss of SMAD4 Expression and Early Systemic Tumor Recurrence in Resected Left-Sided Pancreatic Cancer

Chang Moo Kang, Ho Kyoung Hwang, Jiae Park, Changsoo Kim, Seong-Kyoung Cho, Mijin Yun, Woo Jung Lee
2016 Medicine  
SUV max can predict loss of SMAD4 in resected left-sided pancreatic cancer. SUV max may be a clinical biomarker for detecting loss of SMAD4 expression and predicting early systemic metastasis.  ...  This study investigated the oncologic impact of loss of SMAD4 expression in resected left-sided pancreatic cancer and its correlation with tumor metabolism.  ...  The signal intensity of FDG-uptake in preoperative PET-CT scan is related to SMAD4 expression in resected left-sided pancreatic cancer.  ... 
doi:10.1097/md.0000000000003452 pmid:27124039 pmcid:PMC4998702 fatcat:xe26i3jquzb4hhf6q2hbpp6ipy

Prognostic Significance of Volume-Based FDG PET/CT Parameters in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiation Therapy

Hye Jin Choi, Jeong Won Lee, Beodeul Kang, Si Young Song, Jong Doo Lee, Jae-Hoon Lee
2014 Yonsei medical journal  
Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of primary pancreatic cancers were measured on FDG PET/CT scans.  ...  pancreatic cancer (LAPC) treated with chemoradiation therapy (CRT).  ...  cancer lesions measured on pretreatment FDG PET/CT scans can help to predict survival outcomes in patients with pancreatic cancer  ... 
doi:10.3349/ymj.2014.55.6.1498 pmid:25323885 pmcid:PMC4205688 fatcat:fmczkbxtnvh3xd36iogj2wuz2m

Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients with Pancreatic Cancer

J. W. Lee, C. M. Kang, H. J. Choi, W. J. Lee, S. Y. Song, J.-H. Lee, J. D. Lee
2014 Journal of Nuclear Medicine  
Conclusion: MTV and TLG are independent prognostic factors for predicting RFS and OS in patients with pancreatic cancer.  ...  Thus, 18 F-FDG PET/CT can provide useful prognostic information for patients undergoing resection of pancreatic cancer with curative intent irrespective of neoadjuvant treatment.  ...  To date, there has been only 1 study that has evaluated the use of volumetric parameters on 18 F-FDG PET/CT for predicting clinical outcomes in patients with pancreatic cancer (19) . Parlak et al.  ... 
doi:10.2967/jnumed.113.131847 pmid:24711649 fatcat:ndevh37ub5dqvc6rlqsrfq2dlm

Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection

Gabin Yun, Young Hoon Kim, Yoon Jin Lee, Bohyoung Kim, Jin-Hyeok Hwang, Dong Joon Choi
2018 Scientific Reports  
/scientificreports/ 2 ScieNtific REPORTs | (2018) 8:7226 | cancer measured on preoperative CT images might be useful for predicting the clinical outcome of patients with pancreas head cancer after curative  ...  The value of image based texture features as a powerful method to predict prognosis and assist clinical management in cancer patients has been established recently.  ...  We speculate that pancreatic head cancer with a lower average may reflect an imaging phenotype 40 , who demonstrated that hypo-attenuating pancreatic cancer in the portal-venous phase on CT scans showed  ... 
doi:10.1038/s41598-018-25627-x pmid:29740111 pmcid:PMC5940761 fatcat:mmcqx7p77baitkvale6ahiijwq

Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Exhibit Differential Growth and Metabolic Patterns in the Pre-Diagnostic Period: Implications for Early Detection

Mohamed Zaid, Dalia Elganainy, Prashant Dogra, Annie Dai, Lauren Widmann, Pearl Fernandes, Zhihui Wang, Maria J. Pelaez, Javier R. Ramirez, Aatur D. Singhi, Anil K. Dasyam, Randall E. Brand (+11 others)
2020 Frontiers in Oncology  
, we evaluated 55 patients who developed PDAC as a second primary cancer and underwent serial pre-diagnostic (T0) and diagnostic (T1) CT-scans.  ...  BackgroundPreviously, we characterized subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed-tomography (CT) scans, whereby conspicuous (high delta) PDAC tumors are more likely to have aggressive  ...  FUNDING We gratefully acknowledge support from the Andrew Sabin Family Fellowship, the Sheikh Ahmed Center for Pancreatic Cancer Research, institutional funds from The University of Texas MD Anderson Cancer  ... 
doi:10.3389/fonc.2020.596931 pmid:33344245 pmcid:PMC7738633 fatcat:hgg7wqdirfg3bf6e4ex2tfzcxu

