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Clinical Clues of Pre-Symptomatic Pancreatic Ductal Adenocarcinoma Prior to Its Diagnosis: A Retrospective Review of CT Scans and Laboratory Tests
2022
Clinics and Practice
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We tried to find out useful clinical clues of pre-symptomatic area prior to pancreatic cancer diagnosis compared to normal controls. ...
Most pancreatic ductal adenocarcinoma cases are unresectable at the time of diagnosis. Only early diagnosis and curative resection can help prolong survival. ...
The study patients were evaluated for clinical changes and CT scans 36, 24, 12 and 6 months prior to pancreatic cancer diagnosis. ...
doi:10.3390/clinpract12010008
pmid:35076498
pmcid:PMC8788273
fatcat:wbogzhbrxbgkvagnoacfagzabu
Prognostic Predicting Role of Contrast-Enhanced Computed Tomography for Locally Advanced Pancreatic Adenocarcinoma
2019
BioMed Research International
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However, the value of semiquantitative and quantitative assessments of CECT parameters used to predict survival in PAC remains unknown. ...
Our results showed that TER can be used to predict survival in LAPAC, and we developed a nomogram for determining the prognosis of patients with LAPAC. ...
Our results suggest that pretreatment CECT scans can be used to predict survival in advance pancreatic cancer. ...
doi:10.1155/2019/1356264
pmid:31886169
pmcid:PMC6899328
fatcat:zaeoygycgjgu7h3tyjbcjzuwwe
A Bio-Imaging Signature as a Predictor of Clinical Outcomes in Locally Advanced Pancreatic Cancer
2020
Cancers
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Purpose: To evaluate the predictive value of 18F-FDG PET/CT semiquantitative parameters of the primary tumour and CA 19-9 levels assessed before treatment in patients with locally advanced pancreatic cancer ...
(LP) and overall survival (OS). ...
mainly polarised on the association between PET/CT variables and survival. ...
doi:10.3390/cancers12082016
pmid:32717967
fatcat:3vptbaflarhjjayol4btsn2j5a
Prognostic value of SUVmax measured by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography in Patients with Pancreatic Cancer
2012
Nuclear medicine and molecular imaging
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factors in patients with pancreatic cancer. ...
The relationship between FDG uptake and survival was analyzed using the Kaplan-Meier with log-Rank test and Cox's proportionalhazard regression methods. ...
Schellenberg et. al. evaluated 55 locally advanced pancreatic cancer patients undergoing radiotherapy, and also showed that clinical SUVmax independently predicts overall survival and progression-free ...
doi:10.1007/s13139-012-0151-y
pmid:24900062
pmcid:PMC4043042
fatcat:4dno67jo75ds3opouxzntjh3ya
Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18F-FDG PET/CT in patients with pancreatic cancer
2014
Journal of Clinical Oncology
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Conclusion: MTV and TLG are independent prognostic factors for predicting RFS and OS in patients with pancreatic cancer. ...
Thus, 18 F-FDG PET/CT can provide useful prognostic information for patients undergoing resection of pancreatic cancer with curative intent irrespective of neoadjuvant treatment. ...
be used to predict clinical outcomes before surgery. ...
doi:10.1200/jco.2014.32.3_suppl.190
fatcat:foeqfdmx3jh53emxixvccqtgfy
Maximum Standard Uptake Value as a Clinical Biomarker for Detecting Loss of SMAD4 Expression and Early Systemic Tumor Recurrence in Resected Left-Sided Pancreatic Cancer
2016
Medicine
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SUV max can predict loss of SMAD4 in resected left-sided pancreatic cancer. SUV max may be a clinical biomarker for detecting loss of SMAD4 expression and predicting early systemic metastasis. ...
This study investigated the oncologic impact of loss of SMAD4 expression in resected left-sided pancreatic cancer and its correlation with tumor metabolism. ...
The signal intensity of FDG-uptake in preoperative PET-CT scan is related to SMAD4 expression in resected left-sided pancreatic cancer. ...
doi:10.1097/md.0000000000003452
pmid:27124039
pmcid:PMC4998702
fatcat:xe26i3jquzb4hhf6q2hbpp6ipy
Prognostic Significance of Volume-Based FDG PET/CT Parameters in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiation Therapy
2014
Yonsei medical journal
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Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of primary pancreatic cancers were measured on FDG PET/CT scans. ...
pancreatic cancer (LAPC) treated with chemoradiation therapy (CRT). ...
cancer lesions measured on pretreatment FDG PET/CT scans can help to predict survival outcomes in patients with pancreatic cancer ...
doi:10.3349/ymj.2014.55.6.1498
pmid:25323885
pmcid:PMC4205688
fatcat:fmczkbxtnvh3xd36iogj2wuz2m
Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients with Pancreatic Cancer
2014
Journal of Nuclear Medicine
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Conclusion: MTV and TLG are independent prognostic factors for predicting RFS and OS in patients with pancreatic cancer. ...
Thus, 18 F-FDG PET/CT can provide useful prognostic information for patients undergoing resection of pancreatic cancer with curative intent irrespective of neoadjuvant treatment. ...
To date, there has been only 1 study that has evaluated the use of volumetric parameters on 18 F-FDG PET/CT for predicting clinical outcomes in patients with pancreatic cancer (19) . Parlak et al. ...
doi:10.2967/jnumed.113.131847
pmid:24711649
fatcat:ndevh37ub5dqvc6rlqsrfq2dlm
Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection
2018
Scientific Reports
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/scientificreports/ 2 ScieNtific REPORTs | (2018) 8:7226 | cancer measured on preoperative CT images might be useful for predicting the clinical outcome of patients with pancreas head cancer after curative ...
The value of image based texture features as a powerful method to predict prognosis and assist clinical management in cancer patients has been established recently. ...
We speculate that pancreatic head cancer with a lower average may reflect an imaging phenotype 40 , who demonstrated that hypo-attenuating pancreatic cancer in the portal-venous phase on CT scans showed ...
doi:10.1038/s41598-018-25627-x
pmid:29740111
pmcid:PMC5940761
fatcat:mmcqx7p77baitkvale6ahiijwq
Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Exhibit Differential Growth and Metabolic Patterns in the Pre-Diagnostic Period: Implications for Early Detection
2020
Frontiers in Oncology
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, we evaluated 55 patients who developed PDAC as a second primary cancer and underwent serial pre-diagnostic (T0) and diagnostic (T1) CT-scans. ...
BackgroundPreviously, we characterized subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed-tomography (CT) scans, whereby conspicuous (high delta) PDAC tumors are more likely to have aggressive ...
FUNDING We gratefully acknowledge support from the Andrew Sabin Family Fellowship, the Sheikh Ahmed Center for Pancreatic Cancer Research, institutional funds from The University of Texas MD Anderson Cancer ...
doi:10.3389/fonc.2020.596931
pmid:33344245
pmcid:PMC7738633
fatcat:hgg7wqdirfg3bf6e4ex2tfzcxu
Quantitative Imaging Biomarkers of the Whole Liver Tumor Burden Improve Survival Prediction in Metastatic Pancreatic Cancer
2021
Cancers
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Finding prognostic biomarkers with high accuracy in patients with pancreatic cancer (PC) remains a challenging problem. ...
These combined clinical and imaging-based models have significantly higher predictive performance in discriminating survival than the underlying clinical models alone (p < 0.003). ...
WLTB Segmentations and QIBs Only contrast-enhanced CT scans were used for further evaluation. All CT scans were reviewed blinded to clinical data independently in a randomized manner. ...
doi:10.3390/cancers13225732
pmid:34830885
pmcid:PMC8616514
fatcat:eb3hrqfryjgyrpdtc4kal7ceay
Computed Tomography Radiomics Signatures: Sensitive biomarkers for clinical decision support in pancreatic cancer- a pilot study
[article]
2021
medRxiv
pre-print
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These signatures have the potential to be used to support clinical decision-making in pancreatic cancer treatment. ...
Aim: To evaluate if suitably designed computed tomography (CT) radiomic signatures are sensitive to tumour transformation, and able to predict disease free survival (DFS) and overall survival (OS) time ...
Relatively few investigations of the use of CT radiomic features for pancreatic cancer prognostics have considered multivariate models. ...
doi:10.1101/2021.12.03.21267217
fatcat:27nzx53bvvbgpg3ltfwt6apdk4
Prevalence and significance of subcentimeter hepatic lesions in patients with localized pancreatic adenocarcinoma
2012
Practical Radiation Oncology
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Using Cox regression, we calculated adjusted hazard ratios (HR) to determine the association between presence of liver and pulmonary lesions and overall survival. ...
Objectives-To determine the prevalence and significance of incidental hepatic and pulmonary sub-centimeter lesions in patients with localized pancreatic cancer. ...
While sub-centimeter lesions were quite common in our cohort of patients with pancreatic cancer, their appearance was variable and often ambiguous. ...
doi:10.1016/j.prro.2012.02.004
pmid:24674191
pmcid:PMC4350367
fatcat:32omfmi2andhtpf5zoz4zq4iti
Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer
2009
Clinical Cancer Research
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Conclusions: Sarcopenia in overweight/obese patients with advanced pancreatic cancer is an occult condition but can be identified using CT scans. ...
Purpose: The average weight-losing pancreatic cancer patient undergoing palliative therapy is frequently overweight rather than underweight, and this can confound conventional measures used for risk stratification ...
CT image analysis. CT scans used for analysis were done solely for routine cancer care. ...
doi:10.1158/1078-0432.ccr-09-1525
pmid:19887488
fatcat:lhglqazn7ndllluyjniiued5gm
Prognostic Evaluation Based on Dual-Time 18F-FDG PET/CT Radiomics Features in Patients with Locally Advanced Pancreatic Cancer Treated by Stereotactic Body Radiation Therapy
2022
Journal of Oncology
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Materials and Methods. This retrospective study included 70 LAPC patients who received early and delayed 18F-FDG PET/CT scans before SBRT treatment. ...
Purpose is to explore the prognostic value of radiomics features from dual-time 18F-FDG PET/CT images for locally advanced pancreatic cancer (LAPC) patients treated with stereotactic body radiation therapy ...
#62101551 and the "Climbing" program-234 plan of Changhai Hospital #2019YPT002. ...
doi:10.1155/2022/6528865
pmid:35874634
pmcid:PMC9303166
fatcat:76jjzpph35dxdarqjnwy7wpnai
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