Quantitative Imaging Biomarkers of the Whole Liver Tumor Burden Improve Survival Prediction in Metastatic Pancreatic Cancer

Leonie Gebauer, Jan H. Moltz, Alexander Mühlberg, Julian W. Holch, Thomas Huber, Johanna Enke, Nils Jäger, Michael Haas, Stephan Kruger, Stefan Boeck, Michael Sühling, Alexander Katzmann (+5 others)
2021 Cancers  
Finding prognostic biomarkers with high accuracy in patients with pancreatic cancer (PC) remains a challenging problem.  ...  These combined clinical and imaging-based models have significantly higher predictive performance in discriminating survival than the underlying clinical models alone (p < 0.003).  ...  WLTB Segmentations and QIBs Only contrast-enhanced CT scans were used for further evaluation. All CT scans were reviewed blinded to clinical data independently in a randomized manner.  ... 
doi:10.3390/cancers13225732 pmid:34830885 pmcid:PMC8616514 fatcat:eb3hrqfryjgyrpdtc4kal7ceay

Computed Tomography Radiomics Signatures: Sensitive biomarkers for clinical decision support in pancreatic cancer- a pilot study [article]

Abbas Habibalahi, Daniel Moses, Jared Campbell, Saabah Mahbub, Andrew Barbour, Jaswinder Samra, Koroush Haghighi, Val Gebski, David Goldstein, Ewa Goldys
2021 medRxiv   pre-print
These signatures have the potential to be used to support clinical decision-making in pancreatic cancer treatment.  ...  Aim: To evaluate if suitably designed computed tomography (CT) radiomic signatures are sensitive to tumour transformation, and able to predict disease free survival (DFS) and overall survival (OS) time  ...  Relatively few investigations of the use of CT radiomic features for pancreatic cancer prognostics have considered multivariate models.  ... 
doi:10.1101/2021.12.03.21267217 fatcat:27nzx53bvvbgpg3ltfwt6apdk4

Prevalence and significance of subcentimeter hepatic lesions in patients with localized pancreatic adenocarcinoma

Shereef M. Elnahal, Atul B. Shinagare, Jackie Szymonifka, Theodore S. Hong, Peter C. Enzinger, Harvey J. Mamon
2012 Practical Radiation Oncology  
Using Cox regression, we calculated adjusted hazard ratios (HR) to determine the association between presence of liver and pulmonary lesions and overall survival.  ...  Objectives-To determine the prevalence and significance of incidental hepatic and pulmonary sub-centimeter lesions in patients with localized pancreatic cancer.  ...  While sub-centimeter lesions were quite common in our cohort of patients with pancreatic cancer, their appearance was variable and often ambiguous.  ... 
doi:10.1016/j.prro.2012.02.004 pmid:24674191 pmcid:PMC4350367 fatcat:32omfmi2andhtpf5zoz4zq4iti

Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer

B. H.L. Tan, L. A. Birdsell, L. Martin, V. E. Baracos, K. C.H. Fearon
2009 Clinical Cancer Research  
Conclusions: Sarcopenia in overweight/obese patients with advanced pancreatic cancer is an occult condition but can be identified using CT scans.  ...  Purpose: The average weight-losing pancreatic cancer patient undergoing palliative therapy is frequently overweight rather than underweight, and this can confound conventional measures used for risk stratification  ...  CT image analysis. CT scans used for analysis were done solely for routine cancer care.  ... 
doi:10.1158/1078-0432.ccr-09-1525 pmid:19887488 fatcat:lhglqazn7ndllluyjniiued5gm

Prognostic Evaluation Based on Dual-Time 18F-FDG PET/CT Radiomics Features in Patients with Locally Advanced Pancreatic Cancer Treated by Stereotactic Body Radiation Therapy

Fei Wang, Chao Cheng, Shengnan Ren, Zhongyi Wu, Tao Wang, Xiaodong Yang, Changjing Zuo, Zhuangzhi Yan, Zhaobang Liu, Dong-Hua Yang
2022 Journal of Oncology  
Materials and Methods. This retrospective study included 70 LAPC patients who received early and delayed 18F-FDG PET/CT scans before SBRT treatment.  ...  Purpose is to explore the prognostic value of radiomics features from dual-time 18F-FDG PET/CT images for locally advanced pancreatic cancer (LAPC) patients treated with stereotactic body radiation therapy  ...  #62101551 and the "Climbing" program-234 plan of Changhai Hospital #2019YPT002.  ... 
doi:10.1155/2022/6528865 pmid:35874634 pmcid:PMC9303166 fatcat:76jjzpph35dxdarqjnwy7wpnai
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